HK1081866A1 - Use of hesperidin or one of its derivatives for making a medicine for bone formation stimulation - Google Patents
Use of hesperidin or one of its derivatives for making a medicine for bone formation stimulationInfo
- Publication number
- HK1081866A1 HK1081866A1 HK06102318.5A HK06102318A HK1081866A1 HK 1081866 A1 HK1081866 A1 HK 1081866A1 HK 06102318 A HK06102318 A HK 06102318A HK 1081866 A1 HK1081866 A1 HK 1081866A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- derivatives
- hesperidin
- bone formation
- medicine
- making
- Prior art date
Links
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 title abstract 2
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 title abstract 2
- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 title abstract 2
- APSNPMVGBGZYAJ-GLOOOPAXSA-N clematine Natural products COc1cc(ccc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 APSNPMVGBGZYAJ-GLOOOPAXSA-N 0.000 title abstract 2
- VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 title abstract 2
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 title abstract 2
- 229940025878 hesperidin Drugs 0.000 title abstract 2
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 title abstract 2
- 230000011164 ossification Effects 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 230000000638 stimulation Effects 0.000 title 1
- 208000006386 Bone Resorption Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000024279 bone resorption Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0208171A FR2841472B1 (fr) | 2002-06-28 | 2002-06-28 | Composition nutritionnelle ou therapeutique contenant le compose hesperidine ou l'un de ses derives |
| PCT/FR2003/002005 WO2004002496A1 (fr) | 2002-06-28 | 2003-06-27 | Utilisation de l'hesperidine ou l'un de ses derives pour la fabrication d'un medicament destine a stimuler la formation osseuse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1081866A1 true HK1081866A1 (en) | 2006-05-26 |
Family
ID=29725026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK06102318.5A HK1081866A1 (en) | 2002-06-28 | 2006-02-22 | Use of hesperidin or one of its derivatives for making a medicine for bone formation stimulation |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8859612B2 (es) |
| EP (1) | EP1536806B1 (es) |
| JP (1) | JP2005537241A (es) |
| CN (2) | CN101822687A (es) |
| AT (1) | ATE370739T1 (es) |
| AU (1) | AU2003255695B2 (es) |
| CA (1) | CA2491167C (es) |
| DE (1) | DE60315842T2 (es) |
| ES (1) | ES2291685T3 (es) |
| FR (1) | FR2841472B1 (es) |
| HK (1) | HK1081866A1 (es) |
| PT (1) | PT1536806E (es) |
| RU (1) | RU2320346C2 (es) |
| WO (1) | WO2004002496A1 (es) |
| ZA (1) | ZA200500835B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2368442B1 (en) | 2005-07-27 | 2014-12-17 | Symrise AG | Use of hesperetin for enhancing the sweet taste |
| AU2006338273B2 (en) * | 2006-02-10 | 2011-10-13 | Mannatech, Inc. | All natural multivitamin and multimineral dietary supplement formulations for enhanced absorption and biological utilization |
| US20070218111A1 (en) * | 2006-03-16 | 2007-09-20 | Western Holdings, Llc | Strontium compositions for bones |
