SI1718338T1 - Sestavki in metode za ciljno usmerjeno in vitro in in vivo dostavo zdravila v celice sesalcev preko bakterijsko pridobljenih intaktnih minicelic - Google Patents
Sestavki in metode za ciljno usmerjeno in vitro in in vivo dostavo zdravila v celice sesalcev preko bakterijsko pridobljenih intaktnih minicelicInfo
- Publication number
- SI1718338T1 SI1718338T1 SI200531990T SI200531990T SI1718338T1 SI 1718338 T1 SI1718338 T1 SI 1718338T1 SI 200531990 T SI200531990 T SI 200531990T SI 200531990 T SI200531990 T SI 200531990T SI 1718338 T1 SI1718338 T1 SI 1718338T1
- Authority
- SI
- Slovenia
- Prior art keywords
- vitro
- targeted
- compositions
- methods
- drug delivery
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
- A61K47/6879—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Botany (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54059004P | 2004-02-02 | 2004-02-02 | |
EP20050702361 EP1718338B1 (en) | 2004-02-02 | 2005-01-27 | Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
PCT/IB2005/000204 WO2005079854A1 (en) | 2004-02-02 | 2005-01-27 | Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1718338T1 true SI1718338T1 (sl) | 2015-09-30 |
Family
ID=34885947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200531990T SI1718338T1 (sl) | 2004-02-02 | 2005-01-27 | Sestavki in metode za ciljno usmerjeno in vitro in in vivo dostavo zdravila v celice sesalcev preko bakterijsko pridobljenih intaktnih minicelic |
Country Status (19)
Country | Link |
---|---|
US (3) | US9867785B2 (sl) |
EP (2) | EP1718338B1 (sl) |
JP (2) | JP5060787B2 (sl) |
CN (2) | CN102028953B (sl) |
AU (2) | AU2005215254B2 (sl) |
CA (2) | CA2788707C (sl) |
DK (2) | DK1718338T3 (sl) |
ES (2) | ES2765426T3 (sl) |
HK (1) | HK1155665A1 (sl) |
HR (1) | HRP20150828T8 (sl) |
HU (1) | HUE025292T2 (sl) |
ME (1) | ME02251B (sl) |
NZ (1) | NZ549139A (sl) |
PL (1) | PL1718338T3 (sl) |
PT (1) | PT1718338E (sl) |
RS (1) | RS54149B1 (sl) |
SG (3) | SG135174A1 (sl) |
SI (1) | SI1718338T1 (sl) |
WO (1) | WO2005079854A1 (sl) |
Families Citing this family (35)
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US9044381B2 (en) | 2003-06-24 | 2015-06-02 | Baxter International Inc. | Method for delivering drugs to the brain |
US8986736B2 (en) | 2003-06-24 | 2015-03-24 | Baxter International Inc. | Method for delivering particulate drugs to tissues |
CN102028953B (zh) | 2004-02-02 | 2013-10-30 | 恩杰内克分子递送有限公司 | 经细菌来源的完整微细胞在体外和体内将药物靶向递送至哺乳动物细胞的组合物和方法 |
JP2008502706A (ja) | 2004-06-15 | 2008-01-31 | バクスター・インターナショナル・インコーポレイテッド | 固体微粒子治療剤のエキソビボ適用 |
ES2535235T3 (es) | 2004-08-26 | 2015-05-07 | Engeneic Molecular Delivery Pty Ltd | Administración de ácidos nucleicos funcionales a células de mamífero a través de minicélulas intactas obtenidas a partir de bacterias |
CA2933978C (en) | 2007-03-30 | 2018-08-21 | Engeneic Molecular Delivery Pty. Ltd. | Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells |
JP2010540466A (ja) | 2007-09-24 | 2010-12-24 | ザ ユニバーシティ オブ クイーンズランド | 分子送達ベシクル |
KR20180041269A (ko) * | 2008-01-22 | 2018-04-23 | 아라임 파마슈티칼즈, 인크. | 조직 손상 관련 질환 및 장애를 예방 및 치료하기 위한 조직 보호 펩티드 및 펩티드 유사체 |
RU2496482C2 (ru) | 2008-03-05 | 2013-10-27 | Бакстер Интернэшнл Инк. | Композиции и способы для доставки лекарственных средств |
KR101813824B1 (ko) | 2008-06-25 | 2017-12-29 | 벡션 테라퓨틱스 엘엘씨 | 조절된 유전자 자살 메커니즘 조성물 및 방법 |
US10952965B2 (en) | 2009-05-15 | 2021-03-23 | Baxter International Inc. | Compositions and methods for drug delivery |
