HK1100945A1 - Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents - Google Patents
Salts of isophosphoramide mustard and analogs thereof as anti-tumor agentsInfo
- Publication number
- HK1100945A1 HK1100945A1 HK07108953.1A HK07108953A HK1100945A1 HK 1100945 A1 HK1100945 A1 HK 1100945A1 HK 07108953 A HK07108953 A HK 07108953A HK 1100945 A1 HK1100945 A1 HK 1100945A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- analogs
- salts
- tumor agents
- isophosphoramide mustard
- isophosphoramide
- Prior art date
Links
- BKCJZNIZRWYHBN-UHFFFAOYSA-N Isophosphamide mustard Chemical class ClCCNP(=O)(O)NCCCl BKCJZNIZRWYHBN-UHFFFAOYSA-N 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/222—Amides of phosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62208704P | 2004-10-25 | 2004-10-25 | |
| US67270705P | 2005-04-18 | 2005-04-18 | |
| PCT/US2005/038523 WO2006047575A2 (en) | 2004-10-25 | 2005-10-25 | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1100945A1 true HK1100945A1 (en) | 2007-11-16 |
Family
ID=35788704
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK07108953.1A HK1100945A1 (en) | 2004-10-25 | 2007-08-16 | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
| HK15110402.4A HK1209752A1 (en) | 2004-10-25 | 2015-10-22 | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15110402.4A HK1209752A1 (en) | 2004-10-25 | 2015-10-22 | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US7678778B2 (ja) |
| EP (3) | EP2336139A3 (ja) |
| JP (1) | JP5336082B2 (ja) |
| KR (2) | KR20130041384A (ja) |
| CN (3) | CN101087800B (ja) |
| AU (1) | AU2005299385B2 (ja) |
| CA (1) | CA2585125C (ja) |
| DK (2) | DK1805192T3 (ja) |
| ES (2) | ES2397165T3 (ja) |
| HK (2) | HK1100945A1 (ja) |
| IL (3) | IL182752A (ja) |
| NO (1) | NO20072478L (ja) |
| NZ (2) | NZ589418A (ja) |
| PL (1) | PL1805192T3 (ja) |
| PT (1) | PT1805192E (ja) |
| SI (1) | SI1805192T1 (ja) |
| WO (1) | WO2006047575A2 (ja) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101087800B (zh) | 2004-10-25 | 2015-01-07 | 德克技术公司 | 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐 |
| US7964583B2 (en) | 2006-02-17 | 2011-06-21 | Ziopharm Oncology, Inc. | Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents |
| JP5659010B2 (ja) * | 2007-04-06 | 2015-01-28 | ジオファーム オンコロジー， インコーポレイテッドＺｉｏｐｈａｒｍ Ｏｎｃｏｌｏｇｙ，Ｉｎｃ． | イソホスホルアミドマスタードの塩およびそれらの類似体 |
| EP2318013A4 (en) * | 2008-07-31 | 2013-07-24 | Ziopharm Oncology Inc | SYNTHESIS AND FORMULATION OF ISOPHOSPHORAMIDE MUSTARD SALTS AND THEIR ANALOGUES |
| JP5779106B2 (ja) * | 2009-02-24 | 2015-09-16 | デック−テック， インコーポレイテッド | 抗腫瘍剤としての４−ヒドロペルオキシイホスファミドの錯体 |
| CN102659841B (zh) * | 2012-04-24 | 2015-03-25 | 石家庄学院 | 多元酚磷酰胺衍生物及其制备方法与应用 |
| CA2899206C (en) | 2013-01-24 | 2019-07-09 | Transderm, Inc. | Compositions for transdermal delivery of mtor inhibitors |
| WO2017044453A1 (en) * | 2015-09-10 | 2017-03-16 | Becton, Dickinson And Company | Cyclophosphamide analogs for use as immunogens and assay conjugates for an immunoassay of cyclophosphamide and ifosfamide |
| CN110520097B (zh) | 2017-01-06 | 2023-10-27 | 帕尔维拉治疗股份有限公司 | Mtor抑制剂的无水组合物及其使用方法 |
| US11199529B2 (en) | 2017-09-21 | 2021-12-14 | Becton, Dickinson And Company | Hazardous contaminant collection kit and rapid testing |
| JP2021530463A (ja) | 2018-07-02 | 2021-11-11 | パルヴェラ セラピューティクス、インク． | ｍＴＯＲ阻害剤の無水組成物および使用方法 |
| CN112888698A (zh) * | 2018-09-25 | 2021-06-01 | 美国政府(由卫生和人类服务部的部长所代表) | 2’-卤代-4’-硫代-2’-脱氧-5-氮杂胞苷类似物及其使用方法 |
| CN212748381U (zh) | 2019-01-28 | 2021-03-19 | 贝克顿·迪金森公司 | 一种有害污染物检测系统和一种有害污染物收集装置 |
| CN111973583A (zh) * | 2020-07-29 | 2020-11-24 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 芹菜素在制备促进缺血超长随意皮瓣存活药物的作用 |
| CN111943979B (zh) | 2020-10-19 | 2020-12-22 | 南京卓康医药科技有限公司 | 一种异环磷酰胺中间体及其制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU427945A1 (ru) | 1972-07-24 | 1974-05-15 | Институт элементоорганических соединений | СПОСОБ ПОЛУЧЕНИЯа ПОЛИФТОРАЛКИЛЗАМЕЩЕННЫХБЕНЗИЛДИХЛОРФОСФАТОВ |
| JPS5159886A (ja) | 1974-11-20 | 1976-05-25 | Shionogi Seiyaku Kk | |
| ZA851062B (en) * | 1984-03-01 | 1985-11-27 | Asta Werke Ag Chem Fab | Salts of oxazaphosphorine derivatives and process for their production |
