GR860023B - Method for the preparation of peptidic derivatives with a azote polycyclic structure - Google Patents
Method for the preparation of peptidic derivatives with a azote polycyclic structureInfo
- Publication number
- GR860023B GR860023B GR860023A GR860100023A GR860023B GR 860023 B GR860023 B GR 860023B GR 860023 A GR860023 A GR 860023A GR 860100023 A GR860100023 A GR 860100023A GR 860023 B GR860023 B GR 860023B
- Authority
- GR
- Greece
- Prior art keywords
- polycyclic structure
- azote
- preparation
- optionally substituted
- carbon atoms
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- SLBZCKMOHSBDJK-UHFFFAOYSA-N [amino-[amino-(hydroxymethylsulfanyl)-sulfanylmethyl]sulfinyl-sulfanylmethyl]sulfanylmethanol Chemical compound OCSC(S)(N)S(=O)C(N)(S)SCO SLBZCKMOHSBDJK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8500140A FR2575753B1 (fr) | 1985-01-07 | 1985-01-07 | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR860023B true GR860023B (en) | 1986-05-06 |
Family
ID=9315046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR860023A GR860023B (en) | 1985-01-07 | 1986-01-07 | Method for the preparation of peptidic derivatives with a azote polycyclic structure |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4720484A (enExample) |
| EP (1) | EP0190058B1 (enExample) |
| JP (1) | JPS61161298A (enExample) |
| AT (1) | ATE31537T1 (enExample) |
| AU (1) | AU578781B2 (enExample) |
| CA (1) | CA1270596A (enExample) |
| DE (1) | DE3660010D1 (enExample) |
| ES (1) | ES8707552A1 (enExample) |
| FR (1) | FR2575753B1 (enExample) |
| GR (1) | GR860023B (enExample) |
| IE (1) | IE58273B1 (enExample) |
| NZ (1) | NZ214722A (enExample) |
| OA (1) | OA08182A (enExample) |
| PT (1) | PT81793B (enExample) |
| ZA (1) | ZA86105B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2610934B1 (fr) * | 1987-02-13 | 1989-05-05 | Adir | Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2616663B1 (fr) * | 1987-06-16 | 1989-08-18 | Adir | Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| IE63490B1 (en) * | 1988-11-24 | 1995-05-03 | Hoechst Ag | Peptides having bradykinin antagonist action |
| US5648333A (en) * | 1988-11-24 | 1997-07-15 | Hoechst Aktiengesellschaft | Peptides having bradykinin antagonist action |
| FR2649110B1 (fr) * | 1989-06-29 | 1994-10-21 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US5028593A (en) * | 1989-08-15 | 1991-07-02 | Board Of Regents, The University Of Texas System | Tuftsin analogs |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| EP0454302A3 (en) * | 1990-03-30 | 1992-10-14 | Banyu Pharmaceutical Co., Ltd. | Tuftsin derivatives |
| FR2663336B1 (fr) * | 1990-06-18 | 1992-09-04 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5391705A (en) * | 1991-03-15 | 1995-02-21 | Merrell Dow Pharmaceuticals Inc. | Polyfluorinated tripeptide thrombin inhibitors |
| US6177405B1 (en) * | 1992-07-22 | 2001-01-23 | Kenji Nishioka | Cyclic analogs of tuftsin |
| US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
| CA2216532A1 (en) * | 1995-03-29 | 1996-10-31 | S. Jane Desolms | Inhibitors of farnesyl-protein transferase |
| US6069232A (en) * | 1995-10-02 | 2000-05-30 | Hoechst Marion Roussel, Inc. | Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors |
| US5739354A (en) * | 1996-03-26 | 1998-04-14 | Hoechst Marion Roussel, Inc. | Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide |
| JP4080541B2 (ja) | 1996-10-18 | 2008-04-23 | バーテックス ファーマシューティカルズ インコーポレイテッド | セリンプロテアーゼ、特にｃ型肝炎ウイルスｎｓ３プロテアーゼの阻害因子 |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| DE60217114T2 (de) * | 2001-07-11 | 2007-10-25 | Vertex Pharmaceuticals Inc., Cambridge | Verbrückte bizyklische serinproteaseinhibitoren |
| MXPA04005557A (es) * | 2002-03-01 | 2005-05-17 | Warner Lambert Co | Metodo para tratar la osteoartritis. |
| PE20050374A1 (es) | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
| US8076352B2 (en) * | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
| US7767689B2 (en) * | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
| US8076353B2 (en) * | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
| KR20120073287A (ko) | 2004-03-15 | 2012-07-04 | 피티씨 테라퓨틱스, 인크. | 혈관형성을 억제하는데 유용한 카르볼린 유도체 |
| EP1740173A4 (en) | 2004-03-23 | 2009-05-27 | Genentech Inc | AZABICYCLOOCTAN IAP INHIBITORS |
| MY165401A (en) * | 2004-04-07 | 2018-03-21 | Novartis Ag | Inhibitors of iap |
