ES345831A1 - A Process for the Production of Substituted Phenyl Acetic Acids - Google Patents

A Process for the Production of Substituted Phenyl Acetic Acids

Info

Publication number
ES345831A1
ES345831A1 ES345831A ES345831A ES345831A1 ES 345831 A1 ES345831 A1 ES 345831A1 ES 345831 A ES345831 A ES 345831A ES 345831 A ES345831 A ES 345831A ES 345831 A1 ES345831 A1 ES 345831A1
Authority
ES
Spain
Prior art keywords
general formula
anilino
hydrogen
alkyl
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES345831A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES345831A1 publication Critical patent/ES345831A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

o-Anilino-phenylacetic acid derivatives of the general formula wherein R 1 and R 2 are each a C 1-4 alkyl or C 1-4 alkoxy group or a fluorine, chlorine or bromine atom R 3 is hydrogen or is defined as R 1 and R 2 R 4 is hydrogen, a C 1-4 alkyl or C 1-4 alkoxy group, a fluorine, chlorine or bromine atom or the trifluoromethyl group and R 5 is hydrogen or a C 1-4 alkyl group, are prepared by heating an o-anilino-acetophenone of the general formula with sulphur and morpholine according to the Willgerodt-Kindler method and hydrolysing the resulting 4 - [(o - anilinophenyl) - thioacetyl]- morpholine of the general formula o-Anilino-acetophenones of the second general formula above are prepared by reacting (ethoxymagnesium)-malonic acid diethyl ester with an appropriately substituted N-phenyl-anthranilic acid chloride in absolute ethanol and heating the resulting substituted (N-phenyl-anthraniloyl)-malonic acid diethyl ester in an acidic medium.
ES345831A 1966-10-07 1967-10-06 A Process for the Production of Substituted Phenyl Acetic Acids Expired ES345831A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1451766A CH470349A (en) 1966-10-07 1966-10-07 Process for the production of new substituted phenylacetic acids

Publications (1)

Publication Number Publication Date
ES345831A1 true ES345831A1 (en) 1968-11-16

Family

ID=4401487

Family Applications (1)

Application Number Title Priority Date Filing Date
ES345831A Expired ES345831A1 (en) 1966-10-07 1967-10-06 A Process for the Production of Substituted Phenyl Acetic Acids

Country Status (12)

Country Link
AT (1) AT273935B (en)
BE (1) BE704820A (en)
CH (1) CH470349A (en)
DK (1) DK120243B (en)
ES (1) ES345831A1 (en)
FI (1) FI47880C (en)
GB (1) GB1183968A (en)
GR (1) GR37760B (en)
NL (1) NL6713629A (en)
NO (1) NO121047B (en)
SE (1) SE345997B (en)
YU (1) YU32369B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU83138A1 (en) * 1981-02-16 1981-09-11 T Eckert TOPICAL PHARMACEUTICAL PREPARATIONS, CONTAINING SALTS OF ALKANCARBONIC ACIDS AND NEW CARBONIC ACID SALTS AND METHOD FOR THE PRODUCTION THEREOF
AT370721B (en) * 1981-02-24 1983-04-25 Ciba Geigy Ag METHOD FOR PRODUCING NEW SALTS OF 2- (2,6-DICHLORANILINO) -PHENYLACETIC ACID, THE

Also Published As

Publication number Publication date
BE704820A (en) 1968-04-08
NO121047B (en) 1971-01-11
SE345997B (en) 1972-06-19
AT273935B (en) 1969-08-25
FI47880B (en) 1974-01-02
FI47880C (en) 1974-04-10
YU194267A (en) 1974-04-30
YU32369B (en) 1974-10-31
GB1183968A (en) 1970-03-11
CH470349A (en) 1969-03-31
DK120243B (en) 1971-05-03
NL6713629A (en) 1968-04-08
GR37760B (en) 1969-07-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19860809