WO2011002239A2 (ko) | 2009-07-01 | 2011-01-06 | 주식회사이언메딕스 | 포유류의 유핵세포에서 유래된 마이크로베시클 및 이의 용도 |
IT1401457B1 (it) * | 2010-06-11 | 2013-07-26 | Fond I R C C S Istituto Neurologico Carlo Besta | Carrier di tipo cellulare per il trasporto mirato di almeno una molecola e/o almeno un composto molecolare ad almeno una cellula bersaglio in un mammifero umano o non umano |
US9149542B2 (en) | 2010-07-01 | 2015-10-06 | Aeon Medix Inc. | Microvesicles derived from cell protoplast and use thereof |
DK2675474T3 (en) * | 2011-02-15 | 2019-04-23 | Vaxiion Therapeutics Llc | THERAPEUTIC COMPOSITIONS AND PROCEDURES FOR TARGETED ADMINISTRATION OF BIOACTIVE MOLECULES BY BACK-TERIAL MINICLES BASED ON ANTIBODY AND FC-CONTAINING TAR-GETING MOLECULES |
SG11201403062YA (en) * | 2011-12-13 | 2014-07-30 | Engeneic Molecular Delivery Pty Ltd | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
JP6479662B2 (ja) | 2012-10-02 | 2019-03-06 | バキシオン セラピューティクス,リミテッド ライアビリティ カンパニー | 免疫調節ミニ細胞および使用方法 |
US9733222B2 (en) * | 2012-10-03 | 2017-08-15 | Waters Technologies Corporation | Rapid analysis of steroids and steroid derivatives |
BR112015018877A2 (pt) * | 2013-02-07 | 2017-08-22 | Externautics Spa | Método para preparar uma composição farmacêutica, e, composição farmacêutica imunogênica |
US10314916B2 (en) | 2013-06-11 | 2019-06-11 | House Wellness Foods Corporation | Carrier for delivery of substance to phagocytes |
MX2016004285A (es) | 2013-10-04 | 2016-07-08 | Engeneic Molecular Delivery Pty Ltd | Tratamiento de tumor por combinacion con minicelulas dirigidas a ligando, biespecificas, cargadas con farmacos e interferon-gamma. |
EP3200765A4 (en) * | 2014-10-03 | 2018-05-30 | EnGeneIC Molecular Delivery Pty Ltd | Enhanced loading of intact, bacterially derived vesicles with small molecule compounds |
CN104388459B (zh) * | 2014-10-29 | 2017-03-08 | 四川农业大学 | 使细菌自主产微细胞的方法及一株自产微细胞细菌突变株 |
KR101708424B1 (ko) | 2015-03-04 | 2017-02-20 | 전남대학교산학협력단 | 코리네박테리움 속 박테리아 및 이로부터 유래된 미니셀 그리고 이의 용도 |
KR101858840B1 (ko) | 2016-01-15 | 2018-05-16 | 단국대학교 천안캠퍼스 산학협력단 | 집먼지진드기 유래 알레르겐에 의한 과민반응 면역조절제 |
US10940112B2 (en) | 2016-05-04 | 2021-03-09 | L.E.A.F. Holdings Group Llc | Targeted liposomal gemcitabine compositions and methods thereof |
EP3522935A4 (en) | 2016-10-06 | 2020-05-13 | EnGeneIC Molecular Delivery Pty Ltd. | BACTERIAL MINICELLS FOR THE DELIVERY OF NUCLEIC ACID ADJUVANTS AND METHODS OF USE THEREOF |
US11642362B2 (en) | 2017-07-06 | 2023-05-09 | National University Of Singapore | Methods of inhibiting cell proliferation and METTL8 activity |
WO2019204154A1 (en) | 2018-04-18 | 2019-10-24 | Reyoung Corporation | Compositions and methods for treating liver cancer |
WO2019217164A1 (en) | 2018-05-09 | 2019-11-14 | Reyoung Corporation | Compositions and methods for treating cancer and other diseases |
JP2021532106A (ja) | 2018-07-23 | 2021-11-25 | エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド | 細菌由来ミニ細胞を含む組成物およびそれを使用する方法 |
US20220151947A1 (en) * | 2019-04-08 | 2022-05-19 | University Of Massachusetts | Localization of payload delivery systems to tumor sites via beacon cell targeting |
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US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
CN114053430A (zh) * | 2020-07-29 | 2022-02-18 | 深圳先进技术研究院 | 一种负载纳米载药颗粒的细菌及其制备方法和应用 |
