HK1078610A1 - Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene - Google Patents

Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene

Info

Publication number
HK1078610A1
HK1078610A1 HK05110355.3A HK05110355A HK1078610A1 HK 1078610 A1 HK1078610 A1 HK 1078610A1 HK 05110355 A HK05110355 A HK 05110355A HK 1078610 A1 HK1078610 A1 HK 1078610A1
Authority
HK
Hong Kong
Prior art keywords
cells
transferrin
differentiating
bone marrow
inducing bone
Prior art date
Application number
HK05110355.3A
Other languages
English (en)
Inventor
Marl Dezawa
Hajime Sawada
Hiroshi Kanno
Masahiko Takano
Original Assignee
Sanbio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2002030003A external-priority patent/JP3948971B2/ja
Application filed by Sanbio Inc filed Critical Sanbio Inc
Publication of HK1078610A1 publication Critical patent/HK1078610A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK05110355.3A 2002-02-06 2005-11-18 Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene HK1078610A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002030003A JP3948971B2 (ja) 2001-08-30 2002-02-06 Ｎｏｔｃｈ遺伝子の導入を用いて骨髄間質細胞を神経細胞及び骨格筋細胞に分化・誘導する方法
PCT/JP2003/001260 WO2003066856A1 (en) 2002-02-06 2003-02-06 METHOD OF DIFFERENTIATING/INDUCING BONE MARROW INTERSTITIAL CELLS INTO NERVE CELLS AND SKELETON MUSCLE CELLS BY TRANSFERRING Notch GENE

Publications (1)

Publication Number Publication Date
HK1078610A1 true HK1078610A1 (en) 2006-03-17

Family

ID=27677898

Family Applications (2)

Application Number Title Priority Date Filing Date
HK05110355.3A HK1078610A1 (en) 2002-02-06 2005-11-18 Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene
HK10104703.8A HK1139039A1 (en) 2002-02-06 2010-05-14 Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK10104703.8A HK1139039A1 (en) 2002-02-06 2010-05-14 Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene

Country Status (10)

Country Link
US (7) US7682825B2 (zh)
EP (2) EP1479767B1 (zh)
CN (2) CN100497621C (zh)
AU (1) AU2003207064B2 (zh)
CA (1) CA2475288C (zh)
DK (1) DK1479767T3 (zh)
ES (1) ES2431518T3 (zh)
HK (2) HK1078610A1 (zh)
PT (1) PT1479767E (zh)
WO (1) WO2003066856A1 (zh)

