ES2113126T3 - Compuestos quirales, su preparacion y uso para la produccion de verapamil y analogos. - Google Patents

Compuestos quirales, su preparacion y uso para la produccion de verapamil y analogos.

Info

Publication number
ES2113126T3
ES2113126T3 ES94927719T ES94927719T ES2113126T3 ES 2113126 T3 ES2113126 T3 ES 2113126T3 ES 94927719 T ES94927719 T ES 94927719T ES 94927719 T ES94927719 T ES 94927719T ES 2113126 T3 ES2113126 T3 ES 2113126T3
Authority
ES
Spain
Prior art keywords
verapamil
analogs
preparation
production
chiral compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94927719T
Other languages
English (en)
Inventor
Raymond Mccague
Shouming Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chirotech Technology Ltd
Original Assignee
Chiroscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiroscience Ltd filed Critical Chiroscience Ltd
Application granted granted Critical
Publication of ES2113126T3 publication Critical patent/ES2113126T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

UN PROCESO PARA PREPARAR UN ENANTIOMERO SUSTANCIALMENTE UNICO (R O S) DE R''-NH-(CH{SUB,2}){SUB,3}-C(AR) (CN)-R; EL PROCESO COMPRENDE REACCIONAR JUNTOS R-CH(AR)-CN Y X-(CH{SUB,2}){SUB,3}-A PARA DAR X-(CH{SUB,2}){SUB,3}-CH(AR) (CN)-R, REACCIONANDO ESTO CON METILAMINA PARA DAR R''-NH(CH{SUB,2}){SUB,3}-CH(AR) (CN)-R, Y RESOLVIENDO ESTO EN UN ENANTIOMERO SUSTANCIALMENTE UNICO DE LOS MISMOS, DONDE AR ES ARIL, R Y R'' SON CADA UNA INDEPENDIENTEMENTE C{SUB,1-20}ALQUILO, X ES UN HALO ATOMO Y A ES UN GRUPO DE SALIDA, Y LA RESOLUCION ES LLEVA A CABO UTILIZANDO UN ACIDO QUIRAL. EL PROCESO ES PARTICULARMENTE UTIL PARA PREPARAR VERAPAMILO, Y ANALOGOS DEL MISMO, EN FORMA DE ENANTIOMERICA UNICA.
ES94927719T 1993-09-27 1994-09-26 Compuestos quirales, su preparacion y uso para la produccion de verapamil y analogos. Expired - Lifetime ES2113126T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939319918A GB9319918D0 (en) 1993-09-27 1993-09-27 Chiral compounds and their preparation

Publications (1)

Publication Number Publication Date
ES2113126T3 true ES2113126T3 (es) 1998-04-16

Family

ID=10742593

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94927719T Expired - Lifetime ES2113126T3 (es) 1993-09-27 1994-09-26 Compuestos quirales, su preparacion y uso para la produccion de verapamil y analogos.

Country Status (13)

Country Link
EP (1) EP0721448B1 (es)
JP (1) JPH09502995A (es)
CN (1) CN1038838C (es)
AT (1) ATE163920T1 (es)
AU (1) AU676773B2 (es)
CA (1) CA2171431A1 (es)
DE (1) DE69409001T2 (es)
ES (1) ES2113126T3 (es)
FI (1) FI961356A0 (es)
GB (1) GB9319918D0 (es)
HK (1) HK1007657A1 (es)
NO (1) NO305594B1 (es)
WO (1) WO1995009150A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19502967A1 (de) * 1995-01-31 1996-08-01 Basf Ag Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen
US5892093A (en) * 1996-02-08 1999-04-06 Darwin Discovery Limited Resolution
AU705865B2 (en) * 1996-02-08 1999-06-03 Darwin Discovery Limited Resolution of 4-cyano-4-(3,4-dimethoxyphenyl) -5-methylhexanoic acid
GB9616549D0 (en) * 1996-08-06 1996-09-25 Chiroscience Ltd Therapeutic product and its use
GB9616504D0 (en) * 1996-08-06 1996-09-25 Chiroscience Ltd Therapeutic product and its use
AU3778497A (en) * 1996-08-06 1998-02-25 Darwin Discovery Limited Therapeutic utilities of verapamil enantiomers
ITMI20071160A1 (it) * 2007-06-07 2008-12-08 Cosma S P A Procedimento di risoluzione del verapamil

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2059923C3 (de) * 1970-12-05 1979-01-25 Knoll Ag, 6700 Ludwigshafen l-a-Isopropyl-o-[(N-methyl-N-homoveratryl)v-aminopropyl] -3,4-dimethoxyphenylacetonitril, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel
DE3603032A1 (de) * 1986-01-31 1987-08-06 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
CA2032872A1 (en) * 1989-12-21 1991-06-22 Philippe R. Bovy W-amino-.alpha.-phenylalkanonitrile derivatives
DE4203547A1 (de) * 1992-02-07 1993-08-12 Knoll Ag Verfahren zur racemattrennung von verapamil

Also Published As

Publication number Publication date
CA2171431A1 (en) 1995-04-06
NO961224D0 (no) 1996-03-26
GB9319918D0 (en) 1993-11-10
AU676773B2 (en) 1997-03-20
AU7702594A (en) 1995-04-18
DE69409001D1 (de) 1998-04-16
WO1995009150A1 (en) 1995-04-06
DE69409001T2 (de) 1998-07-02
HK1007657A1 (en) 1999-04-16
FI961356A (fi) 1996-03-25
NO305594B1 (no) 1999-06-28
CN1131941A (zh) 1996-09-25
EP0721448A1 (en) 1996-07-17
NO961224L (no) 1996-03-26
EP0721448B1 (en) 1998-03-11
FI961356A0 (fi) 1996-03-25
JPH09502995A (ja) 1997-03-25
CN1038838C (zh) 1998-06-24
ATE163920T1 (de) 1998-03-15

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