HK1084024A1 - Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer - Google Patents
Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancerInfo
- Publication number
- HK1084024A1 HK1084024A1 HK06104252A HK06104252A HK1084024A1 HK 1084024 A1 HK1084024 A1 HK 1084024A1 HK 06104252 A HK06104252 A HK 06104252A HK 06104252 A HK06104252 A HK 06104252A HK 1084024 A1 HK1084024 A1 HK 1084024A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- substituted
- group
- aryl group
- drug resistant
- bonded
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44040603P | 2003-01-15 | 2003-01-15 | |
PCT/US2004/001089 WO2004064826A1 (en) | 2003-01-15 | 2004-01-15 | Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1084024A1 true HK1084024A1 (en) | 2006-07-21 |
Family
ID=32771813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06104252A HK1084024A1 (en) | 2003-01-15 | 2006-04-07 | Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer |
Country Status (14)
Country | Link |
---|---|
US (1) | US7763658B2 (sl) |
EP (1) | EP1583524B1 (sl) |
JP (1) | JP4852409B2 (sl) |
AT (1) | ATE336991T1 (sl) |
AU (1) | AU2004206865B2 (sl) |
CA (1) | CA2512797C (sl) |
CY (1) | CY1106246T1 (sl) |
DE (1) | DE602004002087T2 (sl) |
DK (1) | DK1583524T3 (sl) |
ES (1) | ES2271839T3 (sl) |
HK (1) | HK1084024A1 (sl) |
PT (1) | PT1583524E (sl) |
TW (1) | TWI330079B (sl) |
WO (1) | WO2004064826A1 (sl) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI252847B (en) * | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
TWI297335B (en) * | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
TWI332943B (en) * | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
JP5647759B2 (ja) | 2004-03-29 | 2015-01-07 | ユニヴァーシティ オブ サウス フロリダ | トリシリビン及び関連化合物による、腫瘍及び癌の有効な治療 |
US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
ES2430373T3 (es) | 2004-06-23 | 2013-11-20 | Synta Pharmaceuticals Corp. | Sales de bis(tio-hidrazida amida) para tratamiento de cánceres |
WO2006033913A2 (en) * | 2004-09-16 | 2006-03-30 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amides) for treament of hyperplasia |
EP1827410A2 (en) * | 2004-11-19 | 2007-09-05 | Synta Pharmaceuticals Corporation | Bis(thio-hydrazide amides) for increasing hsp70 expression |
WO2006062732A2 (en) * | 2004-11-19 | 2006-06-15 | Synta Pharmaceuticals Corp. | Compounds acting at the centrosome |
WO2006113572A1 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
US8017654B2 (en) * | 2005-04-15 | 2011-09-13 | Synta Pharmaceuticals Corp. | Combination cancer therapy with bis(thiohydrazide) amide compounds |
MX2007014314A (es) * | 2005-05-16 | 2008-02-11 | Synta Pharmaceuticals Corp | Sintesis de sales de bis(tio-hidrazida amida). |
JP2009504740A (ja) * | 2005-08-16 | 2009-02-05 | シンタ ファーマシューティカルズ コーポレーション | ビス(チオ−ヒドラジドアミド)製剤 |
AU2007288338B2 (en) | 2006-08-21 | 2012-05-03 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
CA2661440A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
WO2008024301A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
AU2007288334A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
WO2008024298A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for inhibiting angiogenesis |
WO2008024305A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
EP2076254A2 (en) * | 2006-08-31 | 2009-07-08 | Synta Pharmaceuticals Corporation | Combination with bis(thiohydrazide amides) for treating cancer |
AU2007294969A1 (en) * | 2006-09-11 | 2008-03-20 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) formulation |
US9498528B2 (en) * | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
TW200829543A (en) | 2006-09-15 | 2008-07-16 | Synta Pharmaceuticals Corp | Purification of bis(thiohydrazide amides) |
US8618170B2 (en) * | 2007-11-09 | 2013-12-31 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
