HK1089157A1 - 8-aza-bicyclo(3.2.1)octane derivatives an their use as preparing monoamine neurotransmitter re-uptake inhibitors - Google Patents

8-aza-bicyclo(3.2.1)octane derivatives an their use as preparing monoamine neurotransmitter re-uptake inhibitors

Info

Publication number
HK1089157A1
HK1089157A1 HK06109422A HK06109422A HK1089157A1 HK 1089157 A1 HK1089157 A1 HK 1089157A1 HK 06109422 A HK06109422 A HK 06109422A HK 06109422 A HK06109422 A HK 06109422A HK 1089157 A1 HK1089157 A1 HK 1089157A1
Authority
HK
Hong Kong
Prior art keywords
aza
bicyclo
uptake inhibitors
monoamine neurotransmitter
octane derivatives
Prior art date
Application number
HK06109422A
Other languages
English (en)
Inventor
Dan Peters
Brigitte Eriksen
Elsebet Ostergaard Nielsen
Jorgen Scheel-Kruger
Gunnar Olsen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of HK1089157A1 publication Critical patent/HK1089157A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK06109422A 2003-06-24 2006-08-25 8-aza-bicyclo(3.2.1)octane derivatives an their use as preparing monoamine neurotransmitter re-uptake inhibitors HK1089157A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200300939 2003-06-24
DKPA200301487 2003-10-09
DKPA200400228 2004-02-13
PCT/EP2004/051167 WO2004113334A1 (fr) 2003-06-24 2004-06-18 Nouveaux derives de 8-aza-bicyclo[3.2.1]octane et utilisation en tant qu'inhibiteurs de la reabsorption des neurotransmetteurs monoamine

Publications (1)

Publication Number Publication Date
HK1089157A1 true HK1089157A1 (en) 2006-11-24

Family

ID=36754881

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06109422A HK1089157A1 (en) 2003-06-24 2006-08-25 8-aza-bicyclo(3.2.1)octane derivatives an their use as preparing monoamine neurotransmitter re-uptake inhibitors

Country Status (18)

