HK1006225A1 - Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides - Google Patents

Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides

Info

Publication number
HK1006225A1
HK1006225A1 HK98105458A HK98105458A HK1006225A1 HK 1006225 A1 HK1006225 A1 HK 1006225A1 HK 98105458 A HK98105458 A HK 98105458A HK 98105458 A HK98105458 A HK 98105458A HK 1006225 A1 HK1006225 A1 HK 1006225A1
Authority
HK
Hong Kong
Prior art keywords
pct
date
pseudopeptides
sec
prevention
Prior art date
Application number
HK98105458A
Other languages
English (en)
Inventor
Scott I Klein
Bruce F Molino
Original Assignee
Rhone Poulenc Rorer Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Pharma filed Critical Rhone Poulenc Rorer Pharma
Publication of HK1006225A1 publication Critical patent/HK1006225A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK98105458A 1993-10-15 1998-06-16 Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides HK1006225A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13882093A 1993-10-15 1993-10-15
PCT/US1994/012135 WO1995010295A1 (fr) 1993-10-15 1994-10-17 Peptides et pseudopeptides a groupe azacycloalkylalcanoyle ayant des proprietes antithrombotiques

Publications (1)

Publication Number Publication Date
HK1006225A1 true HK1006225A1 (en) 1999-02-19

Family

ID=22483811

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98105458A HK1006225A1 (en) 1993-10-15 1998-06-16 Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides

Country Status (28)

Country Link
US (1) US5866685A (fr)
EP (1) EP0812205B1 (fr)
JP (1) JP3032297B2 (fr)
KR (1) KR100304332B1 (fr)
CN (1) CN1135717A (fr)
AT (1) ATE199727T1 (fr)
AU (1) AU703854B2 (fr)
BG (1) BG63166B1 (fr)
BR (1) BR9407839A (fr)
CA (1) CA2174097C (fr)
CZ (1) CZ291378B6 (fr)
DE (1) DE69426897T2 (fr)
DK (1) DK0812205T3 (fr)
ES (1) ES2155122T3 (fr)
FI (1) FI961634A (fr)
GR (1) GR3035581T3 (fr)
HK (1) HK1006225A1 (fr)
HU (1) HU222248B1 (fr)
NO (1) NO961460L (fr)
NZ (1) NZ275948A (fr)
PL (1) PL181749B1 (fr)
PT (1) PT812205E (fr)
RO (1) RO115520B1 (fr)
RU (1) RU2134695C1 (fr)
SG (1) SG64919A1 (fr)
SK (1) SK47796A3 (fr)
UA (1) UA44258C2 (fr)
WO (1) WO1995010295A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274705B1 (en) 1996-05-02 2001-08-14 Aventis Pharmaceuticals Products Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
CZ291378B6 (cs) * 1993-10-15 2003-02-12 Aventis Pharmaceuticals Inc. Pseudopeptidové sloučeniny jako antitrombotické látky, farmaceutické prostředky obsahující tyto sloučeniny a meziprodukty
US5780590A (en) * 1993-10-15 1998-07-14 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
ATE390438T1 (de) * 1996-08-21 2008-04-15 Aventis Pharma Inc Stabile, nicht-hygroskopische, kristalline form von n-än-n(4-(piperidin-4-yl)butanoyl)-n- ethylglycyl verbindungen
JP4498471B2 (ja) * 1996-11-27 2010-07-07 アヴェンティス ファーマシューティカルズ インコーポレイテッド 抗―Ｘａ活性を有する化合物及び血小板凝集拮抗剤化合物を含有する製薬組成物
WO1999019294A1 (fr) * 1997-05-14 1999-04-22 Aventis Pharmaceuticals Products Inc. Legal/Patents Preparation des pseudotetrapeptides azacycloalkylalcanoyles
HUP0003788A3 (en) * 1997-10-10 2001-05-28 Aventis Pharmaceuticals Inc Co Azacycloalkylalkanoyl pseudotetrapeptides intermediates and processes for preparation thereof
AU2844800A (en) * 1998-12-30 2000-07-24 Aventis Pharmaceuticals Products Inc. Process for preparing a stable non-hygroscopic crystalline n-(n-(n- piperdin- 4-yl)butanoyl)- n.ethylglycyl)- (l)-aspartyl) -ss-cyclohexylalanine amide
CN101735307B (zh) * 2008-11-18 2012-05-30 北京航空航天大学 一种血小板膜糖蛋白寡肽或其修饰物/衍生物以及它们的应用
CN104582507A (zh) * 2012-06-11 2015-04-29 克利夫兰诊所基金会 心血管疾病和血栓形成的治疗与预防

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
FR2608160B1 (fr) * 1986-12-15 1989-03-31 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US4992463A (en) * 1988-07-20 1991-02-12 Monsanto Company Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
EP0494248A4 (en) * 1989-09-29 1992-08-26 Rhone-Poulenc Rorer International (Holdings) Inc. Anti-thrombotic peptides and pseudopeptides
US5051405A (en) * 1989-10-10 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptides and pseudopeptides
US5064814A (en) * 1990-04-05 1991-11-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptide and pseudopeptide derivatives
IL99539A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
IL99538A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
EP0584066A4 (fr) * 1991-04-11 1994-10-12 Rhone Poulenc Rorer Int Derives peptidiques et pseudopeptidiques antithrombotiques.
CZ291378B6 (cs) * 1993-10-15 2003-02-12 Aventis Pharmaceuticals Inc. Pseudopeptidové sloučeniny jako antitrombotické látky, farmaceutické prostředky obsahující tyto sloučeniny a meziprodukty

Also Published As

Publication number Publication date
RU2134695C1 (ru) 1999-08-20
EP0812205A1 (fr) 1997-12-17
EP0812205B1 (fr) 2001-03-14
HU222248B1 (hu) 2003-05-28
PL313975A1 (en) 1996-08-05
BG100544A (bg) 1996-11-29
NO961460D0 (no) 1996-04-12
EP0812205A4 (fr) 1999-03-31
UA44258C2 (uk) 2002-02-15
CA2174097A1 (fr) 1995-04-20
AU703854B2 (en) 1999-04-01
FI961634A0 (fi) 1996-04-12
AU8123794A (en) 1995-05-04
SG64919A1 (en) 1999-05-25
ATE199727T1 (de) 2001-03-15
CA2174097C (fr) 2002-06-04
PL181749B1 (pl) 2001-09-28
ES2155122T3 (es) 2001-05-01
BG63166B1 (bg) 2001-05-31
CZ108496A3 (en) 1996-12-11
KR100304332B1 (ko) 2001-11-26
GR3035581T3 (en) 2001-06-29
FI961634A (fi) 1996-05-23
SK47796A3 (en) 1997-03-05
NZ275948A (en) 1997-02-24
DE69426897T2 (de) 2001-07-05
CN1135717A (zh) 1996-11-13
HU9600983D0 (en) 1996-06-28
NO961460L (no) 1996-06-17
JP3032297B2 (ja) 2000-04-10
DK0812205T3 (da) 2001-04-17
WO1995010295A1 (fr) 1995-04-20
DE69426897D1 (de) 2001-04-19
US5866685A (en) 1999-02-02
CZ291378B6 (cs) 2003-02-12
PT812205E (pt) 2001-08-30
HUT73856A (en) 1996-09-30
RO115520B1 (ro) 2000-03-30
JPH09507213A (ja) 1997-07-22
BR9407839A (pt) 1997-05-13

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20051017