| CN101537003B (zh) * | 2006-06-15 | 2010-12-08 | 安徽医科大学 | 7,3'-二甲氧基橙皮素在制备抗炎免疫药物中的应用 |
| EP1891967B1 (en) * | 2006-08-24 | 2019-11-20 | Société des Produits Nestlé S.A. | Long-lasting absorption of flavonoids |
| JP2009234924A (ja) * | 2008-03-25 | 2009-10-15 | Kinji Ishida | 免疫回復剤及びそれを含有する飼料組成物 |
| EP2289343A1 (en) | 2009-07-29 | 2011-03-02 | Nestec S.A. | Flavanones-containing food compositions |
| EP2286669A1 (en) | 2009-07-29 | 2011-02-23 | Nestec S.A. | Flavanones-containing food compositions |
| FR3005419B1 (fr) | 2013-05-13 | 2015-09-04 | Agronomique Inst Nat Rech | Utilisation d'une association de deux composes pour le traitement et/ou la prevention de troubles osseux |
| US20200108088A1 (en) * | 2013-05-29 | 2020-04-09 | Societe Des Produits Nestle S.A. | Compositions for use in cartilage breakdown |
| CN106176782B (zh) * | 2016-07-06 | 2021-04-20 | 天津中医药大学 | 墨旱莲化学成分作为植物雌激素的用途 |
| US20180228023A1 (en) * | 2017-02-09 | 2018-08-09 | International Business Machines Corporation | Angled fiberglass cloth weaves |
| US11517603B2 (en) * | 2017-09-21 | 2022-12-06 | Hokuriku University | Bone remodeling accelerator |
| CN111067915A (zh) * | 2020-01-09 | 2020-04-28 | 昆明医科大学 | 老鹳草素在制备用于治疗维生素d不足和/或缺乏疾病的药物中的用途 |
| RU2742030C1 (ru) * | 2020-06-11 | 2021-02-01 | Общество с ограниченной ответственностью "ЦитоНИР" (ООО "ЦитоНИР") | Конъюгат гесперидина и способ его получения |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB486898A (en) | 1936-12-12 | 1938-06-13 | Ig Farbenindustrie Ag | Manufacture of substances resembling vitamines from plants |
| US2400693A (en) * | 1943-03-06 | 1946-05-21 | Fruit Growers Exchange Ca | Method of manufacturing hesperidin |
| US2442110A (en) * | 1943-11-22 | 1948-05-25 | Fruit Growers Exchange Ca | Process for the recovery of hesperidin |
| GB858784A (en) | 1957-08-27 | 1961-01-18 | Takeda Pharmaceutical | Water-soluble methylhesperidins and their production |
| US4761406A (en) | 1985-06-06 | 1988-08-02 | The Procter & Gamble Company | Regimen for treating osteoporosis |
| FR2679134B1 (fr) * | 1991-07-19 | 1993-10-22 | Sablon Louis | Compositions cosmetiques pour la regulation de la pigmentation cutanee comprenant un extrait d'eclipta alba. |
| JPH0725761A (ja) * | 1993-07-09 | 1995-01-27 | Kureha Chem Ind Co Ltd | 軟骨保護剤 |
| US5506211A (en) * | 1994-05-09 | 1996-04-09 | The Uab Research Foundation | Genistein for use in inhibiting osteroclasts |
| FR2725365B1 (fr) | 1994-10-07 | 1996-11-08 | Oreal | Composition nettoyante et/ou demaquillante contenant un alcool et un compose phosphate |
| JPH08188593A (ja) | 1995-01-10 | 1996-07-23 | Wakayama Agribio Kenkyu Center:Kk | 柑橘類に含有されるヘスペリジンの抽出方法および回収方法 |
| JP3833775B2 (ja) | 1996-06-26 | 2006-10-18 | 株式会社林原生物化学研究所 | 酵素処理ヘスペリジンおよびその製造方法ならびに酵素処理ヘスペリジンの使用方法 |
| KR100213895B1 (ko) * | 1996-10-14 | 1999-08-02 | 박원훈 | 감귤류 과피 추출물, 이로부터 분리 정제된 헤스페리딘 또는 나린진을 포함하는 심혈관 질환 예방및 치료제 조성물 |
| EP0908524B1 (en) * | 1997-03-24 | 2004-02-04 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Process for producing alpha-monoglucosylhesperidin-rich substance |
