ATE31537T1 - Peptidderivate mit polyzyklischer stickstoffstruktur, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen. - Google Patents

Peptidderivate mit polyzyklischer stickstoffstruktur, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Info

Publication number
ATE31537T1
ATE31537T1 AT86400010T AT86400010T ATE31537T1 AT E31537 T1 ATE31537 T1 AT E31537T1 AT 86400010 T AT86400010 T AT 86400010T AT 86400010 T AT86400010 T AT 86400010T AT E31537 T1 ATE31537 T1 AT E31537T1
Authority
AT
Austria
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
peptide derivatives
optionally substituted
Prior art date
Application number
AT86400010T
Other languages
German (de)
English (en)
Inventor
Michel Vincent
Georges Remond
Claude Cudennec
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of ATE31537T1 publication Critical patent/ATE31537T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
AT86400010T 1985-01-07 1986-01-06 Peptidderivate mit polyzyklischer stickstoffstruktur, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen. ATE31537T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8500140A FR2575753B1 (fr) 1985-01-07 1985-01-07 Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP86400010A EP0190058B1 (fr) 1985-01-07 1986-01-06 Nouveaux dérivés peptidiques à structure polycyclique azotée, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ATE31537T1 true ATE31537T1 (de) 1988-01-15

Family

ID=9315046

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86400010T ATE31537T1 (de) 1985-01-07 1986-01-06 Peptidderivate mit polyzyklischer stickstoffstruktur, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Country Status (15)

Country Link
US (1) US4720484A (enExample)
EP (1) EP0190058B1 (enExample)
JP (1) JPS61161298A (enExample)
AT (1) ATE31537T1 (enExample)
AU (1) AU578781B2 (enExample)
CA (1) CA1270596A (enExample)
DE (1) DE3660010D1 (enExample)
ES (1) ES8707552A1 (enExample)
FR (1) FR2575753B1 (enExample)
GR (1) GR860023B (enExample)
IE (1) IE58273B1 (enExample)
NZ (1) NZ214722A (enExample)
OA (1) OA08182A (enExample)
PT (1) PT81793B (enExample)
ZA (1) ZA86105B (enExample)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2610934B1 (fr) * 1987-02-13 1989-05-05 Adir Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2616663B1 (fr) * 1987-06-16 1989-08-18 Adir Nouveaux tripeptides a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
US5648333A (en) * 1988-11-24 1997-07-15 Hoechst Aktiengesellschaft Peptides having bradykinin antagonist action
FR2649110B1 (fr) * 1989-06-29 1994-10-21 Adir Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5028593A (en) * 1989-08-15 1991-07-02 Board Of Regents, The University Of Texas System Tuftsin analogs
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
EP0454302A3 (en) * 1990-03-30 1992-10-14 Banyu Pharmaceutical Co., Ltd. Tuftsin derivatives
FR2663336B1 (fr) * 1990-06-18 1992-09-04 Adir Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
US6177405B1 (en) * 1992-07-22 2001-01-23 Kenji Nishioka Cyclic analogs of tuftsin
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
EP0837875A4 (en) * 1995-03-29 1998-10-07 Merck & Co Inc INHIBITORS OF FARNESYL PROTEIN TRANSFERASE
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
IN183120B (enExample) 1996-10-18 1999-09-11 Vertex Pharma
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
EP1404704B9 (en) 2001-07-11 2008-02-20 Vertex Pharmaceuticals Incorporated Bridged bicyclic serine protease inhibitors
JP2005519098A (ja) * 2002-03-01 2005-06-30 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 変形性関節症の治療方法
UY28500A1 (es) 2003-09-05 2005-04-29 Vertex Pharma Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc.
US8076353B2 (en) * 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076352B2 (en) * 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
PL1737461T3 (pl) * 2004-03-15 2013-05-31 Ptc Therapeutics Inc Pochodne karbolinowe użyteczne w hamowaniu angiogenezy
CA2558615C (en) * 2004-03-23 2013-10-29 Genentech, Inc. Azabicyclo-octane inhibitors of iap
EP2253614B1 (en) 2004-04-07 2012-09-19 Novartis AG Inhibitors of IAP
MXPA06014969A (es) * 2004-07-02 2007-02-08 Genentech Inc Inhibidores de iap.
ATE477254T1 (de) * 2004-12-20 2010-08-15 Genentech Inc Pyrrolidine als inhibitoren von iap
WO2007016589A2 (en) * 2005-08-02 2007-02-08 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7964624B1 (en) * 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
CN101374829A (zh) * 2005-12-19 2009-02-25 健泰科生物技术公司 Iap的抑制剂
EP2340836A1 (en) 2006-02-27 2011-07-06 Vertex Pharmceuticals Incorporated Co-crystals comprising VX-950 and their pharmaceutical compositions
NZ571280A (en) * 2006-03-16 2011-10-28 Vertex Pharma Deuterated hepatitis C protease inhibitors
PE20110224A1 (es) * 2006-08-02 2011-04-05 Novartis Ag PROCEDIMIENTO PARA LA SINTESIS DE UN PEPTIDOMIMETICO DE Smac INHIBIDOR DE IAP, Y COMPUESTOS INTERMEDIARIOS PARA LA SINTESIS DEL MISMO
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
JP2010513561A (ja) * 2006-12-19 2010-04-30 ジェネンテック， インコーポレイテッド Ｉａｐのイミダゾピリジンインヒビター
AU2008219704A1 (en) * 2007-02-27 2008-09-04 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
EP2463284A1 (en) * 2007-02-27 2012-06-13 Vertex Pharmceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
CN101687787A (zh) * 2007-04-30 2010-03-31 健泰科生物技术公司 Iap的抑制剂
AU2008297015B2 (en) * 2007-08-30 2013-08-22 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical compositions comprising the same
KR20100110870A (ko) * 2008-01-11 2010-10-13 제넨테크, 인크. Ｉａｐ의 억제제
NZ590550A (en) 2008-08-02 2013-05-31 Genentech Inc Inhibitors of Apoptosis (IAP) for treating cancer
US20110218211A1 (en) * 2008-08-16 2011-09-08 Genentech, Inc. Azaindole inhibitors of iap
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
MX346043B (es) 2012-01-06 2017-03-03 Novus Int Inc Tensioactivos basados en sulfoxido.
PL2812372T3 (pl) 2012-02-09 2018-12-31 Novus International Inc. Cykliczne dimery zawierające heteroatom
WO2014011857A1 (en) 2012-07-12 2014-01-16 Novus International Inc. Matrix and layer compositions for protection of bioactives
SG11201803979PA (en) 2015-11-12 2018-06-28 Novus Int Inc Sulfur-containing compounds as solvents
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5647895B2 (enExample) * 1973-06-08 1981-11-12
US4353823A (en) * 1981-09-01 1982-10-12 Chipens Gunar I Synthetic analog of tuftisin

