PL1718338T3 - Kompozycje oraz sposoby do celowanego dostarczania leku in vitro oraz in vivo do ssaczych komórek poprzez bakteriopochodne nienaruszone minikomórki - Google Patents
Kompozycje oraz sposoby do celowanego dostarczania leku in vitro oraz in vivo do ssaczych komórek poprzez bakteriopochodne nienaruszone minikomórkiInfo
- Publication number
- PL1718338T3 PL1718338T3 PL05702361T PL05702361T PL1718338T3 PL 1718338 T3 PL1718338 T3 PL 1718338T3 PL 05702361 T PL05702361 T PL 05702361T PL 05702361 T PL05702361 T PL 05702361T PL 1718338 T3 PL1718338 T3 PL 1718338T3
- Authority
- PL
- Poland
- Prior art keywords
- vitro
- targeted
- compositions
- methods
- drug delivery
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
- A61K47/6879—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54059004P | 2004-02-02 | 2004-02-02 | |
EP20050702361 EP1718338B1 (en) | 2004-02-02 | 2005-01-27 | Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
PCT/IB2005/000204 WO2005079854A1 (en) | 2004-02-02 | 2005-01-27 | Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1718338T3 true PL1718338T3 (pl) | 2015-12-31 |
Family
ID=34885947
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL05702361T PL1718338T3 (pl) | 2004-02-02 | 2005-01-27 | Kompozycje oraz sposoby do celowanego dostarczania leku in vitro oraz in vivo do ssaczych komórek poprzez bakteriopochodne nienaruszone minikomórki |
Country Status (19)
Country | Link |
---|---|
US (3) | US9867785B2 (pl) |
EP (2) | EP1718338B1 (pl) |
JP (2) | JP5060787B2 (pl) |
CN (2) | CN102028953B (pl) |
AU (2) | AU2005215254B2 (pl) |
CA (2) | CA2556248C (pl) |
DK (2) | DK2992901T3 (pl) |
ES (2) | ES2765426T3 (pl) |
HK (1) | HK1155665A1 (pl) |
HR (1) | HRP20150828T8 (pl) |
HU (1) | HUE025292T2 (pl) |
ME (1) | ME02251B (pl) |
NZ (1) | NZ549139A (pl) |
PL (1) | PL1718338T3 (pl) |
PT (1) | PT1718338E (pl) |
RS (1) | RS54149B1 (pl) |
SG (3) | SG135175A1 (pl) |
SI (1) | SI1718338T1 (pl) |
WO (1) | WO2005079854A1 (pl) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
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US8986736B2 (en) | 2003-06-24 | 2015-03-24 | Baxter International Inc. | Method for delivering particulate drugs to tissues |
EP1663158A2 (en) | 2003-06-24 | 2006-06-07 | Baxter International Inc. | Specific delivery of drugs to the brain |
PT1718338E (pt) * | 2004-02-02 | 2015-09-21 | Engeneic Molecular Delivery Pty Ltd | Composições e métodos de libertação direcionada de fármacos in vitro e in vivo por meio de minicélulas intactas derivadas de bactérias |
CA2565972A1 (en) | 2004-06-15 | 2005-12-29 | Baxter International Inc. | Ex-vivo application of solid microparticulate therapeutic agents |
MX2007002294A (es) | 2004-08-26 | 2007-10-19 | Engeneic Molecular Delivery Pty Ltd | Suministro de acidos nucleicos funcionales a celulas mamiferas via minicelulas intactas, derivadas bacterialmente. |
DK2865755T3 (en) | 2007-03-30 | 2017-05-15 | Engeneic Molecular Delivery Pty Ltd | BACTERIAL DERIVATIVE INTACT MINICELLS WITH REGULATORY RNA |
CA2697629A1 (en) | 2007-09-24 | 2009-04-02 | The University Of Queensland | Molecular delivery vesicle |
AU2009206748B2 (en) * | 2008-01-22 | 2014-03-20 | Araim Pharmaceuticals, Inc. | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage |
WO2009111638A1 (en) | 2008-03-05 | 2009-09-11 | Baxter International Inc. | Compositions and methods for drug delivery |
KR101623999B1 (ko) | 2008-06-25 | 2016-05-24 | 벡션 테라퓨틱스 엘엘씨 | 조절된 유전자 자살 메커니즘 조성물 및 방법 |
US10952965B2 (en) | 2009-05-15 | 2021-03-23 | Baxter International Inc. | Compositions and methods for drug delivery |
JP5667180B2 (ja) | 2009-07-01 | 2015-02-12 | イオン メディックス インコーポレイテッド | 哺乳類の有核細胞に由来するマイクロベシクル及びその用途 |
IT1401457B1 (it) * | 2010-06-11 | 2013-07-26 | Fond I R C C S Istituto Neurologico Carlo Besta | Carrier di tipo cellulare per il trasporto mirato di almeno una molecola e/o almeno un composto molecolare ad almeno una cellula bersaglio in un mammifero umano o non umano |
CN103002879B (zh) | 2010-07-01 | 2016-04-20 | 阿昂梅迪克斯公司 | 来自细胞原生质体的微泡及其应用 |
