HK1119680A1 - Heterocyclic aspartyl protease inhibitors - Google Patents
Heterocyclic aspartyl protease inhibitorsInfo
- Publication number
- HK1119680A1 HK1119680A1 HK08111732.2A HK08111732A HK1119680A1 HK 1119680 A1 HK1119680 A1 HK 1119680A1 HK 08111732 A HK08111732 A HK 08111732A HK 1119680 A1 HK1119680 A1 HK 1119680A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- protease inhibitors
- aspartyl protease
- heterocyclic aspartyl
- heterocyclic
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73062205P | 2005-10-27 | 2005-10-27 | |
PCT/US2006/041716 WO2007050721A2 (en) | 2005-10-27 | 2006-10-25 | Heterocyclic aspartyl protease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1119680A1 true HK1119680A1 (en) | 2009-03-13 |
Family
ID=37873175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08111732.2A HK1119680A1 (en) | 2005-10-27 | 2008-10-24 | Heterocyclic aspartyl protease inhibitors |
Country Status (13)
Country | Link |
---|---|
US (3) | US7763606B2 (es) |
EP (1) | EP1940828B1 (es) |
JP (1) | JP2009513656A (es) |
CN (1) | CN101296926A (es) |
AR (1) | AR057983A1 (es) |
AT (1) | ATE478070T1 (es) |
CA (1) | CA2626976A1 (es) |
DE (1) | DE602006016314D1 (es) |
ES (1) | ES2349433T3 (es) |
HK (1) | HK1119680A1 (es) |
PE (1) | PE20070531A1 (es) |
TW (1) | TW200803847A (es) |
WO (1) | WO2007050721A2 (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7763609B2 (en) * | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
WO2006041404A1 (en) * | 2004-10-15 | 2006-04-20 | Astrazeneca Ab | Substituted amino-compounds and uses thereof |
US20090062282A1 (en) * | 2004-10-15 | 2009-03-05 | Astrazeneca Ab | Substituted Amino-Pyrimidones and Uses Thereof |
US20080287399A1 (en) * | 2004-12-14 | 2008-11-20 | Astrazeneca Ab | Substituted Aminopyridines and Uses Thereof |
CN101228163A (zh) | 2005-06-14 | 2008-07-23 | 先灵公司 | 天冬氨酰蛋白酶抑制剂 |
CN101394852A (zh) | 2005-06-14 | 2009-03-25 | 先灵公司 | 作为蛋白酶抑制剂的化合物的制备和用途 |
WO2006138192A1 (en) | 2005-06-14 | 2006-12-28 | Schering Corporation | Aspartyl protease inhibitors |
US20090215801A9 (en) * | 2005-11-15 | 2009-08-27 | Astrazeneca Ab, Sodertaije, Swedenastex Thereapeutics Ltd | Novel 2-Aminopyrimidinone Derivatives And Their Use |
WO2007058582A1 (en) * | 2005-11-15 | 2007-05-24 | Astrazeneca Ab | Novel 2-aminopyrimidinone or 2-aminopyridinone derivatives and their use |
JP2009520686A (ja) * | 2005-11-21 | 2009-05-28 | アストラゼネカ・アクチエボラーグ | 新規な2−アミノ−イミダゾール−4−オン化合物並びに認知障害、アルツハイマー病、神経変性及び認知症の治療に使用する医薬の製造におけるその使用 |
TW200734311A (en) * | 2005-11-21 | 2007-09-16 | Astrazeneca Ab | New compounds |
AR058381A1 (es) * | 2005-12-19 | 2008-01-30 | Astrazeneca Ab | Compuestos derivados de 2-aminopiridin-4-onas y una composicion farmaceutica |
EP2004630A4 (en) * | 2006-04-05 | 2010-05-19 | Astrazeneca Ab | 2-AMINOPYRIMIDIN-4-ONES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF PATHOLOGIES RELATED TO PROTEIN A |
BRPI0712780A2 (pt) | 2006-06-12 | 2012-09-11 | Schering Corp | inibidores de aspartil protease heterocìclicos |
TW200815447A (en) * | 2006-06-14 | 2008-04-01 | Astrazeneca Ab | Novel compounds IV |
US20080051420A1 (en) * | 2006-06-14 | 2008-02-28 | Astrazeneca Ab | New Compounds 317 |
TW200815349A (en) * | 2006-06-22 | 2008-04-01 | Astrazeneca Ab | New compounds |
