GT200900237A - Formas solidas de un inhibidor de cinasa raf.- - Google Patents

Formas solidas de un inhibidor de cinasa raf.-

Info

Publication number
GT200900237A
GT200900237A GT200900237A GT200900237A GT200900237A GT 200900237 A GT200900237 A GT 200900237A GT 200900237 A GT200900237 A GT 200900237A GT 200900237 A GT200900237 A GT 200900237A GT 200900237 A GT200900237 A GT 200900237A
Authority
GT
Guatemala
Prior art keywords
solid forms
cinasa
raf inhibitor
imidazol
trifluoro
Prior art date
Application number
GT200900237A
Other languages
English (en)
Inventor
Hashash Ahmad
Kangwen L Lin
Augustus O Okhamafe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200900237A publication Critical patent/GT200900237A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A LAS FORMAS SÓLIDAS DEL INHIBODOR DE CINASA RAF DE 1-METIL - 5 - ( 2 - ( 5 - (TRIFLUORO - METIL) - 1H - IMIDAZOL - 2 -IL) - PIRIDIN-4-ILOXI)-N-(4- (TRIFLUORO - METIL) - FENIL)- 1H - BENZO [D] - IMIDAZOL -2 - AMINA, ASI COMO A COMPOSICIONES DE LAS MISMAS Y A LA UTILIZACION DE LAS MISMAS.
GT200900237A 2007-03-02 2009-08-31 Formas solidas de un inhibidor de cinasa raf.- GT200900237A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90445507P 2007-03-02 2007-03-02

Publications (1)

Publication Number Publication Date
GT200900237A true GT200900237A (es) 2010-06-24

Family

ID=39456506

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200900237A GT200900237A (es) 2007-03-02 2009-08-31 Formas solidas de un inhibidor de cinasa raf.-

Country Status (25)

Country Link
US (1) US8324389B2 (es)
EP (1) EP2132198A1 (es)
JP (1) JP2010520215A (es)
KR (1) KR20090117833A (es)
CN (1) CN101679372A (es)
AR (1) AR065565A1 (es)
AU (1) AU2008251764B2 (es)
BR (1) BRPI0808526A2 (es)
CA (1) CA2678335A1 (es)
CL (1) CL2008000616A1 (es)
CO (1) CO6230987A2 (es)
EC (1) ECSP099673A (es)
GT (1) GT200900237A (es)
IL (1) IL200441A0 (es)
MA (1) MA31259B1 (es)
MX (1) MX2009009344A (es)
MY (1) MY148438A (es)
NZ (1) NZ579084A (es)
PE (1) PE20081801A1 (es)
RU (1) RU2483064C2 (es)
SG (1) SG179423A1 (es)
TN (1) TN2009000356A1 (es)
TW (1) TW200846341A (es)
WO (1) WO2008140850A1 (es)
ZA (1) ZA200905618B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ580592A (en) * 2007-05-23 2012-02-24 Novartis Ag Raf inhibitors, such as benzimidazole derivatives, for the treatment of thyroid cancer
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
US10098859B2 (en) 2012-09-05 2018-10-16 Amri Ssci, Llc Cocrystals of p-coumaric acid
BR112017027285A2 (pt) * 2015-06-19 2018-09-11 Syn Nat Products Entpr Llc ?cocristal, composição farmacêutica e método para o tratamento de uma doença?
EP3579872A1 (en) 2017-02-10 2019-12-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
US11725185B2 (en) 2017-12-28 2023-08-15 University Of Houston System Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
RU2693004C1 (ru) * 2019-03-15 2019-07-01 Лейсан Фаридовна Минигулова Противоопухолевая композиция цисплатина с ингибитором 6-фосфоглюконатдегидрогеназы

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6627646B2 (en) * 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
NZ535985A (en) * 2002-03-29 2007-04-27 Chiron Corp Substituted benzazoles and use thereof as RAF kinase inhibitors
TW200804345A (en) * 2005-08-30 2008-01-16 Novartis Ag Substituted benzimidazoles and methods of preparation
MX2009000770A (es) * 2006-07-21 2009-01-28 Novartis Ag Formulaciones para eteres de piridilo de bencimidazolilo.
PE20080766A1 (es) * 2006-08-30 2008-06-15 Novartis Ag Sales de benzimidazolil piridil eteres y formulaciones que las contienen

