DE69704833T2 - Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittel - Google Patents

Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittel

Info

Publication number
DE69704833T2
DE69704833T2 DE69704833T DE69704833T DE69704833T2 DE 69704833 T2 DE69704833 T2 DE 69704833T2 DE 69704833 T DE69704833 T DE 69704833T DE 69704833 T DE69704833 T DE 69704833T DE 69704833 T2 DE69704833 T2 DE 69704833T2
Authority
DE
Germany
Prior art keywords
pct
thiazolidine
derivatives
carbonic acid
date oct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69704833T
Other languages
English (en)
Other versions
DE69704833D1 (en
Inventor
R Hellberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Publication of DE69704833D1 publication Critical patent/DE69704833D1/de
Application granted granted Critical
Publication of DE69704833T2 publication Critical patent/DE69704833T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Detergent Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Cigarettes, Filters, And Manufacturing Of Filters (AREA)
  • Stringed Musical Instruments (AREA)
  • Packages (AREA)
DE69704833T 1996-03-25 1997-03-19 Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittel Expired - Fee Related DE69704833T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1402796P 1996-03-25 1996-03-25
PCT/US1997/004387 WO1997035852A1 (en) 1996-03-25 1997-03-19 Thiazolidine-4-carboxylic acid derivatives as cytoprotective agents

Publications (2)

Publication Number Publication Date
DE69704833D1 DE69704833D1 (en) 2001-06-21
DE69704833T2 true DE69704833T2 (de) 2001-09-13

Family

ID=21763110

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69704833T Expired - Fee Related DE69704833T2 (de) 1996-03-25 1997-03-19 Derivate der thiazolidine-4-carbonsäure als cytoprotektive mittel

Country Status (11)

Country Link
US (1) US5846988A (de)
EP (1) EP0842165B1 (de)
JP (1) JPH11507081A (de)
AT (1) ATE201204T1 (de)
CA (1) CA2220024C (de)
DE (1) DE69704833T2 (de)
DK (1) DK0842165T3 (de)
ES (1) ES2156633T3 (de)
GR (1) GR3036142T3 (de)
PT (1) PT842165E (de)
WO (1) WO1997035852A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6676100A (en) 1999-08-17 2001-03-13 University Of Saskatchewan Technologies Inc. Improved treatment for acute physical insult to the central nervous system
US6511950B1 (en) * 2002-07-30 2003-01-28 Earl Jenevein Cleaning composition comprising a salt, chelant, and polyvinyl alcohol
US20060189497A1 (en) * 2002-07-30 2006-08-24 Earl Jenevein Wood preservative
US7045492B2 (en) * 2002-07-30 2006-05-16 Earl Jenevein Cleaning composition comprising cationic surfactants, chelant, and an alcohol solvent mixture
CA2583087C (en) 2003-09-19 2012-07-10 Galileo Pharmaceuticals, Inc. Chroman derivatives
US7297704B2 (en) 2005-02-17 2007-11-20 Wyeth Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives
WO2006130775A2 (en) 2005-06-01 2006-12-07 Edison Pharmaceuticals, Inc. Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomakers
LT1933821T (lt) * 2005-09-15 2020-11-10 Ptc Therapeutics, Inc. Šoninės grandinės variantai redoks aktyviųjų terapijos priemonių, skirtų mitochondrinių ligų ir kitokių būklių gydymui ir energijos biologinių žymenų moduliavimui
EP1986636B1 (de) 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol- und 1,4-benzochinon-derivate zur verwendung in der behandlung von erkrankungen der mitochondrien
US20080188573A1 (en) * 2007-02-02 2008-08-07 Alcon Research, Ltd. Use of thy1-fp transgenic mouse for the identification of ophthalmic agents
US8685951B2 (en) 2007-03-27 2014-04-01 The Board Of Trustees Of The University Of Arkansas Compositions and methods for cytoprotection
CA2736250C (en) 2008-09-10 2016-12-20 Edison Pharmaceuticals, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
KR101395146B1 (ko) 2011-02-09 2014-05-16 부산대학교 산학협력단 피부미백, 항산화 및 ｐｐａｒ 활성을 갖는 신규 화합물 및 이의 의학적 용도
CN113024369A (zh) 2015-12-17 2021-06-25 Ptc医疗公司 用于治疗氧化应急障碍的化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3002989A1 (de) * 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
US4550022A (en) * 1981-10-05 1985-10-29 Alcon Laboratories, Inc. Tissue irrigating solution
FR2547729B1 (fr) * 1983-06-24 1986-05-02 Riker Laboratories Inc Medicament a base d'acide dl thiazolidine carboxylique
FR2547728B1 (fr) * 1983-06-24 1986-05-02 Riker Laboratories Inc Medicament a base d'acide d thiazolidine carboxylique
US4868114A (en) * 1987-08-05 1989-09-19 Regents Of The University Of Minnesota Method for elevating glutathione levels
IT1223565B (it) * 1987-12-21 1990-09-19 Zambon Spa Derivati dell'acido tiazolidin 4 carbossilico ad attivita' farmaceutica
JPH02202818A (ja) * 1988-12-09 1990-08-10 Allergan Inc 白内障の治療における２―置換―チアゾリジン―４―カルボン酸類の用途
US5589464A (en) * 1992-09-01 1996-12-31 Allergan Use of 2-substituted-thiazolidine-4-carboxylic acids for treatment of cataract
US5424321A (en) * 1993-12-08 1995-06-13 Alcon Laboratories, Inc. Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents
DK0682664T3 (da) * 1993-12-08 2001-07-16 Alcon Lab Inc Forbindelser med både potent calciumantagonist og antioxiderende aktivitet og anvendelse deraf som cytobeskyttende midler

Also Published As

Publication number Publication date
CA2220024A1 (en) 1997-10-02
EP0842165B1 (de) 2001-05-16
WO1997035852A1 (en) 1997-10-02
DE69704833D1 (en) 2001-06-21
PT842165E (pt) 2001-08-30
US5846988A (en) 1998-12-08
GR3036142T3 (en) 2001-09-28
EP0842165A1 (de) 1998-05-20
DK0842165T3 (da) 2001-08-06
AU2584097A (en) 1997-10-17
ATE201204T1 (de) 2001-06-15
AU713581B2 (en) 1999-12-02
ES2156633T3 (es) 2001-07-01
JPH11507081A (ja) 1999-06-22
CA2220024C (en) 2002-06-25

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee