HK1098489A1 - A fusion protein comprising human parathyroid hormone 1-34 and expression vector thereof - Google Patents
A fusion protein comprising human parathyroid hormone 1-34 and expression vector thereofInfo
- Publication number
- HK1098489A1 HK1098489A1 HK07105962.6A HK07105962A HK1098489A1 HK 1098489 A1 HK1098489 A1 HK 1098489A1 HK 07105962 A HK07105962 A HK 07105962A HK 1098489 A1 HK1098489 A1 HK 1098489A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- fusion protein
- expression vector
- parathyroid hormone
- human parathyroid
- human
- Prior art date
Links
- 239000013604 expression vector Substances 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- OGBMKVWORPGQRR-UMXFMPSGSA-N teriparatide Chemical compound C([C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CNC=N1 OGBMKVWORPGQRR-UMXFMPSGSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100709954A CN100484958C (zh) | 2006-03-31 | 2006-03-31 | 含有人甲状旁腺素1-34的融合蛋白及其表达载体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1098489A1 true HK1098489A1 (en) | 2007-07-20 |
Family
ID=37656127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK07105962.6A HK1098489A1 (en) | 2006-03-31 | 2007-06-06 | A fusion protein comprising human parathyroid hormone 1-34 and expression vector thereof |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN100484958C (xx) |
| HK (1) | HK1098489A1 (xx) |
| WO (1) | WO2007112676A1 (xx) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011151721A1 (en) | 2010-06-04 | 2011-12-08 | Lupin Limited | Process for production of fusion proteins using truncated e. coli thioredoxin |
| CN102191303A (zh) * | 2010-11-26 | 2011-09-21 | 扬子江药业集团北京海燕药业有限公司 | 基因重组Tα1的表达和制备方法 |
| CN107941983B (zh) * | 2018-01-05 | 2020-05-15 | 北京博康健基因科技有限公司 | 一种rhPTH蛋白或rhPTH蛋白制剂的检测方法和纯度的分析方法 |
| CN110938151B (zh) * | 2019-12-30 | 2023-03-17 | 重庆艾力彼生物科技有限公司 | 用于表达甲状旁腺素pth的融合蛋白及重组质粒、重组工程菌 |
| CN112646826A (zh) * | 2020-12-23 | 2021-04-13 | 无锡和邦生物科技有限公司 | 编码Trx-hPTH（1-34）融合蛋白的基因序列、重组表达质粒、工程菌及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1189565C (zh) * | 2000-09-18 | 2005-02-16 | 中山大学 | 一种高效原核表达载体 |
| CN1424325A (zh) * | 2001-12-12 | 2003-06-18 | 中国科学院上海生物工程研究中心 | 重组人甲状旁腺素1－34肽的生产工艺 |
| CN1212336C (zh) * | 2002-11-29 | 2005-07-27 | 西南生物工程产业化中试基地有限公司 | 重组人甲状旁腺激素pth(1－34)的制备方法 |
| CN1706947A (zh) * | 2004-06-04 | 2005-12-14 | 南京大学生物制药工程研究中心 | 重组人甲状旁腺激素在大肠杆菌中的构建、表达与纯化方法 |
| CN1807456B (zh) * | 2005-01-19 | 2012-09-05 | 丁邦 | 重组人甲状旁腺激素pth1-34的制备方法 |
-
2006
- 2006-03-31 CN CNB2006100709954A patent/CN100484958C/zh active Active
-
2007
- 2007-03-29 WO PCT/CN2007/001024 patent/WO2007112676A1/zh active Application Filing
- 2007-06-06 HK HK07105962.6A patent/HK1098489A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN100484958C (zh) | 2009-05-06 |
| WO2007112676A1 (fr) | 2007-10-11 |
| CN1900120A (zh) | 2007-01-24 |
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