DE69704833T2 - Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittel - Google Patents

Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittel

Info

Publication number
DE69704833T2
DE69704833T2 DE69704833T DE69704833T DE69704833T2 DE 69704833 T2 DE69704833 T2 DE 69704833T2 DE 69704833 T DE69704833 T DE 69704833T DE 69704833 T DE69704833 T DE 69704833T DE 69704833 T2 DE69704833 T2 DE 69704833T2
Authority
DE
Germany
Prior art keywords
pct
thiazolidine
derivatives
carbonic acid
date oct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69704833T
Other languages
English (en)
Other versions
DE69704833D1 (en
Inventor
R Hellberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Application granted granted Critical
Publication of DE69704833D1 publication Critical patent/DE69704833D1/de
Publication of DE69704833T2 publication Critical patent/DE69704833T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Cigarettes, Filters, And Manufacturing Of Filters (AREA)
  • Stringed Musical Instruments (AREA)
  • Packages (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69704833T 1996-03-25 1997-03-19 Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittel Expired - Fee Related DE69704833T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1402796P 1996-03-25 1996-03-25
PCT/US1997/004387 WO1997035852A1 (en) 1996-03-25 1997-03-19 Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents

Publications (2)

Publication Number Publication Date
DE69704833D1 DE69704833D1 (en) 2001-06-21
DE69704833T2 true DE69704833T2 (de) 2001-09-13

Family

ID=21763110

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69704833T Expired - Fee Related DE69704833T2 (de) 1996-03-25 1997-03-19 Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittel

Country Status (11)

Country Link
US (1) US5846988A (de)
EP (1) EP0842165B1 (de)
JP (1) JPH11507081A (de)
AT (1) ATE201204T1 (de)
CA (1) CA2220024C (de)
DE (1) DE69704833T2 (de)
DK (1) DK0842165T3 (de)
ES (1) ES2156633T3 (de)
GR (1) GR3036142T3 (de)
PT (1) PT842165E (de)
WO (1) WO1997035852A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2419845A1 (en) 1999-08-17 2002-02-22 Phyllis G. Paterson Improved treatment for acute physical insult to the central nervous system
US7045492B2 (en) * 2002-07-30 2006-05-16 Earl Jenevein Cleaning composition comprising cationic surfactants, chelant, and an alcohol solvent mixture
US20060189497A1 (en) * 2002-07-30 2006-08-24 Earl Jenevein Wood preservative
US6511950B1 (en) * 2002-07-30 2003-01-28 Earl Jenevein Cleaning composition comprising a salt, chelant, and polyvinyl alcohol
WO2005032544A1 (en) 2003-09-19 2005-04-14 Galileo Pharmaceuticals, Inc. Treatment of mitochondrial diseases
CN101120002A (zh) 2005-02-17 2008-02-06 惠氏公司 环烷基稠合的吲哚、苯并噻吩、苯并呋喃和茚衍生物
EP2471530B1 (de) 2005-06-01 2017-01-11 Edison Pharmaceuticals, Inc. Redoxaktive therapeutik zur behandlung von mitochondrialen erkrankungen und anderen zuständen sowie modulation von energie-biomarkern
JP2009508867A (ja) * 2005-09-15 2009-03-05 エジソン ファーマシューティカルズ， インコーポレイテッド ミトコンドリア病および関連した様態の治療ならびにエネルギーバイオマーカーの調節のための酸化還元活性治療剤のテイル改変体
EP1986636B1 (de) 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol- und 1,4-benzochinon-derivate zur verwendung in der behandlung von erkrankungen der mitochondrien
US20080188573A1 (en) * 2007-02-02 2008-08-07 Alcon Research, Ltd. Use of thy1-fp transgenic mouse for the identification of ophthalmic agents
US8685951B2 (en) 2007-03-27 2014-04-01 The Board Of Trustees Of The University Of Arkansas Compositions and methods for cytoprotection
US8314153B2 (en) 2008-09-10 2012-11-20 Edison Pharmaceuticals, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
KR101395146B1 (ko) 2011-02-09 2014-05-16 부산대학교 산학협력단 피부미백, 항산화 및 ｐｐａｒ 활성을 갖는 신규 화합물 및 이의 의학적 용도
AU2016369616B2 (en) 2015-12-17 2021-03-25 Ptc Therapeutics, Inc. Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3002989A1 (de) * 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
US4550022A (en) * 1981-10-05 1985-10-29 Alcon Laboratories, Inc. Tissue irrigating solution
FR2547729B1 (fr) * 1983-06-24 1986-05-02 Riker Laboratories Inc Medicament a base d'acide dl thiazolidine carboxylique
FR2547728B1 (fr) * 1983-06-24 1986-05-02 Riker Laboratories Inc Medicament a base d'acide d thiazolidine carboxylique
US4868114A (en) * 1987-08-05 1989-09-19 Regents Of The University Of Minnesota Method for elevating glutathione levels
IT1223565B (it) * 1987-12-21 1990-09-19 Zambon Spa Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica
ATE119038T1 (de) * 1988-12-09 1995-03-15 Allergan Inc Verwendung von 2-substituierten thiazolidin-4- carbonsäuren zur behandlung von katarakt.
US5589464A (en) * 1992-09-01 1996-12-31 Allergan Use of 2-substituted-thiazolidine-4-carboxylic acids for treatment of cataract
EP0682664B1 (de) * 1993-12-08 2001-03-14 Alcon Laboratories, Inc. Verbindungen die sowohl starke calcium-antagonistische und antioxydatieve aktivitaet haben und deren verwendung als zellschuetzende mittel.
US5424321A (en) * 1993-12-08 1995-06-13 Alcon Laboratories, Inc. Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents

Also Published As

Publication number Publication date
EP0842165A1 (de) 1998-05-20
ATE201204T1 (de) 2001-06-15
CA2220024C (en) 2002-06-25
JPH11507081A (ja) 1999-06-22
PT842165E (pt) 2001-08-30
ES2156633T3 (es) 2001-07-01
DE69704833D1 (en) 2001-06-21
US5846988A (en) 1998-12-08
GR3036142T3 (en) 2001-09-28
AU713581B2 (en) 1999-12-02
CA2220024A1 (en) 1997-10-02
DK0842165T3 (da) 2001-08-06
AU2584097A (en) 1997-10-17
EP0842165B1 (de) 2001-05-16
WO1997035852A1 (en) 1997-10-02

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee