HK1020752A1 - Methods and compositions for transforming cells - Google Patents

Methods and compositions for transforming cells

Info

Publication number
HK1020752A1
HK1020752A1 HK99105258.8A HK99105258A HK1020752A1 HK 1020752 A1 HK1020752 A1 HK 1020752A1 HK 99105258 A HK99105258 A HK 99105258A HK 1020752 A1 HK1020752 A1 HK 1020752A1
Authority
HK
Hong Kong
Prior art keywords
cell
compositions
sequences
methods
transforming cells
Prior art date
Application number
HK99105258.8A
Other languages
English (en)
Inventor
Philippe Leboulch
Eric Bouhassira
Karen Westerman
Ken Julian Takekoshi
Original Assignee
Massachusetts Institute Of Technology
Albert Einstein College Of Medicine Of Yeshiva Uni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24664451&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1020752(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Institute Of Technology, Albert Einstein College Of Medicine Of Yeshiva Uni filed Critical Massachusetts Institute Of Technology
Publication of HK1020752A1 publication Critical patent/HK1020752A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK99105258.8A 1996-06-14 1999-11-12 Methods and compositions for transforming cells HK1020752A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66408496A 1996-06-14 1996-06-14
US08/743,796 US5928914A (en) 1996-06-14 1996-11-05 Methods and compositions for transforming cells
PCT/US1997/009954 WO1997047758A1 (en) 1996-06-14 1997-06-06 Methods and compositions for transforming cells

Publications (1)

Publication Number Publication Date
HK1020752A1 true HK1020752A1 (en) 2000-05-19

Family

ID=24664451

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99105258.8A HK1020752A1 (en) 1996-06-14 1999-11-12 Methods and compositions for transforming cells

Country Status (9)

