ES409944A1 - Derivatives of pyrroleacetic acids salts thereof and their process of preparation - Google Patents
Derivatives of pyrroleacetic acids salts thereof and their process of preparationInfo
- Publication number
- ES409944A1 ES409944A1 ES409944A ES409944A ES409944A1 ES 409944 A1 ES409944 A1 ES 409944A1 ES 409944 A ES409944 A ES 409944A ES 409944 A ES409944 A ES 409944A ES 409944 A1 ES409944 A1 ES 409944A1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- preparation
- formula
- see formula
- acids salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Procedure for the preparation of derivatives of pyrrolacetic acids, of the general formula (I): **(See formula)** in which R1 represents a phenyl radical substituted by chlorine, fluorine, methyl or methoxy, characterized in that a compound of formula (II) is subjected to hydrolysis **(See formula)** in which R1 has one of the meanings given before and in which **(See formula)** R5, R6 and R7 being alkyl radicals of 2 to 4 carbon atoms, R6 and R7 can also form with the nitrogen atom a heterocycle of the piperidine or morpholine type. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE777207A BE777207A (en) | 1971-12-23 | 1971-12-23 | 3-pyrroleacetic acids - analgesics, antipyretics antiinflammatories prepd by hydrolysis of the corresp acid deriv |
BE785274A BE785274R (en) | 1972-06-22 | 1972-06-22 | Pyrrole-3-acetic acids - useful as antiinflammatory analgesic and anti pyretic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ES409944A1 true ES409944A1 (en) | 1976-03-16 |
Family
ID=25656964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES409944A Expired ES409944A1 (en) | 1971-12-23 | 1972-12-22 | Derivatives of pyrroleacetic acids salts thereof and their process of preparation |
Country Status (19)
Country | Link |
---|---|
JP (1) | JPS5318507B2 (en) |
AR (1) | AR208494A1 (en) |
AT (1) | AT323727B (en) |
AU (1) | AU467602B2 (en) |
CA (1) | CA991193A (en) |
CH (1) | CH563364A5 (en) |
DD (1) | DD104976A5 (en) |
DE (1) | DE2261965A1 (en) |
DK (1) | DK134599B (en) |
ES (1) | ES409944A1 (en) |
FR (1) | FR2164857B1 (en) |
GB (1) | GB1406330A (en) |
HU (1) | HU165900B (en) |
IE (1) | IE37237B1 (en) |
IL (1) | IL41146A (en) |
NL (1) | NL7217521A (en) |
OA (1) | OA04523A (en) |
PL (1) | PL89071B1 (en) |
SE (1) | SE388853B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2645234A1 (en) * | 1976-10-07 | 1978-04-20 | Basf Ag | 2,5-DIALKOXY-3-AMINO-METHYLTETRAHYDROFURANS AND THE METHOD FOR THEIR PRODUCTION |
US4248784A (en) * | 1977-02-25 | 1981-02-03 | Sterling Drug Inc. | Pyrrole-3-acetamides |
DE3026402A1 (en) * | 1980-07-11 | 1982-02-04 | Syntex Corp., Palo Alto, Calif. | Non-steroidal antiinflammatory agents - for treatment of micro:vascular disease, e.g. diabetic retinopathy or diabetic nephropathy |
US4973704A (en) * | 1985-10-25 | 1990-11-27 | Sandoz Pharm. Corp. | Pyrrolyl intermediates in the synthesis of pyrrole analogs of mevalonolactone and derivatives thereof |
US4851427A (en) * | 1985-10-25 | 1989-07-25 | Sandoz Pharm. Corp. | Pyrrole analogs of mevalonolactone, derivatives thereof and pharmaceutical use |
KR900001212B1 (en) * | 1985-10-25 | 1990-02-28 | 산도즈 파마슈티칼스 코오포레이숀 | Mevalonolactones and their derivatives and process and pharmaceutical use, thereof |
US5260451A (en) * | 1989-05-11 | 1993-11-09 | Merckle Gmbh | Substituted pyrrole compounds and use thereof in pharmaceutical compositions |
DE3915450A1 (en) * | 1989-05-11 | 1990-11-15 | Gerd Prof Dr Dannhardt | SUBSTITUTED PYRROL COMPOUNDS AND THEIR USE IN PHARMACY |
US5935990A (en) * | 1996-12-10 | 1999-08-10 | G.D. Searle & Co. | Substituted pyrrolyl compounds for the treatment of inflammation |
ES2555511T3 (en) * | 2006-08-03 | 2016-01-04 | Rottapharm Biotech S.R.L. | Highly selective and effective oral COX-2 inhibitors of 3-substituted 1,5-diaryl-2-alkyl pyrroles |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1228301A (en) * | 1968-04-16 | 1971-04-15 |
-
1972
- 1972-12-18 DE DE19722261965 patent/DE2261965A1/en active Pending
- 1972-12-20 HU HUCO272A patent/HU165900B/hu unknown
- 1972-12-20 GB GB5877272A patent/GB1406330A/en not_active Expired
- 1972-12-20 AU AU50338/72A patent/AU467602B2/en not_active Expired
- 1972-12-21 AR AR245771A patent/AR208494A1/en active
- 1972-12-21 AT AT1093772A patent/AT323727B/en not_active IP Right Cessation
