HK1121396A1 - Pqs and its conjugates as adjuvants and their uses in pharmaceutical compositions pqs - Google Patents

Pqs and its conjugates as adjuvants and their uses in pharmaceutical compositions pqs

Info

Publication number
HK1121396A1
HK1121396A1 HK09101781.2A HK09101781A HK1121396A1 HK 1121396 A1 HK1121396 A1 HK 1121396A1 HK 09101781 A HK09101781 A HK 09101781A HK 1121396 A1 HK1121396 A1 HK 1121396A1
Authority
HK
Hong Kong
Prior art keywords
pqs
conjugates
adjuvants
pharmaceutical compositions
pharmaceutical
Prior art date
Application number
HK09101781.2A
Other languages
English (en)
Inventor
Thomas Ebensen
Michael Morr
Carlos A Guzman
Original Assignee
Helmholtz Infektionsforschung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helmholtz Infektionsforschung filed Critical Helmholtz Infektionsforschung
Publication of HK1121396A1 publication Critical patent/HK1121396A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
HK09101781.2A 2005-11-08 2009-02-25 Pqs and its conjugates as adjuvants and their uses in pharmaceutical compositions pqs HK1121396A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05024266A EP1782826A1 (fr) 2005-11-08 2005-11-08 PQS, c-diGMP et leurs conjugués utilisés comme adjuvants et leur emploi dans des compositions pharmaceutiques
PCT/EP2006/010699 WO2007054283A2 (fr) 2005-11-08 2006-11-08 Pqs et leurs conjugues utiles en tant qu'adjuvants et leurs utilisations dans des compositions pharmaceutiques

Publications (1)

Publication Number Publication Date
HK1121396A1 true HK1121396A1 (en) 2009-04-24

Family

ID=35840427

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09101781.2A HK1121396A1 (en) 2005-11-08 2009-02-25 Pqs and its conjugates as adjuvants and their uses in pharmaceutical compositions pqs

Country Status (7)