Country Link
US (1) US5928914A (ja)
EP (1) EP0914457B1 (ja)
JP (2) JP2000512150A (ja)
AT (1) ATE404684T1 (ja)
AU (1) AU733016B2 (ja)
CA (1) CA2258007A1 (ja)
DE (1) DE69738905D1 (ja)
HK (1) HK1020752A1 (ja)
WO (1) WO1997047758A1 (ja)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ500843A (en) 1995-06-07 2002-03-28 Invitrogen Corp A method of DNA recombination which is selectable to select for cells containing a product and against cells only harbouring the insert donor
US6964861B1 (en) 1998-11-13 2005-11-15 Invitrogen Corporation Enhanced in vitro recombinational cloning of using ribosomal proteins
US7670823B1 (en) * 1999-03-02 2010-03-02 Life Technologies Corp. Compositions for use in recombinational cloning of nucleic acids
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
US6720140B1 (en) 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US6534314B1 (en) * 1996-06-14 2003-03-18 Massachusetts Institute Of Technology Methods and compositions for transforming cells
US5928914A (en) * 1996-06-14 1999-07-27 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Methods and compositions for transforming cells
US5851808A (en) * 1997-02-28 1998-12-22 Baylor College Of Medicine Rapid subcloning using site-specific recombination
EP0981604B1 (en) 1997-04-24 2009-01-07 University of Washington Targeted gene modification by parvoviral vectors
US7351578B2 (en) * 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
NZ520579A (en) 1997-10-24 2004-08-27 Invitrogen Corp Recombinational cloning using nucleic acids having recombination sites and methods for synthesizing double stranded nucleic acids
ES2308327T3 (es) * 1997-11-18 2008-12-01 Pioneer Hi-Bred International, Inc. Composiciones y metodos para modificacion genetica de plantas.
NZ504510A (en) 1997-11-18 2002-10-25 Pioneer Hi Bred Int Methods and compositions for increasing efficiency of excision of a viral replicon from T-DNA that is transferred to a plant by agroinfection
US7102055B1 (en) * 1997-11-18 2006-09-05 Pioneer Hi-Bred International, Inc. Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant
US6262341B1 (en) 1997-11-18 2001-07-17 Pioneer Hi-Bred International, Inc. Method for the integration of foreign DNA into eukaryotic genomes
EP0939120A1 (en) * 1998-02-27 1999-09-01 Gesellschaft für biotechnologische Forschung mbH (GBF) Method for marker-free repetitive DNA expression cassette exchange in the genome of cells or parts of cells
AU1331800A (en) * 1998-10-28 2000-05-15 University Of Washington Targeted gene modification by parvoviral vectors
DE60043985D1 (de) * 1999-07-14 2010-04-22 Transgenic Inc "gen-fallen-vektor" und verfahren zum "einfangen" von genen mittels dieses vektors
WO2001005961A1 (en) * 1999-07-14 2001-01-25 Clontech Laboratories, Inc. Recombinase-based methods for producing expression vectors and compositions for use in practicing the same
DE19941186A1 (de) * 1999-08-30 2001-03-01 Peter Droege Sequenz-spezifische DNA-Rekombination in eukaryotischen Zellen
EP2278021A3 (en) 1999-11-01 2011-05-18 Novartis Vaccines and Diagnostics, Inc. Expression vectors, transfection systems, and method of use thereof
JP4729222B2 (ja) 1999-12-10 2011-07-20 ライフ テクノロジーズ コーポレーション 組換えクローニングにおける独自の選択性を有する複数の組換え部位の使用
WO2001066717A2 (en) * 2000-03-03 2001-09-13 The University Of Utah Gene targeting method
US7244560B2 (en) * 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US6551828B1 (en) 2000-06-28 2003-04-22 Protemation, Inc. Compositions and methods for generating expression vectors through site-specific recombination
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US7560622B2 (en) 2000-10-06 2009-07-14 Pioneer Hi-Bred International, Inc. Methods and compositions relating to the generation of partially transgenic organisms
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
US20030077804A1 (en) * 2001-04-19 2003-04-24 Invitrogen Corporation Compositions and methods for recombinational cloning of nucleic acid molecules
EP1451344A4 (en) * 2001-05-21 2005-03-23 Invitrogen Corp COMPOSITIONS AND METHODS FOR USE IN ISOLATING NUCLEIC ACID MOLECULES
ATE476504T1 (de) 2001-10-01 2010-08-15 Deutsches Krebsforsch Verfahren zur herstellung von protein- bibliotheken und zur selektion von proteinen daraus
AU2002356891A1 (en) * 2001-11-02 2003-05-19 Intradigm Corporation Method and system for inducible recombinational cloning in bacterial cells
JP4968498B2 (ja) 2002-01-23 2012-07-04 ユニバーシティ オブ ユタ リサーチ ファウンデーション ジンクフィンガーヌクレアーゼを用いる、標的化された染色体変異誘発
US7164056B2 (en) 2002-05-03 2007-01-16 Pioneer Hi-Bred International, Inc. Gene targeting using replicating DNA molecules
JP2006502748A (ja) 2002-09-05 2006-01-26 カリフォルニア インスティテュート オブ テクノロジー 遺伝子ターゲッティングを誘発するキメラヌクレアーゼの使用方法
TW200502390A (en) 2002-11-28 2005-01-16 Peter Droege Sequence specific DNA recombination in eukaryotic cells
EP1644538A4 (en) * 2003-06-26 2006-11-08 Invitrogen Corp METHODS AND COMPOSITIONS FOR DETECTING PROMOTER ACTIVITY AND EXPRESSING FUSION PROTEINS
US11311574B2 (en) 2003-08-08 2022-04-26 Sangamo Therapeutics, Inc. Methods and compositions for targeted cleavage and recombination
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
US20120196370A1 (en) 2010-12-03 2012-08-02 Fyodor Urnov Methods and compositions for targeted genomic deletion
DE602004027538D1 (de) 2003-12-01 2010-07-15 Life Technologies Corp Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
US7972854B2 (en) 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US20090068158A1 (en) * 2005-12-09 2009-03-12 Medin Jeffrey A Thymidylate kinase mutants and uses thereof
US20090074733A1 (en) * 2005-12-09 2009-03-19 Medin Jeffrey A Thymidylate kinase mutants and uses thereof
AU2007219615B2 (en) 2006-03-03 2013-11-28 Promis Neurosciences Inc. Methods and compositions to treat and detect misfolded-SOD1 mediated diseases
EP2019860A4 (en) * 2006-05-22 2010-12-15 Hiprocell Llc PROTEIN PRODUCTION USING EUKARYOTIC CELL LINES
CA2584494A1 (en) * 2007-03-27 2008-09-27 Jeffrey A. Medin Vector encoding therapeutic polypeptide and safety elements to clear transduced cells
CA2723320C (en) 2007-05-04 2019-06-11 University Health Network Il-12 immunotherapy for cancer
US8568709B2 (en) * 2008-03-20 2013-10-29 University Health Network Thymidylate kinase fusions and uses thereof
US9834787B2 (en) * 2009-04-09 2017-12-05 Sangamo Therapeutics, Inc. Targeted integration into stem cells
AU2013344375B2 (en) 2012-11-16 2017-09-14 Transposagen Biopharmaceuticals, Inc. Site-specific enzymes and methods of use
US9587237B2 (en) 2013-03-14 2017-03-07 Elwha Llc Compositions, methods, and computer systems related to making and administering modified T cells
US9499855B2 (en) 2013-03-14 2016-11-22 Elwha Llc Compositions, methods, and computer systems related to making and administering modified T cells
KR102637402B1 (ko) 2015-06-17 2024-02-15 포세이다 테라퓨틱스, 인크. 게놈 내 특정 유전자좌에 단백질을 유도하기 위한 조성물 및 방법
WO2019126578A1 (en) 2017-12-20 2019-06-27 Poseida Therapeutics, Inc. Compositions and methods for directing proteins to specific loci in the genome

