GR900100231A - Ανασταλτικές συν?έσεις λιποξυγενάσης βασιζόμενες σε ουρία. - Google Patents

Ανασταλτικές συν?έσεις λιποξυγενάσης βασιζόμενες σε ουρία.

Info

Publication number
GR900100231A
GR900100231A GR900100231A GR900100231A GR900100231A GR 900100231 A GR900100231 A GR 900100231A GR 900100231 A GR900100231 A GR 900100231A GR 900100231 A GR900100231 A GR 900100231A GR 900100231 A GR900100231 A GR 900100231A
Authority
GR
Greece
Prior art keywords
inhibiting compounds
urea based
lipoxygenase inhibiting
μxwvðaæu
zqu
Prior art date
Application number
GR900100231A
Other languages
Greek (el)
English (en)
Inventor
Dee W Brooks
Daniel J Kerkman
Jonathan G Martin
O Adrew Stewart
B James Summers Jr
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of GR900100231A publication Critical patent/GR900100231A/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/08—Naphthothiopyrans; Hydrogenated naphthothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR900100231A 1989-03-30 1990-03-28 Ανασταλτικές συν?έσεις λιποξυγενάσης βασιζόμενες σε ουρία. GR900100231A (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33156689A 1989-03-30 1989-03-30

Publications (1)

Publication Number Publication Date
GR900100231A true GR900100231A (el) 1991-07-31

Family

ID=23294495

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100231A GR900100231A (el) 1989-03-30 1990-03-28 Ανασταλτικές συν?έσεις λιποξυγενάσης βασιζόμενες σε ουρία.

Country Status (5)

Country Link
EP (1) EP0588785A1 (de)
JP (1) JPH04504261A (de)
CA (1) CA2050597A1 (de)
GR (1) GR900100231A (de)
WO (1) WO1990012008A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084575A (en) * 1987-07-31 1992-01-28 American Home Products Corporation Quinoline substituted naphthalenepropionic acid derivatives as anti-inflammatory/antiallergic agents
US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
US5220059A (en) * 1990-04-19 1993-06-15 Abbott Laboratories Lipoxygenase-inhibiting compounds derived from non-steroidal antiinflammatory carboxylic acids
GB9012252D0 (en) * 1990-06-01 1990-07-18 Lilly Industries Ltd Pharmaceutical compounds
US5476873A (en) * 1990-07-25 1995-12-19 Abbott Laboratories Acetylene derivatives having lipoxygenase inhibitory activity
DK0540673T3 (da) * 1990-07-25 1997-03-24 Abbott Lab Acetylen-derivater med lipoxygenaseinhiberende virkning
DE4023742A1 (de) * 1990-07-26 1992-01-30 Gruenenthal Gmbh Substituierte phenylacetylene, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
JPH06256285A (ja) * 1990-12-11 1994-09-13 Pfizer Pharmaceut Co Ltd ヒドロキサム酸誘導体およびその用途
US5283361A (en) * 1991-04-23 1994-02-01 Eli Lilly And Company N-hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]ureas as lipoxygenase inhibitors
US5130485A (en) * 1991-04-23 1992-07-14 Eli Lilly And Company N-hydroxy-N-(3-(2-substituted phenyl)prop-2-enyl)ureas and thioureas useful as 5-lipoxygenase inhibiting agents
US5214204A (en) * 1991-07-19 1993-05-25 Abbott Laboratories Arylamidoalkyl-n-hydroxyurea compounds having lipoxygenase inhibitory activity
DE4124345A1 (de) * 1991-07-23 1993-01-28 Gruenenthal Gmbh Substituierte 3,4-dihydronaphthaline, diese verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
DE4204686A1 (de) * 1992-02-17 1993-08-19 Gruenenthal Gmbh Imidazolylphenolderivate, diese enthaltende arzneimittel sowie ein verfahren zur herstellung dieser verbindungen und arzneimitteln
US5459154A (en) * 1993-11-08 1995-10-17 American Home Products Corporation N-hydroxyureas as 5-lipoxygenase inhibitors and inhibitors of oxidative modification of low density lipoprotein
US5428048A (en) * 1993-11-08 1995-06-27 American Home Products Corporation Aryl-N-hydroxyureas as inhibitors of 5-lipoxygenase and anto-arteriosclerotic agents
US5468760A (en) * 1993-11-08 1995-11-21 American Home Products Corporation Aralkyl-N-hydroxyureas as inhibitors of 5-lipoxygenase and oxidation of low density lipoprotein
US5506261A (en) * 1994-05-09 1996-04-09 Abbott Laboratories Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors of leukotriene biosynthesis
US5612377A (en) * 1994-08-04 1997-03-18 Minnesota Mining And Manufacturing Company Method of inhibiting leukotriene biosynthesis
JP3322885B2 (ja) * 1995-02-02 2002-09-09 日研化学株式会社 Ｎ−ヒドロキシウレア誘導体
AU4059199A (en) * 1998-06-04 1999-12-20 Ihara Chemical Industry Co. Ltd. Phenylacetylene derivatives and agricultural/horticultural bactericides
WO2005121134A1 (en) * 2004-06-14 2005-12-22 F. Hoffmann-La Roche Ag Thiophene derivatives, their manufacture and use as pharmaceutical agents
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
ES2968371T3 (es) 2013-10-10 2024-05-09 Eastern Virginia Medical School Derivados de 4-((2-hidroxi-3-metoxibencil)amino) bencenosulfonamida como inhibidores de la 12-lipoxigenasa

