HK1002457A1 - Angiostatin fragments and methods of use - Google Patents
Angiostatin fragments and methods of useInfo
- Publication number
- HK1002457A1 HK1002457A1 HK98101446A HK98101446A HK1002457A1 HK 1002457 A1 HK1002457 A1 HK 1002457A1 HK 98101446 A HK98101446 A HK 98101446A HK 98101446 A HK98101446 A HK 98101446A HK 1002457 A1 HK1002457 A1 HK 1002457A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- angiostatin
- fragments
- methods
- proliferation inhibitor
- aggregate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/429,743 US5885795A (en) | 1994-04-26 | 1995-04-26 | Methods of expressing angiostatic protein |
US08/605,598 US5861372A (en) | 1996-02-22 | 1996-02-22 | Aggregate angiostatin and method of use |
US08/612,788 US5837682A (en) | 1996-03-08 | 1996-03-08 | Angiostatin fragments and method of use |
PCT/US1996/005856 WO1996035774A2 (fr) | 1995-04-26 | 1996-04-26 | Fragments d'angiostatine, angiostatine agregee et procedes d'utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1002457A1 true HK1002457A1 (en) | 1998-08-28 |
Family
ID=27411639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98101446A HK1002457A1 (en) | 1995-04-26 | 1998-02-25 | Angiostatin fragments and methods of use |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0824546B1 (fr) |
JP (2) | JP3787157B2 (fr) |
CN (1) | CN1195375A (fr) |
AT (1) | ATE368051T1 (fr) |
AU (1) | AU709633B2 (fr) |
BR (1) | BR9608326A (fr) |
CA (1) | CA2219081C (fr) |
CZ (1) | CZ334097A3 (fr) |
DE (1) | DE69637179T2 (fr) |
ES (1) | ES2292174T3 (fr) |
HK (1) | HK1002457A1 (fr) |
HU (1) | HUP9800784A3 (fr) |
MX (1) | MX9708217A (fr) |
NO (1) | NO974943L (fr) |
NZ (1) | NZ307044A (fr) |
PL (1) | PL323256A1 (fr) |
WO (1) | WO1996035774A2 (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5945403A (en) * | 1997-05-30 | 1999-08-31 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
US6358735B1 (en) | 1995-06-30 | 2002-03-19 | University Of Kansas Medical Center | Method for inhibiting angiogenesis and tumors with the isolated NC1 α3 chain monomer of type IV collagen |
US6440729B1 (en) | 1995-06-30 | 2002-08-27 | University Of Kansas Medical Center | Treating angiogenesis-mediated diseases with the α2 monomer of type IV collagen |
KR100477280B1 (ko) * | 1995-12-13 | 2005-07-18 | 아보트 러보러터리즈 | 맥관형성에의한질환치료제 |
US5801012A (en) | 1996-09-17 | 1998-09-01 | Northwestern University | Methods and compositions for generating angiostatin |
JP2001518304A (ja) * | 1997-10-01 | 2001-10-16 | ジー・ディー・サール・アンド・カンパニー | アンギオスタチン成分を含む融合タンパク質及び抗腫瘍療法におけるその使用 |
AU1598599A (en) * | 1997-11-20 | 1999-06-15 | Genetix Pharmaceuticals, Inc. | Anti-angiogenic gene therapy vectors and their use in treating angiogenesis-related diseases |
CA2312287A1 (fr) * | 1997-12-08 | 1999-06-17 | Beth Israel Deaconess Medical Center | Procede de production de proteines anti-angiogeniques, dont l'endostatine, l'angiostatine ou la restine, au moyen d'un systeme d'expression de la levure pichia |
US6797488B1 (en) | 1997-12-08 | 2004-09-28 | Beth Israel Deaconess Medical Center | Methods of producing anti-angiogenic proteins |
CA2263784A1 (fr) * | 1998-03-23 | 1999-09-23 | Megabios Corporation | Proteines a marqueur double et leurs applications |
EP1074264B1 (fr) * | 1998-04-28 | 2008-09-17 | Toshikazu Nakamura | Inhibiteurs de neovascularisation |
US6770457B1 (en) | 1998-05-28 | 2004-08-03 | Korea Green Cross Corporation | Process of purifying angiogenesis inhibitors |
CA2335038A1 (fr) | 1998-06-15 | 1999-12-23 | Arch Development Corporation | Combinaison de facteurs radiotherapeutiques et anti-angiogeniques |
