HK1036997A1 - Peptides - Google Patents
PeptidesInfo
- Publication number
- HK1036997A1 HK1036997A1 HK01107827A HK01107827A HK1036997A1 HK 1036997 A1 HK1036997 A1 HK 1036997A1 HK 01107827 A HK01107827 A HK 01107827A HK 01107827 A HK01107827 A HK 01107827A HK 1036997 A1 HK1036997 A1 HK 1036997A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- peptides
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO19982097A NO315238B1 (no) | 1998-05-08 | 1998-05-08 | Peptider som stammer fra leserammeforskyvingsmutasjoner i TBF<beta>II- eller BAX-genet, og farmasöytiske sammensetninger inneholdende disse,nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slikenukleinsy |
PCT/NO1999/000143 WO1999058552A2 (fr) | 1998-05-08 | 1999-05-03 | Utilisation d'analogues d'acides gras non beta-oxydables pour traiter les etats lies au syndrome x |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1036997A1 true HK1036997A1 (en) | 2002-01-25 |
Family
ID=19902021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK01107827A HK1036997A1 (en) | 1998-05-08 | 2001-11-08 | Peptides |
Country Status (13)
Country | Link |
---|---|
US (4) | US6759046B1 (fr) |
EP (2) | EP2374814B1 (fr) |
JP (1) | JP4591983B2 (fr) |
CN (1) | CN100355781C (fr) |
AR (1) | AR018346A1 (fr) |
AU (1) | AU755712B2 (fr) |
CA (1) | CA2327549C (fr) |
ES (1) | ES2463825T3 (fr) |
HK (1) | HK1036997A1 (fr) |
HU (1) | HUP0101432A3 (fr) |
NO (1) | NO315238B1 (fr) |
PL (1) | PL344341A1 (fr) |
WO (1) | WO1999058552A2 (fr) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO315238B1 (no) * | 1998-05-08 | 2003-08-04 | Gemvax As | Peptider som stammer fra leserammeforskyvingsmutasjoner i TBF<beta>II- eller BAX-genet, og farmasöytiske sammensetninger inneholdende disse,nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slikenukleinsy |
NO314086B1 (no) | 1998-05-08 | 2003-01-27 | Gemvax As | Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til |
GB2361701A (en) * | 2000-04-28 | 2001-10-31 | Norsk Hydro As | DNA polymerase delta mutants |
GB0031430D0 (en) | 2000-12-22 | 2001-02-07 | Norsk Hydro As | Polypeptides |
CA2471735A1 (fr) * | 2001-08-29 | 2003-03-13 | Kyogo Itoh | Desensibilisants |
AU2003232485A1 (en) | 2002-04-18 | 2003-10-27 | Mtm Laboratories Ag | Neopeptides and methods useful for detection and treatment of cancer |
EP1369126A1 (fr) * | 2002-04-18 | 2003-12-10 | MTM Laboratories AG | Utilisation de peptides de régions de microsatellites codantes et mutantes de déphasage pour traiter le cancer |
US20050221350A1 (en) * | 2002-05-29 | 2005-10-06 | Toni Weinschenk | Method for identifying immunoreactive peptides |
US7439042B2 (en) * | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
US8343502B2 (en) * | 2002-12-16 | 2013-01-01 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
WO2004058157A2 (fr) * | 2002-12-16 | 2004-07-15 | Globeimmune, Inc. | Vaccins a base de levure pour immunotherapie |
CN102558334B (zh) * | 2004-09-07 | 2016-08-03 | 伯纳姆研究院 | 选择性锚定到心脏脉管系统上的肽和相关结合物和方法 |
