HK1118016A1 - Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient - Google Patents

Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient

Info

Publication number
HK1118016A1
HK1118016A1 HK08109143.9A HK08109143A HK1118016A1 HK 1118016 A1 HK1118016 A1 HK 1118016A1 HK 08109143 A HK08109143 A HK 08109143A HK 1118016 A1 HK1118016 A1 HK 1118016A1
Authority
HK
Hong Kong
Prior art keywords
agent
active ingredient
heterocyclic compound
tumor
immunosuppressive
Prior art date
Application number
HK08109143.9A
Other languages
English (en)
Inventor
Kazuhiko Haruta
Shinichi Yaguchi
Toshiyuki Matsuno
Yoshio Tsuchida
Tetsuo Watanabe
Kimitomo Yoshioka
Ryogo Yui
Original Assignee
Zenyaku Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zenyaku Kogyo Kk filed Critical Zenyaku Kogyo Kk
Publication of HK1118016A1 publication Critical patent/HK1118016A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK08109143.9A 2005-03-11 2008-08-18 Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient HK1118016A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005069255 2005-03-11
PCT/JP2006/304937 WO2006095906A1 (fr) 2005-03-11 2006-03-13 Agent immunosuppressif et agent anti-tumoral comprenant un compose heterocyclique en tant que principe actif

Publications (1)

Publication Number Publication Date
HK1118016A1 true HK1118016A1 (en) 2009-01-30

Family

ID=36953490

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08109143.9A HK1118016A1 (en) 2005-03-11 2008-08-18 Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient

Country Status (18)

Country Link
US (2) US7750001B2 (fr)
EP (1) EP1864665B1 (fr)
JP (1) JP5089377B2 (fr)
KR (1) KR101296884B1 (fr)
CN (1) CN101137382B (fr)
AU (1) AU2006221285B2 (fr)
BR (1) BRPI0608291A2 (fr)
CA (1) CA2599879C (fr)
CY (1) CY1112886T1 (fr)
DK (1) DK1864665T3 (fr)
ES (1) ES2395196T3 (fr)
HK (1) HK1118016A1 (fr)
PL (1) PL1864665T3 (fr)
PT (1) PT1864665E (fr)
RU (1) RU2443441C2 (fr)
SI (1) SI1864665T1 (fr)
TW (1) TWI381841B (fr)
WO (1) WO2006095906A1 (fr)

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WO2007128672A1 (fr) * 2006-05-03 2007-11-15 Ciba Holding Inc. Hexahydro-1,4-diazépin-5-ones substituées et compositions stabilisées avec ces composés
JP2010503650A (ja) * 2006-09-14 2010-02-04 アストラゼネカ アクチボラグ 増殖性疾患の治療のための、ｐｉ３ｋおよびｍｔｏｒ阻害剤としての２−ベンズイミダゾリル−６−モルホリノ−４−ピペリジン−４−イルピリミジン誘導体
WO2008032060A1 (fr) * 2006-09-14 2008-03-20 Astrazeneca Ab Dérivés de 4-benzimidaz0lyl-6-m0rph0lin0-2-pipérazinylpyrimidine utilisés comme inhibiteurs de p13k et mtor dans le traitement de troubles prolifératifs
CN101595103A (zh) * 2006-09-14 2009-12-02 阿斯利康(瑞典)有限公司 嘧啶衍生物
US20100022534A1 (en) * 2006-09-14 2010-01-28 Astrazeneca 2-benzimidazolyl-6-morpholino-4- (azetidine, pyrrolidine, piperidine or azepine) pyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
PT2409975E (pt) 2007-11-22 2015-07-27 Zenyaku Kogyo Kk Dispersões sólidas compreendendo um corpo amorfo composto por um composto antitumoral heterocíclico
JP2011515462A (ja) * 2008-03-27 2011-05-19 アウククランド ウニセルビセス リミテッド 置換されたピリミジン、及びトリアジン、並びに癌療法におけるこれらの使用
GB2465405A (en) * 2008-11-10 2010-05-19 Univ Basel Triazine, pyrimidine and pyridine analogues and their use in therapy
RU2011137399A (ru) * 2009-02-12 2013-03-20 Астеллас Фарма Инк. Гетероциклическое производное
EP2411387B1 (fr) 2009-03-27 2015-08-19 VetDC, Inc. Pyrimidinyl et 1,3,5-triazinyl benzimidazole sulfonamides et leur utilisation en thérapie anticancéreuse
WO2010110686A1 (fr) 2009-03-27 2010-09-30 Pathway Therapeutics Limited Pyrimidinyl et 1,3,5-triazinyl benzimidazoles et leur utilisation en thérapie anticancéreuse
UY32582A (es) 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
AR080945A1 (es) 2009-07-07 2012-05-23 Pathway Therapeutics Inc Pirimidinil y 1,3,5-triazinil benzimidazoles y su uso en la terapia contra el cancer
GB201007227D0 (en) * 2010-04-30 2010-06-16 Univ Basel Piperazinotriazines
AU2011290189B8 (en) * 2010-08-10 2015-02-19 Astellas Pharma Inc. Heterocyclic compound
KR101940831B1 (ko) 2011-03-28 2019-01-21 메이 파마, 아이엔씨. (알파-치환된 아르알킬아미노 및 헤테로아릴알킬아미노)피리미딘일 및 1,3,5-트라이아진일 벤즈이미다졸, 이들을 함유하는 약학 조성물, 및 증식성 질병의 치료에 사용하기 위한 이들 화합물
CN102429911A (zh) * 2011-12-08 2012-05-02 天津医科大学 Zstk474在制备治疗自身免性疾病药物方面的应用
RU2509770C2 (ru) * 2012-06-22 2014-03-20 Общество с ограниченной ответственностью "Молекулярные Технологии" Новые химические соединения производные 2,4-диамино-1,3,5-триазина для профилактики и лечения заболеваний человека и животных
WO2015047124A1 (fr) * 2013-09-26 2015-04-02 Общество с ограниченной ответственностью "Молекулярные Технологии" Nouveaux composés chimiques dérivés de 2,4-diamino-1,3,5-triazine afin de prévenir et traiter des maladies d'humains et d'animaux
MA40933A (fr) 2014-11-11 2017-09-19 Piqur Therapeutics Ag Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines
CN107428730B (zh) * 2014-11-20 2020-10-16 科学与工业研究会 作为抗癌试剂的1,3,5-三嗪基pi3k抑制剂及其制备方法
CN105130960B (zh) * 2015-07-31 2018-07-06 沈阳药科大学 1,3,5-三嗪类衍生物及其应用
RU2637643C1 (ru) * 2016-09-05 2017-12-05 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фундаментальной и клинической иммунологии" (НИИФКИ) Иммунодепрессант
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
WO2018131659A1 (fr) * 2017-01-11 2018-07-19 国立研究開発法人国立がん研究センター Agent immunothérapeutique
CN117860758A (zh) 2017-05-23 2024-04-12 梅制药公司 联合疗法
WO2019036489A1 (fr) 2017-08-14 2019-02-21 Mei Pharma, Inc. Polythérapie