Country Link
US (3) US7407970B2 (fr)
EP (1) EP1638965A1 (fr)
JP (1) JP2009513491A (fr)
KR (1) KR20060030482A (fr)
CN (1) CN100368409C (fr)
AR (1) AR044883A1 (fr)
AU (1) AU2004249441B2 (fr)
BR (1) BRPI0411608A (fr)
CA (1) CA2530023A1 (fr)
CO (1) CO5630004A2 (fr)
HK (1) HK1089157A1 (fr)
IL (1) IL171990A0 (fr)
IS (1) IS8212A (fr)
NO (1) NO20060360L (fr)
RU (1) RU2344136C2 (fr)
TW (1) TW200510404A (fr)
UA (1) UA82517C2 (fr)
WO (1) WO2004113334A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA82517C2 (uk) * 2003-06-24 2008-04-25 Ньюросерч А/С Нові похідні 8-аза-біцикло[3.2.1]октану та їх застосування як інгібіторів ресорбції моноамінових медіаторів
US20050171079A1 (en) * 2004-02-04 2005-08-04 Schrimpf Michael R. Amino-substituted tricyclic derivatives and methods of use
US7365193B2 (en) 2004-02-04 2008-04-29 Abbott Laboratories Amino-substituted tricyclic derivatives and methods of use
EP1761518A1 (fr) * 2004-06-18 2007-03-14 Neurosearch A/S Nouveaux derives piperidines a substitution d'alkyle en tant qu'inhibiteurs de recaptage de neurotransmetteurs de monoamine
WO2006075004A2 (fr) 2005-01-13 2006-07-20 Neurosearch A/S Nouveaux derives de 8-aza-bicyclo[3.2.1]octane et leur utilisation comme inhibiteurs du recaptage du neurotransmetteur monoamine
CA2620986A1 (fr) * 2005-06-08 2006-12-14 Neurosearch A/S Derives de 3-aryloxy-8-aza-bicyclo[3.2.1.]oct-6-ene et utilisation de ceux-ci comme inhibiteurs du recaptage des neurotransmetteurs monoamines
TW200716627A (en) 2005-06-08 2007-05-01 Neurosearch As Novel compounds
TW200745101A (en) * 2005-09-30 2007-12-16 Organon Nv 9-Azabicyclo[3.3.1]nonane derivatives
US7868017B2 (en) 2005-09-30 2011-01-11 N.V. Organon 9-azabicyclo[3.3.1]nonane derivatives
EP1779851A1 (fr) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Traitement du diabète
TW200804367A (en) * 2005-11-11 2008-01-16 Neurosearch As Novel compounds
TW200806662A (en) * 2005-12-01 2008-02-01 Organon Nv 8-azabicyclo[3.2.1]octane derivatives
US7605170B2 (en) 2005-12-01 2009-10-20 N.V. Organon 8-azabicyclo[3.2.1]octane derivatives
CN102516241B (zh) 2006-05-19 2015-07-29 艾伯维巴哈马有限公司 Cns活性的稠合的双环杂环取代的氮杂双环烷烃衍生物
TW200904815A (en) * 2007-05-09 2009-02-01 Neurosearch As Novel compounds
MX2010004493A (es) * 2007-10-25 2010-06-11 Exelixis Inc Compuestos de tropano.
US20110053984A1 (en) * 2008-03-05 2011-03-03 Neurosearch A/S Novel 4-benzhydryloxy-tetraalkyl-piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2014005274A1 (fr) * 2012-07-03 2014-01-09 海南卫康制药(潜山)有限公司 Composé d'hétérocyclo[3.2.1]octane azoté en position 8 polysubstitué
US10118927B2 (en) 2012-12-27 2018-11-06 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2640829A (en) * 1950-11-10 1953-06-02 Smith Kline French Lab Isoquinolyl heterocyclic ethers
GB969518A (en) * 1961-04-27 1964-09-09 Koninklijke Pharma Fab Nv Tetrahydrodibenzocyclo-octene derivatives
GB1008645A (en) 1963-08-06 1965-11-03 Koninklijke Pharma Fab Nv Dibenzocycloheptane derivatives
GB1164555A (en) * 1966-09-20 1969-09-17 Chinoin Gyogyszer Es Vegyeszet New Tropine Derivatives
US3655675A (en) * 1968-09-09 1972-04-11 Sterling Drug Inc N-(n-heteryl)-acylanilides
US3657253A (en) * 1970-08-31 1972-04-18 Robins Co Inc A H 3-aryloxy-8-carbamoylnortropanes
FR2476088A2 (fr) 1979-01-16 1981-08-21 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
IL61642A0 (en) 1979-12-20 1981-01-30 Beecham Group Ltd Aniline derivatives,their preparation and pharmalceutical compositions containing them
EP0067615B1 (fr) 1981-06-17 1986-01-08 Beecham Group Plc Dérivés thioalkyl d'azabicyclobenzamides, leur procédé de préparation et les compositions pharmaceutiques les contenant
JPS6070183A (ja) * 1983-09-28 1985-04-20 C Uyemura & Co Ltd 化学銅めっき方法
ZA848275B (en) * 1983-12-28 1985-08-28 Degussa New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring
GB8718445D0 (en) * 1987-08-04 1987-09-09 Wyeth John & Brother Ltd Pyridyl-ethers
CA1307790C (fr) * 1987-08-04 1992-09-22 Ian Anthony Cliffe Ethers
US4861889A (en) * 1988-03-14 1989-08-29 Hoechst-Roussel Pharmaceuticals, Inc. 3-(2,3,4,5,6-pentafluorophenoxy)-8-azabicyclo[3.2.1]octanes
JP3087763B2 (ja) * 1990-11-30 2000-09-11 三井化学株式会社 新規な複素環式化合物およびそれを含有する医薬組成物
US5710168A (en) * 1991-10-23 1998-01-20 Pfizer Inc. 2-piperidino-1-alkanol derivatives as neuroprotective agents
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
US6046213A (en) * 1994-08-18 2000-04-04 Pfizer Inc. Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives
US5852037A (en) * 1995-11-13 1998-12-22 Eli Lilly And Company Method for treating anxiety
PT885220E (pt) 1996-02-22 2001-11-30 Neurosearch As Derivados de tropano a sua preparacao e utilizacao
DE19629652A1 (de) * 1996-03-06 1998-01-29 Thomae Gmbh Dr K 4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US6632823B1 (en) * 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
US6248752B1 (en) 1998-02-27 2001-06-19 Charles Duane Smith Azabicyclooctane compositions and methods for enhancing chemotherapy
WO2000027790A1 (fr) * 1998-11-11 2000-05-18 Smithkline Beecham P.L.C. Composes a base de mutiline
MXPA01011978A (es) * 1999-05-21 2002-05-06 Pfizer Prod Inc Nuevas combinaciones farmaceuticas para inhibidores de la nos.
AU2001249250A1 (en) * 2000-03-29 2001-10-08 Research Triangle Institute Selective ligands for the delta opioid receptor
CA2364178C (fr) * 2000-12-05 2006-01-10 Yasuhiro Katsu N-benzenesulfonyl-l-prolines utilisees comme antagonistes de la bradykinine
EP1397358A1 (fr) 2001-05-23 2004-03-17 Neurosearch A/S Derives du tropane et utilisation de ces derniers comme inhibiteurs de recaptage du neurotransmetteur monoamine
EA200500033A1 (ru) * 2002-07-18 2005-06-30 Пфайзер Продактс Инк. Бициклические производные пиперидина в качестве антагонистов хемокинового рецептора ccr1
UA82517C2 (uk) * 2003-06-24 2008-04-25 Ньюросерч А/С Нові похідні 8-аза-біцикло[3.2.1]октану та їх застосування як інгібіторів ресорбції моноамінових медіаторів