US7501486B2 (en) | 2004-09-07 | 2009-03-10 | Burnham Institute For Medical Research | Peptides that selectively home to heart vasculature and related conjugates and methods |
AU2005295317B2 (en) * | 2004-10-18 | 2011-10-13 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
KR20080043775A (ko) * | 2005-07-11 | 2008-05-19 | 글로브이뮨 | 표적 치료용 회피 돌연변이체에 대한 면역 반응의 유발방법 및 조성물 |
US9732131B2 (en) | 2006-02-27 | 2017-08-15 | Calviri, Inc. | Identification and use of novopeptides for the treatment of cancer |
EP1994181A4 (fr) * | 2006-02-27 | 2010-05-19 | Univ Arizona | Identification et utilisation de novopeptides pour le traitement du cancer |
ES2657480T3 (es) | 2006-08-11 | 2018-03-05 | Life Sciences Research Partners Vzw | Péptidos inmunogénicos y su uso en trastornos inmunitarios |
KR20100015661A (ko) * | 2007-03-19 | 2010-02-12 | 글로브이뮨 | 암의 표적 치료법의 돌연변이성 이탈의 표적 절제를 위한 조성물 및 방법 |
US20080293050A1 (en) * | 2007-05-25 | 2008-11-27 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Gene analysis for determination of a treatment characteristic |
CA2715611C (fr) | 2008-02-14 | 2018-03-13 | Life Sciences Research Partners Vzw | Immunotherapie ciblant des agents pathogenes intracellulaires |
ES2545885T3 (es) | 2008-02-14 | 2015-09-16 | Life Sciences Research Partners Vzw | Eliminación de respuestas inmunitarias contra vectores virales |
ES2650236T3 (es) | 2008-02-14 | 2018-01-17 | Life Sciences Research Partners Vzw | Linfocitos T CD4+ con propiedades citolíticas |
CA2715517C (fr) | 2008-02-14 | 2018-07-24 | Life Sciences Research Partners Vzw | Peptides immunogenes et leur utilisation pour la prevention ou le traitement du rejet d'une allogreffe |
CA2724440C (fr) * | 2008-02-14 | 2018-01-09 | Life Sciences Research Partners Vzw | Strategies de prevention et/ou de traitement de reponses immunitaires dirigees contre des facteurs allogenes solubles |
AU2009214039B2 (en) * | 2008-02-14 | 2013-09-19 | Katholieke Universiteit Leuven | Immunogenic control of tumours and tumour cells |
JP2012503011A (ja) | 2008-09-19 | 2012-02-02 | グローブイミューン,インコーポレイテッド | 慢性c型肝炎ウイルス感染の免疫療法 |
GB0821616D0 (en) | 2008-11-26 | 2008-12-31 | Lytix Biopharma As | Compounds |
CN105132395A (zh) | 2009-03-09 | 2015-12-09 | 生物蛋白有限公司 | Mirac蛋白 |
PT2643345T (pt) | 2010-11-25 | 2021-04-14 | Imnate Sarl | Péptidos imunogénicos para utilizar na prevenção e/ou no tratamento de doenças infecciosas, doenças autoimunes, respostas imunitárias a alofatores, doenças alérgicas, tumores, rejeição de enxertos e respostas imunitárias contra vetores virais usados para a terapêutica de genes ou na vacinação genética |
MX355759B (es) | 2011-10-28 | 2018-04-27 | Oncotherapy Science Inc | Peptidos topk y vacunas que incluyen los mismos. |
GB201201511D0 (en) | 2012-01-30 | 2012-03-14 | Univ Leuven Kath | Modified epitopes for boosting CD4+ T-cell responses |
WO2013150532A1 (fr) * | 2012-04-04 | 2013-10-10 | Yeda Research And Development Co. Ltd. | Conjugués de lipopeptide comprenant un sphingolipide et des peptides dérivés de gp41 du vih |