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1293460C (en) * 1985-10-07 1991-12-24 Brian Lee Sauer Site-specific recombination of dna in yeast
NZ225470A (en) * 1987-07-21 1990-06-26 Du Pont Stable and viable recombinant viral vectors
US5252479A (en) * 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
EP0626999A4 (en) * 1992-01-24 1997-04-09 Life Technologies Inc Modulation of enzyme activities in the -i(in vivo) cloning of dna.
FR2737731B1 (fr) * 1995-08-07 1997-10-10 Pasteur Institut Sequence de retroelements naturels ou synthetiques ayant pour fonction de permettre l'insertion de sequences nucleotidiques dans une cellule eucaryote
US5928914A (en) * 1996-06-14 1999-07-27 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Methods and compositions for transforming cells

Also Published As

Publication number Publication date
AU733016B2 (en) 2001-05-03
ATE404684T1 (de) 2008-08-15
DE69738905D1 (de) 2008-09-25
WO1997047758A1 (en) 1997-12-18
JP5765547B2 (ja) 2015-08-19
EP0914457A1 (en) 1999-05-12
CA2258007A1 (en) 1997-12-18
US5928914A (en) 1999-07-27
AU3306297A (en) 1998-01-07
JP2000512150A (ja) 2000-09-19
JP2010063463A (ja) 2010-03-25
EP0914457B1 (en) 2008-08-13

Similar Documents

Publication Publication Date Title
HK1020752A1 (en) Methods and compositions for transforming cells
EP0945515A3 (en) Production of proteins using homologous recombination
AU4784996A (en) Homologous recombination in mismatch repair inactivated eukaryotic cells
PL335695A1 (en) Method of integrating genes into a specific place of mammal cell genome by honologous recombination and vectors serving that purpose
WO1999015682A3 (en) Gene silencing materials and methods
CA2306188A1 (en) A novel method for the integration of foreign dna into eukaryotic genomes
EP1017423A4 (en) Pig cloning using donor cell nuclei from differentiated cells
MY137837A (en) Novel method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
ATE267871T1 (de) Binärer bac-vektor
CA2195303A1 (en) Method for selecting high-expressing host cells
AU6755096A (en) Mammalian artificial chromosomes
AU2002304258A1 (en) Method for the stable inversion of dna sequence by site-specific recombination and dna vectors and transgenic cells thereof
CA2179656A1 (en) Chromosomal expression of heterologous genes in bacterial cells
AU6118998A (en) Pluripotent cells having disrupted intrinsic genes
AU1278695A (en) Homologous recombination antibody expression system for murine cells
DE3853474D1 (de) Vektor zur integrationsstellenunabhängigen genexpression in säugetier-wirtszellen.
TR199802503A2 (xx) Endojen gen aktivasyonu i�in h�crelerin optimizasyonu.
AU2149099A (en) Pseudo-type retroviral vectors with modifiable surface capsid proteins
CA2102594A1 (en) Gene manipulation and expression using genomic elements
EP0048081A3 (en) Dna capable of replication and stable mitotic maintenance in a host eukaryote, method of preparation thereof and eukaryotic cell containing same
ES2109194B1 (es) Un procedimiento para producir la enzima d-aminoacido oxidasa de rhodotorula gracilis en celulas hospedantes.
GB9701492D0 (en) Transfection of embryonic stem cells
WO1998003669A3 (en) Vectors for inhibiting hiv and tumor growth
GB9605308D0 (en) Sertoli cells as transplantation facilitator for cell transplatation
WO2002036760A3 (en) Methods for expressing endogenous genes by restriction enzyme mediated integration

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140606

ARF Application filed for restoration

Effective date: 20151207