GT200000062A - Derivado sustituido de pirazol. - Google Patents

Derivado sustituido de pirazol.

Info

Publication number
GT200000062A
GT200000062A GT200000062A GT200000062A GT200000062A GT 200000062 A GT200000062 A GT 200000062A GT 200000062 A GT200000062 A GT 200000062A GT 200000062 A GT200000062 A GT 200000062A GT 200000062 A GT200000062 A GT 200000062A
Authority
GT
Guatemala
Prior art keywords
pirazol
substituted derivative
increase
well
guanilatociclass
Prior art date
Application number
GT200000062A
Other languages
English (en)
Inventor
Alexander Straub
Achim Feurer
Cristina Alonso-Alija
Elke Stahl
Johannes-Peter Stasch
Elisabeth Perzborn
Klaus Dembowsky
Armin Kern
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200000062A publication Critical patent/GT200000062A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN DERIVADO SUSTITUIDO DE PIRAZOL DE FORMULA I, ASI COMO A SUS ISOMEROS Y SALES, AL PROCEDIMIENTO PARA SU OBTENCION Y A SU USO COMO MEDICAMENTO, ESPECIALMENTE COMO MEDICAMENTO PARA EL TRATAMIENTO DE AFECCIONES CARDIOVASCULARES. ESPECIALMENTE DA LUGAR A RELAJACION VASCULAR, INHIBICION DE LA AGREGACION DE TROMBOCITOS Y DISMINUCION DE LA PRESION SANGUINEA, ASI COMO A UN AUMENTO DEL FLUJO SANGUINEO CORONARIO. ESTOS EFECTOS ESTAN MEDIADOS POR UNA ESTIMULACION DIRECTA DE LA GUANILATOCICLASA SOLUBLE Y UN AUMENTO DEL CGMP INTRACELULAR.
GT200000062A 1999-05-04 2000-05-04 Derivado sustituido de pirazol. GT200000062A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19920352A DE19920352A1 (de) 1999-05-04 1999-05-04 Substituiertes Pyrazolderivat

Publications (1)

Publication Number Publication Date
GT200000062A true GT200000062A (es) 2001-10-26

Family

ID=7906844

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200000062A GT200000062A (es) 1999-05-04 2000-05-04 Derivado sustituido de pirazol.

Country Status (6)

Country Link
AU (1) AU4554500A (es)
DE (1) DE19920352A1 (es)
GT (1) GT200000062A (es)
PE (1) PE20010111A1 (es)
UY (1) UY26133A1 (es)
WO (1) WO2000066582A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10021069A1 (de) * 2000-04-28 2001-10-31 Bayer Ag Substituiertes Pyrazolderivat
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10122894A1 (de) * 2001-05-11 2002-11-14 Bayer Ag Neue Sulfonat-substituierte Pyrazolopyridinderivate
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
DE10132416A1 (de) * 2001-07-04 2003-01-16 Bayer Ag Neue Morpholin-überbrückte Pyrazolopyridinderivate
DE10217799A1 (de) * 2002-04-22 2003-11-06 Bayer Ag Stents
DE10242941A1 (de) * 2002-09-16 2004-03-18 Bayer Ag Substituiertes Pyrazolderivat
DE102007028320A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028406A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028319A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028407A1 (de) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
EP2138178A1 (en) 2008-06-28 2009-12-30 Bayer Schering Pharma Aktiengesellschaft Oxazolidninones for the treatment fo chronic obstructive pulmonary disease (COPD) and/or asthma
RS61609B1 (sr) 2011-11-25 2021-04-29 Adverio Pharma Gmbh Supstituisani 5-fluor-1h-pirazolopiridin u kristalnom obliku
US9783614B2 (en) 2012-05-10 2017-10-10 Bayer Pharma Aktiengesellschaft Antibodies capable of binding to the coagulation Factor XI and/or its activated form factor Xia and uses thereof
AU2016371762A1 (en) 2015-12-14 2018-06-21 Cyclerion Therapeutics, Inc. Use of sGC stimulators for the treatment of gastrointestinal sphincter dysfunction
WO2018111795A2 (en) 2016-12-13 2018-06-21 Ironwood Pharmaceuticals, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
AU2018252099B2 (en) 2017-04-11 2021-08-12 Sunshine Lake Pharma Co., Ltd. Fluorine-substituted indazole compounds and uses thereof
WO2020014504A1 (en) 2018-07-11 2020-01-16 Cyclerion Therapeutics, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF MITOCHONRIAL DISORDERS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19649460A1 (de) * 1996-11-26 1998-05-28 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) * 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate

Also Published As

Publication number Publication date
PE20010111A1 (es) 2001-04-12
UY26133A1 (es) 2000-12-29
WO2000066582A1 (de) 2000-11-09
AU4554500A (en) 2000-11-17
DE19920352A1 (de) 2000-11-09

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