HK1133012A1 - Pyrimidinones as casein kinase ii (ck2) modulators - Google Patents

Pyrimidinones as casein kinase ii (ck2) modulators

Info

Publication number
HK1133012A1
HK1133012A1 HK09112217.3A HK09112217A HK1133012A1 HK 1133012 A1 HK1133012 A1 HK 1133012A1 HK 09112217 A HK09112217 A HK 09112217A HK 1133012 A1 HK1133012 A1 HK 1133012A1
Authority
HK
Hong Kong
Prior art keywords
casein kinase
pyrimidinones
modulators
formula
pathways
Prior art date
Application number
HK09112217.3A
Other languages
English (en)
Inventor
Elena S Koltun
Patrick Kearney
Naing Aay
Arlyn Arcalas
Wai Ki Vicky Chan
Jeffry Kimo Curtis
Hongwang Du
Ping Huang
Brian Kane
Moon Hwan Kim
Michael Pack
Amy L Tsuhako
Wei Xu
Cristiana A Zaharia
Peiwen Zhou
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of HK1133012A1 publication Critical patent/HK1133012A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK09112217.3A 2007-04-25 2009-12-28 Pyrimidinones as casein kinase ii (ck2) modulators HK1133012A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92635807P 2007-04-25 2007-04-25
PCT/US2008/005419 WO2008143759A1 (fr) 2007-04-25 2008-04-24 Pyrimidones en tant que modulateurs de la caséine kinase ii (ck2)

Publications (1)

Publication Number Publication Date
HK1133012A1 true HK1133012A1 (en) 2010-03-12

Family

ID=39645308

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09112217.3A HK1133012A1 (en) 2007-04-25 2009-12-28 Pyrimidinones as casein kinase ii (ck2) modulators

Country Status (9)

Country Link
US (1) US8324231B2 (fr)
EP (1) EP2074114B1 (fr)
JP (1) JP5330375B2 (fr)
KR (1) KR20100017359A (fr)
CN (1) CN102317281A (fr)
AU (1) AU2008253684B2 (fr)
HK (1) HK1133012A1 (fr)
MX (1) MX2009011579A (fr)
WO (1) WO2008143759A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102408380B (zh) * 2011-12-22 2014-04-16 浙江大学 5-氨基嘧啶硫酮类化合物及其制备方法
JP6437452B2 (ja) 2013-01-14 2018-12-12 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物
MX2015009057A (es) 2013-01-15 2015-10-05 Incyte Corp Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de cinasa pim.
TW201605866A (zh) 2013-08-23 2016-02-16 英塞特公司 可用作ｐｉｍ激酶抑制劑之呋喃并－及噻吩并－吡啶甲醯胺化合物
CN103804312B (zh) * 2014-02-17 2016-04-20 四川百利药业有限责任公司 一类氮杂环化合物及其制备方法和用途
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
EP3186237A1 (fr) * 2014-08-28 2017-07-05 Medizinische Universität Wien Nouveaux dérivés de chalcone hétéro-aromatique et leur utilisation médicale
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
WO2017059251A1 (fr) 2015-10-02 2017-04-06 Incyte Corporation Composés hétérocycliques utiles en tant qu'inhibiteurs de la kinase pim
EP3474855B1 (fr) 2016-06-24 2022-01-26 Polaris Pharmaceuticals, Inc. Inhibiteurs de ck2, leurs compositions et méthodes associées
EP3484864A1 (fr) * 2016-07-13 2019-05-22 Centre National de la Recherche Scientifique - CNRS Dérivés de pyrimidinone et leurs utilisations pour neutraliser l'activité biologique des chimiokines
US11242334B2 (en) 2017-08-22 2022-02-08 Js Innopharm (Shanghai) Ltd. Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compound, and methods of use thereof
AR113922A1 (es) 2017-12-08 2020-07-01 Incyte Corp Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
KR102337404B1 (ko) * 2020-01-03 2021-12-10 연세대학교 산학협력단 조직 재생용 조성물
CN111217862B (zh) * 2020-02-26 2023-01-31 陕西科技大学 一种4-芳基-6-二茂铁基-3,4-二氢嘧啶-2(1h)-酮的制备方法
GB202213163D0 (en) * 2022-09-08 2022-10-26 Cambridge Entpr Ltd Novel compounds, compositions and therapeutic uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2118315C3 (de) * 1970-04-20 1975-04-03 Sumitomo Chemical Co., Ltd., Osaka (Japan) 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US3950526A (en) * 1970-04-20 1976-04-13 Sumitomo Chemical Company, Limited Quinazoline derivatives in pharmaceutical compositions for treating pain and inflammation
AU777869B2 (en) * 1999-09-24 2004-11-04 Shire Canada Inc. Method for the treatment or prevention of viral infection using nucleoside analogues
WO2007048065A2 (fr) * 2005-10-21 2007-04-26 Exelixis, Inc. Pyrimidinones en tant que modulateurs de caseine kinase ii (ck2)
RU2008145225A (ru) * 2006-04-19 2010-05-27 Новартис АГ (CH) Соединения индазола и способы ингибирования cd7
CN102317266A (zh) * 2007-04-25 2012-01-11 埃克塞利希斯股份有限公司 作为pim调节剂的6-苯基嘧啶酮类

Also Published As

Publication number Publication date
MX2009011579A (es) 2009-11-11
WO2008143759A1 (fr) 2008-11-27
AU2008253684A1 (en) 2008-11-27
AU2008253684B2 (en) 2014-02-27
JP2010525068A (ja) 2010-07-22
US20100144770A1 (en) 2010-06-10
JP5330375B2 (ja) 2013-10-30
CN102317281A (zh) 2012-01-11
EP2074114B1 (fr) 2013-03-06
KR20100017359A (ko) 2010-02-16
EP2074114A1 (fr) 2009-07-01
US8324231B2 (en) 2012-12-04

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170424