US6201104B1 (en) * | 1998-12-04 | 2001-03-13 | Entremed, Inc. | Angiogenesis—inhibiting protein binding peptides and proteins and methods of use |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
CA2360690A1 (fr) * | 1999-01-28 | 2000-08-03 | Michael S. O'reilly | Fragments de region kringle 4 de plasminogene et procedes d'utilisation |
US7157556B1 (en) | 1999-02-10 | 2007-01-02 | The Children's Medical Center Corporation | Deglycosylated kringle 1-3 region fragments of plasminogen and methods of use |
CA2361334C (fr) * | 1999-02-10 | 2014-06-03 | Entremed, Inc. | Fragments deglycosyles des regions kringle 1-3 de plasminogene et methodes d'utilisation |
PE20020376A1 (es) * | 2000-09-29 | 2002-05-13 | Abbott Lab | Polipeptidos antiangiogenicos y metodos para inhibir la angiogenesis |
AU2003226349B2 (en) * | 2002-04-11 | 2008-01-31 | Children's Medical Center Corporation | Methods for inhibiting vascular hyperpermeability |
EP1713511B1 (fr) * | 2004-01-09 | 2011-11-09 | Mogam Biotechnology Research Institute | Agent therapeutique pour le traitement du cancer comportant un gene lk68 ou lk8 des kringles de l'apolipoproteine (a) en tant que principe actif, et procede de traitement du cancer utilisant cet agent therapeutique |
JPWO2005079835A1 (ja) * | 2004-02-24 | 2007-08-02 | 株式会社ティーティーシー | Blアンジオスタチンを含む制がん剤 |
ITMI20041962A1 (it) * | 2004-10-15 | 2005-01-15 | Istituto Naz Per La Ricerca S | "peptide di angiostatina e suoi impieghio terapeutici" |
CN101219219B (zh) * | 2007-01-10 | 2013-02-13 | 北京普罗吉生物科技发展有限公司 | 包含血管抑素或其片段的复合物、其制备方法及应用 |
WO2010070746A1 (fr) * | 2008-12-17 | 2010-06-24 | 株式会社ティムス | Polypeptide de type angiostatine canine |
JP5749229B2 (ja) * | 2012-07-31 | 2015-07-15 | 京セラドキュメントソリューションズ株式会社 | ジェスチャー管理プログラム及び情報処理装置 |
CN106890324A (zh) * | 2015-12-18 | 2017-06-27 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗糖尿病肾病的方法 |
CN108778307A (zh) | 2015-12-18 | 2018-11-09 | 泰伦基国际有限公司 | 一种预防和治疗糖尿病肾病的方法 |
WO2018107701A1 (fr) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | Nouveau médicament pour réduire le glucose sanguin et améliorer la tolérance au glucose |
SG11202001595SA (en) | 2017-08-31 | 2020-03-30 | Singapore Health Serv Pte Ltd | Angio-3 for treatment of retinal angiogenic diseases |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5885795A (en) * | 1994-04-26 | 1999-03-23 | The Children's Medical Center Corporation | Methods of expressing angiostatic protein |
-
1996
- 1996-04-26 DE DE69637179T patent/DE69637179T2/de not_active Expired - Lifetime
- 1996-04-26 CA CA002219081A patent/CA2219081C/fr not_active Expired - Lifetime
- 1996-04-26 CN CN96194077A patent/CN1195375A/zh active Pending
- 1996-04-26 NZ NZ307044A patent/NZ307044A/en not_active IP Right Cessation
- 1996-04-26 EP EP96913208A patent/EP0824546B1/fr not_active Expired - Lifetime
- 1996-04-26 HU HU9800784A patent/HUP9800784A3/hu unknown
- 1996-04-26 BR BR9608326-3A patent/BR9608326A/pt unknown
- 1996-04-26 ES ES96913208T patent/ES2292174T3/es not_active Expired - Lifetime
- 1996-04-26 WO PCT/US1996/005856 patent/WO1996035774A2/fr active IP Right Grant
- 1996-04-26 PL PL96323256A patent/PL323256A1/xx unknown
- 1996-04-26 AT AT96913208T patent/ATE368051T1/de active
- 1996-04-26 AU AU55795/96A patent/AU709633B2/en not_active Expired
- 1996-04-26 JP JP53410496A patent/JP3787157B2/ja not_active Expired - Lifetime
- 1996-04-26 MX MX9708217A patent/MX9708217A/es unknown
- 1996-04-26 CZ CZ973340A patent/CZ334097A3/cs unknown
-