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US20030203481A1 (en) * | 2002-02-25 | 2003-10-30 | Surber Mark W. | Conjugated minicells |
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PL1694361T3 (pl) | 2003-12-09 | 2011-08-31 | Engeneic Molecular Delivery Pty Ltd | Ukierunkowane dostarczanie genów do niefagocytujących komórek ssaczych z zastosowaniem nienaruszonych minikomórek pochodzących od bakterii |
CN102028953B (zh) | 2004-02-02 | 2013-10-30 | 恩杰内克分子递送有限公司 | 经细菌来源的完整微细胞在体外和体内将药物靶向递送至哺乳动物细胞的组合物和方法 |
ES2535235T3 (es) | 2004-08-26 | 2015-05-07 | Engeneic Molecular Delivery Pty Ltd | Administración de ácidos nucleicos funcionales a células de mamífero a través de minicélulas intactas obtenidas a partir de bacterias |
WO2006066048A2 (en) | 2004-12-17 | 2006-06-22 | Beth Israel Deaconess Medical Center | Compositions for bacterial mediated gene silencing and methods of using same |
PL2712618T3 (pl) | 2006-06-23 | 2017-07-31 | Engeneic Molecular Delivery Pty Ltd. | Ukierunkowane dostarczanie leków, terapeutycznych kwasów nukleinowych i funkcjonalnych kwasów nukleinowych do komórek ssaczych przez nienaruszone, uśmiercone komórki bakteryjne |
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2005
- 2005-01-27 CN CN2010105992452A patent/CN102028953B/zh active Active
- 2005-01-27 ES ES15162946T patent/ES2765426T3/es active Active
- 2005-01-27 CA CA2788707A patent/CA2788707C/en active Active
- 2005-01-27 RS RS20150509A patent/RS54149B1/en unknown
- 2005-01-27 JP JP2006551944A patent/JP5060787B2/ja active Active
- 2005-01-27 PT PT57023616T patent/PT1718338E/pt unknown
- 2005-01-27 AU AU2005215254A patent/AU2005215254B2/en active Active
- 2005-01-27 DK DK05702361.6T patent/DK1718338T3/en active
- 2005-01-27 ES ES05702361.6T patent/ES2544652T3/es active Active
- 2005-01-27 EP EP20050702361 patent/EP1718338B1/en active Active
- 2005-01-27 WO PCT/IB2005/000204 patent/WO2005079854A1/en active Application Filing
- 2005-01-27 NZ NZ549139A patent/NZ549139A/en not_active IP Right Cessation
- 2005-01-27 SG SG200705647-6A patent/SG135174A1/en unknown
- 2005-01-27 HU HUE05702361A patent/HUE025292T2/en unknown
- 2005-01-27 DK DK15162946.6T patent/DK2992901T3/da active
- 2005-01-27 SG SG200705648-4A patent/SG135175A1/en unknown
- 2005-01-27 EP EP15162946.6A patent/EP2992901B1/en active Active
- 2005-01-27 ME MEP-2015-509A patent/ME02251B/me unknown
- 2005-01-27 CN CN2005800068041A patent/CN1925873B/zh active Active
- 2005-01-27 CA CA2556248A patent/CA2556248C/en active Active
- 2005-01-27 PL PL05702361T patent/PL1718338T3/pl unknown
- 2005-01-27 SI SI200531990T patent/SI1718338T1/sl unknown
- 2005-01-27 SG SG201100772-1A patent/SG169373A1/en unknown
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2010
- 2010-02-05 AU AU2010200599A patent/AU2010200599B2/en active Active
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2011
- 2011-04-22 JP JP2011096273A patent/JP5571031B2/ja active Active
- 2011-09-22 HK HK11110025.5A patent/HK1155665A1/xx unknown
-
2014
- 2014-04-09 US US14/249,214 patent/US9867785B2/en active Active
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2015
- 2015-08-03 HR HRP20150828TT patent/HRP20150828T8/hr unknown
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2018
- 2018-01-12 US US15/870,000 patent/US10799461B2/en active Active
- 2018-06-05 US US16/000,480 patent/US20180280311A1/en not_active Abandoned
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