TW200831484A (en) * | 2006-12-20 | 2008-08-01 | Astrazeneca Ab | New compounds |
TW200902499A (en) * | 2007-05-15 | 2009-01-16 | Astrazeneca Ab | New compounds |
TW200902503A (en) * | 2007-05-15 | 2009-01-16 | Astrazeneca Ab | New compounds |
MX2010002674A (es) | 2007-09-06 | 2010-03-25 | Schering Corp | Moduladores de gamma secretasa. |
US8487099B2 (en) | 2007-11-05 | 2013-07-16 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
MX2010006378A (es) * | 2007-12-11 | 2010-09-07 | Schering Corp | Moduladores de gamma secretasa. |
PE20091834A1 (es) | 2008-04-22 | 2009-12-19 | Schering Corp | Compuestos de 2-imino-3-metilpirrolopirimidinona tiofenilo-sustituida como inhibidores de bace-1 y composiciones que los contienen |
CA2742486A1 (en) | 2008-11-13 | 2010-05-20 | Schering Corporation | Gamma secretase modulators |
WO2010056195A1 (en) * | 2008-11-14 | 2010-05-20 | Astrazeneca Ab | New compounds 575 |
TW201020244A (en) * | 2008-11-14 | 2010-06-01 | Astrazeneca Ab | New compounds |
US20100125081A1 (en) * | 2008-11-14 | 2010-05-20 | Astrazeneca Ab | New compounds 574 |
AU2009330233A1 (en) | 2008-12-22 | 2011-07-07 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
TW201035103A (en) | 2008-12-22 | 2010-10-01 | Schering Corp | Gamma secretase modulators |
US20120245158A1 (en) | 2009-06-16 | 2012-09-27 | Xianhai Huang | Gamma secretase modulators |
US20120232108A1 (en) | 2009-06-16 | 2012-09-13 | Xianhai Huang | Gamma secretase modulators |
US20120238546A1 (en) | 2009-06-16 | 2012-09-20 | Zhaoning Zhu | Gamma secretase modulators |
EP2281824A1 (en) | 2009-08-07 | 2011-02-09 | Noscira, S.A. | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders |
EP2485920B1 (en) | 2009-10-08 | 2016-04-27 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use |
US8557826B2 (en) | 2009-10-08 | 2013-10-15 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions, and their use |
UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
WO2011044187A1 (en) | 2009-10-08 | 2011-04-14 | Schering Corporation | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
JP2013542973A (ja) | 2010-11-22 | 2013-11-28 | ノスシラ、ソシエダッド、アノニマ | 神経変性疾患または神経変性状態を治療するためのビピリジンスルホンアミド誘導体 |
EP2694489B1 (en) | 2011-04-07 | 2017-09-06 | Merck Sharp & Dohme Corp. | C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
WO2012138590A1 (en) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
EP2747769B1 (en) | 2011-08-22 | 2017-08-02 | Merck Sharp & Dohme Corp. | 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use |
JP6482458B2 (ja) | 2012-03-19 | 2019-03-13 | バック・インスティテュート・フォー・リサーチ・オン・エイジング | App特異性のbace(asbi)およびその使用 |
WO2014062553A1 (en) | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
US9422277B2 (en) | 2012-10-17 | 2016-08-23 | Merck Sharp & Dohme Corp. | Tricyclic substituted thiadiazine dioxide compounds as BACE inhibitors, compositions and their use |
US9489013B2 (en) | 2012-12-20 | 2016-11-08 | Merck Sharp & Dohme Corp. | C6-azaspiro iminothiadiazine dioxides as bace inhibitors, compositions, and their use |
WO2014099788A1 (en) | 2012-12-21 | 2014-06-26 | Merck Sharp & Dohme Corp. | C5-spiro iminothiadiazine dioxides as bace inhibitors |