1997
- 1997-10-24 NO NO974943A patent/NO974943L/no not_active Application Discontinuation
-
1998
- 1998-02-25 HK HK98101446A patent/HK1002457A1/xx not_active IP Right Cessation
-
2000
- 2000-10-06 JP JP2000308481A patent/JP2001151691A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU709633B2 (en) | 1999-09-02 |
JP2001151691A (ja) | 2001-06-05 |
EP0824546A2 (fr) | 1998-02-25 |
CA2219081A1 (fr) | 1996-11-14 |
NO974943D0 (no) | 1997-10-24 |
HUP9800784A2 (hu) | 1998-07-28 |
CN1195375A (zh) | 1998-10-07 |
ATE368051T1 (de) | 2007-08-15 |
WO1996035774A2 (fr) | 1996-11-14 |
CA2219081C (fr) | 2004-02-24 |
JPH11508228A (ja) | 1999-07-21 |
AU5579596A (en) | 1996-11-29 |
MX9708217A (es) | 1997-12-31 |
EP0824546B1 (fr) | 2007-07-25 |
DE69637179T2 (de) | 2008-04-10 |
WO1996035774A3 (fr) | 1997-02-13 |
CZ334097A3 (cs) | 1998-04-15 |
ES2292174T3 (es) | 2008-03-01 |
HUP9800784A3 (en) | 2000-07-28 |
PL323256A1 (en) | 1998-03-16 |
BR9608326A (pt) | 2000-03-08 |
JP3787157B2 (ja) | 2006-06-21 |
NZ307044A (en) | 2002-03-01 |
NO974943L (no) | 1997-12-18 |
DE69637179D1 (de) | 2007-09-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1002457A1 (en) | Angiostatin fragments and methods of use | |
CA2291892A1 (fr) | Fragments d'angiostatine et leur procede d'utilisation | |
EA199800391A1 (ru) | Ингибирование роста опухоли антисмысловыми олигонуклеотидами к il-8 и il-8 рецептору | |
DE60032783D1 (en) | Thrombopoietinmimetika | |
PT1019040E (pt) | Inibicao da actividade de p38-quinase por meio de arilureias | |
HK1091228A1 (en) | Methods for making recombinant proteins using apoptosis inhibitors | |
ES2169864T3 (es) | Anticuerpos monoclonales anti-endoglina y su uso en terapia anti-angiogenesis. | |
PL331240A1 (en) | Cut off soluble tumour necrosis factor receptors of i and ii type | |
ATE354372T1 (de) | Verwendung von mif-antagonisten zur krebstherapie | |
UA66793C2 (uk) | Лептин як стримувач швидкого збільшення пухлини клітини | |
CA2259960A1 (fr) | Retro-regulation de la regeneration de l'adn pour augmenter la sensibilite a la suppression induite par p53 | |
PL327181A1 (en) | Benzofurane carboxyamides and sulphonamides | |
NZ334592A (en) | Protein growth factor related to TNF-beta and coupled with a toxic moiety for use in treating prostate cancer | |
WO2003026580A3 (fr) | Enveloppes therapeutiques interactives | |
DE60044350D1 (de) | Prostata-spezifisches gen pcgem1 und methoden zu dessen verwendung zur erkennung, behandlung und prävention von prostatakrebs | |
ATE211921T1 (de) | Verwendung von gonadotropin zur behandlung der gestartigen hypertrophie der prostata | |
EA199700241A1 (ru) | Новые, определенные по составу смеси ферментов для выделения клеток и лечения ран | |
WO1999057133A3 (fr) | NOUVEAUX INHIBITEURS D'ACTIVATION NF-λB | |
WO2000044391A3 (fr) | Fragments de region kringle 4 de plasminogene et procedes d'utilisation | |
DE69431603D1 (de) | Oligopeptide hergeleitet von fragmenten des c-reaktiven proteins | |
AU6291799A (en) | Use of calreticulin and calreticulin fragments to inhibit endothelial cell growth and angiogenesis, and suppress tumor growth | |
AU4823999A (en) | Methods and compositions for treating diseases mediated by transglutaminase activity | |
IS5613A (is) | Notkun CD137 til að stuðla að fjölgun jaðar-einkjörnunga | |
AU2990300A (en) | Deglycosylated kringle 1-5 region fragments of plasminogen and methods of use | |
AU9294698A (en) | Methods and compositions for enhanced wound healing |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |
Effective date: 20160425 |