HK1003031A1 - Condensed pyrimidine derivatives and their use as angiotensine ii antagonists - Google Patents

Condensed pyrimidine derivatives and their use as angiotensine ii antagonists Download PDF

Info

Publication number
HK1003031A1
HK1003031A1 HK98102075A HK98102075A HK1003031A1 HK 1003031 A1 HK1003031 A1 HK 1003031A1 HK 98102075 A HK98102075 A HK 98102075A HK 98102075 A HK98102075 A HK 98102075A HK 1003031 A1 HK1003031 A1 HK 1003031A1
Authority
HK
Hong Kong
Prior art keywords
compound
formula
methyl
pyrimidin
pharmaceutically acceptable
Prior art date
Application number
HK98102075A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1003031B (en
Inventor
Watson Ellingboe John
Nikaido Madelene
Franroz Bagli Jehan
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by Wyeth filed Critical Wyeth
Publication of HK1003031A1 publication Critical patent/HK1003031A1/en
Publication of HK1003031B publication Critical patent/HK1003031B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK98102075.7A 1991-10-24 1998-03-12 Condensed pyrimidine derivatives and their use as angiotensine ii antagonists HK1003031B (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560 1992-04-07
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
US782025 1992-06-25
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US901485 1992-06-25

Publications (2)

Publication Number Publication Date
HK1003031A1 true HK1003031A1 (en) 1998-09-30
HK1003031B HK1003031B (en) 1998-09-30

Family

ID=

Also Published As

Publication number Publication date
EP0539086A3 (en) 1993-06-16
CN1039324C (zh) 1998-07-29
EP0539086B1 (en) 1997-12-29
JPH05222039A (ja) 1993-08-31
FI103971B1 (fi) 1999-10-29
GR3025926T3 (en) 1998-04-30
ATE161537T1 (de) 1998-01-15
CA2080705A1 (en) 1993-04-25
AU2607992A (en) 1993-04-29
EP0539086A2 (en) 1993-04-28
FI924397A0 (fi) 1992-09-30
FI103971B (fi) 1999-10-29
AU653635B2 (en) 1994-10-06
KR100286624B1 (ko) 2001-05-02
IL103436A0 (en) 1993-03-15
CN1072682A (zh) 1993-06-02
HUT62893A (en) 1993-06-28
HU211915A9 (en) 1996-01-29
SG47626A1 (en) 1998-04-17
CN1175414A (zh) 1998-03-11
IL103436A (en) 1996-03-31
DE69223734D1 (de) 1998-02-05
SK322192A3 (en) 1999-11-08
LV12047B (en) 1998-08-20
NO924121L (no) 1993-04-26
KR930007949A (ko) 1993-05-20
LV12047A (lv) 1998-05-20
NO301275B1 (no) 1997-10-06
ES2111617T3 (es) 1998-03-16
TW226375B (OSRAM) 1994-07-11
FI924397L (fi) 1993-04-25
HU9203161D0 (en) 1992-12-28
SK280292B6 (sk) 1999-11-08
UA27748C2 (uk) 2000-10-16
CA2080705C (en) 2002-12-03
DE69223734T2 (de) 1998-04-16
HU218786B (hu) 2000-12-28
JP3240192B2 (ja) 2001-12-17
DK0539086T3 (da) 1998-02-02
NO924121D0 (no) 1992-10-23

Similar Documents

Publication Publication Date Title
EP0539086B1 (en) Condensed pyrimidine derivatives and their use as angiotensine II antagonists
US5149699A (en) Substituted pyridopyrimidines useful as antgiotensin II antagonists
US5225414A (en) Substituted azoles, a process for their preparation, and their use
EP0611368B1 (en) Substituted aminopyrimidines as angiotensin ii antagonists
JP3260415B2 (ja) アンギオテンシンｉｉ拮抗作用を有する複素環化合物
EP0445811B1 (en) Nitrogen-containing heterocyclic compounds, their production and use
US5466692A (en) Substituted pyridopyrimidines and antihypertensives
WO1993008170A1 (en) Substituted heterocycles as angiotensin ii antagonists
US5330989A (en) Heterocycles substituted with biphenyl-3-cyclobutene-1,2-dione derivatives
US5283242A (en) Substituted benzimidazoles and quinazolines as antihypertensives
US5256654A (en) Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US4596799A (en) 9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines
HK1003031B (en) Condensed pyrimidine derivatives and their use as angiotensine ii antagonists
EP0618207B1 (en) Substituted pyridopyrimidines as antihypertensives
GB2265899A (en) Substituted pyrimidines
US6096754A (en) N-3 substituted pyrimidin-4-ones with AII antagonistic activity
HK1011358B (en) Substituted pyridopyrimidines as antihypertensives

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20041014