GR37760B - METHOD FOR THE PREPARATION OF NEW SUBSTITUTED PHENYLOACIC ACIDS. - Google Patents
METHOD FOR THE PREPARATION OF NEW SUBSTITUTED PHENYLOACIC ACIDS.Info
- Publication number
- GR37760B GR37760B GR670137760A GR670137760A GR37760B GR 37760 B GR37760 B GR 37760B GR 670137760 A GR670137760 A GR 670137760A GR 670137760 A GR670137760 A GR 670137760A GR 37760 B GR37760 B GR 37760B
- Authority
- GR
- Greece
- Prior art keywords
- formula
- preparation
- lower alkyl
- hydrogen
- type
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
έθοδος διά την παρασκευήν νέων υποκατεστημένων φαινυλοξεικών οξέων του τύπου Ι, (ΤΥΠΟΣ Ι) εις τον οποίον τα R1 και R2, ανεξαρτήτως το εν του άλλου, σημαίνουν κατωτέρας αλκυλ- ή αλκοξυομάδας ή άτομα αλογόνου έως ατομικού αριθμού 35, το R3 υδρογόνον ή ένα υποκαταστάτην αντίστοιχον του ορισμού διά τα R1 και R2, το R4 υδρογόνον, μίαν κατωτέραν αλκυλ-, ή αλκοξυομάδα, εν άτομον αλογόνου έως ατομικού αριθμού 35 ή την τριφθοριομεθυλομάδα, και το R5 σημαίνει υδρογόνον ή μίαν κατωτέραν αλκυλομάδα, χαρακτηριζομένη εκ του ότι θερμαίνομεν μίαν ένωσιν του γενικού τύπου ΙΙ (ΤΥΠΟΣ ΙΙ) εις τον οποίον τα R1, R2, R3, R4 και R5 έχουν την εις τον τύπον Ι δοθείσαν σημασίαν, κατά την μέθοδος των WILLGERODT-KINDLER μετά θείου και μορφολίνης και υδρολύομεν το κατ' αρχάς λαμβανόμενον μορφολίδιον του γενικού τύπου ΙΙΙ (ΤΥΠΟΣ ΙΙΙΙ) εις τον οποίον τα R1, R2, R3, R4 και R5 έχουν την εις τον τύπον Ι δοθείσαν σημασίαν.process for the preparation of novel substituted phenylacetic acids of formula I, (TYPE I) in which R1 and R2, independently of one another, mean lower alkyl- or alkoxy groups or halogen to atomic numbers 35, the R3 hydrogen or a substituent corresponding to the definition for R1 and R2, the R4 hydrogen, a lower alkyl, or alkoxy group, in a halogen to atomic number 35 or trifluoromethyl group, and R5 means hydrogen or a lower alkyl group, characterized in that a compound of general formula II is heated (TYPE II) in which R1, R2, R3, R4 and R5 have the significance given in formula I, by the method of WILLGERODT-KINDLER with sulfur and morpholine and hydrolyzing the morpholide initially obtained of general formula III (TYPE III) in which R1, R2, R3, R4 and R5 have the meaning given in formula I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1451766A CH470349A (en) | 1966-10-07 | 1966-10-07 | Process for the production of new substituted phenylacetic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR37760B true GR37760B (en) | 1969-07-12 |
Family
ID=4401487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR670137760A GR37760B (en) | 1966-10-07 | 1967-10-06 | METHOD FOR THE PREPARATION OF NEW SUBSTITUTED PHENYLOACIC ACIDS. |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT273935B (en) |
| BE (1) | BE704820A (en) |
| CH (1) | CH470349A (en) |
| DK (1) | DK120243B (en) |
| ES (1) | ES345831A1 (en) |
| FI (1) | FI47880C (en) |
| GB (1) | GB1183968A (en) |
| GR (1) | GR37760B (en) |
| NL (1) | NL6713629A (en) |
| NO (1) | NO121047B (en) |
| SE (1) | SE345997B (en) |
| YU (1) | YU32369B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT370721B (en) * | 1981-02-24 | 1983-04-25 | Ciba Geigy Ag | METHOD FOR PRODUCING NEW SALTS OF 2- (2,6-DICHLORANILINO) -PHENYLACETIC ACID, THE |
| LU83138A1 (en) * | 1981-02-16 | 1981-09-11 | T Eckert | TOPICAL PHARMACEUTICAL PREPARATIONS, CONTAINING SALTS OF ALKANCARBONIC ACIDS AND NEW CARBONIC ACID SALTS AND METHOD FOR THE PRODUCTION THEREOF |
-
1966
- 1966-10-07 CH CH1451766A patent/CH470349A/en not_active IP Right Cessation
-
1967
- 1967-10-04 FI FI265567A patent/FI47880C/en active
- 1967-10-06 YU YU194267A patent/YU32369B/en unknown
- 1967-10-06 ES ES345831A patent/ES345831A1/en not_active Expired
- 1967-10-06 DK DK497867A patent/DK120243B/en not_active IP Right Cessation
- 1967-10-06 AT AT910467A patent/AT273935B/en active
- 1967-10-06 NO NO17002467A patent/NO121047B/no unknown
- 1967-10-06 SE SE1371067A patent/SE345997B/xx unknown
- 1967-10-06 NL NL6713629A patent/NL6713629A/xx unknown
- 1967-10-06 GR GR670137760A patent/GR37760B/en unknown
- 1967-10-06 BE BE704820D patent/BE704820A/xx unknown
- 1967-10-06 GB GB4572467A patent/GB1183968A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH470349A (en) | 1969-03-31 |
| DK120243B (en) | 1971-05-03 |
| FI47880B (en) | 1974-01-02 |
| AT273935B (en) | 1969-08-25 |
| FI47880C (en) | 1974-04-10 |
| YU32369B (en) | 1974-10-31 |
| ES345831A1 (en) | 1968-11-16 |
| YU194267A (en) | 1974-04-30 |
| NO121047B (en) | 1971-01-11 |
| BE704820A (en) | 1968-04-08 |
| SE345997B (en) | 1972-06-19 |
| NL6713629A (en) | 1968-04-08 |
| GB1183968A (en) | 1970-03-11 |
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