JP6199746B2 (ja) | 2011-02-15 | 2017-09-20 | バキシオン セラピューティクス,リミテッド ライアビリティ カンパニー | 抗体およびFc含有標的化分子に基づく生理活性分子の標的送達のための細菌ミニ細胞による治療用組成物および方法 |
MX359410B (es) * | 2011-12-13 | 2018-09-27 | Engeneic Molecular Delivery Pty Ltd | Minicélulas intactas derivadas bacterialmente para suministro de agentes terapéuticos a tumores cerebrales. |
AU2013327059B2 (en) | 2012-10-02 | 2018-11-08 | Vaxiion Therapeutics, Llc | Immunomodulatory minicells and methods of use |
US9733222B2 (en) * | 2012-10-03 | 2017-08-15 | Waters Technologies Corporation | Rapid analysis of steroids and steroid derivatives |
US20160120818A1 (en) * | 2013-02-07 | 2016-05-05 | Glaxosmithline Biological Sa | Pharmaceutical compositions comprising vesicles |
US10314916B2 (en) | 2013-06-11 | 2019-06-11 | House Wellness Foods Corporation | Carrier for delivery of substance to phagocytes |
CA2926161C (en) | 2013-10-04 | 2023-03-14 | Engeneic Molecular Delivery Pty Ltd | Combination tumor treatment with drug-loaded, bispecific ligand-targeted minicells and interferon-gamma |
JP7029957B2 (ja) * | 2014-10-03 | 2022-03-04 | エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド | インタクトな細菌由来のベシクルへの低分子化合物の充填の向上 |
CN104388459B (zh) * | 2014-10-29 | 2017-03-08 | 四川农业大学 | 使细菌自主产微细胞的方法及一株自产微细胞细菌突变株 |
KR101708424B1 (ko) * | 2015-03-04 | 2017-02-20 | 전남대학교산학협력단 | 코리네박테리움 속 박테리아 및 이로부터 유래된 미니셀 그리고 이의 용도 |
KR101858840B1 (ko) * | 2016-01-15 | 2018-05-16 | 단국대학교 천안캠퍼스 산학협력단 | 집먼지진드기 유래 알레르겐에 의한 과민반응 면역조절제 |
WO2017192863A1 (en) | 2016-05-04 | 2017-11-09 | L.E.A.F. Holdings Group Llc | Targeted liposomal gemcitabine compositions and methods thereof |
CN110022905B (zh) | 2016-10-06 | 2024-02-06 | 安吉尼科分子传输公司 | 用于递送核酸佐剂的细菌小细胞和使用其的方法 |
EP3649242A2 (en) | 2017-07-06 | 2020-05-13 | National University of Singapore | Methods of inhibiting cell proliferation and mettl8 activity |
WO2019204154A1 (en) | 2018-04-18 | 2019-10-24 | Reyoung Corporation | Compositions and methods for treating liver cancer |
WO2019217164A1 (en) | 2018-05-09 | 2019-11-14 | Reyoung Corporation | Compositions and methods for treating cancer and other diseases |
CN112689511A (zh) | 2018-07-23 | 2021-04-20 | 安吉尼科分子传输公司 | 包含细菌源微细胞的组合物及其使用方法 |
EP3952645A4 (en) * | 2019-04-08 | 2023-08-23 | University Of Massachusetts | LOCALIZATION OF PAYLOAD DELIVERY SYSTEMS TO TUMOR SITES USING BEACON CELL TARGETING |
WO2020222161A1 (en) * | 2019-05-01 | 2020-11-05 | Engeneic Molecular Delivery Pty Ltd | Compositions comprising bacterially derived intact minicells for theranostic applications |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
CN114053430A (zh) * | 2020-07-29 | 2022-02-18 | 深圳先进技术研究院 | 一种负载纳米载药颗粒的细菌及其制备方法和应用 |
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CA1270198A (en) | 1984-08-08 | 1990-06-12 | Marcel B. Bally | Encapsulation of antineoplastic agents in liposomes |
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IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
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US5549910A (en) * | 1989-03-31 | 1996-08-27 | The Regents Of The University Of California | Preparation of liposome and lipid complex compositions |
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US5800833A (en) | 1995-02-27 | 1998-09-01 | University Of British Columbia | Method for loading lipid vesicles |
AU5557796A (en) | 1995-04-18 | 1996-11-07 | Dehlinger, Peter J. | Liposome drug-loading method and composition |
US5837282A (en) | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
IL145778A0 (en) | 1999-04-21 | 2002-07-25 | American Home Prod | Methods and compositions for inhibiting the function of polynucleotide sequences |
US6635448B2 (en) | 2000-08-21 | 2003-10-21 | Clonexdevelopment, Inc. | Methods and compositions for increasing protein yield from a cell culture |
IL157794A0 (en) | 2001-03-07 | 2004-03-28 | Childrens Medical Center | Method to screen peptide display libraries using minicell display |
