HK1045526B - 皂草苷配基衍生物及其在治療認知障礙中的用途 - Google Patents

皂草苷配基衍生物及其在治療認知障礙中的用途

Info

Publication number
HK1045526B
HK1045526B HK02106663.1A HK02106663A HK1045526B HK 1045526 B HK1045526 B HK 1045526B HK 02106663 A HK02106663 A HK 02106663A HK 1045526 B HK1045526 B HK 1045526B
Authority
HK
Hong Kong
Prior art keywords
treatment
cognitive dysfunction
sapogenin derivatives
sapogenin
derivatives
Prior art date
Application number
HK02106663.1A
Other languages
English (en)
Other versions
HK1045526A1 (en
Inventor
Barraclough Paul
Hanson Jim
Gunning Phil
Rees Daryl
Xia Zongqin
Hu Yaer
Original Assignee
Phytopharm Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytopharm Plc filed Critical Phytopharm Plc
Publication of HK1045526A1 publication Critical patent/HK1045526A1/xx
Publication of HK1045526B publication Critical patent/HK1045526B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
HK02106663.1A 1999-09-29 2002-09-11 皂草苷配基衍生物及其在治療認知障礙中的用途 HK1045526B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9923077.3A GB9923077D0 (en) 1999-09-29 1999-09-29 Sapogenin derivatives and their use
PCT/GB2000/003745 WO2001023407A1 (en) 1999-09-29 2000-09-29 Sapogenin derivatives and their use in the treatment of cognitive dysfunction

Publications (2)

Publication Number Publication Date
HK1045526A1 HK1045526A1 (en) 2002-11-29
HK1045526B true HK1045526B (zh) 2005-04-22

Family

ID=10861838

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02106663.1A HK1045526B (zh) 1999-09-29 2002-09-11 皂草苷配基衍生物及其在治療認知障礙中的用途

Country Status (14)

Country Link
US (2) US20020183294A1 (zh)
EP (2) EP1548025A3 (zh)
JP (1) JP2003510333A (zh)
CN (2) CN1377367A (zh)
AT (1) ATE277072T1 (zh)
AU (1) AU7538200A (zh)
BR (1) BR0014355A (zh)
CA (1) CA2385410C (zh)
DE (1) DE60014136T2 (zh)
ES (1) ES2228608T3 (zh)
GB (1) GB9923077D0 (zh)
HK (1) HK1045526B (zh)
MX (1) MXPA02003306A (zh)
WO (1) WO2001023407A1 (zh)

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GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
RU2332999C2 (ru) * 2002-03-27 2008-09-10 ФИТОФАРМ ПиЭлСи Терапевтические способы и применения сапогенинов и их производных
AU2003229877B8 (en) * 2002-03-27 2008-06-12 Phytopharm Plc Theraputic methods and uses of sapogenins and their derivatives
DE60326437D1 (de) * 2002-03-27 2009-04-16 Phytopharm Plc Godmanchester Therapeutische verwendung von sapogeninen
US20080182801A1 (en) 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
GB0329667D0 (en) * 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
GB0513881D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
GB0409567D0 (en) 2004-04-28 2004-06-02 Phytopharm Plc Chemical compounds
GB0512726D0 (en) * 2005-06-22 2005-07-27 Btg Int Ltd Multiple sclerosis therapy and diagnosis
GB0513888D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
GB0513883D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Diagnosis of Atherosclerosis
JP2010510309A (ja) * 2006-11-20 2010-04-02 サトリ・ファーマシューティカルズ・インコーポレイテッド 神経変性障害の治療に有用な化合物
EP2073638B1 (en) 2006-11-20 2013-05-15 Satori Pharmaceuticals, Inc. Synthesis of compounds useful as modulators of amyloid-beta production
WO2010084356A1 (en) 2009-01-24 2010-07-29 Phytopharm Plc Treatment of neurotrophic factor mediated disorders
TR201911199T4 (tr) * 2009-03-27 2019-08-21 Moleac Pte Ltd Hücre büyümesini arttırmak için tedavi.
BR112013001422A2 (pt) 2010-07-20 2019-09-24 Phytopharm Plc metodo para tratar ou previnir disturbios induzidos por l-dopa, agonista dopamina e/ou acentuador de dopamina em um individuo que necessita dos mesmos, agente, composição, uso de ou mais agentes e metodo para tratar a doença de parkinson
CU20110244A7 (es) * 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
WO2013149580A1 (en) * 2012-04-03 2013-10-10 Chiming Che Timosaponin compounds
CN102924559B (zh) * 2012-11-16 2015-10-28 沈阳药科大学 菝葜皂苷元衍生物及其制备和应用
CN108264535A (zh) 2016-12-30 2018-07-10 中国科学院上海药物研究所 一种抗抑郁化合物及其制备方法和应用

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LU81256A1 (fr) * 1979-05-15 1980-12-16 Oreal Composition cosmetique capillaire notamment pour le lavage et/ou le demelage des cheveux,a base d'un extrait de plantes contenant des saponosides
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Also Published As

Publication number Publication date
WO2001023407A1 (en) 2001-04-05
CA2385410A1 (en) 2001-04-05
EP1224206A1 (en) 2002-07-24
DE60014136T2 (de) 2005-10-06
EP1548025A3 (en) 2008-11-19
BR0014355A (pt) 2002-07-16
AU7538200A (en) 2001-04-30
US20080021004A1 (en) 2008-01-24
CN1377367A (zh) 2002-10-30
CN101143147A (zh) 2008-03-19
CA2385410C (en) 2008-05-20
HK1045526A1 (en) 2002-11-29
EP1224206B1 (en) 2004-09-22
ATE277072T1 (de) 2004-10-15
MXPA02003306A (es) 2002-10-04
US20020183294A1 (en) 2002-12-05
JP2003510333A (ja) 2003-03-18
GB9923077D0 (en) 1999-12-01
EP1548025A2 (en) 2005-06-29
DE60014136D1 (de) 2004-10-28
ES2228608T3 (es) 2005-04-16

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Legal Events

Date Code Title Description
CHPA Change of a particular in the register (except of change of ownership)
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090929