EP2225201A2 (en) * | 2007-11-28 | 2010-09-08 | Synta Pharmaceuticals Corp. | Polymorphs of n-malonyl-bis(n'-methyl-n'-thiobenzoylhydrazide) |
WO2009105257A1 (en) * | 2008-02-21 | 2009-08-27 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
WO2009123704A2 (en) * | 2008-03-31 | 2009-10-08 | Synta Pharmaceuticals Corp. | Process for preparing bis(thiohydrazide amides) |
KR20110073613A (ko) | 2008-10-22 | 2011-06-29 | 신타 파마슈티칼스 코프. | 비스(티오하이드라자이드 아마이드) 화합물의 전이금속착체 |
BRPI0919931A2 (pt) * | 2008-10-22 | 2019-09-24 | Synta Pharmaceuticals Corp | complexos de metal de transição de um composto de bis[tiohidrazida] |
US8525776B2 (en) * | 2008-10-27 | 2013-09-03 | Lenovo (Singapore) Pte. Ltd | Techniques for controlling operation of a device with a virtual touchscreen |
CA2745065A1 (en) | 2008-12-01 | 2010-06-10 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
US8822532B2 (en) | 2009-12-04 | 2014-09-02 | Synta Pharmaceuticals Corp. | Bis[thiohydrazide amide] compounds for treating leukemia |
US8815945B2 (en) | 2010-04-20 | 2014-08-26 | Masazumi Nagai | Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers |
CA2854186A1 (en) * | 2011-11-10 | 2013-05-16 | Jim SANG | Administration of a bis(thiohydrazide amide) compound for treating cancers |
US20130149392A1 (en) | 2011-12-12 | 2013-06-13 | Synta Pharmaceuticals Corp. | Method of treating non-small cell lung cancer with bis-(thiohydrazide)amide compounds |
EP3024457A4 (en) | 2013-07-26 | 2017-06-28 | Update Pharma Inc. | Compositions to improve the therapeutic benefit of bisantrene |
BR112019001398A2 (pt) | 2016-07-29 | 2019-05-07 | Janssen Pharmaceutica Nv | métodos para tratamento de câncer de próstata |
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US6602907B1 (en) * | 2001-06-08 | 2003-08-05 | University Of Central Florida | Treatment of breast cancer |
TWI252847B (en) * | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
US6924312B2 (en) * | 2001-07-10 | 2005-08-02 | Synta Pharmaceuticals Corp. | Taxol enhancer compounds |
TWI332943B (en) * | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
TWI297335B (en) * | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
TWI283670B (en) * | 2001-11-28 | 2007-07-11 | Sod Conseils Rech Applic | 5-sulphanyl-4h-1,2,4-triazole derivatives and their use as a medicament |
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AU2006228035B2 (en) | 2003-01-15 | 2010-02-18 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer |
EA009919B1 (ru) | 2003-02-11 | 2008-04-28 | Вернэлис (Кембридж) Лимитед | Соединения изоксазола |
KR100575251B1 (ko) | 2003-03-03 | 2006-05-02 | 재단법인서울대학교산학협력재단 | p38/JTV-1을 유효성분으로 하는 암 치료용 약학적조성물 및 암 치료용 약학적 조성물의 스크리닝 방법 |
EP1493445A1 (en) | 2003-07-04 | 2005-01-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibition of stress-induced ligand-dependent EGFR activation |
TWI339206B (en) | 2003-09-04 | 2011-03-21 | Vertex Pharma | Compositions useful as inhibitors of protein kinases |
KR100544347B1 (ko) * | 2003-12-11 | 2006-01-23 | 한국생명공학연구원 | 디아릴이소옥사졸계 화합물을 유효성분으로 함유하는 암 예방 및 치료용 약학적 조성물 |
MXPA06011046A (es) | 2004-03-26 | 2007-03-21 | Amphora Discovery Corp | Ciertos compuestos basados en triazol, composiciones, y usos de los mismos. |
ES2430373T3 (es) | 2004-06-23 | 2013-11-20 | Synta Pharmaceuticals Corp. | Sales de bis(tio-hidrazida amida) para tratamiento de cánceres |
WO2006033913A2 (en) | 2004-09-16 | 2006-03-30 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amides) for treament of hyperplasia |
WO2006062732A2 (en) | 2004-11-19 | 2006-06-15 | Synta Pharmaceuticals Corp. | Compounds acting at the centrosome |
EP1827410A2 (en) * | 2004-11-19 | 2007-09-05 | Synta Pharmaceuticals Corporation | Bis(thio-hydrazide amides) for increasing hsp70 expression |