Country Link
US (2) US9597391B2 (fr)
EP (3) EP1782826A1 (fr)
AU (2) AU2006312692B2 (fr)
CA (2) CA2624905C (fr)
ES (1) ES2390895T3 (fr)
HK (1) HK1121396A1 (fr)
WO (2) WO2007054283A2 (fr)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1782826A1 (fr) 2005-11-08 2007-05-09 GBF Gesellschaft für Biotechnologische Forschung mbH PQS, c-diGMP et leurs conjugués utilisés comme adjuvants et leur emploi dans des compositions pharmaceutiques
US9061048B2 (en) 2010-12-15 2015-06-23 The Regents Of The University Of California Cyclic di-AMP induction of type I interferon
JP5650780B2 (ja) 2012-04-04 2015-01-07 日東電工株式会社 ワクチン組成物
EP2841098A4 (fr) 2012-04-23 2016-03-02 Allertein Therapeutics Llc Nanoparticules pour le traitement d'allergies
AU2013271375B2 (en) 2012-06-08 2018-03-22 Aduro Biotech, Inc. Compositions and methods for cancer immunotherapy
SG11201502796RA (en) 2012-12-13 2015-05-28 Aduro Biotech Inc Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
ES2678194T3 (es) * 2012-12-19 2018-08-09 Board Of Regents, The University Of Texas System Determinación farmacéutica de una vía de señalización de dinucleótido cíclico de mamífero
KR102050931B1 (ko) 2013-02-05 2019-12-02 닛토덴코 가부시키가이샤 경피 투여용 wt1 펩티드 암 백신 테이프제
US10206985B2 (en) 2013-02-05 2019-02-19 Nitto Denko Corporation WT1 peptide cancer vaccine composition for mucosal administration
KR20140100416A (ko) 2013-02-05 2014-08-14 닛토덴코 가부시키가이샤 경피 투여용 wt1 펩티드 암 백신 조성물
RU2687144C2 (ru) 2013-02-05 2019-05-07 Нитто Денко Корпорейшн Композиция противораковой вакцины, содержащей пептид wt1, для трансдермального введения
BR112015027327B1 (pt) 2013-04-29 2022-08-02 Rutgers, The State University Of New Jersey Composto, modulador de cgas, composição farmacêutica compreendendo o referido composto ou modulador
JP2016518140A (ja) 2013-05-03 2016-06-23 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア I型インターフェロンの環状ジヌクレオチド誘導法
HUE046942T2 (hu) 2013-05-18 2020-04-28 Aduro Biotech Inc Készítmények és eljárások "Interferongén-stimulátor"-tól függõ jelátvitel aktiválására
EP2996472B1 (fr) * 2013-05-18 2019-03-27 Aduro Biotech, Inc. Compositions et procédés d'inhibition de la signalisation dépendante du « stimulateur des gènes interférons »
US9549944B2 (en) 2013-05-18 2017-01-24 Aduro Biotech, Inc. Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
EP3027227A4 (fr) 2013-07-31 2018-05-23 Memorial Sloan Kettering Cancer Center Cristaux sting et modulateurs associés
CA2931146C (fr) 2013-11-22 2022-06-28 Brock University Utilisation de dinucleotides cycliques fluores comme adjuvants de vaccin oral
CA2941353C (fr) 2014-03-03 2019-08-20 Yamasa Corporation Acide diguanylique 3',5'-cyclique sous forme cristalline
JP6321135B2 (ja) * 2014-03-14 2018-05-09 ヤマサ醤油株式会社 3’,5’−サイクリックジアデニル酸の包接化合物、およびその製造法
SG11201609021QA (en) 2014-06-04 2016-11-29 Glaxosmithkline Ip Dev Ltd Cyclic di-nucleotides as modulators of sting
US10010607B2 (en) 2014-09-16 2018-07-03 Institut Curie Method for preparing viral particles with cyclic dinucleotide and use of said particles for inducing immune response
GB201501462D0 (en) 2015-01-29 2015-03-18 Glaxosmithkline Ip Dev Ltd Novel compounds
CN107530415A (zh) 2015-03-10 2018-01-02 艾杜罗生物科技公司 用于活化“干扰素基因刺激物”依赖性信号传导的组合物和方法
US11453697B1 (en) 2015-08-13 2022-09-27 Merck Sharp & Dohme Llc Cyclic di-nucleotide compounds as sting agonists
CA2995365C (fr) 2015-08-13 2021-10-12 Merck Sharp & Dohme Corp. Composes de di-nucleotide cyclique en tant qu'agonistes sting (stimulateur de gene interferon)
CN107849084B (zh) 2015-12-03 2021-09-14 葛兰素史密斯克莱知识产权发展有限公司 作为sting调节剂的环状嘌呤二核苷酸
US20180369268A1 (en) * 2015-12-16 2018-12-27 Aduro Biotech, Inc. Methods for identifying inhibitors of "stimulator of interferon gene"- dependent interferon production
CN108779473A (zh) 2016-03-16 2018-11-09 法国居里学院 用于制备具有环二核苷酸的病毒颗粒的方法和所述颗粒用于治疗癌症的用途
EP3692996A1 (fr) 2016-03-18 2020-08-12 Immune Sensor, LLC Composés di-nucléotides cycliques et leurs procédés d'utilisation
MX2020009947A (es) 2016-04-07 2021-10-26 Glaxosmithkline Ip Dev Ltd Amidas heterocíclicas útiles como moduladores de proteínas.
WO2017175156A1 (fr) 2016-04-07 2017-10-12 Glaxosmithkline Intellectual Property Development Limited Amides hétérocycliques utiles en tant que modulateurs de protéine
EP3448393A1 (fr) 2016-04-25 2019-03-06 Invivogen Nouveaux complexes de composés immunostimulateurs, et leurs utilisations
US10696985B1 (en) 2016-06-06 2020-06-30 Vanderbilt University Reversibly crosslinked endosomolytic polymer vesicles for cytosolic drug delivery
US11098077B2 (en) 2016-07-05 2021-08-24 Chinook Therapeutics, Inc. Locked nucleic acid cyclic dinucleotide compounds and uses thereof
WO2018013924A1 (fr) 2016-07-15 2018-01-18 Massachusetts Institute Of Technology Nanoparticules synthétiques pour l'administration de composés immunomodulateurs
NL2017267B1 (en) 2016-07-29 2018-02-01 Aduro Biotech Holdings Europe B V Anti-pd-1 antibodies
NL2017270B1 (en) 2016-08-02 2018-02-09 Aduro Biotech Holdings Europe B V New anti-hCTLA-4 antibodies
CN110036001B (zh) 2016-10-04 2022-03-22 默沙东公司 作为STING激动剂的苯并[b]噻吩化合物
WO2018068132A1 (fr) * 2016-10-11 2018-04-19 The Governors Of The University Of Alberta Compositions immunogènes à base du virus de l'hépatite c comprenant en tant qu'adjuvant un dinucléotide cyclique ou une archaeosome et leurs procédés d'utilisation
JOP20170192A1 (ar) 2016-12-01 2019-01-30 Takeda Pharmaceuticals Co داي نوكليوتيد حلقي
