GT201200293A - Marcadores predictivos útiles en el tratamiento del síndrome frágil x (fxs) - Google Patents
Marcadores predictivos útiles en el tratamiento del síndrome frágil x (fxs)Info
- Publication number
- GT201200293A GT201200293A GT201200293A GT201200293A GT201200293A GT 201200293 A GT201200293 A GT 201200293A GT 201200293 A GT201200293 A GT 201200293A GT 201200293 A GT201200293 A GT 201200293A GT 201200293 A GT201200293 A GT 201200293A
- Authority
- GT
- Guatemala
- Prior art keywords
- treatment
- fxs
- predictive markers
- useful predictive
- fragile syndrome
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A MARCADORES PREDICTIVOS ÚTILES PARA PREDECIR SÍ UN INDIVIDUO QUE TENGA EL SÍNDROME X FRÁGIL RESPONDERÁ CLÍNICAMENTE AL TRATAMIENTO CON UN AGENTE TERAPÉUTICO PARTICULAR, BASADA EN EL HALLAZGO DE QUE SE PUEDEN UTILIZAR BIOMARCADORES PARTICULARES PARA SELECCIONAR AQUELLOS INDIVIDUOS QUE PADEZCAN DICHO SÍNDROME
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33029910P | 2010-04-30 | 2010-04-30 | |
US37919710P | 2010-09-01 | 2010-09-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT201200293A true GT201200293A (es) | 2014-06-09 |
Family
ID=44121075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT201200293A GT201200293A (es) | 2010-04-30 | 2012-10-30 | Marcadores predictivos útiles en el tratamiento del síndrome frágil x (fxs) |
Country Status (21)
Country | Link |
---|---|
US (1) | US20130052644A1 (es) |
EP (1) | EP2563934A1 (es) |
JP (1) | JP2013524840A (es) |
KR (1) | KR20130100906A (es) |
CN (1) | CN102869791A (es) |
AU (1) | AU2011245372A1 (es) |
BR (1) | BR112012027816A2 (es) |
CA (1) | CA2797854A1 (es) |
CL (1) | CL2012003027A1 (es) |
EC (1) | ECSP12012317A (es) |
GT (1) | GT201200293A (es) |
IL (1) | IL222534A0 (es) |
MA (1) | MA34263B1 (es) |
MX (1) | MX2012012615A (es) |
PE (1) | PE20130213A1 (es) |
RU (1) | RU2012151273A (es) |
SG (1) | SG184458A1 (es) |
TN (1) | TN2012000485A1 (es) |
TW (1) | TW201142293A (es) |
WO (1) | WO2011137206A1 (es) |
ZA (1) | ZA201207481B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
CA3162352A1 (en) | 2010-10-01 | 2012-04-05 | Modernatx, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
US20130274294A1 (en) * | 2010-12-20 | 2013-10-17 | David Carcache | 4-(Hetero)Aryl-Ethynyl-Octahydro-Indole-1-Esters |
DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
PT3682905T (pt) | 2011-10-03 | 2022-04-07 | Modernatx Inc | Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações |
LT2791160T (lt) | 2011-12-16 | 2022-06-10 | Modernatx, Inc. | Modifikuotos mrnr sudėtys |
WO2013131981A1 (en) | 2012-03-08 | 2013-09-12 | Novartis Ag | Predictive markers useful in the diagnosis and treatment of fragile x syndrome (fxs) |
CA2868996A1 (en) | 2012-04-02 | 2013-10-10 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
WO2014152600A2 (en) * | 2013-03-15 | 2014-09-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Measurement of cellular fmrp levels for high throughput drug screening and diagnosis of fragile x syndrome |
JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
CA2926645C (en) * | 2013-10-14 | 2022-10-25 | Indiana University Research And Technology Corporation | Use of acamprosate to modulate erk 1/2 activation in animal models for fxs and asd and individuals diagnosed with fxs and asd |
CN103981253A (zh) * | 2014-03-27 | 2014-08-13 | 江苏佰龄全基因生物医学技术有限公司 | 一种用于检测脆性x染色体综合征的cgg重复数及agg插入信息的pcr试剂盒 |
EP4244631A1 (en) * | 2020-11-13 | 2023-09-20 | Children's Hospital Medical Center | Refined uses of gabaa receptor modulators in treatment of fragile x syndrome |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
US6143504A (en) * | 1998-10-27 | 2000-11-07 | Arch Development Corporation | Methods and compositions for the diagnosis of fragile X syndrome |
GB0128996D0 (en) | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
CN1894241A (zh) | 2002-08-09 | 2007-01-10 | 阿斯利康(瑞典)有限公司 | 作为代谢型谷氨酸受体-5调节剂的“1,2,4” 噁二唑 |
JP4453297B2 (ja) | 2003-05-27 | 2010-04-21 | トヨタ自動車株式会社 | 車両用遊星歯車式多段変速機 |
TW200801005A (en) | 2005-08-15 | 2008-01-01 | Astrazeneca Ab | Acetylenic piperazines as metabotropic glutamate receptor antagonists |
US20090042195A1 (en) * | 2005-10-07 | 2009-02-12 | Bradford Coffee | Methods and systems for screening for and diagnosing dna methylation associated abnormalities and sex chromosome aneuploidies |
US7855053B2 (en) * | 2006-07-19 | 2010-12-21 | The Regents Of The University Of California | Methods for detecting the presence of expanded CGG repeats in the FMR1 gene 5′ untranslated region |
