HK1108686A1 - 3-azetidinecarboxylic acid derivatives for use as immunosuppressants - Google Patents
3-azetidinecarboxylic acid derivatives for use as immunosuppressantsInfo
- Publication number
- HK1108686A1 HK1108686A1 HK08102099.8A HK08102099A HK1108686A1 HK 1108686 A1 HK1108686 A1 HK 1108686A1 HK 08102099 A HK08102099 A HK 08102099A HK 1108686 A1 HK1108686 A1 HK 1108686A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- immunosuppressants
- acid derivatives
- azetidinecarboxylic acid
- azetidinecarboxylic
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Virology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005124353 | 2005-04-22 | ||
PCT/JP2006/308387 WO2006115188A1 (ja) | 2005-04-22 | 2006-04-21 | ヘテロ環化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1108686A1 true HK1108686A1 (en) | 2008-05-16 |
Family
ID=37214804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK08102099.8A HK1108686A1 (en) | 2005-04-22 | 2008-02-26 | 3-azetidinecarboxylic acid derivatives for use as immunosuppressants |
Country Status (17)
Country | Link |
---|---|
US (1) | US7687491B2 (xx) |
EP (1) | EP1873153B1 (xx) |
JP (1) | JPWO2006115188A1 (xx) |
KR (1) | KR20070121013A (xx) |
CN (1) | CN101203512A (xx) |
AU (1) | AU2006240789B2 (xx) |
BR (1) | BRPI0609994A2 (xx) |
CA (1) | CA2605594A1 (xx) |
DE (1) | DE602006015297D1 (xx) |
HK (1) | HK1108686A1 (xx) |
IL (1) | IL186665A0 (xx) |
NO (1) | NO20076010L (xx) |
NZ (1) | NZ563522A (xx) |
RU (1) | RU2382781C2 (xx) |
TW (1) | TW200642683A (xx) |
WO (1) | WO2006115188A1 (xx) |
ZA (1) | ZA200709051B (xx) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI408139B (zh) | 2006-09-07 | 2013-09-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
SI2069336T1 (sl) | 2006-09-07 | 2013-03-29 | Actelion Pharmaceuticals Ltd. | Derivati piridin-4-ila kot imunomodulirna sredstva |
MX2009002234A (es) | 2006-09-08 | 2009-03-16 | Actelion Pharmaceuticals Ltd | Derivados de piridin-3-il como agentes inmunomoduladores. |
US20110207704A1 (en) * | 2006-12-15 | 2011-08-25 | Abbott Laboratories | Novel Oxadiazole Compounds |
NZ577111A (en) * | 2006-12-15 | 2012-05-25 | Abbott Lab | Novel oxadiazole compounds |
JO2701B1 (en) | 2006-12-21 | 2013-03-03 | جلاكسو جروب ليميتد | Vehicles |
CN101627034B (zh) | 2007-03-16 | 2013-05-15 | 埃科特莱茵药品有限公司 | 氨基-吡啶衍生物作为s1p1/edg1受体激动剂 |
CL2008001099A1 (es) | 2007-04-19 | 2008-10-24 | Glaxo Group Ltd | Compuestos derivados de indazol; y su uso para tratar enfermedades mediadas por los receptores s1p1, tales como esclerosis multiple, enfermedad autoinmune, trastornos inflamatorios, diabetes, entre otras. |
BRPI0820868A2 (pt) | 2007-12-10 | 2019-09-24 | Actelion Pharmaceuticals Ltd | composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado |
GB0725101D0 (en) | 2007-12-21 | 2008-01-30 | Glaxo Group Ltd | Compounds |
PE20091339A1 (es) | 2007-12-21 | 2009-09-26 | Glaxo Group Ltd | Derivados de oxadiazol con actividad sobre receptores s1p1 |
US20110028448A1 (en) * | 2008-03-06 | 2011-02-03 | Martin Bolli | Pyridine compounds |
DK2252609T3 (da) | 2008-03-07 | 2013-06-24 | Actelion Pharmaceuticals Ltd | Pyridin-2-yl-derivater som immunomodulerende midler |
CN102007107B (zh) | 2008-03-07 | 2014-07-23 | 埃科特莱茵药品有限公司 | 氨甲基苯衍生物 |
GB0807910D0 (en) * | 2008-04-30 | 2008-06-04 | Glaxo Group Ltd | Compounds |
WO2009153307A1 (en) * | 2008-06-20 | 2009-12-23 | Glaxo Group Limited | Compounds |
NZ592748A (en) | 2008-10-17 | 2013-01-25 | Akaal Pharma Pty Ltd | 2-Amino-(oxadiazol-3-yl)-benzofuran derivatives and their use as S1P receptor modulators |