Also Published As

Publication number Publication date
AU5185486A (en) 1986-07-10
FR2575753A1 (fr) 1986-07-11
IE860021L (en) 1986-07-07
AU578781B2 (en) 1988-11-03
DE3660010D1 (en) 1988-02-04
PT81793B (pt) 1988-05-27
US4720484A (en) 1988-01-19
ES550716A0 (es) 1987-08-01
NZ214722A (en) 1988-09-29
GR860023B (en) 1986-05-06
EP0190058A1 (fr) 1986-08-06
JPS61161298A (ja) 1986-07-21
OA08182A (fr) 1987-10-30
ES8707552A1 (es) 1987-08-01
JPH0229080B2 (enExample) 1990-06-27
IE58273B1 (en) 1993-08-25
CA1270596A (fr) 1990-06-19
PT81793A (fr) 1986-02-01
ZA86105B (en) 1986-10-29
FR2575753B1 (fr) 1987-02-20
EP0190058B1 (fr) 1987-12-23

Similar Documents

Publication Publication Date Title
ATE31537T1 (de) Peptidderivate mit polyzyklischer stickstoffstruktur, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ZA919181B (en) Oxazolopyridine derivatives,processes for preparing these and pharmaceutical compositions containing them
DE69006116D1 (de) Peptid-Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen.
DE3862596D1 (de) Peptidderivate mit polyzyklischer stickstoffstruktur, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DE68917211D1 (de) N-(5,6,7,8-Tetrahydropyrido(2,3-d)pyrimidin-6-yl-alkanoyl)-glutaminsäure-Derivate.
ZA884276B (en) Tripeptide derivatives having a polycyclic nitrogenous structure,process for the preparation thereof and pharmaceutical compositions containing them
AU639154B2 (en) New imidazole compounds, a process for the preparation thereof, and pharmaceutical compositions containing them
DE68905361D1 (de) Trienische derivate mit chromenischer struktur, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen.
ATE46347T1 (de) Immunostimulierende peptide.
DE69017771D1 (de) Thymopentin-Analoge mit allen umgekehrten Verbindungen, Verfahren zur deren Herstellung und deren Verwendung zur Herstellung von pharmazeutischen Zusammensetzungen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee