HK1121760A1 - Novel n-(fluoro-pyrazinyl)-phenylsulfonamides as moodulators of chemokine receptor ccr4. - Google Patents

Novel n-(fluoro-pyrazinyl)-phenylsulfonamides as moodulators of chemokine receptor ccr4.

Info

Publication number
HK1121760A1
HK1121760A1 HK09101721.5A HK09101721A HK1121760A1 HK 1121760 A1 HK1121760 A1 HK 1121760A1 HK 09101721 A HK09101721 A HK 09101721A HK 1121760 A1 HK1121760 A1 HK 1121760A1
Authority
HK
Hong Kong
Prior art keywords
moodulators
phenylsulfonamides
pyrazinyl
fluoro
novel
Prior art date
Application number
HK09101721.5A
Other languages
English (en)
Inventor
David Cheshire
Nicholas Kindon
Antonio Mete
Bryan Roberts
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HK1121760A1 publication Critical patent/HK1121760A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C07D241/22—Benzenesulfonamido pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK09101721.5A 2005-12-12 2009-02-24 Novel n-(fluoro-pyrazinyl)-phenylsulfonamides as moodulators of chemokine receptor ccr4. HK1121760A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0502733 2005-12-12
PCT/SE2006/001409 WO2007069978A1 (en) 2005-12-12 2006-12-11 Novel n-(fluoro-pyrazinyl)-phenylsulfonamid.es as moodulators of chemokine receptor ccr4.

Publications (1)

Publication Number Publication Date
HK1121760A1 true HK1121760A1 (en) 2009-04-30

Family

ID=38163190

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09101721.5A HK1121760A1 (en) 2005-12-12 2009-02-24 Novel n-(fluoro-pyrazinyl)-phenylsulfonamides as moodulators of chemokine receptor ccr4.

Country Status (21)