JP5890769B2 (ja) * | 2012-12-13 | 2016-03-22 | ループレヒト−カルルス・ウニヴェルジテート・ハイデルベルクRuprecht−Karls−Universitaet Heidelberg | がんの予防及び治療のためのmsi特異的なフレームシフトペプチド(fsp) |
US9205140B2 (en) | 2012-12-13 | 2015-12-08 | Ruprecht-Karls-Universität | MSI-specific frameshift peptides (FSP) for prevention and treatment of cancer |
GB201309469D0 (en) | 2013-05-28 | 2013-07-10 | Imcyse Sa | Detection of CD4+ T lymphocytes |
GB201418433D0 (en) | 2014-10-17 | 2014-12-03 | Imcyse Sa | Novel immunogenic peptides |
HUE065689T2 (hu) | 2014-11-26 | 2024-06-28 | The United States Of America | Anti-mutált KRAS T sejt receptorok |
KR20180006945A (ko) | 2015-05-13 | 2018-01-19 | 아게누스 인코포레이티드 | 암 치료 및 예방용 백신 |
US10729791B2 (en) | 2015-05-18 | 2020-08-04 | Imcyse Sa | Animal models for evaluating pharmaceutical compounds |
JP2016028025A (ja) * | 2015-07-29 | 2016-02-25 | ループレヒト−カルルス・ウニヴェルジテート・ハイデルベルクRuprecht−Karls−Universitaet Heidelberg | がんの予防及び治療のためのmsi特異的なフレームシフトペプチド(fsp) |
CA2995771A1 (fr) | 2015-09-25 | 2017-03-30 | Imcyse Sa | Procedes et composes ameliores pour supprimer des reponses immunitaires a des agents therapeutiques |
WO2017069627A1 (fr) * | 2015-10-23 | 2017-04-27 | Universiteit Twente | Peptides de liaison à l'intégrine et leurs utilisations |
CN108495649A (zh) | 2016-01-08 | 2018-09-04 | 瓦西博迪公司 | 治疗性抗癌新表位疫苗 |
ES2944259T3 (es) * | 2016-03-15 | 2023-06-20 | Inst Nat Sante Rech Med | Procedimiento para activar la respuesta antitumoral de linfocitos T CD8+ de un paciente afectado con un cáncer |
KR20220132023A (ko) | 2016-04-19 | 2022-09-29 | 임시스 에스에이 | 신규 면역원성 CD1d 결합 펩티드 |
GB201608052D0 (en) * | 2016-05-09 | 2016-06-22 | Univ Oslo Hf | T-cell receptors which recognise frameshift mutants of TGF-beta RII |
WO2018039302A1 (fr) * | 2016-08-23 | 2018-03-01 | The Cleveland Clinic Foundation | Traitement du cancer à l'aide de peptides bloquant cx26 |
US11260101B2 (en) | 2017-02-28 | 2022-03-01 | Jinan University | Repair peptide for use in promoting post-traumatic tissue repair and regeneration, and application thereof |
CN108503690B (zh) * | 2017-02-28 | 2020-07-03 | 暨南大学 | 一种促进创伤后组织修复与再生的修复肽及其应用 |
EP3630130B1 (fr) * | 2017-06-02 | 2022-08-31 | Arizona Board of Regents on behalf of Arizona State University | Procédé de création de vaccins anticancéreux personnalisés |
US12025615B2 (en) | 2017-09-15 | 2024-07-02 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods of classifying response to immunotherapy for cancer |
JP2021522239A (ja) | 2018-04-26 | 2021-08-30 | アジェナス インコーポレイテッド | 熱ショックタンパク質結合ペプチド組成物およびその使用方法 |
EP3827262A1 (fr) | 2018-07-26 | 2021-06-02 | Frame Pharmaceuticals B.V. | Vaccins contre le cancer pour le cancer du sein |
WO2020022903A1 (fr) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Vaccins à base de arid1a, cdkn2a, kmt2b, kmt2d, tp53 et pten contre le cancer |
CA3106570A1 (fr) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Vaccins contre le cancer pour le cancer de l'uterus |
WO2020022900A1 (fr) | 2018-07-26 | 2020-01-30 | Frame Pharmaceuticals B.V. | Vaccins contre le cancer pour le cancer du rein |