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US7682825B2 (en) 2002-02-06 2010-03-23 Sanbio, Inc. Differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene
US20050265983A1 (en) * 2002-11-17 2005-12-01 Eldad Melamed Methods, nucleic acid constructs and cells for treating neurodegenerative disorders
KR100975254B1 (ko) * 2003-03-25 2010-08-11 도쿠리쓰교세이호징 가가쿠 기주쓰 신코 기코 줄기 세포의 분화 유도 및 분화능의 제어
PL1737950T3 (pl) * 2004-04-12 2012-02-29 Sanbio Inc Komórki wykazujące cechy neuronalnych komórek progenitorowych
JP4581085B2 (ja) * 2004-12-24 2010-11-17 国立大学法人京都大学 骨格筋細胞の分化誘導方法
US20060216276A1 (en) * 2005-03-07 2006-09-28 Mari Dezawa Use of materials for treatment of central nervous system lesions
GB0504881D0 (en) * 2005-03-09 2005-04-13 Univ Edinburgh Directed neural differentiation
EP2323017B1 (en) * 2005-03-23 2016-06-29 QUALCOMM Incorporated Method and system for digital pen assembly
EP2465924A3 (en) 2005-06-16 2013-01-02 Ramot at Tel-Aviv University Ltd. Isolated cells and populations comprising same for the treament of cns diseases
WO2008102460A1 (en) * 2007-02-23 2008-08-28 Sanbio Inc. Transplantation of bone marrow stromal cell-induced neural stem cells for promoting fuctional recovery after spinal cord injury
WO2009023251A1 (en) * 2007-08-15 2009-02-19 Sanbio, Inc. Methods and compositions for treating neural degeneration
US10702554B2 (en) * 2007-12-03 2020-07-07 Sanbio, Inc. Extracellular matrix from pluripotent cells
DK2222839T3 (en) 2007-12-03 2015-12-21 Sanbio Inc Methods and compositions for modulating differentiation of pluripotent cells
WO2009134409A2 (en) * 2008-04-30 2009-11-05 Sanbio, Inc. Neural regenerating cells with alterations in dna methylation
EP3514229A1 (en) 2008-05-28 2019-07-24 Ramot at Tel-Aviv University Ltd. Mesenchymal stem cells for the treatment of cns diseases
EP2440660A4 (en) * 2009-06-10 2013-08-28 Brainstem Biotec Ltd METHODS, SYSTEMS, AND COMPOSITIONS FOR NEURONAL DIFFERENTIATION OF PLURIPOTENT STROMAL CELLS
EP2694080B1 (en) 2011-04-06 2018-03-14 SanBio, Inc. Methods and compositions for modulating peripheral immune function
US20120263681A1 (en) * 2011-04-12 2012-10-18 Fujifilm Corporation Composition comprising cell and biocompatible polymer
CN112386681A (zh) 2012-01-27 2021-02-23 桑比欧公司 用于调节血管生成和血管发生的方法和组合物
US9803175B2 (en) 2012-02-22 2017-10-31 Exostem Biotec Ltd. Generation of neural stem cells and motor neurons
EP2849766B1 (en) * 2012-05-16 2019-03-06 SanBio, Inc. Cells for use in the treatment of brain injury
JP6362596B2 (ja) 2012-08-06 2018-07-25 ブレインストーム セル セラペウティクス リミテッド 神経栄養因子を分泌する間葉系幹細胞の作製方法
JP5856029B2 (ja) * 2012-08-31 2016-02-09 阿部　博幸 間葉系幹細胞を未分化増殖させる方法、および間葉系幹細胞を濃縮する方法
EP2906293B1 (en) 2012-10-09 2018-12-12 SanBio, Inc. Methods and compositions for treatment of retinal degeneration
JP6628253B2 (ja) 2014-02-11 2020-01-08 ブレインストーム セル セラペウティクス リミテッド 細胞の適性を判定する方法
CN111668430A (zh) 2014-05-13 2020-09-15 赛尔格有限责任公司 功能化的多孔膜及其制造和使用方法
WO2016161290A1 (en) 2015-04-01 2016-10-06 Sanbio, Inc. Methods and compositions for stimulation of cell proliferation and provision of biologically active mixtures of fgf2 isoforms
CN106399381B (zh) * 2015-07-30 2019-11-26 中国农业大学 miR-34c在体外诱导骨骼肌细胞分化中的应用
CA3030866A1 (en) 2016-07-21 2018-01-25 Sanbio, Inc. Msc growth predictor assays
JP7220149B2 (ja) 2016-12-28 2023-02-09 サンバイオ，インコーポレイティド 細胞送達システム及びその動作方法
CN111793607B (zh) * 2017-07-28 2022-05-17 杨涛 定向诱导hiPSC分化为神经细胞体系中培养神经元细胞的基础培养基
EP3694985A1 (en) 2017-10-13 2020-08-19 IMBA-Institut für Molekulare Biotechnologie GmbH Enhanced reprogramming of somatic cells

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US7682825B2 (en) 2002-02-06 2010-03-23 Sanbio, Inc. Differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene
US20060216276A1 (en) * 2005-03-07 2006-09-28 Mari Dezawa Use of materials for treatment of central nervous system lesions
WO2009023251A1 (en) * 2007-08-15 2009-02-19 Sanbio, Inc. Methods and compositions for treating neural degeneration
DK2222839T3 (en) 2007-12-03 2015-12-21 Sanbio Inc Methods and compositions for modulating differentiation of pluripotent cells
WO2009134409A2 (en) * 2008-04-30 2009-11-05 Sanbio, Inc. Neural regenerating cells with alterations in dna methylation

Also Published As

Publication number Publication date
US20100144034A1 (en) 2010-06-10
US20100310523A1 (en) 2010-12-09
CA2475288A1 (en) 2003-08-14
ES2431518T3 (es) 2013-11-26
EP1479767A1 (en) 2004-11-24
US9399046B2 (en) 2016-07-26
DK1479767T3 (da) 2013-11-25
HK1139039A1 (en) 2010-09-10
EP1479767A4 (en) 2005-02-16
US20190136183A1 (en) 2019-05-09
US7682825B2 (en) 2010-03-23
US20120009160A1 (en) 2012-01-12
CN100497621C (zh) 2009-06-10
US20130209428A1 (en) 2013-08-15
CA2475288C (en) 2014-09-02
AU2003207064A1 (en) 2003-09-02
CN101584869A (zh) 2009-11-25
EP1479767B1 (en) 2013-08-21
US8361456B2 (en) 2013-01-29
CN1639335A (zh) 2005-07-13
CN101584869B (zh) 2013-03-27
PT1479767E (pt) 2013-11-07
US8969078B2 (en) 2015-03-03
US10196605B2 (en) 2019-02-05
WO2003066856A1 (en) 2003-08-14
US20160304835A1 (en) 2016-10-20
AU2003207064B2 (en) 2006-07-13
US20160151418A9 (en) 2016-06-02
US8133725B2 (en) 2012-03-13
US20060166362A1 (en) 2006-07-27
EP2270146A1 (en) 2011-01-05
US11512284B2 (en) 2022-11-29

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