Country Link
US (2) US20080293742A1 (xx)
EP (1) EP1968951B1 (xx)
JP (1) JP2009519332A (xx)
KR (1) KR20080091139A (xx)
CN (1) CN101370793B (xx)
AR (1) AR058319A1 (xx)
AT (1) ATE513819T1 (xx)
AU (1) AU2006325573A1 (xx)
BR (1) BRPI0619602A2 (xx)
CA (1) CA2631342A1 (xx)
CL (1) CL2006003449A1 (xx)
EC (1) ECSP088603A (xx)
ES (1) ES2366807T3 (xx)
HK (1) HK1121760A1 (xx)
IL (1) IL191761A0 (xx)
NO (1) NO20083070L (xx)
RU (1) RU2008122401A (xx)
TW (1) TW200730512A (xx)
UY (1) UY29999A1 (xx)
WO (1) WO2007069978A1 (xx)
ZA (1) ZA200804921B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI328007B (en) * 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
ES2474615T3 (es) * 2009-04-22 2014-07-09 Axikin Pharmaceuticals, Inc. Antagonistas de CCR3 arilsulfonamidas 2,5-disustituidas
ES2939606T3 (es) * 2013-09-02 2023-04-25 Univ Melbourne Un método de tratamiento
CN104447756A (zh) * 2014-11-10 2015-03-25 常州大学 一种五氟磺草胺中间体的制备方法
CN104402890A (zh) * 2014-11-10 2015-03-11 常州大学 一种制备五氟磺草胺的方法
AU2018360766A1 (en) 2017-11-06 2020-05-21 Rapt Therapeutics, Inc. Anticancer agents
CN110028501B (zh) 2018-01-12 2022-02-22 迈德欣国际有限公司 化合物及其制备方法和用途
CN108929279A (zh) * 2018-07-27 2018-12-04 同济大学 一种含氟氨基吡嗪类化合物及其制备方法与应用
CN113893220A (zh) * 2020-07-07 2022-01-07 迈德欣国际有限公司 鼻粘膜给药剂型和其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB928151A (en) * 1959-07-14 1963-06-06 Farmaceutici Italia Pyrazine derivatives
US5962490A (en) * 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
CZ291386B6 (cs) 1996-02-13 2003-02-12 Zeneca Limited Chinazolinové deriváty jako inhibitory VEGF, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
ES2169355T3 (es) 1996-03-05 2002-07-01 Astrazeneca Ab Derivados de 4-anilinoquinazolina.
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
US6638937B2 (en) * 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
EP1289952A1 (en) 2000-05-31 2003-03-12 AstraZeneca AB Indole derivatives with vascular damaging activity
EP1301497A1 (en) 2000-07-07 2003-04-16 Angiogene Pharmaceuticals Limited Colchinol derivatives as vascular damaging agents
CA2410562A1 (en) 2000-07-07 2002-01-31 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
SE0102439D0 (sv) * 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
AU2002358390A1 (en) 2001-12-18 2003-06-30 Astrazeneca Ab Novel compounds
TWI328007B (en) * 2002-01-16 2010-08-01 Astrazeneca Ab Novel compounds
SE0301650D0 (sv) * 2003-06-04 2003-06-04 Astrazeneca Ab Novel compounds
SE0301654D0 (sv) * 2003-06-05 2003-06-05 Astrazeneca Ab Novel compounds
SE0301653D0 (sv) * 2003-06-05 2003-06-05 Astrazeneca Ab Novel compounds
SE0302304D0 (sv) * 2003-08-27 2003-08-27 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
US20100144759A1 (en) 2010-06-10
CN101370793B (zh) 2012-01-04
ZA200804921B (en) 2009-09-30
CN101370793A (zh) 2009-02-18
JP2009519332A (ja) 2009-05-14
CA2631342A1 (en) 2007-06-21
IL191761A0 (en) 2008-12-29
ES2366807T3 (es) 2011-10-25
WO2007069978A1 (en) 2007-06-21
AU2006325573A1 (en) 2007-06-21
ECSP088603A (es) 2008-08-29
TW200730512A (en) 2007-08-16
US20080293742A1 (en) 2008-11-27
BRPI0619602A2 (pt) 2011-10-11
AR058319A1 (es) 2008-01-30
NO20083070L (no) 2008-08-28
RU2008122401A (ru) 2010-01-20
UY29999A1 (es) 2007-07-31
KR20080091139A (ko) 2008-10-09
EP1968951B1 (en) 2011-06-22
ATE513819T1 (de) 2011-07-15
CL2006003449A1 (es) 2008-02-08
EP1968951A1 (en) 2008-09-17

Similar Documents

Publication Publication Date Title
HK1121760A1 (en) Novel n-(fluoro-pyrazinyl)-phenylsulfonamides as moodulators of chemokine receptor ccr4.
IL229521A0 (en) A new preparation
AP2314A (en) 3- 4-heteroarylcyclohexylamino cyclopentanecarboxamides as modulators of chemokine receptors.
IL185901A0 (en) Novel composition
ZA200709595B (en) Query composition using autolists
GB0513692D0 (en) Novel pharmaceutical compositions
EP2099454A4 (en) AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS
ZA200606315B (en) Novel amido-substituted hydroxy-6-phenylphenanthridines
EP1969123A4 (en) NEW ENZYMES
HUP0600858A2 (en) Piperizinyilpiperidine derivatives as chemokine receptor antagonists
IL191602A0 (en) 3-aminocyclopentanecarboxamides as modulators of chemokine receptors
IL188643A0 (en) N-(heteroaryl)-1-heteroarylalkyl-1h-indole-2-
IL190094A0 (en) Amino-alkyl-amide derivatives as ccr3 receptor liquids
IL186972A0 (en) Novel lactam compound
GB0502479D0 (en) Novel compositions
GB0502475D0 (en) Novel compositions
IL184737A (en) Worm remedy
GB0505760D0 (en) Novel composition
GB0525321D0 (en) Novel compositions
GB0501146D0 (en) Novel benzamide derivatives
IL185640A0 (en) Use of 2-anilino-3 ,4-dihydro-quinazolines as 5ht5a receptor antagonists
GB0513367D0 (en) Novel composition
GB0524803D0 (en) Novel compositions
HK1101657A2 (en) Novel composition
GB0526351D0 (en) Novel benzamide derivatives

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20151211