US7011946B2 (en) | 2001-05-22 | 2006-03-14 | Trustees Of Tufts College | In vivo assay for identification of antimicrobial agents |
US20030194798A1 (en) * | 2001-05-24 | 2003-10-16 | Surber Mark W. | Minicell compositions and methods |
US20030166099A1 (en) * | 2001-06-05 | 2003-09-04 | Sabbadini Roger A. | Minicells comprising membrane proteins |
JP4458846B2 (ja) * | 2001-10-15 | 2010-04-28 | エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド | invitroおよびinvivoにおけるDNA導入および遺伝子療法のためのベクターとしての完全なミニ細胞 |
EP2272946B9 (en) * | 2002-02-25 | 2015-06-24 | Vaxiion Therapeutics, LLC | Minicell compositions and methods |
US20030203481A1 (en) * | 2002-02-25 | 2003-10-30 | Surber Mark W. | Conjugated minicells |
US20030207833A1 (en) | 2002-02-25 | 2003-11-06 | Neil Berkley | Pharmaceutical compositions with minicells |
US7611885B2 (en) | 2003-06-24 | 2009-11-03 | Engeneic Molecular Delivery Pty, Ltd. | Pharmaceutically compatible method for purifying intact bacterial minicells |
PL1694361T3 (pl) | 2003-12-09 | 2011-08-31 | Engeneic Molecular Delivery Pty Ltd | Ukierunkowane dostarczanie genów do niefagocytujących komórek ssaczych z zastosowaniem nienaruszonych minikomórek pochodzących od bakterii |
PT1718338E (pt) * | 2004-02-02 | 2015-09-21 | Engeneic Molecular Delivery Pty Ltd | Composições e métodos de libertação direcionada de fármacos in vitro e in vivo por meio de minicélulas intactas derivadas de bactérias |
MX2007002294A (es) | 2004-08-26 | 2007-10-19 | Engeneic Molecular Delivery Pty Ltd | Suministro de acidos nucleicos funcionales a celulas mamiferas via minicelulas intactas, derivadas bacterialmente. |
EP1838838B1 (en) | 2004-12-17 | 2010-09-01 | Beth Israel Deaconess Medical Center | Compositions for bacterial mediated gene silencing and methods of using same |
EP2040725B1 (en) | 2006-06-23 | 2014-01-15 | EnGeneIC Molecular Delivery Pty Ltd. | Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells |
-
2005
- 2005-01-27 PT PT57023616T patent/PT1718338E/pt unknown
- 2005-01-27 SG SG200705648-4A patent/SG135175A1/en unknown
- 2005-01-27 EP EP20050702361 patent/EP1718338B1/en active Active
- 2005-01-27 DK DK15162946.6T patent/DK2992901T3/da active
- 2005-01-27 RS RS20150509A patent/RS54149B1/en unknown
- 2005-01-27 WO PCT/IB2005/000204 patent/WO2005079854A1/en active Application Filing
- 2005-01-27 ES ES15162946T patent/ES2765426T3/es active Active
- 2005-01-27 CA CA2556248A patent/CA2556248C/en active Active
- 2005-01-27 HU HUE05702361A patent/HUE025292T2/en unknown
- 2005-01-27 CN CN2010105992452A patent/CN102028953B/zh active Active
- 2005-01-27 SG SG201100772-1A patent/SG169373A1/en unknown
- 2005-01-27 CA CA2788707A patent/CA2788707C/en active Active
- 2005-01-27 CN CN2005800068041A patent/CN1925873B/zh active Active
- 2005-01-27 ES ES05702361.6T patent/ES2544652T3/es active Active
- 2005-01-27 PL PL05702361T patent/PL1718338T3/pl unknown
- 2005-01-27 ME MEP-2015-509A patent/ME02251B/me unknown
- 2005-01-27 EP EP15162946.6A patent/EP2992901B1/en active Active
- 2005-01-27 DK DK05702361.6T patent/DK1718338T3/en active
- 2005-01-27 JP JP2006551944A patent/JP5060787B2/ja active Active
- 2005-01-27 SI SI200531990T patent/SI1718338T1/sl unknown
- 2005-01-27 NZ NZ549139A patent/NZ549139A/en not_active IP Right Cessation
- 2005-01-27 AU AU2005215254A patent/AU2005215254B2/en active Active
- 2005-01-27 SG SG200705647-6A patent/SG135174A1/en unknown
-
2010
- 2010-02-05 AU AU2010200599A patent/AU2010200599B2/en active Active
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2011
- 2011-04-22 JP JP2011096273A patent/JP5571031B2/ja active Active
- 2011-09-22 HK HK11110025.5A patent/HK1155665A1/xx unknown
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2014
- 2014-04-09 US US14/249,214 patent/US9867785B2/en active Active
-
2015
- 2015-08-03 HR HRP20150828TT patent/HRP20150828T8/hr unknown
-
2018
- 2018-01-12 US US15/870,000 patent/US10799461B2/en active Active
- 2018-06-05 US US16/000,480 patent/US20180280311A1/en not_active Abandoned
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