HK1124775A1 - Alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof - Google Patents
Alkyl phospholipid derivatives with reduced cytotoxicity and uses thereofInfo
- Publication number
- HK1124775A1 HK1124775A1 HK09102356.5A HK09102356A HK1124775A1 HK 1124775 A1 HK1124775 A1 HK 1124775A1 HK 09102356 A HK09102356 A HK 09102356A HK 1124775 A1 HK1124775 A1 HK 1124775A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- reduced cytotoxicity
- phospholipid derivatives
- alkyl phospholipid
- alkyl
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/04—Amoebicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75143805P | 2005-12-19 | 2005-12-19 | |
EP05027823A EP1800684A1 (en) | 2005-12-20 | 2005-12-20 | Novel alkyl phospholipid derivatives and uses thereof |
PCT/EP2006/069873 WO2007071658A2 (en) | 2005-12-19 | 2006-12-19 | Alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1124775A1 true HK1124775A1 (en) | 2009-07-24 |
Family
ID=37942171
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09102356.5A HK1124775A1 (en) | 2005-12-19 | 2009-03-12 | Alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1962862B1 (xx) |
JP (1) | JP5232009B2 (xx) |
KR (1) | KR101378005B1 (xx) |
AR (1) | AR058397A1 (xx) |
AU (1) | AU2006328479B2 (xx) |
CA (1) | CA2632449A1 (xx) |
HK (1) | HK1124775A1 (xx) |
IL (1) | IL191695A (xx) |
NO (1) | NO20082862L (xx) |
PL (1) | PL1962862T3 (xx) |
RU (1) | RU2469727C2 (xx) |
UY (1) | UY30042A1 (xx) |
WO (1) | WO2007071658A2 (xx) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008068037A1 (en) * | 2006-12-08 | 2008-06-12 | Jado Technologies Gmbh | Cholesterylamines for the treatment and prevention of infectious diseases |
DE102007014375A1 (de) | 2007-03-26 | 2008-10-02 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Oleylphosphocholin |
AT505515B1 (de) * | 2007-08-02 | 2009-04-15 | Orphanidis Pharma Res | Verwendung von miltefosin zur herstellung eines medikaments zur behandlung der cryptosporidiose beim menschen |
WO2009090063A1 (en) * | 2008-01-16 | 2009-07-23 | Jado Technologies Gmbh | Steroid sapogenin, androstane and triterpenoid sapogenin derivatives for the treatment and prevention of infectious diseases |
WO2010020276A1 (en) * | 2008-08-19 | 2010-02-25 | Orphanidis Pharma Research Gmbh | Treatment of coccidian parasites |
ES2732941T3 (es) * | 2011-03-04 | 2019-11-26 | Oblita Therapeutics Bvba | Oleilfosfocolina para el tratamiento de la micosis |
CN102584926B (zh) * | 2012-01-12 | 2014-10-15 | 浙江大学 | 利用基于胆固醇和磷酸胆碱两亲小分子制备超分子水凝胶的方法 |
RU2487708C1 (ru) * | 2012-03-12 | 2013-07-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Уральская государственная медицинская академия Министерства здравоохранения и социального развития Российской Федерации" (ГБОУ ВПО УГМА Минздравсоцразвития России) | Способ лечения парвовирусной инфекции в19 у детей раннего возраста |
CA3024129A1 (en) | 2016-05-16 | 2017-11-23 | The Board Of Regents Of The University Of Texas System | Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids |
CA3076615A1 (en) | 2017-09-21 | 2019-03-28 | The Scripps Research Institute | Novel therapies for treating and preventing chronic rhinosinusitis |
ES2739773B2 (es) * | 2018-08-02 | 2020-11-17 | Univ Alicante | Compuestos zwitterionicos de acidos 2-fosfocolina carboxilicos y su uso como agentes citotoxicos |
CN115003309B (zh) * | 2019-12-02 | 2024-05-24 | 阿里量子解决方法公司 | 一种具有结构式i的化合物的晶型 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5984824A (ja) * | 1982-11-08 | 1984-05-16 | Takeda Chem Ind Ltd | 抗腫瘍剤 |
CA1338627C (en) | 1985-12-04 | 1996-10-01 | Hansjorg Eibl | Pharmaceuticals based on phosphoric acid esters for use in tumor therapy, and process for their preparation |
EP0284395B1 (en) | 1987-03-24 | 1993-06-23 | Nippon Chemiphar Co., Ltd. | Novel glycerol derivative and anti-hypertensive agent |
DE3942933A1 (de) * | 1989-12-23 | 1991-06-27 | Boehringer Mannheim Gmbh | Verwendung von alkylphospholipiden als antivirale arzneimittel und neue phospholipid-derivate |
DE4111105A1 (de) * | 1991-04-05 | 1992-10-08 | Max Planck Gesellschaft | Neue erucyl-, brassidyl- und nervonylderivate |
DE59205998D1 (de) * | 1991-07-04 | 1996-05-23 | Asta Medica Ag | Arzneimittel mit antineoplastischer Wirkung enthaltend als Wirkstoff Octadecyl-[2-(N-methylpiperidino)-ethyl]-phosphat und Verfahren zu dessen Herstellung |
DE4132344A1 (de) | 1991-09-27 | 1993-04-01 | Max Planck Gesellschaft | Verfahren zur herstellung eines arzneimittels zur oralen oder topischen verabreichung bei der behandlung von leishmaniasis |