SG164378A1 (en) | 2005-02-17 | 2010-09-29 | Synta Pharmaceuticals Corp | Compounds for the treatment of proliferative disorders |
US8017654B2 (en) | 2005-04-15 | 2011-09-13 | Synta Pharmaceuticals Corp. | Combination cancer therapy with bis(thiohydrazide) amide compounds |
WO2006113493A2 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of determining cancer prognosis via natural killer cell activity |
WO2006113572A1 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
MX2007014314A (es) | 2005-05-16 | 2008-02-11 | Synta Pharmaceuticals Corp | Sintesis de sales de bis(tio-hidrazida amida). |
JP2009504740A (ja) * | 2005-08-16 | 2009-02-05 | シンタ ファーマシューティカルズ コーポレーション | ビス(チオ−ヒドラジドアミド)製剤 |
EP2034996A2 (en) | 2006-05-25 | 2009-03-18 | Synta Pharmaceuticals Corporation | Triazole compounds that modulate hsp90 activity |
WO2008024305A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) for treating melanoma |
AU2007288338B2 (en) | 2006-08-21 | 2012-05-03 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
AU2007288334A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
CA2661440A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
WO2008024298A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for inhibiting angiogenesis |
WO2008024301A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
EP2076254A2 (en) * | 2006-08-31 | 2009-07-08 | Synta Pharmaceuticals Corporation | Combination with bis(thiohydrazide amides) for treating cancer |
AU2007294969A1 (en) * | 2006-09-11 | 2008-03-20 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) formulation |
JP2010503674A (ja) | 2006-09-14 | 2010-02-04 | シンタ ファーマシューティカルズ コーポレーション | 血管形成治療用化合物 |
TW200829543A (en) * | 2006-09-15 | 2008-07-16 | Synta Pharmaceuticals Corp | Purification of bis(thiohydrazide amides) |
WO2008082579A1 (en) | 2007-01-03 | 2008-07-10 | Synta Pharmaceuticals Corp. | Method for treating cancer |
TW200922550A (en) | 2007-08-07 | 2009-06-01 | Synta Pharmaceuticals Corp | Compounds for treating proliferative disorders |
-
2004
- 2004-01-14 TW TW093100878A patent/TWI330079B/zh not_active IP Right Cessation
- 2004-01-15 DE DE602004002087T patent/DE602004002087T2/de not_active Expired - Lifetime
- 2004-01-15 PT PT04702560T patent/PT1583524E/pt unknown
- 2004-01-15 US US10/758,589 patent/US7763658B2/en not_active Expired - Fee Related
- 2004-01-15 EP EP04702560A patent/EP1583524B1/en not_active Expired - Lifetime
- 2004-01-15 JP JP2006500976A patent/JP4852409B2/ja not_active Expired - Fee Related
- 2004-01-15 AT AT04702560T patent/ATE336991T1/de active
- 2004-01-15 DK DK04702560T patent/DK1583524T3/da active
- 2004-01-15 ES ES04702560T patent/ES2271839T3/es not_active Expired - Lifetime
- 2004-01-15 CA CA2512797A patent/CA2512797C/en not_active Expired - Fee Related
- 2004-01-15 WO PCT/US2004/001089 patent/WO2004064826A1/en active IP Right Grant
- 2004-01-15 AU AU2004206865A patent/AU2004206865B2/en not_active Ceased
-
2006
- 2006-04-07 HK HK06104252A patent/HK1084024A1/xx not_active IP Right Cessation
- 2006-11-16 CY CY20061101668T patent/CY1106246T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP1583524B1 (en) | 2006-08-23 |
WO2004064826A1 (en) | 2004-08-05 |
CA2512797C (en) | 2012-02-21 |
TW200418449A (en) | 2004-10-01 |
DE602004002087T2 (de) | 2007-03-08 |
AU2004206865A1 (en) | 2004-08-05 |
CA2512797A1 (en) | 2004-08-05 |
AU2004206865B2 (en) | 2006-07-13 |
DE602004002087D1 (de) | 2006-10-05 |
CY1106246T1 (el) | 2011-06-08 |
US7763658B2 (en) | 2010-07-27 |
US20040225016A1 (en) | 2004-11-11 |
JP4852409B2 (ja) | 2012-01-11 |
EP1583524A1 (en) | 2005-10-12 |
JP2006515626A (ja) | 2006-06-01 |
PT1583524E (pt) | 2006-12-29 |
ATE336991T1 (de) | 2006-09-15 |
DK1583524T3 (da) | 2006-12-27 |
ES2271839T3 (es) | 2007-04-16 |
TWI330079B (en) | 2010-09-11 |
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