| PL264222A1 (en) * | 1986-02-22 | 1988-04-14 | Method of obtaining novel heterocyclic compounds with 2-(2-/n,n-bis-(2-chloroethyl)-diamido-phosphoryloxy/ethyl)group | |
| US5055459A (en) * | 1986-06-30 | 1991-10-08 | Board Of Regents, The University Of Texas | Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates |
| US4841085A (en) * | 1986-06-30 | 1989-06-20 | Board Of Regents, University Of Texas System | Aldophosphamides |
| ATE181551T1 (de) | 1992-04-17 | 1999-07-15 | Abbott Lab | Taxol-derivate |
| US5468499A (en) * | 1993-11-15 | 1995-11-21 | Ohio State University | Liposomes containing the salt of phosphoramide mustard and related compounds |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| CA2373634C (en) * | 1999-05-24 | 2010-04-13 | Southern Research Institute | Isophosphoramide mustard analogs and use thereof |
| CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| CA2406160A1 (en) | 2000-04-13 | 2001-10-25 | Hsc Research And Development Limited Partnership | Compounds for modulating cell proliferation |
| DE10064312C2 (de) * | 2000-12-22 | 2003-05-22 | Degussa | Cholinpyruvat-Hydrat, Verfahren zu dessen Herstellung, Cholinpyruvat-Hydrat enthaltende Formulierung sowie deren Verwendung |
| DE60330407D1 (de) | 2002-08-23 | 2010-01-14 | Sloan Kettering Inst Cancer | Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung |
| CN101087800B (zh) * | 2004-10-25 | 2015-01-07 | 德克技术公司 | 作为抗肿瘤剂的异磷酰胺氮芥及其类似物的盐 |
| JP5659010B2 (ja) * | 2007-04-06 | 2015-01-28 | ジオファーム オンコロジー， インコーポレイテッドＺｉｏｐｈａｒｍ Ｏｎｃｏｌｏｇｙ，Ｉｎｃ． | イソホスホルアミドマスタードの塩およびそれらの類似体 |
| EP2318013A4 (en) * | 2008-07-31 | 2013-07-24 | Ziopharm Oncology Inc | SYNTHESIS AND FORMULATION OF ISOPHOSPHORAMIDE MUSTARD SALTS AND THEIR ANALOGUES |
-
2005
- 2005-10-25 CN CN200580044803.6A patent/CN101087800B/zh not_active Expired - Fee Related
- 2005-10-25 NZ NZ589418A patent/NZ589418A/en not_active IP Right Cessation
- 2005-10-25 PL PL05821125T patent/PL1805192T3/pl unknown
- 2005-10-25 CA CA2585125A patent/CA2585125C/en not_active Expired - Fee Related
- 2005-10-25 JP JP2007538185A patent/JP5336082B2/ja not_active Expired - Fee Related
- 2005-10-25 PT PT58211251T patent/PT1805192E/pt unknown
- 2005-10-25 US US11/257,766 patent/US7678778B2/en not_active Expired - Fee Related
- 2005-10-25 KR KR1020137008506A patent/KR20130041384A/ko not_active Application Discontinuation
- 2005-10-25 WO PCT/US2005/038523 patent/WO2006047575A2/en active Application Filing
- 2005-10-25 EP EP10178414A patent/EP2336139A3/en not_active Withdrawn
- 2005-10-25 ES ES05821125T patent/ES2397165T3/es active Active
- 2005-10-25 SI SI200531655T patent/SI1805192T1/sl unknown
- 2005-10-25 AU AU2005299385A patent/AU2005299385B2/en not_active Ceased
- 2005-10-25 CN CN2013100286502A patent/CN103172662A/zh active Pending
- 2005-10-25 EP EP05821125A patent/EP1805192B1/en not_active Not-in-force
- 2005-10-25 US US11/666,215 patent/US8232262B2/en not_active Expired - Fee Related
- 2005-10-25 DK DK05821125.1T patent/DK1805192T3/da active
- 2005-10-25 NZ NZ555323A patent/NZ555323A/en not_active IP Right Cessation
- 2005-10-25 EP EP10178422.1A patent/EP2336140B1/en not_active Not-in-force
- 2005-10-25 KR KR1020077011864A patent/KR101292026B1/ko not_active IP Right Cessation
- 2005-10-25 CN CN201410730089.7A patent/CN104558023A/zh active Pending
- 2005-10-25 ES ES10178422.1T patent/ES2565929T3/es active Active
- 2005-10-25 DK DK10178422.1T patent/DK2336140T3/en active
-
2007
- 2007-04-23 IL IL182752A patent/IL182752A/en not_active IP Right Cessation
- 2007-05-16 NO NO20072478A patent/NO20072478L/no not_active Application Discontinuation
- 2007-08-16 HK HK07108953.1A patent/HK1100945A1/xx not_active IP Right Cessation
-
2011
- 2011-03-24 IL IL211936A patent/IL211936A/en not_active IP Right Cessation
- 2011-03-24 IL IL211935A patent/IL211935A0/en unknown
-
2012
- 2012-07-03 US US13/541,522 patent/US8795659B2/en not_active Expired - Fee Related
-
2014
- 2014-07-10 US US14/328,125 patent/US9346836B2/en not_active Expired - Fee Related
-
2015
- 2015-10-22 HK HK15110402.4A patent/HK1209752A1/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20161025 |