HK1045156A1 - N-酰基-3，4-脫氫脯氨酸和n-酰基-3，4-脫氫哌啶-2-羧酸衍生物的製備工藝 - Google Patents

N-酰基-3，4-脫氫脯氨酸和n-酰基-3，4-脫氫哌啶-2-羧酸衍生物的製備工藝 Download PDF

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Publication number
HK1045156A1
HK1045156A1 HK02106153.8A HK02106153A HK1045156A1 HK 1045156 A1 HK1045156 A1 HK 1045156A1 HK 02106153 A HK02106153 A HK 02106153A HK 1045156 A1 HK1045156 A1 HK 1045156A1
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HK
Hong Kong
Prior art keywords
alkyl
acryl
dehydropiperidine
formula
reaction
Prior art date
Application number
HK02106153.8A
Other languages
English (en)
Chinese (zh)
Inventor
B‧夏弗
G‧赫尔姆辰
U‧卡兹梅尔
G‧赫爾姆辰
S‧施莱克
H‧斯塔尔
U‧卡兹梅爾
V‧沃尔法特
S‧施萊克
H‧斯塔爾
V‧沃爾法特
Original Assignee
Abbott Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co. Kg filed Critical Abbott Gmbh & Co. Kg
Publication of HK1045156A1 publication Critical patent/HK1045156A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK02106153.8A 1999-03-26 2000-03-17 N-酰基-3，4-脫氫脯氨酸和n-酰基-3，4-脫氫哌啶-2-羧酸衍生物的製備工藝 HK1045156A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19913699.8 1999-03-26
DE19913699A DE19913699A1 (de) 1999-03-26 1999-03-26 Verfahren zur Herstellung von 3,4-Dihydroprolinen und 3,4-Dehydropiperidinen
PCT/EP2000/002377 WO2000058284A1 (de) 1999-03-26 2000-03-17 Verfahren zur herstellung von n-acyl-3,4 - dehydroprolin und n-acyl-3,4 - dehydropiperidin-2-carbonsäure derivaten

Publications (1)

Publication Number Publication Date
HK1045156A1 true HK1045156A1 (zh) 2002-11-15

Family

ID=7902464

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02106153.8A HK1045156A1 (zh) 1999-03-26 2000-03-17 N-酰基-3，4-脫氫脯氨酸和n-酰基-3，4-脫氫哌啶-2-羧酸衍生物的製備工藝

Country Status (22)

Country Link
US (1) US6579971B1 (enExample)
EP (1) EP1165509B1 (enExample)
JP (1) JP3868210B2 (enExample)
KR (1) KR20010104730A (enExample)
CN (1) CN1345310A (enExample)
AT (1) ATE278665T1 (enExample)
AU (1) AU3962500A (enExample)
BR (1) BR0009330A (enExample)
CA (1) CA2368479C (enExample)
CZ (1) CZ20013456A3 (enExample)
DE (2) DE19913699A1 (enExample)
ES (1) ES2230088T3 (enExample)
HK (1) HK1045156A1 (enExample)
HU (1) HUP0200420A2 (enExample)
IL (1) IL145525A0 (enExample)
MX (1) MXPA01009679A (enExample)
NO (1) NO20014645L (enExample)
RU (1) RU2001129097A (enExample)
TR (1) TR200102747T2 (enExample)
TW (1) TWI276626B (enExample)
WO (1) WO2000058284A1 (enExample)
ZA (1) ZA200107629B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100396666C (zh) * 2005-12-14 2008-06-25 郑州大学 （4s）-1-叔丁氧羰基-4-氨基-l-脯氨酸乙酯及其合成工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291040A (en) * 1979-10-22 1981-09-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
DE59409568D1 (de) 1993-09-09 2000-11-30 Schering Ag Wirkstoffe und gas enthaltende mikropartikel
DE19630082A1 (de) * 1996-07-26 1998-01-29 Basf Ag Verfahren zur Herstellung von 3-Pyrrolin-2-carbonsäure-Derivaten
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
DE19723473A1 (de) * 1997-06-04 1998-12-10 Basf Ag Verfahren zur Herstellung von chiralen 3,4-Didehydroprolinen
AU753196B2 (en) 1998-02-09 2002-10-10 Bracco Research S.A. Targeted delivery of biologically active media

Also Published As

Publication number Publication date
EP1165509B1 (de) 2004-10-06
BR0009330A (pt) 2002-01-08
RU2001129097A (ru) 2004-03-20
NO20014645D0 (no) 2001-09-25
US6579971B1 (en) 2003-06-17
KR20010104730A (ko) 2001-11-26
JP2002540190A (ja) 2002-11-26
DE50008117D1 (de) 2004-11-11
TR200102747T2 (tr) 2002-02-21
CA2368479C (en) 2005-03-01
NO20014645L (no) 2001-09-25
JP3868210B2 (ja) 2007-01-17
IL145525A0 (en) 2002-06-30
CN1345310A (zh) 2002-04-17
AU3962500A (en) 2000-10-16
CA2368479A1 (en) 2000-10-05
ATE278665T1 (de) 2004-10-15
DE19913699A1 (de) 2000-09-28
ES2230088T3 (es) 2005-05-01
TWI276626B (en) 2007-03-21
MXPA01009679A (es) 2002-03-14
WO2000058284A1 (de) 2000-10-05
CZ20013456A3 (cs) 2002-05-15
ZA200107629B (en) 2002-09-17
HUP0200420A2 (hu) 2002-05-29
EP1165509A1 (de) 2002-01-02

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