HK1064391A1 - Template-fixed peptidomimetics with antimicrobial activity - Google Patents

Template-fixed peptidomimetics with antimicrobial activity

Info

Publication number
HK1064391A1
HK1064391A1 HK04107145A HK04107145A HK1064391A1 HK 1064391 A1 HK1064391 A1 HK 1064391A1 HK 04107145 A HK04107145 A HK 04107145A HK 04107145 A HK04107145 A HK 04107145A HK 1064391 A1 HK1064391 A1 HK 1064391A1
Authority
HK
Hong Kong
Prior art keywords
template
antimicrobial activity
fixed peptidomimetics
peptidomimetics
fixed
Prior art date
Application number
HK04107145A
Other languages
English (en)
Inventor
Daniel Obrecht
John Anthony Robinson
Jan Wim Vrijbloed
Original Assignee
Polyphor Ltd
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ltd, Univ Zuerich filed Critical Polyphor Ltd
Publication of HK1064391A1 publication Critical patent/HK1064391A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
HK04107145A 2001-02-23 2004-09-17 Template-fixed peptidomimetics with antimicrobial activity HK1064391A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0102072 2001-02-23
PCT/EP2002/001711 WO2002070547A1 (en) 2001-02-23 2002-02-18 Template-fixed peptidomimetics with antimicrobial activity

Publications (1)

Publication Number Publication Date
HK1064391A1 true HK1064391A1 (en) 2005-01-28

Family

ID=8164309

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04107145A HK1064391A1 (en) 2001-02-23 2004-09-17 Template-fixed peptidomimetics with antimicrobial activity

Country Status (10)

Country Link
US (1) US7253146B2 (xx)
EP (1) EP1363934B1 (xx)
JP (1) JP4310106B2 (xx)
CN (1) CN1255428C (xx)
AU (1) AU2002247724B2 (xx)
BR (2) BRPI0207502B1 (xx)
CA (1) CA2439178C (xx)
ES (1) ES2527339T3 (xx)
HK (1) HK1064391A1 (xx)
WO (1) WO2002070547A1 (xx)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2496215C (en) * 2002-08-20 2013-07-16 Polyphor Ltd. Template-fixed peptidomimetics with antibacterial activity
AU2002368282A1 (en) * 2002-10-02 2004-05-04 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
US7855179B2 (en) 2002-10-02 2010-12-21 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
AU2003232254A1 (en) * 2003-05-02 2004-11-23 Polyphor Ag Template-fixed peptidomimetics as medicaments against hiv and cancer
AU2003232253A1 (en) * 2003-05-02 2004-11-23 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
WO2004111077A1 (en) 2003-06-18 2004-12-23 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor
ES2491166T3 (es) * 2003-11-15 2014-09-05 Polyphor Ltd. Miméticos de lazo de horquilla beta fijados a patrón y su utilización en exposición en fagos
KR101420198B1 (ko) * 2005-02-17 2014-08-13 폴리포 리미티드 프로테아제 저해 활성을 가지는 주형-고정된 β-헤어핀 구조의 펩티드모방체
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
CN101668421B (zh) 2006-11-16 2014-05-21 凯制药公司 用于治疗甲状旁腺功能亢进和高钙血症的聚阳离子钙调节肽
US8633163B2 (en) 2007-01-29 2014-01-21 Polyphor Ltd. Template-fixed peptidomimetics
CA2677045C (en) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
PT2132221E (pt) * 2007-02-28 2010-10-26 Univ Zuerich Peptidomiméticos fixados num molde
KR101623985B1 (ko) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
US20110230426A1 (en) 2008-08-08 2011-09-22 Polyphor Ag Template-fixed peptidomimetics
WO2010060479A1 (en) * 2008-11-26 2010-06-03 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
EP2459208B1 (en) 2009-07-29 2016-09-28 Kai Pharmaceuticals, Inc. Therapeutic agents for reducing parathyroid hormone levels
US8895499B2 (en) 2010-08-05 2014-11-25 Polyphor Ag β-hairpin peptidomimetics
CA2807685C (en) 2010-08-13 2020-10-06 Aileron Therapeutics, Inc. P53 derived peptidomimetic macrocycle
PT2717896T (pt) 2011-06-08 2016-12-23 Kai Pharmaceuticals Inc Agentes terapêuticos para a regulação do fósforo sérico
JP6294227B2 (ja) 2011-10-07 2018-03-14 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ Ｆｐｒ１の阻害剤としてのテンプレート固定ペプチド模倣薬
JP6342808B2 (ja) 2011-10-18 2018-06-13 エイルロン セラピューティクス，インコーポレイテッド ペプチドミメティック大環状化合物
AU2013221433B2 (en) 2012-02-15 2018-01-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CN107216380A (zh) 2012-02-15 2017-09-29 爱勒让治疗公司 拟肽大环化合物
LT2882770T (lt) 2012-08-08 2017-10-10 Polyphor Ag Deriniai su per šoninę grandinę ciklizuotu peptidu
AU2012387696B2 (en) * 2012-08-15 2017-09-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-microbial activity of synthetic peptides
CA2887285A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
MX366089B (es) * 2013-03-30 2019-06-27 Polyphor Ag Peptidomimeticos beta-horquilla.
ES2750528T3 (es) * 2013-03-30 2020-03-26 Polyphor Ag Peptidomiméticos en horquilla beta
CN112245565A (zh) 2014-09-24 2021-01-22 艾瑞朗医疗公司 拟肽大环化合物及其用途
SG11201702175YA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
CA2963224A1 (en) * 2014-09-30 2016-04-07 Polyphor Ag Beta-hairpin peptidomimetics
EP3201219B1 (en) 2014-09-30 2021-11-17 Polyphor Ag Beta-hairpin peptidomimetics
MX2017011834A (es) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
EA201791948A1 (ru) 2015-03-23 2018-04-30 Полифор Аг Бета-шпилечные пептидомиметики
US20180092357A1 (en) * 2015-04-09 2018-04-05 Isp Investments Llc Synergistic preservative compositions
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
AU2018362978A1 (en) 2017-11-10 2020-05-14 Polyphor Ag Beta-hairpin peptidomimetics
EP4063380A1 (en) * 2021-03-24 2022-09-28 Stichting VU Inhibitors of the wnt signaling pathway and uses thereof
WO2023227771A1 (en) 2022-05-27 2023-11-30 Fundación Privada Instituto De Salud Global Barcelona Cyclic peptides with antibacterial activity against multidrug resistant (mdr) pathogens

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US5916872A (en) * 1996-07-24 1999-06-29 Intrabiotics Pharmaceuticals, Inc. Cyclic peptides having broad spectrum antimicrobial activity
CA2382931C (en) * 1999-08-30 2011-01-25 Polyphor Ag Synthesis of template-fixed .beta.-hairpin loop mimetics

Also Published As

Publication number Publication date
WO2002070547A8 (en) 2003-10-30
US7253146B2 (en) 2007-08-07
CA2439178C (en) 2013-06-04
JP4310106B2 (ja) 2009-08-05
US20040171066A1 (en) 2004-09-02
CN1255428C (zh) 2006-05-10
AU2002247724B2 (en) 2008-02-07
WO2002070547A1 (en) 2002-09-12
CA2439178A1 (en) 2002-09-12
EP1363934B1 (en) 2014-10-08
BRPI0207502B1 (pt) 2018-10-09
BR0207502A (pt) 2004-03-09
EP1363934A1 (en) 2003-11-26
JP2004534738A (ja) 2004-11-18
CN1498225A (zh) 2004-05-19
ES2527339T3 (es) 2015-01-23

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190218