HK1007657A1 - Chiral nitriles their preparation and their use for the manufacture of verapamil and analogues - Google Patents

Chiral nitriles their preparation and their use for the manufacture of verapamil and analogues

Info

Publication number
HK1007657A1
HK1007657A1 HK98106718A HK98106718A HK1007657A1 HK 1007657 A1 HK1007657 A1 HK 1007657A1 HK 98106718 A HK98106718 A HK 98106718A HK 98106718 A HK98106718 A HK 98106718A HK 1007657 A1 HK1007657 A1 HK 1007657A1
Authority
HK
Hong Kong
Prior art keywords
verapamil
analogues
manufacture
preparation
cir
Prior art date
Application number
HK98106718A
Other languages
English (en)
Inventor
Raymond Mccague
Shonming Wang
Original Assignee
Chiroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd
Publication of HK1007657A1 publication Critical patent/HK1007657A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK98106718A 1993-09-27 1998-06-25 Chiral nitriles their preparation and their use for the manufacture of verapamil and analogues HK1007657A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939319918A GB9319918D0 (en) 1993-09-27 1993-09-27 Chiral compounds and their preparation
PCT/GB1994/002091 WO1995009150A1 (en) 1993-09-27 1994-09-26 Chiral nitriles, their preparation and their use for the manufacture of verapamil and analogues

Publications (1)

Publication Number Publication Date
HK1007657A1 true HK1007657A1 (en) 1999-04-16

Family

ID=10742593

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98106718A HK1007657A1 (en) 1993-09-27 1998-06-25 Chiral nitriles their preparation and their use for the manufacture of verapamil and analogues

Country Status (13)

Country Link
EP (1) EP0721448B1 (xx)
JP (1) JPH09502995A (xx)
CN (1) CN1038838C (xx)
AT (1) ATE163920T1 (xx)
AU (1) AU676773B2 (xx)
CA (1) CA2171431A1 (xx)
DE (1) DE69409001T2 (xx)
ES (1) ES2113126T3 (xx)
FI (1) FI961356A0 (xx)
GB (1) GB9319918D0 (xx)
HK (1) HK1007657A1 (xx)
NO (1) NO305594B1 (xx)
WO (1) WO1995009150A1 (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19502967A1 (de) * 1995-01-31 1996-08-01 Basf Ag Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen
US5892093A (en) * 1996-02-08 1999-04-06 Darwin Discovery Limited Resolution
WO1997029081A1 (en) * 1996-02-08 1997-08-14 Darwin Discovery Limited Resolution of 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexanoic acid
GB9616549D0 (en) * 1996-08-06 1996-09-25 Chiroscience Ltd Therapeutic product and its use
GB9616504D0 (en) * 1996-08-06 1996-09-25 Chiroscience Ltd Therapeutic product and its use
WO1998005321A1 (en) * 1996-08-06 1998-02-12 Darwin Discovery Limited Therapeutic utilities of verapamil enantiomers
ITMI20071160A1 (it) * 2007-06-07 2008-12-08 Cosma S P A Procedimento di risoluzione del verapamil

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2059923C3 (de) * 1970-12-05 1979-01-25 Knoll Ag, 6700 Ludwigshafen l-a-Isopropyl-o-[(N-methyl-N-homoveratryl)v-aminopropyl] -3,4-dimethoxyphenylacetonitril, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel
DE3603032A1 (de) * 1986-01-31 1987-08-06 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
PT96284A (pt) * 1989-12-21 1991-09-30 Searle & Co Processo para a preparacao de derivados de omega-amino-alfa-fenilalcanonitrilo
DE4203547A1 (de) * 1992-02-07 1993-08-12 Knoll Ag Verfahren zur racemattrennung von verapamil

Also Published As

Publication number Publication date
WO1995009150A1 (en) 1995-04-06
DE69409001D1 (de) 1998-04-16
NO961224D0 (no) 1996-03-26
EP0721448A1 (en) 1996-07-17
CN1038838C (zh) 1998-06-24
AU7702594A (en) 1995-04-18
CA2171431A1 (en) 1995-04-06
ES2113126T3 (es) 1998-04-16
EP0721448B1 (en) 1998-03-11
NO961224L (no) 1996-03-26
FI961356A (fi) 1996-03-25
FI961356A0 (fi) 1996-03-25
GB9319918D0 (en) 1993-11-10
AU676773B2 (en) 1997-03-20
ATE163920T1 (de) 1998-03-15
DE69409001T2 (de) 1998-07-02
CN1131941A (zh) 1996-09-25
JPH09502995A (ja) 1997-03-25
NO305594B1 (no) 1999-06-28

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)