- 1972-12-21 SE SE7216774A patent/SE388853B/en unknown
- 1972-12-21 DK DK638372AA patent/DK134599B/en unknown
- 1972-12-21 IE IE1781/72A patent/IE37237B1/en unknown
- 1972-12-21 PL PL1972159744A patent/PL89071B1/en unknown
- 1972-12-22 CA CA159,778A patent/CA991193A/en not_active Expired
- 1972-12-22 ES ES409944A patent/ES409944A1/en not_active Expired
- 1972-12-22 FR FR7245868A patent/FR2164857B1/fr not_active Expired
- 1972-12-22 DD DD168267*A patent/DD104976A5/xx unknown
- 1972-12-22 NL NL7217521A patent/NL7217521A/xx unknown
- 1972-12-22 IL IL41146A patent/IL41146A/en unknown
- 1972-12-22 CH CH1882972A patent/CH563364A5/fr not_active IP Right Cessation
- 1972-12-23 OA OA54792A patent/OA04523A/en unknown
- 1972-12-23 JP JP404973A patent/JPS5318507B2/ja not_active Expired
Also Published As
Publication number | Publication date |
---|---|
AR208494A1 (en) | 1977-02-15 |
JPS5318507B2 (en) | 1978-06-15 |
JPS4868562A (en) | 1973-09-18 |
AU5033872A (en) | 1974-06-20 |
SE388853B (en) | 1976-10-18 |
DK134599C (en) | 1977-05-09 |
CH563364A5 (en) | 1975-06-30 |
DD104976A5 (en) | 1974-04-05 |
IE37237L (en) | 1973-06-23 |
AT323727B (en) | 1975-07-25 |
CA991193A (en) | 1976-06-15 |
NL7217521A (en) | 1973-06-26 |
FR2164857B1 (en) | 1976-03-05 |
DE2261965A1 (en) | 1973-06-28 |
PL89071B1 (en) | 1976-10-30 |
FR2164857A1 (en) | 1973-08-03 |
DK134599B (en) | 1976-12-06 |
HU165900B (en) | 1974-12-28 |
GB1406330A (en) | 1975-09-17 |
AU467602B2 (en) | 1974-06-20 |
OA04523A (en) | 1980-03-30 |
IE37237B1 (en) | 1977-06-08 |
IL41146A (en) | 1977-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES403503A1 (en) | Procedure for the preparation of piperidine derivatives and their use as stabilizers (Machine-translation by Google Translate, not legally binding) | |
ES394369A1 (en) | Pharmacologically active 3-piperazinyl-carbonyloxy-2-pyridyl-isoindolin-1-ones | |
ES409944A1 (en) | Derivatives of pyrroleacetic acids salts thereof and their process of preparation | |
ES331339A1 (en) | Procedure for the preparation of substitute alkylpenidines. (Machine-translation by Google Translate, not legally binding) | |
ES410190A1 (en) | Novel metallized heterocyclic derivatives | |
ES408615A1 (en) | Novel oxazolidone derivatives and preparation thereof | |
ES389473A1 (en) | Derivatives of 3-aminocarbonyl-2-oxazolidinone and their process of preparation | |
ES440438A1 (en) | Procedure for the preparation of new derivatives of fenilbutazona. (Machine-translation by Google Translate, not legally binding) | |
ES296634A1 (en) | Procedure for the production of new heterocyclic compounds (Machine-translation by Google Translate, not legally binding) | |
ES418841A1 (en) | Derivatives of pyridine-3-acetic acid | |
ES400414A1 (en) | Procedure for the preparation of N-substituted piperidine derivatives and their use as stabilizers. (Machine-translation by Google Translate, not legally binding) | |
GB1453394A (en) | Phenylpropylamine derivatives | |
ES411737A1 (en) | Heterocyclic triglycidyl compounds and a process for their production | |
ES326789A1 (en) | Procedure for the obtaining of esters of the tiol-o tionotilfosforico or phosphonic acid. (Machine-translation by Google Translate, not legally binding) | |
ES274910A1 (en) | Iminodibenzyl derivatives | |
ES321807A1 (en) | Procedure for the synthesis of new derivatives of 1,2,3,6-tetrahidropiridina. (Machine-translation by Google Translate, not legally binding) | |
ES410198A1 (en) | Semi-carbazides and thiosemicarbazides and their preparation | |
ES405080A1 (en) | Bis-(para-chlorophenoxy)carbinol and ethers thereof | |
ES320084A1 (en) | Procedure for the preparation of derivatives of difenylamine. (Machine-translation by Google Translate, not legally binding) | |
ES414340A1 (en) | Piperazine derivatives | |
ES304704A1 (en) | Procedure for the obtaining of derivatives of tieno-benzotiapirano. (Machine-translation by Google Translate, not legally binding) | |
ES408560A1 (en) | Procedure for the obtaining of methanophosphonic acids. (Machine-translation by Google Translate, not legally binding) | |
ES399820A1 (en) | Aminopropanol derivatives | |
ES294219A1 (en) | Procedure for the production of tiaxantene derivatives (Machine-translation by Google Translate, not legally binding) | |
ES404115A1 (en) | Novel 1-benzoyloxy-2-lower alkylamino-benzocycloalkane derivatives |