GR861357B - Improved method for the isolation and purification of hepatitis b surface antigen - Google Patents
Improved method for the isolation and purification of hepatitis b surface antigenInfo
- Publication number
- GR861357B GR861357B GR861357A GR860101357A GR861357B GR 861357 B GR861357 B GR 861357B GR 861357 A GR861357 A GR 861357A GR 860101357 A GR860101357 A GR 860101357A GR 861357 B GR861357 B GR 861357B
- Authority
- GR
- Greece
- Prior art keywords
- hepatitis
- isolation
- purification
- improved method
- surface antigen
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
- 239000004202 carbamide Substances 0.000 abstract 2
- 239000003599 detergent Substances 0.000 abstract 2
- 229950008882 polysorbate Drugs 0.000 abstract 2
- 229920000136 polysorbate Polymers 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008119 colloidal silica Substances 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
- 210000005253 yeast cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Magnetic Heads (AREA)
- Adornments (AREA)
- Insulated Conductors (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/739,415 US4649192A (en) | 1985-05-30 | 1985-05-30 | Method for the isolation and purification of hepatitis B surface antigen using polysorbate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR861357B true GR861357B (en) | 1986-09-25 |
Family
ID=24972199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR861357A GR861357B (en) | 1985-05-30 | 1986-05-26 | Improved method for the isolation and purification of hepatitis b surface antigen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4649192A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0204680B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS61280438A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE42679T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU589331B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1259922A (cg-RX-API-DMAC7.html) |
| DE (1) | DE3663108D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK247586A (cg-RX-API-DMAC7.html) |
| ES (1) | ES8706444A1 (cg-RX-API-DMAC7.html) |
| GR (1) | GR861357B (cg-RX-API-DMAC7.html) |
| PT (1) | PT82644B (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA863935B (cg-RX-API-DMAC7.html) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683294A (en) * | 1985-04-03 | 1987-07-28 | Smith Kline Rit, S.A. | Process for the extraction and purification of proteins from culture media producing them |
| JPS63501121A (ja) * | 1985-08-15 | 1988-04-28 | アムジエン | 酵母細胞からb型肝炎表面抗原を抽出するための細胞溶解法および緩衝液 |
| US4742158A (en) * | 1986-04-25 | 1988-05-03 | Merck & Co., Inc. | Purification of hepatitis pre-S antigens by polymerized serum albumin affinity binding |
| JPH0789951B2 (ja) * | 1986-06-18 | 1995-10-04 | 財団法人阪大微生物病研究会 | 遺伝子発現産物の精製法 |
| RU1389060C (ru) * | 1986-08-13 | 1993-06-30 | Институт иммунологии | Способ получени рекомбинатной вакцины к гепатиту В |
| US4683293A (en) * | 1986-10-20 | 1987-07-28 | Phillips Petroleum Company | Purification of pichia produced lipophilic proteins |
| US5026828A (en) * | 1987-02-27 | 1991-06-25 | Merck & Co., Inc. | Method of purifying recombinant pres-1/S-2/S/S hepatitis B antigen from yeast |
| ATE91304T1 (de) * | 1987-02-27 | 1993-07-15 | Merck & Co Inc | Verfahren zur herstellung des pres 1/s2/shepatitis-b-antigens aus hefe. |
| IL86833A0 (en) * | 1987-06-22 | 1988-11-30 | Medico Labs | Peptide containing immunogenic particles |
| US4883865A (en) * | 1987-09-30 | 1989-11-28 | Merck & Co. Inc. | Recovery of pres2+s antigen |
| US5004688A (en) * | 1988-04-15 | 1991-04-02 | Phillips Petroleum Company | Purification of hepatitis proteins |
| US5030720A (en) * | 1988-09-01 | 1991-07-09 | Merck & Co., Inc. | Pres2+S hepatitis B vaccine derived from plasma |
| EP0491077A1 (en) * | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | A composition used as a therapeutic agent against chronic viral hepatic diseases |
| US5102989A (en) * | 1991-03-15 | 1992-04-07 | Merck & Co., Inc. | Method of stabilizing recombinant hepatitis B virus surface proteins from recombinant host cells |
| EP0533492A3 (en) * | 1991-09-18 | 1994-08-10 | Amgen Inc | A hepatitis b vaccine formulation incorporating a bile acid salt |
