AR018346A1 - Peptidos mutantes promotores de la inmunidad celular t, composiciones farmaceuticas y vacunas formuladas con dichos peptidos para el tratamiento decanceres; uso de dichos peptidos, metodo para identificar dichos peptidos y secuencias de adn que codifican dichos peptidos mutantes y vectores y plasmid - Google Patents

Peptidos mutantes promotores de la inmunidad celular t, composiciones farmaceuticas y vacunas formuladas con dichos peptidos para el tratamiento decanceres; uso de dichos peptidos, metodo para identificar dichos peptidos y secuencias de adn que codifican dichos peptidos mutantes y vectores y plasmid

Info

Publication number
AR018346A1
AR018346A1 ARP990102199A ARP990102199A AR018346A1 AR 018346 A1 AR018346 A1 AR 018346A1 AR P990102199 A ARP990102199 A AR P990102199A AR P990102199 A ARP990102199 A AR P990102199A AR 018346 A1 AR018346 A1 AR 018346A1
Authority
AR
Argentina
Prior art keywords
peptides
mutant
decancer
codify
plasmid
Prior art date
Application number
ARP990102199A
Other languages
English (en)
Original Assignee
Gemvax As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gemvax As filed Critical Gemvax As
Publication of AR018346A1 publication Critical patent/AR018346A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se trata de péptidos de producir inmunidad celular T, que comprende: a) un fragmento de al menos 8 aminoácidos, de una proteína mutante que proviene de unmutante en el marco de lectura en un gel de células cancerígenas y b) tienen al menos un aminoácido de la parte mutante de una secuencia de proteínascodificadas por dicho gen; y c) comprenden de 0 a 10 aminoácidos del extremo carboxilo de la parte normal de la secuencia de proteína que precede al extremoamino de la secuencia mutante y puede extenderse más, hacia el extremo carboxilo de la parte mutante de la proteína, segun se determina por un nuevo codonterminador generado por la mutacion por un cambio en el marco de lectura; d) induce, ya sea en toda su longitud o después del procesamiento realizado por unacélula presentadora de antígenos, respuestas de los linfocitos T.
ARP990102199A 1998-05-08 1999-05-10 Peptidos mutantes promotores de la inmunidad celular t, composiciones farmaceuticas y vacunas formuladas con dichos peptidos para el tratamiento decanceres; uso de dichos peptidos, metodo para identificar dichos peptidos y secuencias de adn que codifican dichos peptidos mutantes y vectores y plasmid AR018346A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NO19982097A NO315238B1 (no) 1998-05-08 1998-05-08 Peptider som stammer fra leserammeforskyvingsmutasjoner i TBF<beta>II- eller BAX-genet, og farmasöytiske sammensetninger inneholdende disse,nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slikenukleinsy

Publications (1)

Publication Number Publication Date
AR018346A1 true AR018346A1 (es) 2001-11-14

Family

ID=19902021

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990102199A AR018346A1 (es) 1998-05-08 1999-05-10 Peptidos mutantes promotores de la inmunidad celular t, composiciones farmaceuticas y vacunas formuladas con dichos peptidos para el tratamiento decanceres; uso de dichos peptidos, metodo para identificar dichos peptidos y secuencias de adn que codifican dichos peptidos mutantes y vectores y plasmid

Country Status (13)

Country Link
US (4) US6759046B1 (es)
EP (2) EP2374814B1 (es)
JP (1) JP4591983B2 (es)
CN (1) CN100355781C (es)
AR (1) AR018346A1 (es)
AU (1) AU755712B2 (es)
CA (1) CA2327549C (es)
ES (1) ES2463825T3 (es)
HK (1) HK1036997A1 (es)
HU (1) HUP0101432A3 (es)
NO (1) NO315238B1 (es)
PL (1) PL344341A1 (es)
WO (1) WO1999058552A2 (es)

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Also Published As

Publication number Publication date
EP1078000A2 (en) 2001-02-28
ES2463825T3 (es) 2014-05-29
HK1036997A1 (en) 2002-01-25
JP4591983B2 (ja) 2010-12-01
WO1999058552A3 (en) 2000-03-02
US20070004632A1 (en) 2007-01-04
EP2374814B1 (en) 2014-03-19
HUP0101432A2 (hu) 2001-08-28
US7863244B2 (en) 2011-01-04
US6759046B1 (en) 2004-07-06
EP1078000B1 (en) 2017-03-29
CN1305495A (zh) 2001-07-25
WO1999058552A2 (en) 1999-11-18
NO982097L (no) 1999-11-09
EP2374814A2 (en) 2011-10-12
CN100355781C (zh) 2007-12-19
CA2327549C (en) 2014-10-07
NO315238B1 (no) 2003-08-04
US20050074849A1 (en) 2005-04-07
JP2002519999A (ja) 2002-07-09
CA2327549A1 (en) 1999-11-18
AU755712B2 (en) 2002-12-19
EP2374814A3 (en) 2012-01-11
NO982097D0 (no) 1998-05-08
AU5451699A (en) 1999-11-29
US8614177B2 (en) 2013-12-24
HUP0101432A3 (en) 2004-01-28
PL344341A1 (en) 2001-11-05
US7192927B2 (en) 2007-03-20
US20110105721A1 (en) 2011-05-05

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