| WO1998050026A1 (en) * | 1997-05-01 | 1998-11-12 | Novogen Inc | Treatment or prevention of menopausal symptoms and osteoporosis |
| DE19742025A1 (de) | 1997-09-24 | 1999-03-25 | Beiersdorf Ag | Verwendung von Flavonen und Flavonoiden zur Hautaufhellung oder zur Verhinderung der durch oxidative Proteinaggregation hervorgerufenen Altersflecken |
| WO1999021549A1 (en) * | 1997-10-28 | 1999-05-06 | Korea Institute Of Science And Technology | Hesperidin and hesperetin as inhibitor of acyl coa-cholesterol-o-acyltransferase, inhibitor of macrophage-lipid complex accumulation on the arterial wall and preventive or treating agent for hepatic diseases |
| US20010046977A1 (en) * | 1997-11-25 | 2001-11-29 | Merck & Co., Inc. | Use of alendronate for the prevention of osteoporosis |
| JP4295840B2 (ja) * | 1997-12-09 | 2009-07-15 | 株式会社林原生物化学研究所 | 血行改善剤 |
| KR100284129B1 (ko) | 1998-06-03 | 2001-03-02 | 박호군 | 헤스페리딘또는헤스페레틴을포함하는혈소판응집억제용조성물 |
| ID28460A (id) * | 1998-07-08 | 2001-05-24 | Lipogenics Inc | Komposisi dan metoda untuk perlakuan dan pencegahan penyakit tulang dengan menggunakan tocotrienol |
| KR20000019717A (ko) * | 1998-09-15 | 2000-04-15 | 박호군 | 루틴 및 쿼세틴을 포함하는 고지혈증, 동맥경화증 및 간 질환의예방 및 치료용 조성물 |
| GB9821671D0 (en) * | 1998-10-05 | 1998-12-02 | Muhlbauer Roman C | Plant extracts for the treatment of increased bone resorption |
| JP2001114675A (ja) * | 1999-10-12 | 2001-04-24 | Fancl Corp | ビタミン組成物 |
| EP1127572A3 (en) * | 2000-02-25 | 2003-05-02 | Basf Aktiengesellschaft | Use of flavones for treating cycloxygenase-2 mediated diseases |
| AU2001253113B2 (en) * | 2000-04-20 | 2005-02-03 | Pharmacia & Upjohn Company | Use of thioamide oxazolidinones for the treatment of bone resorption and osteoporosis |
| KR100408231B1 (ko) * | 2000-08-14 | 2003-12-01 | 한국 한의학 연구원 | 골다공증 예방 및 치료용 플라보노이드 유도체 |
| JP4813652B2 (ja) * | 2000-12-04 | 2011-11-09 | 丸善製薬株式会社 | マトリックスメタロプロテアーゼ阻害剤 |
| JP2002234844A (ja) * | 2000-12-05 | 2002-08-23 | Toyo Seito Kk | 骨密度向上剤およびその利用 |
-
2002
- 2002-06-28 FR FR0208171A patent/FR2841472B1/fr not_active Expired - Fee Related
-
2003
- 2003-06-27 PT PT03761660T patent/PT1536806E/pt unknown
- 2003-06-27 WO PCT/FR2003/002005 patent/WO2004002496A1/fr active IP Right Grant
- 2003-06-27 CA CA2491167A patent/CA2491167C/fr not_active Expired - Fee Related
- 2003-06-27 US US10/519,386 patent/US8859612B2/en not_active Expired - Fee Related
- 2003-06-27 ES ES03761660T patent/ES2291685T3/es not_active Expired - Lifetime
- 2003-06-27 RU RU2005102093/15A patent/RU2320346C2/ru not_active IP Right Cessation
- 2003-06-27 JP JP2004516888A patent/JP2005537241A/ja active Pending
- 2003-06-27 DE DE60315842T patent/DE60315842T2/de not_active Expired - Lifetime
- 2003-06-27 CN CN201010155745A patent/CN101822687A/zh active Pending
- 2003-06-27 CN CN038203480A patent/CN1678327B/zh not_active Expired - Fee Related
- 2003-06-27 AU AU2003255695A patent/AU2003255695B2/en not_active Ceased
- 2003-06-27 EP EP03761660A patent/EP1536806B1/fr not_active Expired - Lifetime
- 2003-06-27 AT AT03761660T patent/ATE370739T1/de not_active IP Right Cessation
-
2005
- 2005-01-27 ZA ZA200500835A patent/ZA200500835B/en unknown
-
2006