CN106928298B (zh) * 2017-03-13 2021-10-22 杭州星鳌生物科技有限公司 环二核苷酸cGAMP衍生物的结构组成、制备方法及其在抗肿瘤中的应用
AU2018252546A1 (en) 2017-04-13 2019-10-10 Sairopa B.V. Anti-SIRPα antibodies
CA3058966A1 (fr) 2017-04-14 2018-10-18 Tollnine, Inc. Polynucleotides immunomodulateurs, conjugues d'anticorps de ceux-ci, et procedes d'utilisation associes
US11324820B2 (en) 2017-04-18 2022-05-10 Alnylam Pharmaceuticals, Inc. Methods for the treatment of subjects having a hepatitis b virus (HBV) infection
UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
US11466047B2 (en) 2017-05-12 2022-10-11 Merck Sharp & Dohme Llc Cyclic di-nucleotide compounds as sting agonists
US11969499B2 (en) 2017-06-16 2024-04-30 William Marsh Rice University Hydrogel delivery of sting immunotherapy for treatment cancer
JP7186764B2 (ja) * 2017-07-28 2022-12-09 ブリストル-マイヤーズ スクイブ カンパニー 抗癌剤としての環状ジヌクレオチド
MA49772A (fr) 2017-08-04 2021-04-21 Merck Sharp & Dohme Agonistes benzo[b]thiophène de sting pour le traitement du cancer
MA49773A (fr) 2017-08-04 2021-04-21 Merck Sharp & Dohme Combinaisons d'antagonistes de pd-1 et d'agonistes de sting benzo[b
JP2020535128A (ja) 2017-09-19 2020-12-03 マサチューセッツ インスティテュート オブ テクノロジー キメラ抗原受容体t細胞治療のための組成物およびその使用
BR112020006780A2 (pt) 2017-10-05 2020-10-06 Glaxosmithkline Intellectual Property Development Limited moduladores do estimulador de genes do interferon (sting)
JP7262451B2 (ja) 2017-10-05 2023-04-21 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド Stingアゴニストの投与方法
JP2020536106A (ja) 2017-10-05 2020-12-10 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited Hivの処置に有用なインターフェロン遺伝子の刺激物質(sting)の調節物質
EP3707151B1 (fr) 2017-11-10 2022-01-05 Takeda Pharmaceutical Company Limited Composés modulateurs de sting, et procédés de fabrication et d'utilisation
EP3728283B1 (fr) * 2017-12-20 2023-11-22 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. Dinucléotides 3'3' cycliques ayant une liaison phosphonate activant la protéine adaptatrice de sting
US11685761B2 (en) 2017-12-20 2023-06-27 Merck Sharp & Dohme Llc Cyclic di-nucleotide compounds as sting agonists
WO2019139879A1 (fr) * 2018-01-09 2019-07-18 N-Fold Llc Immunomodulation
EP3774765A4 (fr) 2018-04-03 2021-12-29 Merck Sharp & Dohme Corp. Composés aza-benzothiophènes utilisés en tant qu'agonistes de sting
CN111971277B (zh) 2018-04-03 2023-06-06 默沙东有限责任公司 作为sting激动剂的苯并噻吩及相关化合物
GB201807924D0 (en) 2018-05-16 2018-06-27 Ctxt Pty Ltd Compounds
JP7445897B2 (ja) * 2018-08-03 2024-03-08 国立大学法人 東京大学 細胞性免疫を誘導する経鼻ワクチン
AR114551A1 (es) 2018-08-13 2020-09-16 Alnylam Pharmaceuticals Inc COMPOSICIONES DE AGENTES DE ARNhd CONTRA EL VIRUS DE HEPATITIS B (HBV) Y MÉTODOS PARA SU USO
WO2020049534A1 (fr) 2018-09-07 2020-03-12 Novartis Ag Agoniste de sting et polythérapie correspondante pour le traitement du cancer
WO2020092633A1 (fr) 2018-10-30 2020-05-07 Vanderbilt University Copolymères greffés, procédés de formation de copolymères greffés et procédés d'utilisation correspondants
TW202104214A (zh) 2019-04-05 2021-02-01 英商葛蘭素史密斯克藍智慧財產發展有限公司 化合物
EP3966222A4 (fr) 2019-05-09 2023-10-04 Aligos Therapeutics, Inc. Composés di-nucléosidiques cycliques modifiés servant de modulateurs sting
GB201910304D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
GB201910305D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
CA3149494A1 (fr) 2019-08-12 2021-02-18 Purinomia Biotech, Inc. Methodes et compositions pour favoriser et potentialiser des reponses immunitaires a mediation par des lymphocytes t par ciblage adcc de cellules exprimant cd39
EP3785719A1 (fr) 2019-08-28 2021-03-03 Helmholtz-Zentrum für Infektionsforschung GmbH Nouvelle utilisation de dinucléotides cycliques
WO2021074695A1 (fr) 2019-10-16 2021-04-22 Avacta Life Sciences Limited FRACTIONS DE MÉDICAMENTS BISPÉCIFIQUES DE L'INHIBITEUR DE PD-L1 ET DE L'INHIBITEUR DE TGFβ
CN113058033A (zh) * 2019-12-16 2021-07-02 远大赛威信生命科学(南京)有限公司 一种用于预防和治疗乙型肝炎的药物组合物及其用途
EP4110830A1 (fr) 2020-02-28 2023-01-04 Tallac Therapeutics, Inc. Conjugaison à médiation par la transglutaminase
WO2021198064A1 (fr) * 2020-03-31 2021-10-07 Consejo Superior De Investigaciones Científicas Procédé in vitro de détection d'infections provoquées par pseudomonas aeruginosa
WO2021221782A1 (fr) 2020-05-01 2021-11-04 Massachusetts Institute Of Technology Ligands chimériques ciblant des récepteurs antigéniques et leurs utilisations
WO2021221783A1 (fr) 2020-05-01 2021-11-04 Massachusetts Institute Of Technology Procédés d'identification de ligands de ciblage de récepteur antigénique chimérique et leurs utilisations
EP3936514B1 (fr) * 2020-07-10 2023-05-24 Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. Dinucléotides cycliques 3'3' avec un alcénylène
MX2023005381A (es) 2020-11-09 2023-05-23 Takeda Pharmaceuticals Co Conjugados de anticuerpo y farmaco.
AU2021401426A1 (en) 2020-12-17 2023-06-22 Trustees Of Tufts College Fap-activated radiotheranostics, and uses related thereto
WO2022234003A1 (fr) 2021-05-07 2022-11-10 Avacta Life Sciences Limited Polypeptides se liant à cd33 avec protéine stefin a
TW202334196A (zh) 2021-10-07 2023-09-01 英商阿法克塔生命科學有限公司 Pd-l1結合多肽
WO2023168112A1 (fr) 2022-03-04 2023-09-07 Massachusetts Institute Of Technology Vaccin conjugué de protéine-amphiphile transmucosal
WO2023218243A1 (fr) 2022-05-12 2023-11-16 Avacta Life Sciences Limited Protéines de fusion de liaison lag-3/pd-l1