EA201100297A1 (ru) | 2008-08-04 | 2011-10-31 | Новартис Аг | Биотесты на белок polyq |
US20100248239A1 (en) * | 2009-03-24 | 2010-09-30 | Mayo Foundation For Medical Education And Research | Methods and materials for detecting fragile x mutations |
-
2011
- 2011-04-28 PE PE2012002106A patent/PE20130213A1/es not_active Application Discontinuation
- 2011-04-28 BR BR112012027816A patent/BR112012027816A2/pt not_active IP Right Cessation
- 2011-04-28 RU RU2012151273/10A patent/RU2012151273A/ru not_active Application Discontinuation
- 2011-04-28 WO PCT/US2011/034244 patent/WO2011137206A1/en active Application Filing
- 2011-04-28 SG SG2012074035A patent/SG184458A1/en unknown
- 2011-04-28 JP JP2013508235A patent/JP2013524840A/ja active Pending
- 2011-04-28 CA CA2797854A patent/CA2797854A1/en not_active Abandoned
- 2011-04-28 US US13/695,214 patent/US20130052644A1/en not_active Abandoned
- 2011-04-28 CN CN2011800219070A patent/CN102869791A/zh active Pending
- 2011-04-28 AU AU2011245372A patent/AU2011245372A1/en not_active Abandoned
- 2011-04-28 EP EP11719705A patent/EP2563934A1/en not_active Withdrawn
- 2011-04-28 MX MX2012012615A patent/MX2012012615A/es not_active Application Discontinuation
- 2011-04-28 MA MA35412A patent/MA34263B1/fr unknown
- 2011-04-28 KR KR1020127031312A patent/KR20130100906A/ko not_active Application Discontinuation
- 2011-04-29 TW TW100115217A patent/TW201142293A/zh unknown
-
2012
- 2012-10-05 ZA ZA2012/07481A patent/ZA201207481B/en unknown
- 2012-10-05 TN TNP2012000485A patent/TN2012000485A1/en unknown
- 2012-10-18 IL IL222534A patent/IL222534A0/en unknown
- 2012-10-29 CL CL2012003027A patent/CL2012003027A1/es unknown
- 2012-10-30 GT GT201200293A patent/GT201200293A/es unknown
- 2012-11-29 EC ECSP12012317 patent/ECSP12012317A/es unknown
Also Published As
Publication number | Publication date |
---|---|
TW201142293A (en) | 2011-12-01 |
SG184458A1 (en) | 2012-11-29 |
RU2012151273A (ru) | 2014-06-10 |
US20130052644A1 (en) | 2013-02-28 |
MA34263B1 (fr) | 2013-05-02 |
CL2012003027A1 (es) | 2014-02-14 |
CA2797854A1 (en) | 2011-11-03 |
ECSP12012317A (es) | 2013-01-31 |
BR112012027816A2 (pt) | 2017-08-08 |
MX2012012615A (es) | 2012-12-17 |
ZA201207481B (en) | 2013-06-26 |
CN102869791A (zh) | 2013-01-09 |
WO2011137206A1 (en) | 2011-11-03 |
TN2012000485A1 (en) | 2014-04-01 |
JP2013524840A (ja) | 2013-06-20 |
PE20130213A1 (es) | 2013-03-19 |
IL222534A0 (en) | 2012-12-31 |
EP2563934A1 (en) | 2013-03-06 |
AU2011245372A1 (en) | 2012-11-29 |
KR20130100906A (ko) | 2013-09-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GT201200293A (es) | Marcadores predictivos útiles en el tratamiento del síndrome frágil x (fxs) | |
CU20140025A7 (es) | Pirimidinas anilladas sustituidas | |
BR112012009135A2 (pt) | composição polímera termoplástica | |
BR112012029917A2 (pt) | composições de nanotransportador com adjuvante desacoplado | |
BR112013030599A2 (pt) | núcleo absorvente para artigos absorventes descartáveis | |
BR112015001101A2 (pt) | formas cristalinas de um inibidor de prolil hidroxilase | |
EA201270619A1 (ru) | Применение бетанехола для лечения ксеростомии | |
BR112012019529A2 (pt) | inibidores de d-nitrosoglutationa redutase | |
BR112012032033A2 (pt) | novas formas de dosagem de libertação modificada de inibidor de xantina oxidorredutase ou inibidores de xantina oxidase | |
TWD158887S (zh) | 粉餅盒 | |
GT201200284A (es) | Composición farmacéutica | |
BR112012016894A2 (pt) | lactobacilos com ação antioxidante. | |
BR112013011259A2 (pt) | condições de tratamento associadas com nível aumentado de eotaxina com 25-hidroxivitamina d3 | |
EA201590503A1 (ru) | Альфа-1-микроглобулин для применения в лечении заболеваний, связанных с митохондриями | |
BR112013027403A2 (pt) | composições que compreendem uma antimetabólito de glicose e selênio | |
TWD163459S (zh) | 錶用機心 | |
PE20151669A1 (es) | Compuestos de azetidiniloxifenilpirrolidina | |
AR082215A1 (es) | Composicion farmaceutica agradable al paladar | |
UA112760C2 (uk) | Теобромін у комбінації з гвайфенезином для лікування кашлю | |
BR112013018287A2 (pt) | derivados monoterpenos de chalcona ou de diidrochalcona e sua utilização como agentes de despigmentação | |
ECSP13012603A (es) | Nueva formulacion del cetp(1) | |
CL2012002079A1 (es) | Compuestos derivados del alquil-6-arilsulfamoil-ciclohexen-carboxilato para suprimir un trastorno periferico inducido por agente anti-cancerigeno. | |
UA108126C2 (uk) | Спосіб отримання співполімеру натрійкарбоксиметилцелюлози й госиполу | |
BR112013000506A2 (pt) | núcleo absorvente | |
BR112012033437A2 (pt) | núcleo absorvente |