- 2006-02-22 HK HK06102318.5A patent/HK1081866A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2491167A1 (fr) | 2004-01-08 |
| FR2841472B1 (fr) | 2006-02-24 |
| AU2003255695B2 (en) | 2008-04-03 |
| RU2320346C2 (ru) | 2008-03-27 |
| ZA200500835B (en) | 2005-08-11 |
| WO2004002496A1 (fr) | 2004-01-08 |
| US20060034893A1 (en) | 2006-02-16 |
| EP1536806A1 (fr) | 2005-06-08 |
| JP2005537241A (ja) | 2005-12-08 |
| DE60315842T2 (de) | 2008-05-21 |
| FR2841472A1 (fr) | 2004-01-02 |
| PT1536806E (pt) | 2007-11-05 |
| AU2003255695A1 (en) | 2004-01-19 |
| CA2491167C (fr) | 2012-05-15 |
| RU2005102093A (ru) | 2005-08-10 |
| US8859612B2 (en) | 2014-10-14 |
| CN101822687A (zh) | 2010-09-08 |
| CN1678327A (zh) | 2005-10-05 |
| CN1678327B (zh) | 2013-04-17 |
| DE60315842D1 (de) | 2007-10-04 |
| ATE370739T1 (de) | 2007-09-15 |
| EP1536806B1 (fr) | 2007-08-22 |
| ES2291685T3 (es) | 2008-03-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1081866A1 (en) | Use of hesperidin or one of its derivatives for making a medicine for bone formation stimulation | |
| AR023130A1 (es) | Composiciones para promover el crecimiento | |
| AU2003267203A8 (en) | Method for administering thermotherapy to prevent the growth of tumors | |
| DE50310516D1 (de) | Fredericamycin-derivate | |
| HK1089107A1 (en) | Delivery of therapeutic compounds to the brain and other tissues | |
| SI1673104T1 (sl) | Dostava terapevtskih spojin moĹľganom in drugim tkivom | |
| EP1638605A4 (en) | DISTRIBUTION OF THERAPEUTIC COMPOUNDS TO THE BRAIN AND OTHER TISSUE | |
| RS94703A (en) | Cdk inhibiting pyrimidines, production thereof and their use as medicaments | |
| GB0222495D0 (en) | Compounds | |
| MX2007004111A (es) | Sal y formas cristalinas de la misma de un farmaco. | |
| BRPI0407897A (pt) | derivados de cianopiridina úteis no tratamento de cáncer e outros distúrbios | |
| TW200626576A (en) | Bicyclic amides as kinase inhibitors | |
| MY140840A (en) | Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals | |
| DE60322451D1 (de) | 4-Tetrazolyl-4-Phenylpiperidinderivate zur Schmerzbehandlung | |
| TNSN04203A1 (en) | Benzoxazinone-derived compounds, their preparation and use as medicaments | |
| IL172564A0 (en) | N-PHENYL-PIPERAZINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF THE 5HT2c RECEPTOR ASSOCIATED DISEASES | |
| MY152921A (en) | Aryl-quinazoline/aryl-2-amino-phenyl methanone derivatives | |
| MY133995A (en) | 6-phenylpyrrolopyrimidinedione derivatives | |
| AU2003272472A8 (en) | Use of beta glucans for the treatment of osteoporosis and other diseases of bone resorption | |
| ATE541567T1 (de) | Pharmazeutische zusammensetzung zur prävention und behandlung von metabolischen knochenerkrankungen mit alpha-arylmethoxyacrylat- derivaten | |
| MXPA04004306A (es) | Uso de antagonistas del receptor de endotelina para el tratamiento de enfermedades tumorales. | |
| DE50305587D1 (en) | 2-heteroarylcarbonsäureamide | |
| CA2534577A1 (en) | Method for promoting bone growth | |
| SG162614A1 (en) | Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors | |
| AU2003258630A1 (en) | Pyrimidine derivatives as selective cox-2 inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20170627 |