| SI1778718T1 (sl) * | 2004-07-02 | 2015-01-30 | Genentech, Inc. | Inhibitorji IAP |
| EA019420B1 (ru) * | 2004-12-20 | 2014-03-31 | Дженентех, Инк. | Пирролидиновые ингибиторы иап (ингибиторов апоптоза) |
| AU2006275413B2 (en) * | 2005-08-02 | 2012-07-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| US7964624B1 (en) * | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| RU2451025C2 (ru) * | 2005-12-19 | 2012-05-20 | Дженентек, Инк. | Ингибиторы iap |
| US8039475B2 (en) | 2006-02-27 | 2011-10-18 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| US20070225297A1 (en) * | 2006-03-16 | 2007-09-27 | Perni Robert B | Deuterated hepatitis C protease inhibitors |
| PE20110224A1 (es) * | 2006-08-02 | 2011-04-05 | Novartis Ag | PROCEDIMIENTO PARA LA SINTESIS DE UN PEPTIDOMIMETICO DE Smac INHIBIDOR DE IAP, Y COMPUESTOS INTERMEDIARIOS PARA LA SINTESIS DEL MISMO |
| EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| US8063218B2 (en) * | 2006-12-19 | 2011-11-22 | Genentech, Inc. | Imidazopyridine inhibitors of IAP |
| PL2114924T3 (pl) * | 2007-02-27 | 2012-07-31 | Vertex Pharmceuticals Incorporated | Ko-kryształy i kompozycje farmaceutyczne je zawierające |
| AU2008219704A1 (en) * | 2007-02-27 | 2008-09-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| BRPI0809867A2 (pt) * | 2007-04-30 | 2014-09-30 | Genentech Inc | Composto, método de indução da apoptose em uma célula, método de sensibilização de uma célula para um sinal apoptótico, método para inibir a ligação de uma proteína iap a uma proteína caspase e métodos |
| MX2010002407A (es) * | 2007-08-30 | 2010-03-26 | Vertex Pharma | Cocristales y composiciones farmaceuticas que los comprenden. |
| ES2398791T3 (es) * | 2008-01-11 | 2013-03-21 | Genentech, Inc. | Inhibidores de IAP |
| WO2010017035A2 (en) | 2008-08-02 | 2010-02-11 | Genentech, Inc. | Inhibitors of iap |
| JP2012500272A (ja) * | 2008-08-16 | 2012-01-05 | ジェネンテック， インコーポレイテッド | Ｉａｐのアザインドールインヒビター |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
| EP2800737B1 (en) | 2012-01-06 | 2020-02-19 | Novus International Inc. | Sulfoxide-based surfactants |
| DK2812372T3 (en) | 2012-02-09 | 2018-11-05 | Novus Int Inc | HETEROATOM WITH CYCLIC DIMERS |
| PL2871973T3 (pl) | 2012-07-12 | 2019-02-28 | Novus International Inc. | Kompozycje matrycy i warstwy do ochrony środków bioaktywnych |
| EP3374428A4 (en) | 2015-11-12 | 2019-06-05 | Novus International Inc. | SULFUR COMPOUNDS AS SOLVENTS |
| US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5647895B2 (enExample) * | 1973-06-08 | 1981-11-12 | ||
| US4353823A (en) * | 1981-09-01 | 1982-10-12 | Chipens Gunar I | Synthetic analog of tuftisin |
-
1985
- 1985-01-07 FR FR8500140A patent/FR2575753B1/fr not_active Expired
-
1986
- 1986-01-06 AT AT86400010T patent/ATE31537T1/de not_active IP Right Cessation
- 1986-01-06 NZ NZ214722A patent/NZ214722A/xx unknown
- 1986-01-06 PT PT81793A patent/PT81793B/pt not_active IP Right Cessation
- 1986-01-06 JP JP61000483A patent/JPS61161298A/ja active Granted
- 1986-01-06 CA CA000499067A patent/CA1270596A/fr not_active Expired - Lifetime
- 1986-01-06 EP EP86400010A patent/EP0190058B1/fr not_active Expired
- 1986-01-06 DE DE8686400010T patent/DE3660010D1/de not_active Expired
- 1986-01-06 AU AU51854/86A patent/AU578781B2/en not_active Ceased
- 1986-01-06 IE IE2186A patent/IE58273B1/en not_active IP Right Cessation
- 1986-01-07 ZA ZA86105A patent/ZA86105B/xx unknown
- 1986-01-07 ES ES550716A patent/ES8707552A1/es not_active Expired
- 1986-01-07 GR GR860023A patent/GR860023B/el unknown
- 1986-01-07 OA OA58759A patent/OA08182A/xx unknown
- 1986-11-20 US US06/933,093 patent/US4720484A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ214722A (en) | 1988-09-29 |
| AU5185486A (en) | 1986-07-10 |
| DE3660010D1 (en) | 1988-02-04 |
| PT81793B (pt) | 1988-05-27 |
| ES8707552A1 (es) | 1987-08-01 |
| ZA86105B (en) | 1986-10-29 |
| FR2575753B1 (fr) | 1987-02-20 |
| CA1270596A (fr) | 1990-06-19 |
| OA08182A (fr) | 1987-10-30 |
| IE58273B1 (en) | 1993-08-25 |
| EP0190058B1 (fr) | 1987-12-23 |
| IE860021L (en) | 1986-07-07 |
| PT81793A (fr) | 1986-02-01 |
| FR2575753A1 (fr) | 1986-07-11 |
| JPH0229080B2 (enExample) | 1990-06-27 |
| ATE31537T1 (de) | 1988-01-15 |
| EP0190058A1 (fr) | 1986-08-06 |
| US4720484A (en) | 1988-01-19 |
| JPS61161298A (ja) | 1986-07-21 |
| ES550716A0 (es) | 1987-08-01 |
| AU578781B2 (en) | 1988-11-03 |
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