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0292699A2 (de) * 1987-04-24 1988-11-30 Abbott Laboratories Harnstoff-Derivate mit lipoxygenasehemmender Wirkung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU506399B2 (en) * 1975-12-30 1980-01-03 Showa Denko Kabushiki Kaisha 3-(2-aryl-2-propyl) ureas
DE2936410A1 (de) * 1979-09-08 1981-03-26 Agfa-Gevaert Ag, 51373 Leverkusen Verfahren zur stabilisierung farbphotographischer materialien sowie farbphotographisches material
US4618692A (en) * 1981-09-03 1986-10-21 Asta-Werke Aktiengesellschaft 4-carbamoyloxy-oxazaphosphorins
US4607053A (en) * 1984-05-17 1986-08-19 E. R. Squibb & Sons, Inc. Arylhydroxamates useful as antiallergy agents
US4728670A (en) * 1986-06-04 1988-03-01 E. R. Squibb & Sons, Inc. Biphenyl hydroxamic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0292699A2 (de) * 1987-04-24 1988-11-30 Abbott Laboratories Harnstoff-Derivate mit lipoxygenasehemmender Wirkung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: 1-8; CLAIM NOT SEARCHED: 9 *

Also Published As

Publication number Publication date
EP0588785A4 (de) 1991-12-30
CA2050597A1 (en) 1990-10-01
JPH04504261A (ja) 1992-07-30
EP0588785A1 (de) 1994-03-30
WO1990012008A1 (en) 1990-10-18

Similar Documents

Publication Publication Date Title
GR900100231A (el) Ανασταλτικές συν?έσεις λιποξυγενάσης βασιζόμενες σε ουρία.
GR1000126B (el) Απορροφητικα υλικα που περικλειουν εναν πηκτικο παραγοντα και απορροφητικα αντικειμενα που περιεχουν τετοια υλικα.
GR900100206A (el) Μέ?οδος παρασκευής νέων συν?έσεων ινσουλίνης.
GR890100168A (el) Βελτιωμένη διαμόρφωση ?ύλακος για συρραπτικές διατάξεις εσωτερικών οργάνων.
GR890100190A (el) Μεθοδος δια την παρασκευη φαρμακευτικων συνθεσεων δια συστηματικην διαδερμικην χορηγησιν.
GR1000129B (el) Κοιλο αντηχειο λειζερ υψηλης ανακλαστικοτητος.
GR900100334A (en) Stabilized compositions comprising an epidermic growth agent
ZA906579B (en) 17 beta-acyl-4-aza-5 alpha-androst-1-ene-3-ones as 5 alpha-reductase inhibitors
GB2232108B (en) Application of wear resisting coating
GR900100180A (el) Μέ?οδος παρασκευής αντιαλλεργικών παραγόντων διϋδροπυριμιδίνης.
GR890100169A (el) Τροποποιημενοι υδροφιλοι πολυεστερες.
EP0391653A3 (en) Lubricant compositions
GB8911287D0 (en) Lubricant compositions
GB9005602D0 (en) Elastic clutch
ZA905101B (en) Improved bipyridilium herbicidal compositions
EP0414490A3 (en) 17 beta-acyl-4-aza-5 alpha-androst-1-ene-3-one as 5 alpha-reductase inhibitors
ZA905305B (en) Lubricant composition
EP0456760A4 (en) Lipoxygenase inhibiting compounds
ZA905621B (en) Compositions for friction elements
GR1000124B (el) Μεθοδος και μηχανικη διαταξη για την παραγωγη ινων ανθρακα.
GB8922715D0 (en) Herbicidal compositions
GR900100190A (el) Διάταξη ανασχέσεως για σπειρώματα πώματος.
GR900100150A (el) Μέ?οδος και συσκευή για συλλογή παραμορφώσιμων ουσιαστικώς κυλινδρικών σωμάτων, ιδιαιτέρως βυσμάτων και για την συσκευασία αυτών.
GB9200239D0 (en) Elastic waistbands for garments
AU5616990A (en) Improved oiled shoreline chemical cleaner