CA2899938C (en) | 2013-02-12 | 2021-10-19 | Buck Institute For Research On Aging | Hydantoins that modulate bace-mediated app processing |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH523264A (de) * | 1967-04-13 | 1972-05-31 | Ciba Geigy Ag | Verfahren zur Herstellung von 2,4 Benzdiazepinen |
EP0118171B1 (en) | 1983-03-04 | 1989-03-22 | Arco Chemical Technology, Inc. | Production of polyurethane-forming components having free-isocyanate or hydroxy groups |
US4550169A (en) * | 1983-11-21 | 1985-10-29 | American Cyanamid Company | Platinum chelates of 2-hydrazino-azoles |
CA2104060A1 (en) * | 1992-11-10 | 1994-05-11 | Robert Ed Johnson | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents |
US7560482B2 (en) | 2001-03-15 | 2009-07-14 | The Johns Hopkins University | Inhibitors of plasmepsins |
JP4283681B2 (ja) * | 2002-03-04 | 2009-06-24 | アンブリリア バイオファーマ インコーポレーテッド | Hivアスパルチルプロテアーゼ阻害剤としての尿素誘導体 |
AU2004294933B2 (en) | 2003-11-21 | 2011-11-17 | Johns Hopkins University | Biomolecule partition motifs and uses thereof |
JP5020638B2 (ja) | 2003-12-15 | 2012-09-05 | シェーリング コーポレイション | 複素環式アスパルチルプロテアーゼインヒビター |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
CN101228163A (zh) | 2005-06-14 | 2008-07-23 | 先灵公司 | 天冬氨酰蛋白酶抑制剂 |
KR20080015861A (ko) | 2005-06-14 | 2008-02-20 | 쉐링 코포레이션 | 아스파르틸 프로테아제 억제제로서의 화합물의 제조방법 및용도 |
CN101198595A (zh) | 2005-06-14 | 2008-06-11 | 先灵公司 | 天冬氨酰基蛋白酶抑制剂 |
-
2006
- 2006-10-25 ES ES06817385T patent/ES2349433T3/es active Active
- 2006-10-25 CA CA002626976A patent/CA2626976A1/en not_active Abandoned
- 2006-10-25 PE PE2006001297A patent/PE20070531A1/es not_active Application Discontinuation
- 2006-10-25 US US11/586,151 patent/US7763606B2/en active Active
- 2006-10-25 CN CNA2006800398031A patent/CN101296926A/zh active Pending
- 2006-10-25 EP EP06817385A patent/EP1940828B1/en active Active
- 2006-10-25 WO PCT/US2006/041716 patent/WO2007050721A2/en active Application Filing
- 2006-10-25 AT AT06817385T patent/ATE478070T1/de not_active IP Right Cessation
- 2006-10-25 DE DE602006016314T patent/DE602006016314D1/de active Active
- 2006-10-25 AR ARP060104660A patent/AR057983A1/es not_active Application Discontinuation
- 2006-10-25 JP JP2008537928A patent/JP2009513656A/ja not_active Ceased
- 2006-10-26 TW TW095139559A patent/TW200803847A/zh unknown
-
2008
- 2008-10-24 HK HK08111732.2A patent/HK1119680A1/xx not_active IP Right Cessation
-
2010
- 2010-06-07 US US12/794,858 patent/US8012960B2/en active Active
-
2011
- 2011-07-27 US US13/191,978 patent/US8202854B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US7763606B2 (en) | 2010-07-27 |
AR057983A1 (es) | 2008-01-09 |
CN101296926A (zh) | 2008-10-29 |
ES2349433T3 (es) | 2011-01-03 |
US8202854B2 (en) | 2012-06-19 |
EP1940828A2 (en) | 2008-07-09 |
ATE478070T1 (de) | 2010-09-15 |
US20100247519A1 (en) | 2010-09-30 |
WO2007050721A2 (en) | 2007-05-03 |
JP2009513656A (ja) | 2009-04-02 |
WO2007050721A3 (en) | 2007-06-14 |
DE602006016314D1 (de) | 2010-09-30 |
EP1940828B1 (en) | 2010-08-18 |
US20070099898A1 (en) | 2007-05-03 |
PE20070531A1 (es) | 2007-07-13 |
CA2626976A1 (en) | 2007-05-03 |
TW200803847A (en) | 2008-01-16 |
US8012960B2 (en) | 2011-09-06 |
US20110280867A1 (en) | 2011-11-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20141025 |