| KR960023066A (ko) * | 1994-12-10 | 1996-07-18 | 성재갑 | 전에스 (s) 2 펩티드 함유 비 (b) 형 간염 표면항원의 정제 방법 |
| UA79735C2 (uk) | 2000-08-10 | 2007-07-25 | Глаксосмітклайн Байолоджікалз С.А. | Очищення антигенів вірусу гепатиту b (hbv) для використання у вакцинах |
| KR100401423B1 (ko) * | 2001-01-10 | 2003-10-17 | 주식회사 엘지생명과학 | 혼합 백신의 제조 방법 |
| US20040057969A1 (en) * | 2002-09-20 | 2004-03-25 | Smith Mark L | Compositions containing stabilized hepatitis antigen and methods of their use |
| CA2617362A1 (en) * | 2005-08-02 | 2007-02-08 | Novartis Vaccines And Diagnostics S.R.L. | Reducing interference between oil-containing adjuvants and surfactant-containing antigens |
| EP2024520B1 (en) | 2006-05-11 | 2014-03-05 | Becton, Dickinson and Company | Method of protein extraction from cells |
| US9207240B2 (en) * | 2007-11-14 | 2015-12-08 | Arbor Vita Corporation | Method of efficient extraction of protein from cells |
| AU2018357917B2 (en) | 2017-10-30 | 2024-08-01 | Takeda Pharmaceutical Company Limited | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2303562A1 (fr) * | 1975-03-14 | 1976-10-08 | Community Blood Council Greate | Nouvelle preparation d'antigene utilisable comme vaccin |
| US4113712A (en) * | 1976-03-08 | 1978-09-12 | The Green Cross Corporation | HBsAG Particle composed of single polypeptide subunits and the preparation procedure |
| US4102996A (en) * | 1977-04-20 | 1978-07-25 | Merck & Co., Inc. | Method of preparing hepatitis B core antigen |
| US4136094A (en) * | 1977-08-31 | 1979-01-23 | The Regents Of The University Of Minnesota | Preparation of intravenous human and animal gamma globulins and isolation of albumin |
| US4234564A (en) * | 1977-12-19 | 1980-11-18 | Merck & Co., Inc. | Hepatitis B core antigen composition |
| US4315919A (en) * | 1980-10-06 | 1982-02-16 | Edward Shanbrom | Depyrogenation process |
| US4314997A (en) * | 1980-10-06 | 1982-02-09 | Edward Shanbrom | Purification of plasma protein products |
| JPH0625069B2 (ja) * | 1981-01-29 | 1994-04-06 | ブリティッシュ・テクノロジー・グループ・リミテッド | B型肝炎ワクチン製造方法 |
| GR76274B (cg-RX-API-DMAC7.html) * | 1981-08-04 | 1984-08-04 | Univ California | |
| NZ201705A (en) * | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4481189A (en) * | 1982-04-14 | 1984-11-06 | New York Blood Center Inc. | Process for preparing sterilized plasma and plasma derivatives |
| JPS59101426A (ja) * | 1982-11-29 | 1984-06-12 | Green Cross Corp:The | B型肝炎感染予防用ワクチンの製造方法 |
| EP0135435A3 (en) * | 1983-08-22 | 1987-03-25 | Merck & Co. Inc. | Immunogenic hbsag derived from transformed yeast |
| JPS60197629A (ja) * | 1984-03-16 | 1985-10-07 | Chemo Sero Therapeut Res Inst | HBs抗原の精製方法 |
-
1985
- 1985-05-30 US US06/739,415 patent/US4649192A/en not_active Expired - Fee Related
-
1986
- 1986-05-21 DE DE8686870069T patent/DE3663108D1/de not_active Expired
- 1986-05-21 EP EP86870069A patent/EP0204680B1/fr not_active Expired
- 1986-05-21 AT AT86870069T patent/ATE42679T1/de not_active IP Right Cessation
- 1986-05-26 AU AU57906/86A patent/AU589331B2/en not_active Ceased
- 1986-05-26 GR GR861357A patent/GR861357B/el unknown
- 1986-05-26 PT PT82644A patent/PT82644B/pt not_active IP Right Cessation
- 1986-05-26 CA CA000509934A patent/CA1259922A/en not_active Expired
- 1986-05-27 DK DK247586A patent/DK247586A/da not_active Application Discontinuation
- 1986-05-27 ZA ZA863935A patent/ZA863935B/xx unknown
- 1986-05-29 JP JP61125590A patent/JPS61280438A/ja active Granted
- 1986-05-29 ES ES555442A patent/ES8706444A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61280438A (ja) | 1986-12-11 |
| EP0204680B1 (fr) | 1989-05-03 |
| DK247586A (da) | 1986-12-01 |
| ES555442A0 (es) | 1987-07-01 |
| AU5790686A (en) | 1986-12-04 |
| ZA863935B (en) | 1987-03-25 |
| US4649192A (en) | 1987-03-10 |
| PT82644A (en) | 1986-06-01 |
| JPH0450294B2 (cg-RX-API-DMAC7.html) | 1992-08-13 |
| ES8706444A1 (es) | 1987-07-01 |
| DE3663108D1 (en) | 1989-06-08 |
| EP0204680A2 (fr) | 1986-12-10 |
| CA1259922A (en) | 1989-09-26 |
| AU589331B2 (en) | 1989-10-05 |
| EP0204680A3 (en) | 1987-01-14 |
| PT82644B (pt) | 1988-03-03 |
| DK247586D0 (da) | 1986-05-27 |
| ATE42679T1 (de) | 1989-05-15 |
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