GR3036142T3 - Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents - Google Patents
Thiazolidine-4-carboxylic acid derivatives as cytoprotective agentsInfo
- Publication number
- GR3036142T3 GR3036142T3 GR20010400996T GR20010400996T GR3036142T3 GR 3036142 T3 GR3036142 T3 GR 3036142T3 GR 20010400996 T GR20010400996 T GR 20010400996T GR 20010400996 T GR20010400996 T GR 20010400996T GR 3036142 T3 GR3036142 T3 GR 3036142T3
- Authority
- GR
- Greece
- Prior art keywords
- pct
- thiazolidine
- carboxylic acid
- cytoprotective agents
- acid derivatives
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 230000001120 cytoprotective effect Effects 0.000 title abstract 2
- DZLNHFMRPBPULJ-UHFFFAOYSA-N thioproline Chemical class OC(=O)C1CSCN1 DZLNHFMRPBPULJ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 230000007760 free radical scavenging Effects 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1402796P | 1996-03-25 | 1996-03-25 | |
PCT/US1997/004387 WO1997035852A1 (en) | 1996-03-25 | 1997-03-19 | Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3036142T3 true GR3036142T3 (en) | 2001-09-28 |
Family
ID=21763110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20010400996T GR3036142T3 (en) | 1996-03-25 | 2001-06-27 | Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents |
Country Status (11)
Country | Link |
---|---|
US (1) | US5846988A (el) |
EP (1) | EP0842165B1 (el) |
JP (1) | JPH11507081A (el) |
AT (1) | ATE201204T1 (el) |
CA (1) | CA2220024C (el) |
DE (1) | DE69704833T2 (el) |
DK (1) | DK0842165T3 (el) |
ES (1) | ES2156633T3 (el) |
GR (1) | GR3036142T3 (el) |
PT (1) | PT842165E (el) |
WO (1) | WO1997035852A1 (el) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1257273A2 (en) | 1999-08-17 | 2002-11-20 | University of Saskatchewan Technologies Inc. | Improved treatment for acute physical insult to the central nervous system |
US6511950B1 (en) * | 2002-07-30 | 2003-01-28 | Earl Jenevein | Cleaning composition comprising a salt, chelant, and polyvinyl alcohol |
US7045492B2 (en) * | 2002-07-30 | 2006-05-16 | Earl Jenevein | Cleaning composition comprising cationic surfactants, chelant, and an alcohol solvent mixture |
US20060189497A1 (en) * | 2002-07-30 | 2006-08-24 | Earl Jenevein | Wood preservative |
WO2005032544A1 (en) | 2003-09-19 | 2005-04-14 | Galileo Pharmaceuticals, Inc. | Treatment of mitochondrial diseases |
WO2006089053A2 (en) | 2005-02-17 | 2006-08-24 | Wyeth | Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives |
EP2471530B1 (en) | 2005-06-01 | 2017-01-11 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
EA021818B1 (ru) * | 2005-09-15 | 2015-09-30 | Эдисон Фармасьютикалз, Инк. | Варианты хвостовой части редокс-активных лекарственных средств для лечения митохондриальных болезней и модуляция биомаркера энергетического обмена q10 |
JP5374162B2 (ja) | 2006-02-22 | 2013-12-25 | エジソン ファーマシューティカルズ, インコーポレイテッド | ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節 |
US20080188573A1 (en) * | 2007-02-02 | 2008-08-07 | Alcon Research, Ltd. | Use of thy1-fp transgenic mouse for the identification of ophthalmic agents |
US8685951B2 (en) | 2007-03-27 | 2014-04-01 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods for cytoprotection |