US12005104B2 (en) | 2018-07-26 | 2024-06-11 | Curevac Netherlands B.V. | Cancer vaccines for colorectal cancer |
LT3840767T (lt) | 2019-05-29 | 2024-02-26 | Hubro Therapeutics As | Peptidai |
EP4038222A4 (fr) | 2019-10-02 | 2023-10-18 | Arizona Board of Regents on behalf of Arizona State University | Procédés et compositions pour identifier des néo-antigènes destinés à être utilisés dans le traitement et la prévention du cancer |
CN110734474B (zh) * | 2019-11-29 | 2021-10-19 | 中山大学 | 一种抗菌肽的筛选方法及其应用 |
CN113061165A (zh) * | 2020-01-02 | 2021-07-02 | 厦门大学 | EB病毒BNLF2b基因编码多肽及其检测用途 |
WO2021142007A1 (fr) * | 2020-01-09 | 2021-07-15 | Arizona Board Of Regents On Behalf Of Arizona State University | Anticorps et procédé de production d'anticorps |
WO2021239980A2 (fr) | 2020-05-28 | 2021-12-02 | Hubro Therapeutics As | Cocktail peptidique |
WO2024052542A2 (fr) | 2022-09-09 | 2024-03-14 | Hubro Therapeutics As | Cocktail de peptides |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9103974D0 (en) * | 1991-02-26 | 1991-04-10 | Norsk Hydro As | Therapeutically useful peptides or peptide fragments |
US5700638A (en) * | 1993-08-26 | 1997-12-23 | Washington University | Cell death regulator |
GB9410922D0 (en) | 1994-06-01 | 1994-07-20 | Townsend Alain R M | Vaccines |
WO1996018409A1 (fr) | 1994-12-14 | 1996-06-20 | The Scripps Research Institute | Activation in vivo de lymphocytes t cytotoxiques specifiques de tumeurs |
US5866323A (en) * | 1995-04-07 | 1999-02-02 | Case Western Reserve University | Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors |
US5958684A (en) | 1995-10-02 | 1999-09-28 | Van Leeuwen; Frederik Willem | Diagnosis of neurodegenerative disease |
US5973018A (en) * | 1995-10-04 | 1999-10-26 | Owens-Corning Fiberglas Technology, Inc. | Process for producing shaped phenolic foams |
US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
AU4907797A (en) | 1996-10-10 | 1998-05-05 | Wistar Institute Of Anatomy And Biology, The | Methods and compositions for inducing a protective immune response to cancers |
GB2328689A (en) * | 1997-08-27 | 1999-03-03 | Norsk Hydro As | Peptides based on the p21 ras proto-oncogene protein for the treatment of cancer |
NO315238B1 (no) * | 1998-05-08 | 2003-08-04 | Gemvax As | Peptider som stammer fra leserammeforskyvingsmutasjoner i TBF<beta>II- eller BAX-genet, og farmasöytiske sammensetninger inneholdende disse,nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slikenukleinsy |
NO314086B1 (no) | 1998-05-08 | 2003-01-27 | Gemvax As | Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til |
GB0031430D0 (en) * | 2000-12-22 | 2001-02-07 | Norsk Hydro As | Polypeptides |
-
1998
- 1998-05-08 NO NO19982097A patent/NO315238B1/no not_active IP Right Cessation
-
1999
- 1999-05-03 AU AU54516/99A patent/AU755712B2/en not_active Expired
- 1999-05-03 EP EP10183767.2A patent/EP2374814B1/fr not_active Expired - Lifetime
- 1999-05-03 EP EP99940722.4A patent/EP1078000B1/fr not_active Expired - Lifetime