WO2010085581A1 (en) | 2009-01-23 | 2010-07-29 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
CN102361869A (zh) | 2009-01-23 | 2012-02-22 | 百时美施贵宝公司 | 在治疗自身免疫性疾病和炎性疾病中作为s1p激动剂的取代的噁二唑衍生物 |
WO2010085584A1 (en) | 2009-01-23 | 2010-07-29 | Bristol-Myers Squibb Company | Pyrazole-i, 2, 4 -oxad iazole derivatives as s.phing0sine-1-ph0sphate agonists |
GB0910674D0 (en) | 2009-06-19 | 2009-08-05 | Glaxo Group Ltd | Novel compounds |
PL2454255T3 (pl) | 2009-07-16 | 2014-04-30 | Idorsia Pharmaceuticals Ltd | Pochodne pirydyn-4-ylowe jako agoniści S1P1/EDG1 |
US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
EP2592071B1 (en) | 2009-10-29 | 2019-09-18 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds |
RU2707067C2 (ru) | 2009-12-04 | 2019-11-22 | Суновион Фармасьютикалз, Инк. | Полициклические соединения и способы их применения |
JP5735634B2 (ja) | 2010-04-23 | 2015-06-17 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | スフィンゴシン−1−リン酸受容体1アゴニストとしての4−(5−イソオキサゾリルまたは5−ピラゾリル−1,2,4−オキサジアゾール−3−イル)−マンデル酸アミド化合物 |
EP2595969B1 (en) | 2010-07-20 | 2015-04-22 | Bristol-Myers Squibb Company | Substituted 3-phenyl-1,2,4-oxadiazole compounds |
KR101508862B1 (ko) * | 2010-08-05 | 2015-04-07 | 조에티스 엘엘씨 | 구충제로서 이속사졸린 유도체 |
WO2012040532A1 (en) | 2010-09-24 | 2012-03-29 | Bristol-Myers Squibb Company | Substituted oxadiazole compounds and their use as s1p1 agonists |
JP2013544811A (ja) | 2010-11-03 | 2013-12-19 | ブリストル−マイヤーズ スクイブ カンパニー | 自己免疫疾患および血管疾患の治療用のs1p1アゴニストとしての複素環式化合物 |
MY163185A (en) | 2011-01-19 | 2017-08-15 | Idorsia Pharmaceuticals Ltd | 2-methoxy-pyridin-4-yl derivatives |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
AR091655A1 (es) | 2012-07-02 | 2015-02-18 | Monsanto Technology Llc | Procesos para la preparacion de 1,2,4-oxadiazoles 3,5-disustituidos |
WO2014063199A1 (en) * | 2012-10-26 | 2014-05-01 | Akaal Pharma Pty Ltd | Organic compounds |
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JP4430941B2 (ja) * | 2002-01-18 | 2010-03-10 | メルク エンド カムパニー インコーポレーテッド | Edg受容体作動薬 |
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CA2524054C (en) * | 2003-05-19 | 2012-04-24 | Irm Llc | Immunosuppressant compounds and compositions |
MY150088A (en) * | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
AU2004251146A1 (en) * | 2003-05-19 | 2005-01-06 | Irm, Llc | Immunosuppressant compounds and compositions |
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2006
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- 2006-04-21 EP EP06732195A patent/EP1873153B1/en not_active Not-in-force
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- 2006-04-21 JP JP2007514661A patent/JPWO2006115188A1/ja not_active Withdrawn
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- 2006-04-21 WO PCT/JP2006/308387 patent/WO2006115188A1/ja active Application Filing
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RU2382781C2 (ru) | 2010-02-27 |
ZA200709051B (en) | 2008-10-29 |
AU2006240789B2 (en) | 2010-03-04 |
WO2006115188A1 (ja) | 2006-11-02 |
US20080113961A1 (en) | 2008-05-15 |
CA2605594A1 (en) | 2006-11-02 |
KR20070121013A (ko) | 2007-12-26 |
NZ563522A (en) | 2010-01-29 |
RU2007138978A (ru) | 2009-04-27 |
JPWO2006115188A1 (ja) | 2008-12-18 |
EP1873153A1 (en) | 2008-01-02 |
AU2006240789A1 (en) | 2006-11-02 |
BRPI0609994A2 (pt) | 2011-10-18 |
EP1873153A4 (en) | 2009-09-30 |
US7687491B2 (en) | 2010-03-30 |
EP1873153B1 (en) | 2010-07-07 |
NO20076010L (no) | 2008-01-21 |
IL186665A0 (en) | 2008-01-20 |
CN101203512A (zh) | 2008-06-18 |
DE602006015297D1 (de) | 2010-08-19 |
TW200642683A (en) | 2006-12-16 |
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