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948882A (en) * 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
DE3420116A1 (de) * 1984-05-30 1985-12-05 Bayer Ag, 5090 Leverkusen Immunstimulierende mittel
GB2257704B (en) * 1991-07-18 1995-03-01 Erba Carlo Spa Cyclic oligonucleotides phosphorothioates
AU3938893A (en) * 1992-03-27 1993-11-08 Abbott Laboratories Haptens, tracers, immunogens and antibodies for quinoline
EP1239923A2 (fr) * 1999-12-20 2002-09-18 New Pharma Research Sweden AB Compositions veterinaires stabilisees, contenant plusieurs agents antiviraux
US20020177715A1 (en) * 2000-08-31 2002-11-28 Pesci Everett C. Novel autoinducer molecules and uses therefor
GB0030729D0 (en) * 2000-12-16 2001-01-31 Univ Nottingham Substituted-4-Quinolones
FR2822849B1 (fr) 2001-03-27 2003-12-12 Usinor Enceinte de traitement sous vide notamment de decarburation d'acier
GB0116312D0 (en) * 2001-07-04 2001-08-29 Univ Nottingham "Compositions containing N-acyl homoserine lactones"
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
DK1490106T3 (da) 2002-04-04 2008-10-27 Helmholtz Infektionsforschung Anvendelse af et lipopeptid eller et lipoprotein som adjuvans ved terapeutiske eller profylaktiske vaccinationer
EP1382352A1 (fr) 2002-07-19 2004-01-21 GBF Gesellschaft für Biotechnologische Forschung mbH Conjugués de bisacylpropylcystéine et leur utilisation
DE10326303A1 (de) * 2003-06-11 2004-12-30 Celares Gmbh Reagenzien zur Modifikation von Biopharmazeutika, deren Herstellung und Anwendung
US8367716B2 (en) * 2003-07-28 2013-02-05 Karaolis David K R Method for attentuating virulence of microbial pathogens and for inhibiting microbial biofilm formation
WO2005087238A2 (fr) * 2004-03-15 2005-09-22 Karaolis David K R Technique de stimulation de reponse immune, inflammatoire ou neuroprospective
EP1782826A1 (fr) * 2005-11-08 2007-05-09 GBF Gesellschaft für Biotechnologische Forschung mbH PQS, c-diGMP et leurs conjugués utilisés comme adjuvants et leur emploi dans des compositions pharmaceutiques