Also Published As

Publication number Publication date
CO5630004A2 (es) 2006-04-28
UA82517C2 (uk) 2008-04-25
IS8212A (is) 2005-12-30
RU2005138591A (ru) 2006-07-27
WO2004113334A1 (fr) 2004-12-29
US20110112139A1 (en) 2011-05-12
US20080269229A1 (en) 2008-10-30
CN1798745A (zh) 2006-07-05
NO20060360L (no) 2006-03-24
BRPI0411608A (pt) 2006-08-08
RU2344136C2 (ru) 2009-01-20
CA2530023A1 (fr) 2004-12-29
AU2004249441A1 (en) 2004-12-29
JP2009513491A (ja) 2009-04-02
EP1638965A1 (fr) 2006-03-29
US7407970B2 (en) 2008-08-05
TW200510404A (en) 2005-03-16
US7888358B2 (en) 2011-02-15
IL171990A0 (en) 2011-08-01
US20060142331A1 (en) 2006-06-29
AU2004249441B2 (en) 2009-11-12
AR044883A1 (es) 2005-10-05
KR20060030482A (ko) 2006-04-10
CN100368409C (zh) 2008-02-13

Similar Documents

Publication Publication Date Title
HK1089157A1 (en) 8-aza-bicyclo(3.2.1)octane derivatives an their use as preparing monoamine neurotransmitter re-uptake inhibitors
HUS1900034I1 (hu) 6,7-telítetlen-7-karbamoil-szubsztituált morfinán-származékok
ZA200610040B (en) Substituted indazoles, compositions containing same, preparation use
ZA200804489B (en) 1-orthofluorophenyl substituted 1, 2, 5-thiazolidinedione derivatives as PTP-AS inhibitors
IL184524A0 (en) Substituted pyrazolo-pyridines, compositions containing them, method for the production thereof, and their use
AP2331A (en) Triazole derivatives as vasopressin antagonists.
IL175300A0 (en) Indirubin-type compounds, compositions, and methods for their use
IL188452A0 (en) 2,4-diamino-pyrimidines used as aurora inhibitors
AP2005003353A0 (en) Diazepinoindole derivatives as kinase inhibitors.
IL192102A0 (en) 1,3-oxazolidin-2-one derivatives useful as cetp inhibitors
GEP20084492B (en) New 4-benzylidene-piperidin derivatives
HK1193094A1 (zh) 可用作單胺再攝取抑制劑的 -取代的 -氨基吡咯烷化合物
ZA200800542B (en) 1,4-Dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them
IL179076A0 (en) Azasugasr derivatives, heparanase inhibitors, method for preparing same, compositions containing same, use thereof
MXPA03009383A (es) DERIVADOS DE HETEROCICLIL ETER DE FENILO COMO INHIBIDORES DE LA REABSORCIoN DE SEROTONINA.
ZA200706157B (en) Substituted pyrroles, compositions containing same, method for making same and use thereof
AU2004212165B2 (en) Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2006075004A3 (fr) Nouveaux derives de 8-aza-bicyclo[3.2.1]octane et leur utilisation comme inhibiteurs du recaptage du neurotransmetteur monoamine
EP1675600A4 (fr) Compositions contenant de l&#39;oxygene tetrametrique et appareils et procedes associes
IL183438A0 (en) Substituted indoles, compositions containing them, method for the production thereof and their use
SI1651223T1 (sl) Tartratne soli 2-metoksimetil-3-(3,4-diklorofenil)-8- azabiciklo(3.2.1)oktana
AU2002355325A1 (en) Substituted amine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AU2002329459A1 (en) 8-azabicyclo(3.2.1)octane ether derivatives and their use as neurokinin receptor antagonists
ZA200704471B (en) Novel naphthyl substituted azabicyclo derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AU2002308263A1 (en) Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120618