HK1006168A1 - Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation - Google Patents

Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation

Info

Publication number
HK1006168A1
HK1006168A1 HK98105268A HK98105268A HK1006168A1 HK 1006168 A1 HK1006168 A1 HK 1006168A1 HK 98105268 A HK98105268 A HK 98105268A HK 98105268 A HK98105268 A HK 98105268A HK 1006168 A1 HK1006168 A1 HK 1006168A1
Authority
HK
Hong Kong
Prior art keywords
preparation
functionalized polyamine
rhodium complexes
chelants
rhodium
Prior art date
Application number
HK98105268A
Other languages
English (en)
Inventor
William J Kruper
Douglas K Pollock
William A Fordyce
Michael J Fazio
Muthiah N Inbasekaran
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of HK1006168A1 publication Critical patent/HK1006168A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C263/00Preparation of derivatives of isocyanic acid
    • C07C263/10Preparation of derivatives of isocyanic acid by reaction of amines with carbonyl halides, e.g. with phosgene
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6887Antibody-chelate conjugates using chelates for therapeutic purposes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0002General or multifunctional contrast agents, e.g. chelated agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0073Rhodium compounds
    • C07F15/008Rhodium compounds without a metal-carbon linkage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Peptides Or Proteins (AREA)
HK98105268A 1987-06-24 1998-06-13 Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation HK1006168A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/065,739 US4994560A (en) 1987-06-24 1987-06-24 Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies

Publications (1)

Publication Number Publication Date
HK1006168A1 true HK1006168A1 (en) 1999-02-12

Family

ID=22064774

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98105268A HK1006168A1 (en) 1987-06-24 1998-06-13 Functionalized polyamine chelants and rhodium complexes thereof and process for their preparation

Country Status (19)

Country Link
US (2) US4994560A (sv)
EP (1) EP0296522B1 (sv)
JP (1) JP2728437B2 (sv)
KR (1) KR970011005B1 (sv)
CN (1) CN1022839C (sv)
AT (1) ATE143364T1 (sv)
CA (1) CA1341349C (sv)
DE (1) DE3855564T2 (sv)
DK (1) DK343288A (sv)
ES (1) ES2091746T3 (sv)
FI (1) FI101378B (sv)
GR (1) GR3021537T3 (sv)
HK (1) HK1006168A1 (sv)
HU (1) HU201333B (sv)
IL (1) IL86835A (sv)
NO (1) NO178928C (sv)
NZ (1) NZ225070A (sv)
PT (1) PT87802B (sv)
ZA (1) ZA884545B (sv)

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WO1990007261A2 (en) * 1988-12-22 1990-07-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
BR8907282A (pt) * 1988-12-23 1991-03-12 Dow Chemical Co Processo para preparar complexos de metal funcionalizados com isotiocianato
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Also Published As

Publication number Publication date
KR890000408A (ko) 1989-03-14
FI883046A0 (fi) 1988-06-23
NZ225070A (en) 1992-10-28
JP2728437B2 (ja) 1998-03-18
IL86835A0 (en) 1988-11-30
ES2091746T3 (es) 1996-11-16
KR970011005B1 (ko) 1997-07-05
FI101378B1 (sv) 1998-06-15
ZA884545B (en) 1990-02-28
US5284644A (en) 1994-02-08
ATE143364T1 (de) 1996-10-15
HU201333B (en) 1990-10-28
AU614973B2 (en) 1991-09-19
DK343288D0 (da) 1988-06-22
EP0296522B1 (en) 1996-09-25
DE3855564D1 (de) 1996-10-31
PT87802B (pt) 1992-10-30
US4994560A (en) 1991-02-19
HUT48636A (en) 1989-06-28
PT87802A (pt) 1989-05-31
IL86835A (en) 1994-01-25
DK343288A (da) 1988-12-25
CA1341349C (en) 2002-03-19
EP0296522A3 (en) 1990-07-04
EP0296522A2 (en) 1988-12-28
FI883046A (fi) 1988-12-25
CN1022839C (zh) 1993-11-24
FI101378B (sv) 1998-06-15
GR3021537T3 (en) 1997-02-28
NO882784L (no) 1988-12-27
JPS6426586A (en) 1989-01-27
NO178928B (no) 1996-03-25
DE3855564T2 (de) 1997-02-13
NO882784D0 (no) 1988-06-23
CN1030588A (zh) 1989-01-25
AU1833288A (en) 1989-01-05
NO178928C (no) 1996-07-03

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