Also Published As

Publication number Publication date
EP1959990B1 (fr) 2012-07-18
EP1959989B1 (fr) 2014-01-01
AU2006312688B2 (en) 2013-05-16
AU2006312692A1 (en) 2007-05-18
WO2007054279A8 (fr) 2007-07-12
US8257734B2 (en) 2012-09-04
WO2007054279A2 (fr) 2007-05-18
US9597391B2 (en) 2017-03-21
EP1782826A1 (fr) 2007-05-09
AU2006312688A1 (en) 2007-05-18
EP1959990A2 (fr) 2008-08-27
US20080286296A1 (en) 2008-11-20
AU2006312692B2 (en) 2013-05-02
EP1959989A2 (fr) 2008-08-27
WO2007054283A3 (fr) 2007-08-09
ES2390895T3 (es) 2012-11-19
CA2624903A1 (fr) 2007-05-18
CA2624903C (fr) 2017-02-28
WO2007054279A3 (fr) 2007-08-30
WO2007054283A2 (fr) 2007-05-18
CA2624905C (fr) 2015-04-28
US20090169609A1 (en) 2009-07-02
CA2624905A1 (fr) 2007-05-18

Similar Documents

Publication Publication Date Title
HK1121396A1 (en) Pqs and its conjugates as adjuvants and their uses in pharmaceutical compositions pqs
IL194429A0 (en) Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
IL242883B (en) Aryl-amino and heteroaryl-amino converted deoxazolines and pharmaceutical preparations containing them
PT1883665T (pt) Composições polilactídeo e usos das mesmas
EP1890677A4 (fr) Compositions pharmaceutiques et leur utilisation
EP2056835A4 (fr) Compositions pharmaceutiques et leurs utilisations
IL190292A (en) History of pyridopyrimidinone and their pharmaceutical preparations
GB0617191D0 (en) Improvements in pharmaceutical compositions
HK1112427A1 (en) Drug delivery compositions and related methods
GB0524962D0 (en) Topical pharmaceutical compositions
HK1128871A1 (en) Pharmaceutical compositions comprising oxalate-reducing bacteria
PT2606874T (pt) Novas composições cosméticas e/ou farmacêuticas e suas aplicações
IL188352A0 (en) Pharmaceutical compositions
ZA200804163B (en) New adjuvants on the basis of bisacyloxypropylcysteine conjugates and derivatives and their uses in pharmaceutical compositions
IL205966A0 (en) Oligomer-tricyclic conjugates, compositions comprising the same and uses thereof
ZA200804103B (en) Pharmaceutical compositions
IL221395A0 (en) Pharmaceutical compositions comprising alpha ketoamide derivatives and uses thereof
EP1848438A4 (fr) Compositions de diaminophenothiazine et utilisations associees
HK1120436A1 (en) Hexosylceramides as adjuvants and their uses in pharmaceutical compositions
GB0614365D0 (en) Pharmaceutical compositions and their use
GB0522045D0 (en) Pharmaceutical compositions
IL186337A0 (en) Stannsoporfin compositions and administration
IL192091A0 (en) Pharmaceutical compositions
EP1937292A4 (fr) Compositions pharmaceutiques a base de lopap et leurs utilisations
EP1845944A4 (fr) Compositions pharmaceutiques

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20171108