HK1055957A1 - 7-Heterocyclyl quinoline and thieno(2,3-B)pyridinederivatives useful as antagonists of gonadotropin releasing hormone - Google Patents

7-Heterocyclyl quinoline and thieno(2,3-B)pyridinederivatives useful as antagonists of gonadotropin releasing hormone

Info

Publication number
HK1055957A1
HK1055957A1 HK03108228A HK03108228A HK1055957A1 HK 1055957 A1 HK1055957 A1 HK 1055957A1 HK 03108228 A HK03108228 A HK 03108228A HK 03108228 A HK03108228 A HK 03108228A HK 1055957 A1 HK1055957 A1 HK 1055957A1
Authority
HK
Hong Kong
Prior art keywords
antagonists
useful
releasing hormone
gonadotropin releasing
pyridinederivatives
Prior art date
Application number
HK03108228A
Other languages
English (en)
Inventor
Zhihua Sui
Mark Macielag
James C Lanter
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of HK1055957A1 publication Critical patent/HK1055957A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK03108228A 2000-12-12 2003-11-12 7-Heterocyclyl quinoline and thieno(2,3-B)pyridinederivatives useful as antagonists of gonadotropin releasing hormone HK1055957A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25482700P 2000-12-12 2000-12-12
US09/992,785 US6583153B2 (en) 2000-12-12 2001-11-14 7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone
PCT/US2001/048119 WO2002048112A2 (en) 2000-12-12 2001-12-11 7-heterocyclyl quinoline and thieno[2,3-b]pyridine derivatives useful as antagonists of gonadotropin releasing hormone

Publications (1)

Publication Number Publication Date
HK1055957A1 true HK1055957A1 (en) 2004-01-30

Family

ID=26944257

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03108228A HK1055957A1 (en) 2000-12-12 2003-11-12 7-Heterocyclyl quinoline and thieno(2,3-B)pyridinederivatives useful as antagonists of gonadotropin releasing hormone

Country Status (14)

Country Link
US (2) US6583153B2 (zh)
EP (2) EP1345907B1 (zh)
JP (1) JP4427251B2 (zh)
CN (1) CN1288137C (zh)
AT (2) ATE450510T1 (zh)
AU (2) AU2903302A (zh)
CA (1) CA2431617C (zh)
CY (2) CY1105712T1 (zh)
DE (2) DE60140700D1 (zh)
DK (2) DK1520855T3 (zh)
ES (2) ES2269499T3 (zh)
HK (1) HK1055957A1 (zh)
PT (2) PT1345907E (zh)
WO (1) WO2002048112A2 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
TW200413351A (en) 2002-08-21 2004-08-01 Astrazeneca Ab Chemical compounds
US20040082612A1 (en) * 2002-10-15 2004-04-29 Baxter Ellen W Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives
CA2631917A1 (en) * 2005-12-05 2007-06-14 Merck & Co., Inc. Quinolone m1 receptor positive allosteric modulators
WO2011049731A1 (en) * 2009-10-21 2011-04-28 Merck Sharp & Dohme Corp. Quinolinone-pyrazolone m1 receptor positive allosteric modulators
CN116239498B (zh) * 2023-05-11 2023-07-21 北京元延医药科技股份有限公司 制备克立硼罗中间体的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659691A (en) 1985-02-08 1987-04-21 Merck & Co., Inc. Novel cyclic Hexapeptide LHRH antagonists
US5140009A (en) 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
US5171835A (en) 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
TW449600B (en) 1994-04-19 2001-08-11 Takeda Chemical Industries Ltd Condensed-ring thiophene derivatives, their production and use
US5607939A (en) 1994-04-28 1997-03-04 Takeda Chemical Industries, Ltd. Condensed heterocyclic compounds, their production and use
WO1995029900A1 (en) 1994-04-29 1995-11-09 Takeda Chemical Industries, Ltd. CONDENSED HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE AS GnRH ANTAGONISTS
CN1072219C (zh) 1995-06-01 2001-10-03 武田药品工业株式会社 二氮杂䓬酮、其生产和用途
CA2229205A1 (en) 1995-10-19 1997-04-24 Shuichi Furuya Thienopyridine derivatives, their productions and use
DE69623655T2 (de) * 1995-10-19 2003-04-24 Takeda Chemical Industries, Ltd. Chinolinderivate als gnrh antagonisten
NZ325060A (en) 1995-12-14 2000-02-28 Merck & Co Inc Non peptide indole derivative and their use as antagonists of gonadotropin releasing hormone
SK77598A3 (en) 1995-12-14 1999-01-11 Merck & Co Inc Nonpeptide derivatives, pharmaceutical composition containing them and their use
WO1997041126A1 (en) 1996-04-26 1997-11-06 Takeda Chemical Industries, Ltd. Thienopyridine derivatives, their production and use
EP0906115A1 (en) 1996-04-30 1999-04-07 Takeda Chemical Industries, Ltd. COMBINED USE OF GnRH AGONIST AND ANTAGONIST
WO1997044037A1 (en) 1996-05-20 1997-11-27 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP0901471A4 (en) 1996-05-20 1999-08-25 Merck & Co Inc GONADOTROPIN RELEASING HORMONE ANTAGONISTS
AU712019B2 (en) 1996-05-20 1999-10-28 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
WO1997044339A1 (en) 1996-05-20 1997-11-27 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
GB9610813D0 (en) 1996-05-23 1996-07-31 Pharmacia Spa Combinatorial solid phase synthesis of a library of benzufuran derivatives

Also Published As

Publication number Publication date
ATE337303T1 (de) 2006-09-15
CA2431617C (en) 2011-07-12
DE60140700D1 (de) 2010-01-14
EP1345907A2 (en) 2003-09-24
EP1520855B1 (en) 2009-12-02
CN1288137C (zh) 2006-12-06
PT1345907E (pt) 2006-11-30
DE60122575T2 (de) 2007-09-13
PT1520855E (pt) 2010-01-06
US20030216429A1 (en) 2003-11-20
EP1345907B1 (en) 2006-08-23
WO2002048112A2 (en) 2002-06-20
EP1520855A1 (en) 2005-04-06
US6583153B2 (en) 2003-06-24
AU2903302A (en) 2002-06-24
US20020123506A1 (en) 2002-09-05
ATE450510T1 (de) 2009-12-15
WO2002048112A3 (en) 2002-08-22
CY1110589T1 (el) 2015-04-29
DK1520855T3 (da) 2010-03-15
JP4427251B2 (ja) 2010-03-03
AU2002229033B2 (en) 2007-09-13
CN1489579A (zh) 2004-04-14
CY1105712T1 (el) 2010-12-22
US6765011B2 (en) 2004-07-20
ES2337898T3 (es) 2010-04-30
DE60122575D1 (de) 2006-10-05
CA2431617A1 (en) 2002-06-20
ES2269499T3 (es) 2007-04-01
DK1345907T3 (da) 2006-11-13
JP2004515541A (ja) 2004-05-27

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Legal Events

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Effective date: 20211210