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US5656643A (en) * 1993-11-08 1997-08-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
JPH0948776A (ja) 1994-09-26 1997-02-18 Dai Ichi Seiyaku Co Ltd ピリミジニルピラゾール誘導体
TW312694B (fr) * 1994-09-26 1997-08-11 Daiichi Seiyaku Co
AU727013B2 (en) * 1997-07-24 2000-11-30 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and antitumor agent comprising the same as effective component
WO2000043385A1 (fr) * 1999-01-25 2000-07-27 Zenyaku Kogyo Kabushiki Kaisha Composes heterocycliques et agents antitumoraux les comprenant en tant que principe actif
WO2001091699A2 (fr) * 2000-05-30 2001-12-06 Advanced Research & Technology Institute Compositions et methodes d'identification d'agents modulateurs de la fonction pten et des mecanismes de la pi-3 kinase
US7141579B2 (en) * 2001-01-30 2006-11-28 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compounds and cerebral function improvers containing the same as the active ingredient
PT1389617E (pt) * 2001-04-27 2007-04-30 Zenyaku Kogyo Kk Composto heterocíclico e agente antitumoral contendo o mesmo como igrediente activo
WO2004032930A1 (fr) 2002-10-11 2004-04-22 Kowa Co., Ltd. Metrode de traitement du cancer
CA2503451C (fr) * 2002-10-25 2011-07-12 Zenyaku Kogyo Kabushiki Kaisha Composes heterocycliques et agent antitumoral contenant ces derniers en tant qu'ingredient actif
EP1569653A1 (fr) * 2002-12-06 2005-09-07 Warner-Lambert Company LLC Benzoxazin-3-ones et derives de ceux-ci utilises en tant qu'inhibiteurs de pi3k
AU2005227954B2 (en) * 2004-03-31 2011-02-10 Zenyaku Kogyo Kabushiki Kaisha Heterocyclic compound and anti-malignant-tumor agent comprising the same as effective component
US20070244110A1 (en) * 2006-04-14 2007-10-18 Zenyaku Kogyo Kabushiki Kaisha Treatment of prostate cancer, melanoma or hepatic cancer

Also Published As

Publication number Publication date
JP5089377B2 (ja) 2012-12-05
RU2443441C2 (ru) 2012-02-27
US7750001B2 (en) 2010-07-06
PT1864665E (pt) 2012-06-27
EP1864665B1 (fr) 2012-05-16
BRPI0608291A2 (pt) 2009-12-22
SI1864665T1 (sl) 2012-09-28
AU2006221285B2 (en) 2011-03-31
AU2006221285A1 (en) 2006-09-14
PL1864665T3 (pl) 2012-10-31
EP1864665A4 (fr) 2008-06-11
CY1112886T1 (el) 2016-04-13
WO2006095906A1 (fr) 2006-09-14
KR101296884B1 (ko) 2013-08-14
JPWO2006095906A1 (ja) 2008-08-21
CN101137382A (zh) 2008-03-05
CA2599879C (fr) 2013-07-02
TWI381841B (zh) 2013-01-11
US20100267700A1 (en) 2010-10-21
TW200642689A (en) 2006-12-16
EP1864665A1 (fr) 2007-12-12
DK1864665T3 (da) 2012-07-23
ES2395196T3 (es) 2013-02-11
RU2007137651A (ru) 2009-04-20
CN101137382B (zh) 2012-11-21
KR20070113285A (ko) 2007-11-28
CA2599879A1 (fr) 2006-09-14
US20080113987A1 (en) 2008-05-15
US8338414B2 (en) 2012-12-25

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