CA2736250C (en) | 2008-09-10 | 2016-12-20 | Edison Pharmaceuticals, Inc. | Treatment of pervasive developmental disorders with redox-active therapeutics |
KR101395146B1 (ko) | 2011-02-09 | 2014-05-16 | 부산대학교 산학협력단 | 피부미백, 항산화 및 ppar 활성을 갖는 신규 화합물 및 이의 의학적 용도 |
CN113024369A (zh) | 2015-12-17 | 2021-06-25 | Ptc医疗公司 | 用于治疗氧化应急障碍的化合物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3002989A1 (de) * | 1980-01-29 | 1981-07-30 | Hoechst Ag, 6000 Frankfurt | Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels |
US4550022A (en) * | 1981-10-05 | 1985-10-29 | Alcon Laboratories, Inc. | Tissue irrigating solution |
FR2547728B1 (fr) * | 1983-06-24 | 1986-05-02 | Riker Laboratories Inc | Medicament a base d'acide d thiazolidine carboxylique |
FR2547729B1 (fr) * | 1983-06-24 | 1986-05-02 | Riker Laboratories Inc | Medicament a base d'acide dl thiazolidine carboxylique |
US4868114A (en) * | 1987-08-05 | 1989-09-19 | Regents Of The University Of Minnesota | Method for elevating glutathione levels |
IT1223565B (it) * | 1987-12-21 | 1990-09-19 | Zambon Spa | Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica |
JPH02202818A (ja) * | 1988-12-09 | 1990-08-10 | Allergan Inc | 白内障の治療における2―置換―チアゾリジン―4―カルボン酸類の用途 |
US5589464A (en) * | 1992-09-01 | 1996-12-31 | Allergan | Use of 2-substituted-thiazolidine-4-carboxylic acids for treatment of cataract |
US5424321A (en) * | 1993-12-08 | 1995-06-13 | Alcon Laboratories, Inc. | Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents |
KR960701033A (ko) * | 1993-12-08 | 1996-02-24 | 그레그 씨.브라운 | 효능있는 칼슘 길항 및 산화방지 활성을 모두 갖는 화합물, 및 세포보호제로서 그것의 사용방법(compounds having both potent calcium antagonist and antioxidant activity and use there of as cytoprotective agents) |
-
1997
- 1997-03-19 WO PCT/US1997/004387 patent/WO1997035852A1/en active IP Right Grant
- 1997-03-19 ES ES97917549T patent/ES2156633T3/es not_active Expired - Lifetime
- 1997-03-19 JP JP9534485A patent/JPH11507081A/ja not_active Withdrawn
- 1997-03-19 DK DK97917549T patent/DK0842165T3/da active
- 1997-03-19 DE DE69704833T patent/DE69704833T2/de not_active Expired - Fee Related
- 1997-03-19 CA CA002220024A patent/CA2220024C/en not_active Expired - Fee Related
- 1997-03-19 US US08/945,132 patent/US5846988A/en not_active Expired - Fee Related
- 1997-03-19 PT PT97917549T patent/PT842165E/pt unknown
- 1997-03-19 AT AT97917549T patent/ATE201204T1/de not_active IP Right Cessation
- 1997-03-19 EP EP97917549A patent/EP0842165B1/en not_active Expired - Lifetime
-
2001
- 2001-06-27 GR GR20010400996T patent/GR3036142T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0842165B1 (en) | 2001-05-16 |
CA2220024A1 (en) | 1997-10-02 |
US5846988A (en) | 1998-12-08 |
WO1997035852A1 (en) | 1997-10-02 |
CA2220024C (en) | 2002-06-25 |
ES2156633T3 (es) | 2001-07-01 |
AU2584097A (en) | 1997-10-17 |
DE69704833D1 (en) | 2001-06-21 |
DK0842165T3 (da) | 2001-08-06 |
ATE201204T1 (de) | 2001-06-15 |
DE69704833T2 (de) | 2001-09-13 |
AU713581B2 (en) | 1999-12-02 |
EP0842165A1 (en) | 1998-05-20 |
JPH11507081A (ja) | 1999-06-22 |
PT842165E (pt) | 2001-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ML | Lapse due to non-payment of fees |