GR3035438T3 - Compositions containing hydroperoxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders - Google Patents

Compositions containing hydroperoxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders

Info

Publication number
GR3035438T3
GR3035438T3 GR20010400269T GR20010400269T GR3035438T3 GR 3035438 T3 GR3035438 T3 GR 3035438T3 GR 20010400269 T GR20010400269 T GR 20010400269T GR 20010400269 T GR20010400269 T GR 20010400269T GR 3035438 T3 GR3035438 T3 GR 3035438T3
Authority
GR
Greece
Prior art keywords
methods
compositions containing
dry eye
acid derivatives
treating dry
Prior art date
Application number
GR20010400269T
Other languages
Greek (el)
English (en)
Inventor
John M Yanni
Daniel A Gamache
Steven T Miller
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of GR3035438T3 publication Critical patent/GR3035438T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GR20010400269T 1995-10-31 2001-02-20 Compositions containing hydroperoxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders GR3035438T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/551,021 US5696166A (en) 1995-10-31 1995-10-31 Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
PCT/US1996/013441 WO1997016179A1 (en) 1995-10-31 1996-08-19 Compositions containing hydroperoxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders

Publications (1)

Publication Number Publication Date
GR3035438T3 true GR3035438T3 (en) 2001-05-31

Family

ID=24199512

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010400269T GR3035438T3 (en) 1995-10-31 2001-02-20 Compositions containing hydroperoxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders

Country Status (12)

