HK1079822A1 - Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis - Google Patents
Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesisInfo
- Publication number
- HK1079822A1 HK1079822A1 HK05111963.5A HK05111963A HK1079822A1 HK 1079822 A1 HK1079822 A1 HK 1079822A1 HK 05111963 A HK05111963 A HK 05111963A HK 1079822 A1 HK1079822 A1 HK 1079822A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cholesterol transport
- reverse cholesterol
- atherogenesis
- vivo
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0493—Steroids, e.g. cholesterol, testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
- A61K51/1224—Lipoprotein vesicles, e.g. HDL and LDL proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41035202P | 2002-09-13 | 2002-09-13 | |
PCT/US2003/029361 WO2004025270A2 (fr) | 2002-09-13 | 2003-09-15 | Methodes permettant de mesurer les taux de transport inverse du cholesterol in vivo utilises comme indice d'anti-atherogenicite |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1079822A1 true HK1079822A1 (en) | 2006-04-13 |
Family
ID=31994119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05111963.5A HK1079822A1 (en) | 2002-09-13 | 2005-12-23 | Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis |
Country Status (11)
Country | Link |
---|---|
US (2) | US7255850B2 (fr) |
EP (1) | EP1546373B1 (fr) |
JP (1) | JP4610337B2 (fr) |
AT (1) | ATE415486T1 (fr) |
AU (1) | AU2003267283B2 (fr) |
CA (1) | CA2498378C (fr) |
DE (1) | DE60324950D1 (fr) |
DK (1) | DK1546373T3 (fr) |
HK (1) | HK1079822A1 (fr) |
SG (1) | SG149699A1 (fr) |
WO (1) | WO2004025270A2 (fr) |
Families Citing this family (22)
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US7001587B2 (en) | 2001-10-24 | 2006-02-21 | The Regents Of The University Of California | Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water |
AU2003217385B2 (en) * | 2002-02-12 | 2008-09-11 | The Regents Of The University Of California | Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation |
WO2004011426A2 (fr) | 2002-07-30 | 2004-02-05 | The Regents Of The University Of California | Procede de mesure automatique a grande echelle des taux de flux moleculaire proteomique ou organeomique par spectrometrie de masse |
DE20211783U1 (de) * | 2002-07-31 | 2002-11-07 | Fa. Hermann Heye i.Ins., 31683 Obernkirchen | Pressstempelmechanismus einer Glasformmaschine |
US20060105339A1 (en) * | 2002-09-04 | 2006-05-18 | Marc Hellerstein | Methods for measuring the rates of replication and death of microbial infectious agents in an infected |
DE60324950D1 (de) | 2002-09-13 | 2009-01-08 | Univ California | Verfahren zur messung der geschwindigkeiten des cholesterinrückwärtstransports in vivo als index für anti-artherogenese |
US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
CA2504313C (fr) | 2002-11-04 | 2012-01-17 | Marc K. Hellerstein | Essai de tolerance au glucose deutere ou aux graisses pour la mesure a haute capacite du metabolisme des sucres ou des acides gras dans le corps |
US7262020B2 (en) * | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
TW200538738A (en) * | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
US20050238577A1 (en) * | 2004-03-29 | 2005-10-27 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
WO2009158328A1 (fr) * | 2008-06-23 | 2009-12-30 | Trustees Of The University Of Pennsylvania | Procédé pour mesure in-vivo du transport inverse du cholestérol |
WO2011009035A1 (fr) * | 2009-07-16 | 2011-01-20 | Trustees Of The University Of Pennsylvania | Procédé de mesure in vivo du transport inverse du cholestérol |
JP2014526685A (ja) | 2011-09-08 | 2014-10-06 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 代謝流量測定、画像化、および顕微鏡法 |
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US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
CN110596365B (zh) * | 2015-05-29 | 2022-11-15 | 希森美康株式会社 | 测定脂蛋白质的胆甾醇负载能力的方法及试剂盒 |
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JP2008519261A (ja) | 2004-10-29 | 2008-06-05 | ターゲット ディスカバリー インク. | 重水素化グルコースを用いたグリカン分析 |
US8613904B2 (en) | 2005-01-26 | 2013-12-24 | The Regents Of The University Of Colorado | Methods for diagnosis and intervention of hepatic disorders |
JP5116662B2 (ja) | 2005-04-06 | 2013-01-09 | ワシントン ユニバーシティ イン セント ルイス | インビボにおける神経系由来生体分子の代謝測定方法 |
US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
TW200711660A (en) | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
-
2003
- 2003-09-15 DE DE60324950T patent/DE60324950D1/de not_active Expired - Lifetime
- 2003-09-15 WO PCT/US2003/029361 patent/WO2004025270A2/fr active Application Filing
- 2003-09-15 US US10/519,121 patent/US7255850B2/en not_active Expired - Lifetime
- 2003-09-15 SG SG200702712-1A patent/SG149699A1/en unknown
- 2003-09-15 AT AT03749756T patent/ATE415486T1/de active
- 2003-09-15 JP JP2004536615A patent/JP4610337B2/ja not_active Expired - Fee Related
- 2003-09-15 DK DK03749756T patent/DK1546373T3/da active
- 2003-09-15 AU AU2003267283A patent/AU2003267283B2/en not_active Ceased
- 2003-09-15 EP EP03749756A patent/EP1546373B1/fr not_active Expired - Lifetime
- 2003-09-15 CA CA2498378A patent/CA2498378C/fr not_active Expired - Fee Related
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2005
- 2005-12-23 HK HK05111963.5A patent/HK1079822A1/xx not_active IP Right Cessation
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2007
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Also Published As
Publication number | Publication date |
---|---|
DK1546373T3 (da) | 2009-03-30 |
EP1546373B1 (fr) | 2008-11-26 |
US7255850B2 (en) | 2007-08-14 |
EP1546373A4 (fr) | 2005-09-28 |
EP1546373A2 (fr) | 2005-06-29 |
CA2498378C (fr) | 2013-12-17 |
DE60324950D1 (de) | 2009-01-08 |
AU2003267283A1 (en) | 2004-04-30 |
US20050249664A1 (en) | 2005-11-10 |
US8021644B2 (en) | 2011-09-20 |
WO2004025270A2 (fr) | 2004-03-25 |
AU2003267283B2 (en) | 2009-09-03 |
JP4610337B2 (ja) | 2011-01-12 |
ATE415486T1 (de) | 2008-12-15 |
SG149699A1 (en) | 2009-02-27 |
CA2498378A1 (fr) | 2004-03-25 |
WO2004025270A3 (fr) | 2005-03-24 |
US20080003179A1 (en) | 2008-01-03 |
JP2005539226A (ja) | 2005-12-22 |
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