US6254879B1 (en) | 1991-09-27 | 2001-07-03 | Max-Planck-Gessellschaft zun Förderung der Wissenschaften e.V. | Methods of treating protozoal diseases |
FR2683915A1 (fr) * | 1991-11-18 | 1993-05-21 | Philips Electronique Lab | Appareil d'examen de milieux par echographie ultrasonore. |
US6172050B1 (en) | 1992-07-11 | 2001-01-09 | Asta Medica Aktiengesellschaft | Phospholipid derivatives |
DE4222910A1 (de) * | 1992-07-11 | 1994-01-13 | Asta Medica Ag | Neue Phospholipidderivate |
DE4233044A1 (de) | 1992-10-01 | 1994-04-07 | Asta Medica Ag | Phospholipidderivate, die höhere Elemente der V. Hauptgruppe enthalten |
US5958906A (en) | 1992-10-01 | 1999-09-28 | Asta-Medica Aktiengesellschaft | Phospholipid derivatives containing higher elements of the fifth main group |
DE19650778C2 (de) | 1996-12-06 | 2001-01-04 | Asta Medica Ag | Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie |
JP3367892B2 (ja) * | 1997-05-22 | 2003-01-20 | 株式会社ヨシツカ精機 | 多段粉末成形プレス |
DE19835611A1 (de) * | 1998-08-06 | 2000-02-10 | Max Planck Gesellschaft | Neuartige Phospholipide mit synthetischen, ungesättigten Alkyl- und Acylketten |
PT1135193E (pt) * | 1998-12-04 | 2003-01-31 | Max Delbrueck Centrum | Agentes para o tratamento de tumores a base de lipossomas e compreendendo tamoxifeno |
US6521879B1 (en) | 2001-04-20 | 2003-02-18 | Rockwell Collins, Inc. | Method and system for controlling an LED backlight in flat panel displays wherein illumination monitoring is done outside the viewing area |
DE10148067A1 (de) * | 2001-09-28 | 2003-04-17 | Max Planck Gesellschaft | Hitzesterilisierbare Alkylphosphocholin-Liposome |
JP2005515224A (ja) * | 2002-01-14 | 2005-05-26 | ダウ グローバル テクノロジーズ インコーポレイティド | テンプレート乳剤からの薬剤ナノ粒子 |
DE10203195A1 (de) * | 2002-01-25 | 2003-08-07 | Zentaris Ag | Verwendung von Alkylphosphocholinen in der Präventivbehandlung von Protozoenerkrankungen |
US7887817B2 (en) * | 2002-01-25 | 2011-02-15 | Aeterna Zentaris Gmbh | Process for preventing protozoal diseases |
CN1646138B (zh) * | 2002-03-25 | 2010-05-26 | 碧欧塞根公司 | 对g2a受体特异性的激动剂配体的制药用途 |
WO2004012744A1 (de) * | 2002-07-30 | 2004-02-12 | Zentaris Gmbh | Anwendung von alkylphosphocholinen in kombination mit antitumormedikamenten |
BR0315840A (pt) * | 2002-10-30 | 2005-09-27 | Makscientific Corp | Fosfolipìdeos de anel substituìdo anti-protozoários |
WO2006081452A2 (en) * | 2005-01-28 | 2006-08-03 | Robert Birch | Co-administration of perifosine with chemotherapeutics |
WO2006122716A1 (en) * | 2005-05-18 | 2006-11-23 | Heidelberg Pharma Gmbh | Use of ether-linked lysophosphatidylcholines and alkylphosphocholines for the treatment of papilloma virus induced warts and sarcoids |
-
2006
- 2006-12-19 UY UY30042A patent/UY30042A1/es not_active Application Discontinuation
- 2006-12-19 AU AU2006328479A patent/AU2006328479B2/en not_active Ceased
- 2006-12-19 KR KR1020087017671A patent/KR101378005B1/ko active IP Right Grant
- 2006-12-19 WO PCT/EP2006/069873 patent/WO2007071658A2/en active Application Filing
- 2006-12-19 CA CA002632449A patent/CA2632449A1/en not_active Abandoned
- 2006-12-19 JP JP2008546419A patent/JP5232009B2/ja not_active Expired - Fee Related
- 2006-12-19 RU RU2008129597/15A patent/RU2469727C2/ru not_active IP Right Cessation
- 2006-12-19 AR ARP060105602A patent/AR058397A1/es unknown
- 2006-12-19 EP EP06847032.7A patent/EP1962862B1/en active Active
- 2006-12-19 PL PL06847032T patent/PL1962862T3/pl unknown
-
2008
- 2008-05-26 IL IL191695A patent/IL191695A/en not_active IP Right Cessation
- 2008-06-23 NO NO20082862A patent/NO20082862L/no not_active Application Discontinuation
-
2009
- 2009-03-12 HK HK09102356.5A patent/HK1124775A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU2006328479B2 (en) | 2012-03-08 |
NO20082862L (no) | 2008-08-27 |
EP1962862B1 (en) | 2013-09-04 |
UY30042A1 (es) | 2007-07-31 |
IL191695A0 (en) | 2009-02-11 |
AU2006328479A1 (en) | 2007-06-28 |
JP2009519999A (ja) | 2009-05-21 |
PL1962862T3 (pl) | 2014-01-31 |
RU2469727C2 (ru) | 2012-12-20 |
EP1962862A2 (en) | 2008-09-03 |
IL191695A (en) | 2013-12-31 |
JP5232009B2 (ja) | 2013-07-10 |
KR101378005B1 (ko) | 2014-03-27 |
WO2007071658A3 (en) | 2007-10-04 |
CA2632449A1 (en) | 2007-06-28 |
KR20080081326A (ko) | 2008-09-09 |
AR058397A1 (es) | 2008-01-30 |
WO2007071658A2 (en) | 2007-06-28 |
RU2008129597A (ru) | 2010-01-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20161219 |