Country Link
US (1) US5696166A (https=)
EP (1) EP0858330B1 (https=)
JP (1) JPH11515024A (https=)
AT (1) ATE198044T1 (https=)
AU (1) AU706373B2 (https=)
CA (1) CA2234367C (https=)
DE (1) DE69611251T2 (https=)
DK (1) DK0858330T3 (https=)
ES (1) ES2152556T3 (https=)
GR (1) GR3035438T3 (https=)
PT (1) PT858330E (https=)
WO (1) WO1997016179A1 (https=)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1269484C (zh) * 1998-09-18 2006-08-16 艾尔科实验室公司 用于治疗青光眼的5－羟色胺激活性激动剂
AU2183900A (en) 1998-12-24 2000-07-31 Alcon Laboratories, Inc. Ep4 receptor agonists for treatment of dry eye
US6462080B1 (en) 1998-12-24 2002-10-08 Alcon Manufacturing, Ltd. Prostaglandin E receptor agonists for treatment of dry eye
TWI225398B (en) * 1999-07-14 2004-12-21 R Tech Ueno Ltd Composition for treatment of external secretion disorders
PL356127A1 (en) 1999-11-09 2004-06-14 Alcon Inc. Omega chain modified 15-hydroxyeicosatetraenoic acid derivatives and methods of their use for the treatment of dry eye
AU1101301A (en) * 1999-11-09 2001-06-06 Alcon Universal Limited 2,2-difluoro 15-hydroxyeicosatetraenoic acid analogs and methods of use
US6458854B2 (en) 1999-11-09 2002-10-01 Alcon Universal Ltd. Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
CA2388044A1 (en) * 1999-11-09 2001-05-17 Alcon, Inc. Hydroxyeicosatetraenoate salts, compositions and methods of use in treating dry eye disorders
EP1228026B1 (en) 1999-11-09 2004-01-02 Alcon Inc. 15-hydroxyeicosatetraenoic acid-related compounds and methods of use
US6353032B1 (en) 1999-11-09 2002-03-05 Alcon Universal Ltd. Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use
CA2386333A1 (en) * 1999-11-09 2001-05-17 Alcon, Inc. 3-heteroatom substituted and two carbon homologs 15-hete and methods of use
PT1418167E (pt) * 1999-11-09 2005-05-31 Alcon Inc Analogos do acido hidroxieicosatetraenoico e metodos para a sua utilizacao no tratamento de doencas do olho seco
EP1228030B1 (en) 1999-11-09 2005-06-01 Alcon Inc. Benzenoid derivatives of 15-hydroxyeicosatetraenoic acid and methods of their use in treating dry eye disorders
MXPA02004702A (es) * 1999-11-09 2004-09-10 Alcon Inc Analogos interrumpidos por heteroatomos de acido 15-hidroxieicosatetraenoico y metodos de uso.
US6803385B2 (en) 1999-11-09 2004-10-12 Alcon, Inc. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
DK1418167T3 (da) * 1999-11-09 2005-04-25 Alcon Inc Hydroxyicosatetraensyreanaloger og fremgangsmåder til deres anvendelse til behandling af öjentörhedslidelser
MXPA02004703A (es) 1999-11-09 2004-09-10 Alcon Inc Composiciones que contienen derivados de acido hidroxieicostetraenoico y metodos de uso para tratar trastornos de resequedad en los ojos.
US6552084B2 (en) 1999-11-09 2003-04-22 Alcon Universal Ltd. Hydroxyeicosatetraenoic acid analogs and methods of their use in treating dry eye disorders
ES2215752T3 (es) 1999-11-09 2004-10-16 Alcon, Inc Lipoxina a4 y analogos para el tratamiento del ojo seco.
US6320062B1 (en) 1999-11-09 2001-11-20 Alcon Universal Ltd. 15-hydroxyeicosatetraenoic acid analogs with enhanced metabolic stability and methods of their use in treating dry eye disorders
US6576663B2 (en) 1999-12-22 2003-06-10 Alcon, Inc. 6-Keto prostaglandin F1α and analogs for treating dry eye
US6277855B1 (en) * 2000-04-21 2001-08-21 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with nicotinic acetylcholine receptor agonists
US20020077358A1 (en) * 2000-10-23 2002-06-20 Alcon Universal Ltd. Use of hydroperoxyeicosatetraenoic acid derivatives following refractive surgery
DK1330246T3 (da) * 2000-10-23 2005-08-08 Alcon Inc Anvendelse af hydroxyicosatetraensyrederivater ved intraokulær kirurgi
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
DE60213230T2 (de) 2001-05-21 2006-11-23 Alcon Inc. Verwendung von NF-Kappa.B Inhibitoren zur Behandlung von Augentrockenheit
US7112588B2 (en) * 2001-05-21 2006-09-26 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
US6740674B2 (en) 2001-05-21 2004-05-25 Alcon, Inc. Use of proteasome inhibitors to treat dry eye disorders
US6872382B1 (en) 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
BR0209882A (pt) * 2001-05-21 2004-06-08 Alcon Inc Método para o tratamento de distúrbios de olho seco
US6645994B1 (en) 2001-06-01 2003-11-11 Alcon, Inc. Method of treating dry eye disorders
US6750250B1 (en) 2001-07-12 2004-06-15 Alcon, Inc. 11,12-oxidoarachidonic acid derivatives and methods of their use in treating dry eye disorders
WO2003030892A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye
US20030109508A1 (en) * 2001-10-11 2003-06-12 Alcon, Inc. Methods for treating dry eye
CA2462272A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye by a combination of an antiinflammatory steroid and a muc-1 secretagogue
WO2003105831A1 (en) * 2002-06-14 2003-12-24 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
WO2003105824A1 (en) * 2002-06-14 2003-12-24 Alcon, Inc. Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
FR2843026B1 (fr) * 2002-08-02 2006-01-06 Goemar Lab Sa Nouveau medicament
CA2497977A1 (en) * 2002-09-20 2004-04-01 Alcon, Inc. Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
AU2003303623A1 (en) * 2002-12-20 2004-07-29 Alcon, Inc. Treatment of dry eye by restoring 15-lipoxygenase activity to ocular surface cells
