HK1058672A1 - Imidazole and benzimidazole caspase inhibitors anduses thereof - Google Patents

Imidazole and benzimidazole caspase inhibitors anduses thereof

Info

Publication number
HK1058672A1
HK1058672A1 HK04101501A HK04101501A HK1058672A1 HK 1058672 A1 HK1058672 A1 HK 1058672A1 HK 04101501 A HK04101501 A HK 04101501A HK 04101501 A HK04101501 A HK 04101501A HK 1058672 A1 HK1058672 A1 HK 1058672A1
Authority
HK
Hong Kong
Prior art keywords
anduses
benzimidazole
imidazole
caspase inhibitors
caspase
Prior art date
Application number
HK04101501A
Other languages
English (en)
Inventor
David Kay
Julian Golec
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of HK1058672A1 publication Critical patent/HK1058672A1/xx

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    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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  • Communicable Diseases (AREA)
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  • Virology (AREA)
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HK04101501A 2000-11-21 2004-03-01 Imidazole and benzimidazole caspase inhibitors anduses thereof HK1058672A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25225200P 2000-11-21 2000-11-21
PCT/US2001/047688 WO2002042278A2 (en) 2000-11-21 2001-11-19 Imidazole and benzimidazole caspase inhibitors and uses thereof

Publications (1)

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HK1058672A1 true HK1058672A1 (en) 2004-05-28

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HK04101501A HK1058672A1 (en) 2000-11-21 2004-03-01 Imidazole and benzimidazole caspase inhibitors anduses thereof

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US (1) US7205327B2 (pt)
EP (1) EP1341767B1 (pt)
JP (2) JP4349802B2 (pt)
KR (1) KR20040020042A (pt)
CN (1) CN1298707C (pt)
AP (1) AP2003002811A0 (pt)
AT (1) ATE359274T1 (pt)
AU (1) AU2002232541A1 (pt)
BG (1) BG107841A (pt)
BR (1) BR0115546A (pt)
CA (1) CA2429630A1 (pt)
CO (1) CO7250442A2 (pt)
CZ (1) CZ20031730A3 (pt)
DE (1) DE60127860T2 (pt)
EA (1) EA200300601A1 (pt)
ES (1) ES2283456T3 (pt)
HK (1) HK1058672A1 (pt)
HR (1) HRP20030494A2 (pt)
HU (1) HUP0301870A3 (pt)
IL (1) IL155937A0 (pt)
IS (1) IS6822A (pt)
MX (1) MXPA03004459A (pt)
NO (1) NO20032270L (pt)
NZ (1) NZ526420A (pt)
PL (1) PL362612A1 (pt)
SK (1) SK7792003A3 (pt)
WO (1) WO2002042278A2 (pt)
ZA (1) ZA200303895B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
US7410956B2 (en) * 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
EP1499898A2 (en) 2002-04-19 2005-01-26 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha
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