HK1137411A1 - 具有快速皮膚穿透速度的帶正電荷的水溶性的前列腺素及相關化合物的前藥 - Google Patents

具有快速皮膚穿透速度的帶正電荷的水溶性的前列腺素及相關化合物的前藥

Info

Publication number
HK1137411A1
HK1137411A1 HK10100922.1A HK10100922A HK1137411A1 HK 1137411 A1 HK1137411 A1 HK 1137411A1 HK 10100922 A HK10100922 A HK 10100922A HK 1137411 A1 HK1137411 A1 HK 1137411A1
Authority
HK
Hong Kong
Prior art keywords
prostaglandins
positively charged
related compounds
skin penetration
charged water
Prior art date
Application number
HK10100922.1A
Other languages
English (en)
Inventor
于崇曦
徐麗娜
Original Assignee
于崇曦
上海泰飛爾生化技術有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 于崇曦, 上海泰飛爾生化技術有限公司 filed Critical 于崇曦
Publication of HK1137411A1 publication Critical patent/HK1137411A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
HK10100922.1A 2006-10-02 2010-01-28 具有快速皮膚穿透速度的帶正電荷的水溶性的前列腺素及相關化合物的前藥 HK1137411A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2006/053594 WO2008041054A1 (en) 2006-10-02 2006-10-02 Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates

Publications (1)

Publication Number Publication Date
HK1137411A1 true HK1137411A1 (zh) 2010-07-30

Family

ID=39268128

Family Applications (2)

Application Number Title Priority Date Filing Date
HK10100922.1A HK1137411A1 (zh) 2006-10-02 2010-01-28 具有快速皮膚穿透速度的帶正電荷的水溶性的前列腺素及相關化合物的前藥
HK15102990.9A HK1202524A1 (zh) 2006-10-02 2015-03-24 具有快速皮膚穿透速度的帶正電荷的水溶性的前列腺素及相關化合物的前藥

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15102990.9A HK1202524A1 (zh) 2006-10-02 2015-03-24 具有快速皮膚穿透速度的帶正電荷的水溶性的前列腺素及相關化合物的前藥

Country Status (10)

Country Link
US (2) US11555014B2 (zh)
EP (2) EP2084124B9 (zh)
JP (1) JP5378219B2 (zh)
CN (1) CN101535240B (zh)
AU (1) AU2006349143B2 (zh)
CA (1) CA2665081C (zh)
ES (1) ES2466346T3 (zh)
HK (2) HK1137411A1 (zh)
PL (1) PL2084124T3 (zh)
WO (1) WO2008041054A1 (zh)

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US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
CN105820107B (zh) 2007-06-04 2022-09-09 泰飞尔公司 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其新的医药用途
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US8530471B2 (en) 2008-05-09 2013-09-10 Allergan, Inc. Therapeutic cyclopentane derivatives
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JP6306067B2 (ja) * 2016-01-08 2018-04-04 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ

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CN105820107B (zh) 2007-06-04 2022-09-09 泰飞尔公司 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其新的医药用途

Also Published As

Publication number Publication date
US11555014B2 (en) 2023-01-17
EP2084124B1 (en) 2014-02-26
CN101535240A (zh) 2009-09-16
EP2084124A4 (en) 2011-11-09
US20090252685A1 (en) 2009-10-08
CN101535240B (zh) 2015-07-22
AU2006349143A1 (en) 2008-04-10
EP2084124A1 (en) 2009-08-05
US20230174476A1 (en) 2023-06-08
PL2084124T3 (pl) 2014-08-29
JP5378219B2 (ja) 2013-12-25
CA2665081A1 (en) 2008-04-10
CA2665081C (en) 2015-12-01
ES2466346T3 (es) 2014-06-10
WO2008041054A1 (en) 2008-04-10
AU2006349143B2 (en) 2013-07-18
HK1202524A1 (zh) 2015-10-02
EP2084124B9 (en) 2015-07-01
EP2781505A1 (en) 2014-09-24
JP2010505808A (ja) 2010-02-25

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