WO2004093878A1 (en) 2003-04-16 2004-11-04 Alcon, Inc. Use of fused pyridazine derivatives for treating dry eye disorders
US8455016B2 (en) 2004-03-12 2013-06-04 Melbj Holdings, Llc Treatment for meibomian gland dysfunction or obstruction
US20050202097A1 (en) * 2004-03-12 2005-09-15 Melbj Holdings, Llc, Florida Lubricant for the ocular surface
US7923471B2 (en) * 2004-05-14 2011-04-12 Alcon, Inc. Method of treating dry eye disorders and uveitis
CN100522147C (zh) * 2004-05-14 2009-08-05 爱尔康公司 5,6,7-三羟基庚酸及其类似物在制备治疗干眼病和眼色素层炎药物中的应用
US7223737B1 (en) 2004-08-13 2007-05-29 Alcon, Inc. Method of treating dry eye disorders using glycosides
US20070265353A1 (en) * 2004-08-27 2007-11-15 Senju Pharmaceutical Co., Ltd. Eye Drops for the Treatment of Dry Eye
WO2006065916A1 (en) * 2004-12-14 2006-06-22 Alcon, Inc. Method of treating dry eye disorders using 13(s)-hode and its analogs
US7745461B1 (en) 2006-02-27 2010-06-29 Alcon Research, Ltd. Method of treating dry eye disorders
US8541426B2 (en) * 2007-07-11 2013-09-24 Pfizer Inc. Pharmaceutical compositions and methods of treating dry eye disorders
US20090048368A1 (en) * 2007-08-13 2009-02-19 Bash Thomas F Polyolefin compositions comprising bio-based starch materials
JP5421272B2 (ja) * 2007-10-12 2014-02-19 リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド 眼病治療のための組成物及び方法
AU2014201375B2 (en) * 2007-10-12 2015-11-05 Resolvyx Pharmaceuticals, Inc. Omega-3 fatty acids, hydroxy polyunsaturated fatty acids, lipoxin compounds, or oxylipin compounds for the treatment of ophthalmic conditions
US20090098136A1 (en) * 2007-10-15 2009-04-16 Alcon Research, Ltd. Use of tnf receptor antagonists for treating dry eye
TW200927192A (en) * 2007-11-19 2009-07-01 Alcon Res Ltd Use of TRPV1 receptor antagonists for treating dry eye and ocular pain
US8207226B1 (en) 2008-06-03 2012-06-26 Alcon Research, Ltd. Use of FAAH antagonists for treating dry eye and ocular pain
GB0907413D0 (en) 2009-04-29 2009-06-10 Equateq Ltd Novel methods
WO2011057183A1 (en) 2009-11-06 2011-05-12 Alcon Research, Ltd. Nutritional supplements for relief of dry eye
EP3068757B1 (en) * 2013-11-15 2019-02-27 DS Biopharma Limited Lysine salt of 15-hydroxy-8(z),11(z),13(e)-eicosatrienoic acid
CN109311976A (zh) 2016-06-20 2019-02-05 诺华股份有限公司 使用TNFα拮抗剂治疗干眼症的方法
US20210315851A1 (en) 2020-04-03 2021-10-14 Afimmune Limited Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991759A (en) * 1975-10-28 1976-11-16 Alza Corporation Method and therapeutic system for treating aqueous deficient dry eye
US4131651A (en) * 1977-10-25 1978-12-26 Barnes-Hind Pharmaceuticals, Inc. Treatment of dry eye
US4409205A (en) * 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4370325A (en) * 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
AU546872B2 (en) * 1982-06-16 1985-09-26 Unilever Plc Skin treatment compositions containing a fatty acid or ester
GB8319073D0 (en) * 1983-07-14 1983-08-17 Efamol Ltd Fatty acid compositions
US4883658A (en) * 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
US4744980A (en) * 1986-04-28 1988-05-17 Holly Frank J Ophthalmic solution for treatment of dry eye syndrome
US4818537A (en) * 1986-10-21 1989-04-04 Liposome Technology, Inc. Liposome composition for treating dry eye
US4966773A (en) * 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
US4914088A (en) * 1987-04-02 1990-04-03 Thomas Glonek Dry eye treatment solution and method
US4906467A (en) * 1988-03-24 1990-03-06 New York Medical College Novel, long-duration treatment for glaucoma
US5075104A (en) * 1989-03-31 1991-12-24 Alcon Laboratories, Inc. Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
US5041434A (en) * 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
DE69115990T2 (de) * 1990-05-29 1996-05-30 Ocular Res Of Bonton Inc Zusammensetzung zur Behandlung von Dry Eye Erkrankungen
US5102670A (en) * 1990-09-14 1992-04-07 Abraham Nader G Method for treating eye disorders by reducing 12(r)-hydroxyeicosatetraenoic acid and 12(r)-dihydroxyeicosatrienoic acid levels
ATE141502T1 (de) * 1991-01-15 1996-09-15 Alcon Lab Inc Verwendung von karrageenan in topischen ophthalmologischen zusammensetzungen
EP0546728A3 (en) * 1991-12-13 1993-09-08 Alcon Laboratories Inc Physiological tear compositions and methods for their preparation
US5290572A (en) * 1992-08-06 1994-03-01 Deo Corporation Opthalmic composition for treating dry eye
US5358706A (en) * 1992-09-30 1994-10-25 Union Carbide Chemicals & Plastics Technology Corporation Muco-adhesive polymers
US5389383A (en) * 1993-06-18 1995-02-14 Allergan, Inc. Method for treating hypoxia-associated ocular complications

Also Published As

Publication number Publication date
CA2234367C (en) 2002-06-04
DE69611251T2 (de) 2001-04-05
EP0858330A1 (en) 1998-08-19
JPH11515024A (ja) 1999-12-21
WO1997016179A1 (en) 1997-05-09
ES2152556T3 (es) 2001-02-01
ATE198044T1 (de) 2000-12-15
DK0858330T3 (da) 2001-01-02
HK1013194A1 (en) 1999-08-20
PT858330E (pt) 2001-03-30
EP0858330B1 (en) 2000-12-13
CA2234367A1 (en) 1997-05-09
US5696166A (en) 1997-12-09
AU706373B2 (en) 1999-06-17
DE69611251D1 (de) 2001-01-18
AU6851696A (en) 1997-05-22

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Legal Events

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