HK1014191A1 - Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof - Google Patents
Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereofInfo
- Publication number
- HK1014191A1 HK1014191A1 HK98115457A HK98115457A HK1014191A1 HK 1014191 A1 HK1014191 A1 HK 1014191A1 HK 98115457 A HK98115457 A HK 98115457A HK 98115457 A HK98115457 A HK 98115457A HK 1014191 A1 HK1014191 A1 HK 1014191A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- bactericidal
- permeability
- increasing protein
- biologically active
- functional domains
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Marine Sciences & Fisheries (AREA)
- Transplantation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/030,644 US5348942A (en) | 1993-03-12 | 1993-03-12 | Therapeutic uses of bactericidal/permeability increasing protein products |
US9320293A | 1993-07-15 | 1993-07-15 | |
US18322294A | 1994-01-14 | 1994-01-14 | |
PCT/US1994/002465 WO1994020532A1 (en) | 1993-03-12 | 1994-03-11 | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1014191A1 true HK1014191A1 (en) | 1999-09-24 |
Family
ID=27363684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98115457A HK1014191A1 (en) | 1993-03-12 | 1998-12-24 | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0690872B1 (xx) |
JP (3) | JP4139863B2 (xx) |
AT (1) | ATE169304T1 (xx) |
AU (1) | AU694108B2 (xx) |
CA (1) | CA2158058C (xx) |
DE (1) | DE69412243T2 (xx) |
DK (1) | DK0690872T3 (xx) |
ES (1) | ES2123134T3 (xx) |
HK (1) | HK1014191A1 (xx) |
NZ (1) | NZ263344A (xx) |
WO (1) | WO1994020532A1 (xx) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
US5858974A (en) * | 1995-07-20 | 1999-01-12 | Xoma Corporation | Anti-fungal peptides |
US5652332A (en) * | 1993-03-12 | 1997-07-29 | Xoma | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
US5770561A (en) * | 1993-07-14 | 1998-06-23 | Xoma Corporation | Method for potentiating BPI protein product bactericidal activity by administration of LBP protein products |
WO1995002414A1 (en) * | 1993-07-14 | 1995-01-26 | Xoma Corporation | Method for potentiating bpi protein product bactericidal activity by administration of lbp protein products |
JPH08503490A (ja) | 1993-08-18 | 1996-04-16 | モルフォシス・ゲゼルシャフト・フュア・プロタインオプティミールング・ミット・ベシュレンクテル・ハフツング | リポ多糖結合性および中和能のあるペプチド |
AU695814B2 (en) * | 1993-09-22 | 1998-08-20 | Xoma Corporation | Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (bpi) protein product and antibiotic |
EP0722333B1 (en) * | 1993-10-05 | 2004-06-16 | XOMA Technology Ltd. | Bpi-protein-products for depressed reticuloendothelial system function |
AU703211B2 (en) * | 1994-01-14 | 1999-03-18 | Xoma Corporation | Anti-fungal methods and materials |
EP0754050B1 (en) * | 1994-01-14 | 2002-06-26 | XOMA Technology Ltd. | Anti gram positive bacterial methods and materials |
US5447913A (en) | 1994-03-11 | 1995-09-05 | Xoma Corporation | Therapeutic uses of bactericidal/permeability-increasing protein dimer products |
US5830860A (en) * | 1994-03-24 | 1998-11-03 | Regents Of The University Of Minnesota | Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
JPH10508576A (ja) * | 1994-09-15 | 1998-08-25 | ゾーマ コーポレイション | 抗真菌性ペプチド |
US5851802A (en) * | 1996-03-22 | 1998-12-22 | Xoma Corporation | Methods for recombinant microbial production of fusion proteins and BPI-derived peptides |
JP2000510845A (ja) * | 1996-05-10 | 2000-08-22 | ゾーマ コーポレイション | ヒト髄膜炎菌血症のためのbpiタンパク質産物の治療用途 |
US5741779A (en) * | 1996-05-10 | 1998-04-21 | Xoma Corporation | Antithrombotic materials and methods |
CN1155403C (zh) * | 1996-05-23 | 2004-06-30 | 爱克索马技术有限公司 | 杀细菌/通透性增加蛋白在制备用于治疗创伤出血病人的药物中的应用 |
US6486125B1 (en) | 1996-05-24 | 2002-11-26 | Regents Of The University Of Minnesota | Synthesis of soluble β-sheet forming peptides |
US5888973A (en) * | 1996-08-09 | 1999-03-30 | Xoma Corporation | Anti-chlamydial uses of BPI protein products |
US6482796B2 (en) | 1996-11-01 | 2002-11-19 | Xoma Corporation | Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients |
US6093573A (en) * | 1997-06-20 | 2000-07-25 | Xoma | Three-dimensional structure of bactericidal/permeability-increasing protein (BPI) |