Also Published As

Publication number Publication date
AU2008251764B2 (en) 2012-09-13
ZA200905618B (en) 2010-05-26
ECSP099673A (es) 2009-11-30
MX2009009344A (es) 2009-09-11
NZ579084A (en) 2012-04-27
BRPI0808526A2 (pt) 2014-08-19
CL2008000616A1 (es) 2008-09-12
MA31259B1 (fr) 2010-03-01
AR065565A1 (es) 2009-06-17
EP2132198A1 (en) 2009-12-16
US8324389B2 (en) 2012-12-04
CN101679372A (zh) 2010-03-24
WO2008140850A1 (en) 2008-11-20
RU2009136308A (ru) 2011-04-10
US20100209418A1 (en) 2010-08-19
TN2009000356A1 (en) 2010-12-31
CA2678335A1 (en) 2008-11-20
AU2008251764A1 (en) 2008-11-20
JP2010520215A (ja) 2010-06-10
PE20081801A1 (es) 2009-01-08
CO6230987A2 (es) 2010-12-20
RU2483064C2 (ru) 2013-05-27
MY148438A (en) 2013-04-30
KR20090117833A (ko) 2009-11-12
TW200846341A (en) 2008-12-01
SG179423A1 (en) 2012-04-27
IL200441A0 (en) 2010-04-29

Similar Documents

Publication Publication Date Title
GT200900237A (es) Formas solidas de un inhibidor de cinasa raf.-
NI201000098A (es) 4-fenilpiran-3,5-dionas, 4-feniltiopiran-3,5-dionas y 2-fenilciclohexan-1,3,5-trionas como herbicidas.
ECSP077981A (es) Formas polimórficas del éster etílico del ácido 3-[(2-{[4-(hexiloxicarbonilamino- imino-metil)-fenilamino]-metil}-1-metil-1h-bencimidazol-5-carbonil)-piridin-2-il- amino]-propiónico
EA201001359A1 (ru) Гетероциклические соединения в качестве ингибиторов cxcr2
CO6801792A2 (es) Formas cristalinas de 5-cloro-n2-(2-isoporpoxi 5-metil-4-piperidin-4-il-fenil)-n4-[2-(propan-2-sulfonil)-fenil]-pirimidin-2,4-diamina.
MA32369B1 (fr) Composes de benzene sulfonamide thiazole et oxazole
UA109547C2 (uk) Композиція для боротьби з захворюванням рослин і спосіб боротьби з захворюванням рослин
BRPI0914772A2 (pt) compostos heterocíclicos 1,2-dissubstituídos
DK2010498T3 (da) Syntese af acylaminoalkenylenamider, der kan anvendes som substans P-antagonister
MX2010008040A (es) Derivados de pirimidina 5-fluoro como fungicidas.
UY34161A (es) 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil) carbamimidoil)pirazina-2-carboxamida, sus usos, y composiciones que la contienen
EA200801630A1 (ru) Соединения пиперазина с гербицидным действием
UY34219A (es) Compuestos de 2-(2,4,5-anilino sustituido)pirimidina
FR2918570B1 (fr) DIGLYCATION DES AGEs.
BRPI0809974A2 (pt) Compostos de pirimidina hidrazida como inibidores de pgds
EA200701396A1 (ru) Триазолофталазины в качестве ингибиторов pde-2
EA201101060A1 (ru) Новые гербициды
UY34480A (es) Compuestos de 2-(fenilo sustituido)-ciclopentan-1,3-diona y derivados de los mismos, composiciones y métodos para controlar malezas.
EA201101146A1 (ru) Новые гербициды
UY37517A (es) Métodos de síntesis de compuestos tiazoles sustituidos
EA201101099A1 (ru) Гербициды, полученные из циклопентадиона
BRPI0812222A2 (pt) Compostos ciclobutenodiona substituídos anti-inflamatórios.
UA106880C2 (uk) Нові гербіциди
MY159828A (en) Kokumi-imparting agent
MA31985B1 (fr) (r)-2-(4-cyclopropanesulfonyl-phényl)-n-pyrazin-2-yl-3-(tétrahydropyran-4-yl)- propionamide cristallin