FI961356A0 - Kiraaliset nitriilit, niiden valmistus ja niiden käyttö verpamiilin ja analogien valmistukseen - Google Patents
Kiraaliset nitriilit, niiden valmistus ja niiden käyttö verpamiilin ja analogien valmistukseenInfo
- Publication number
- FI961356A0 FI961356A0 FI961356A FI961356A FI961356A0 FI 961356 A0 FI961356 A0 FI 961356A0 FI 961356 A FI961356 A FI 961356A FI 961356 A FI961356 A FI 961356A FI 961356 A0 FI961356 A0 FI 961356A0
- Authority
- FI
- Finland
- Prior art keywords
- preparation
- verpamil
- analogs
- cir
- give
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/43—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939319918A GB9319918D0 (en) | 1993-09-27 | 1993-09-27 | Chiral compounds and their preparation |
PCT/GB1994/002091 WO1995009150A1 (en) | 1993-09-27 | 1994-09-26 | Chiral nitriles, their preparation and their use for the manufacture of verapamil and analogues |
Publications (2)
Publication Number | Publication Date |
---|---|
FI961356A FI961356A (fi) | 1996-03-25 |
FI961356A0 true FI961356A0 (fi) | 1996-03-25 |
Family
ID=10742593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI961356A FI961356A0 (fi) | 1993-09-27 | 1996-03-25 | Kiraaliset nitriilit, niiden valmistus ja niiden käyttö verpamiilin ja analogien valmistukseen |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0721448B1 (xx) |
JP (1) | JPH09502995A (xx) |
CN (1) | CN1038838C (xx) |
AT (1) | ATE163920T1 (xx) |
AU (1) | AU676773B2 (xx) |
CA (1) | CA2171431A1 (xx) |
DE (1) | DE69409001T2 (xx) |
ES (1) | ES2113126T3 (xx) |
FI (1) | FI961356A0 (xx) |
GB (1) | GB9319918D0 (xx) |
HK (1) | HK1007657A1 (xx) |
NO (1) | NO305594B1 (xx) |
WO (1) | WO1995009150A1 (xx) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19502967A1 (de) * | 1995-01-31 | 1996-08-01 | Basf Ag | Verfahren zur Racemattrennung von 2-Aryl-2-omega-alkylaminoalkannitrilen |
US5892093A (en) * | 1996-02-08 | 1999-04-06 | Darwin Discovery Limited | Resolution |
JP2000504683A (ja) * | 1996-02-08 | 2000-04-18 | ダーウィン・ディスカバリー・リミテッド | 4―シアノ―4―(3,4―ジメトキシフェニル)―5―メチルヘキサン酸の分割 |
GB9616549D0 (en) * | 1996-08-06 | 1996-09-25 | Chiroscience Ltd | Therapeutic product and its use |
JP2000515539A (ja) * | 1996-08-06 | 2000-11-21 | ダーウィン・ディスカバリー・リミテッド | ベラパミル鏡像体の治療的使用 |
GB9616504D0 (en) * | 1996-08-06 | 1996-09-25 | Chiroscience Ltd | Therapeutic product and its use |
ITMI20071160A1 (it) * | 2007-06-07 | 2008-12-08 | Cosma S P A | Procedimento di risoluzione del verapamil |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2059923C3 (de) * | 1970-12-05 | 1979-01-25 | Knoll Ag, 6700 Ludwigshafen | l-a-Isopropyl-o-[(N-methyl-N-homoveratryl)v-aminopropyl] -3,4-dimethoxyphenylacetonitril, Verfahren zu dessen Herstellung und dieses enthaltende Arzneimittel |
DE3603032A1 (de) * | 1986-01-31 | 1987-08-06 | Basf Ag | Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel |
IE904628A1 (en) * | 1989-12-21 | 1991-07-17 | Searle & Co | w-Amino-Ó-Phenylalkanonitrile Derivatives |
DE4203547A1 (de) * | 1992-02-07 | 1993-08-12 | Knoll Ag | Verfahren zur racemattrennung von verapamil |
-
1993
- 1993-09-27 GB GB939319918A patent/GB9319918D0/en active Pending
-
1994
- 1994-09-26 EP EP94927719A patent/EP0721448B1/en not_active Expired - Lifetime
- 1994-09-26 JP JP7510174A patent/JPH09502995A/ja active Pending
- 1994-09-26 ES ES94927719T patent/ES2113126T3/es not_active Expired - Lifetime
- 1994-09-26 WO PCT/GB1994/002091 patent/WO1995009150A1/en active IP Right Grant
- 1994-09-26 AU AU77025/94A patent/AU676773B2/en not_active Ceased
- 1994-09-26 AT AT94927719T patent/ATE163920T1/de not_active IP Right Cessation
- 1994-09-26 DE DE69409001T patent/DE69409001T2/de not_active Expired - Fee Related
- 1994-09-26 CN CN94193530A patent/CN1038838C/zh not_active Expired - Fee Related
- 1994-09-26 CA CA002171431A patent/CA2171431A1/en not_active Abandoned
-
1996
- 1996-03-25 FI FI961356A patent/FI961356A0/fi unknown
- 1996-03-26 NO NO961224A patent/NO305594B1/no not_active IP Right Cessation
-
1998
- 1998-06-25 HK HK98106718A patent/HK1007657A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO305594B1 (no) | 1999-06-28 |
JPH09502995A (ja) | 1997-03-25 |
FI961356A (fi) | 1996-03-25 |
AU676773B2 (en) | 1997-03-20 |
AU7702594A (en) | 1995-04-18 |
WO1995009150A1 (en) | 1995-04-06 |
CN1131941A (zh) | 1996-09-25 |
EP0721448A1 (en) | 1996-07-17 |
EP0721448B1 (en) | 1998-03-11 |
HK1007657A1 (en) | 1999-04-16 |
NO961224L (no) | 1996-03-26 |
NO961224D0 (no) | 1996-03-26 |
CN1038838C (zh) | 1998-06-24 |
DE69409001T2 (de) | 1998-07-02 |
GB9319918D0 (en) | 1993-11-10 |
CA2171431A1 (en) | 1995-04-06 |
DE69409001D1 (de) | 1998-04-16 |
ES2113126T3 (es) | 1998-04-16 |
ATE163920T1 (de) | 1998-03-15 |
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