CA2298101A1 (en) * | 1997-07-31 | 1999-02-11 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Novel synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome |
US6013631A (en) | 1998-06-19 | 2000-01-11 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) deletion analogs |
US6242219B1 (en) | 1999-03-18 | 2001-06-05 | Xoma (Us) Llc | Methods for recombinant peptide production |
US6515104B1 (en) | 1999-06-25 | 2003-02-04 | Xoma Technology Ltd. | Therapeutic peptide-based constructs derived from domain II of bactericidal/permeability-increasing protein |
US6423825B1 (en) | 1999-06-25 | 2002-07-23 | Xoma Technology Ltd. | Therapeutic derivative compounds derived from domain II of bactericidal/permeability-increasing protein |
DE60008749T2 (de) * | 1999-06-25 | 2005-03-10 | Xoma Technology Ltd., Berkeley | Therapeutische peptide aus untersequenzen von bpi |
WO2001003724A1 (en) * | 1999-07-12 | 2001-01-18 | Xoma Technology Ltd. | Therapeutic uses of bpi protein products for inhibiting h+/k+ atpase activity |
WO2003070751A2 (en) | 2002-02-20 | 2003-08-28 | Regents Of The University Of Minnesota | Partial peptide mimetics and methods |
EP2311962B1 (en) | 2002-03-29 | 2013-03-13 | XOMA Technology Ltd. | Multigenic vectors plasmids and methods for increasing expression of recombinant polypeptides |
SE0301431D0 (sv) * | 2003-05-19 | 2003-05-19 | Dermagen | Novel antimicrobial peptides |
US7878644B2 (en) | 2005-11-16 | 2011-02-01 | Gerber Scientific International, Inc. | Light cure of cationic ink on acidic substrates |
GB201319621D0 (en) * | 2013-11-06 | 2013-12-18 | Norwegian University Of Science And Technology | Antimicrobial agents and their use in therapy |
GB201319620D0 (en) | 2013-11-06 | 2013-12-18 | Norwegian University Of Science And Technology | Immunosuppressive agents and their use in therapy |
GB201507722D0 (en) | 2015-05-06 | 2015-06-17 | Norwegian Univ Sci & Tech Ntnu | Anti-bacterial agents and their use in therapy |
GB201507723D0 (en) * | 2015-05-06 | 2015-06-17 | Norwegian Univ Sci & Tech Ntnu | Anti-bacterial agents and their use in therapy |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1986006279A1 (en) * | 1985-04-30 | 1986-11-06 | Scripps Clinic And Research Foundation | Acute phase protein modulating endotoxic activity of lipopolysaccharides, compositions and methods |
WO1992009621A1 (en) * | 1990-12-03 | 1992-06-11 | New York University | Biologically active bactericidal/permeability-increasing protein fragments |
-
1994
- 1994-03-11 WO PCT/US1994/002465 patent/WO1994020532A1/en active IP Right Grant
- 1994-03-11 ES ES94911490T patent/ES2123134T3/es not_active Expired - Lifetime
- 1994-03-11 AT AT94911490T patent/ATE169304T1/de not_active IP Right Cessation
- 1994-03-11 DE DE69412243T patent/DE69412243T2/de not_active Expired - Lifetime
- 1994-03-11 AU AU63988/94A patent/AU694108B2/en not_active Ceased
- 1994-03-11 EP EP94911490A patent/EP0690872B1/en not_active Expired - Lifetime
- 1994-03-11 CA CA002158058A patent/CA2158058C/en not_active Expired - Fee Related
- 1994-03-11 DK DK94911490T patent/DK0690872T3/da active
- 1994-03-11 NZ NZ263344A patent/NZ263344A/xx unknown
- 1994-03-11 JP JP52025194A patent/JP4139863B2/ja not_active Expired - Fee Related
-
1998
- 1998-12-24 HK HK98115457A patent/HK1014191A1/xx not_active IP Right Cessation
-
2004
- 2004-10-06 JP JP2004294373A patent/JP2005053921A/ja not_active Withdrawn
-
2007
- 2007-12-27 JP JP2007338237A patent/JP2008101026A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ES2123134T3 (es) | 1999-01-01 |
NZ263344A (en) | 1997-08-22 |
JP2005053921A (ja) | 2005-03-03 |
CA2158058A1 (en) | 1994-09-15 |
EP0690872B1 (en) | 1998-08-05 |
JP4139863B2 (ja) | 2008-08-27 |
DE69412243T2 (de) | 1999-03-25 |
CA2158058C (en) | 2000-08-01 |
JP2008101026A (ja) | 2008-05-01 |
AU694108B2 (en) | 1998-07-16 |
DK0690872T3 (da) | 1999-05-10 |
ATE169304T1 (de) | 1998-08-15 |
DE69412243D1 (de) | 1998-09-10 |
AU6398894A (en) | 1994-09-26 |
EP0690872A1 (en) | 1996-01-10 |
JPH08508248A (ja) | 1996-09-03 |
WO1994020532A1 (en) | 1994-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20090311 |