- 1999-05-03 CN CNB998073555A patent/CN100355781C/zh not_active Expired - Lifetime
- 1999-05-03 PL PL99344341A patent/PL344341A1/xx not_active Application Discontinuation
- 1999-05-03 ES ES10183767.2T patent/ES2463825T3/es not_active Expired - Lifetime
- 1999-05-03 US US09/674,973 patent/US6759046B1/en not_active Expired - Lifetime
- 1999-05-03 CA CA2327549A patent/CA2327549C/fr not_active Expired - Lifetime
- 1999-05-03 JP JP2000548356A patent/JP4591983B2/ja not_active Expired - Lifetime
- 1999-05-03 HU HU0101432A patent/HUP0101432A3/hu active IP Right Revival
- 1999-05-03 WO PCT/NO1999/000143 patent/WO1999058552A2/fr active IP Right Grant
- 1999-05-10 AR ARP990102199A patent/AR018346A1/es unknown
-
2001
- 2001-11-08 HK HK01107827A patent/HK1036997A1/xx not_active IP Right Cessation
-
2004
- 2004-02-12 US US10/776,224 patent/US7192927B2/en not_active Expired - Lifetime
-
2006
- 2006-08-03 US US11/498,194 patent/US7863244B2/en not_active Expired - Fee Related
-
2011
- 2011-01-03 US US12/983,510 patent/US8614177B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1078000B1 (fr) | 2017-03-29 |
CA2327549A1 (fr) | 1999-11-18 |
CN100355781C (zh) | 2007-12-19 |
CA2327549C (fr) | 2014-10-07 |
US6759046B1 (en) | 2004-07-06 |
EP2374814B1 (fr) | 2014-03-19 |
PL344341A1 (en) | 2001-11-05 |
NO982097D0 (no) | 1998-05-08 |
US8614177B2 (en) | 2013-12-24 |
AU5451699A (en) | 1999-11-29 |
CN1305495A (zh) | 2001-07-25 |
ES2463825T3 (es) | 2014-05-29 |
HUP0101432A2 (hu) | 2001-08-28 |
JP2002519999A (ja) | 2002-07-09 |
US20050074849A1 (en) | 2005-04-07 |
JP4591983B2 (ja) | 2010-12-01 |
AR018346A1 (es) | 2001-11-14 |
NO315238B1 (no) | 2003-08-04 |
WO1999058552A3 (fr) | 2000-03-02 |
EP2374814A3 (fr) | 2012-01-11 |
NO982097L (no) | 1999-11-09 |
AU755712B2 (en) | 2002-12-19 |
US20110105721A1 (en) | 2011-05-05 |
US20070004632A1 (en) | 2007-01-04 |
US7863244B2 (en) | 2011-01-04 |
WO1999058552A2 (fr) | 1999-11-18 |
HUP0101432A3 (en) | 2004-01-28 |
EP2374814A2 (fr) | 2011-10-12 |
EP1078000A2 (fr) | 2001-02-28 |
US7192927B2 (en) | 2007-03-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1036997A1 (en) | Peptides | |
GB9912852D0 (en) | Peptides | |
HK1039158A1 (zh) | Nlk1相互作用蛋白 | |
GB9825854D0 (en) | Peptide | |
GB9718110D0 (en) | Peptides | |
GB0127673D0 (en) | Polypeptide | |
GB9812675D0 (en) | Peptides | |
GB9700154D0 (en) | Peptides | |
EP1147130A4 (fr) | Peptides d'alpha-conotoxine | |
EP1159288A4 (fr) | Peptides alpha-conotoxine | |
GB9904695D0 (en) | Peptide | |
GB9828704D0 (en) | Proteins | |
GB9816337D0 (en) | Proteins | |
EP0996457A4 (fr) | Peptides liberateurs de f.s.h. | |
GB9807890D0 (en) | Peptides | |
IL144376A0 (en) | Peptides | |
GB9908920D0 (en) | Peptide | |
GB0224538D0 (en) | Polypeptide | |
EP1151100A4 (fr) | Peptides designes tau-conotoxines | |
GB9819038D0 (en) | Protein | |
GB9809566D0 (en) | Protein | |
GB9812607D0 (en) | Protein | |
GB9818368D0 (en) | Vitronectin-derived peptides | |
GB9827603D0 (en) | Peptides | |
GB9800321D0 (en) | Peptides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |