GR3034906T3 - Indoletetralins having dopaminergic activity - Google Patents

Indoletetralins having dopaminergic activity

Info

Publication number
GR3034906T3
GR3034906T3 GR20000402612T GR20000402612T GR3034906T3 GR 3034906 T3 GR3034906 T3 GR 3034906T3 GR 20000402612 T GR20000402612 T GR 20000402612T GR 20000402612 T GR20000402612 T GR 20000402612T GR 3034906 T3 GR3034906 T3 GR 3034906T3
Authority
GR
Greece
Prior art keywords
alkyl
halogen
pct
hydrogen
phenyl
Prior art date
Application number
GR20000402612T
Other languages
English (en)
Inventor
Bengt Ronny Andersson
Per Arvid Emil Carlsson
Lars Olov Hansson
Clas Ake Sonesson
Nils Peter Stjernlof
Kjell Anders Ivan Svensson
Ross Nicholas Waters
Susanne R Haadsma-Svensson
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GR3034906T3 publication Critical patent/GR3034906T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
GR20000402612T 1993-03-25 2000-11-24 Indoletetralins having dopaminergic activity GR3034906T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3756893A 1993-03-25 1993-03-25
PCT/US1994/002800 WO1994021608A1 (en) 1993-03-25 1994-03-21 Indoletetralins having dopaminergic activity

Publications (1)

Publication Number Publication Date
GR3034906T3 true GR3034906T3 (en) 2001-02-28

Family

ID=21895045

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000402612T GR3034906T3 (en) 1993-03-25 2000-11-24 Indoletetralins having dopaminergic activity

Country Status (13)

Country Link
US (1) US5639778A (el)
EP (1) EP0690843B1 (el)
JP (1) JP3298885B2 (el)
AT (1) ATE195935T1 (el)
AU (1) AU679053B2 (el)
DE (1) DE69425736T2 (el)
DK (1) DK0690843T3 (el)
ES (1) ES2149869T3 (el)
GR (1) GR3034906T3 (el)
LV (1) LV12792B (el)
NZ (1) NZ263403A (el)
PT (1) PT690843E (el)
WO (1) WO1994021608A1 (el)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002064091A2 (en) * 2001-02-13 2002-08-22 Palatin Technologies, Inc. Melanocortin metallopeptides for treatment of sexual dysfunction
CN1159292C (zh) * 1996-05-31 2004-07-28 法玛西雅厄普约翰美国公司 用作选择性多巴胺d3配体的芳基取代的环胺类化合物
FR2763335B1 (fr) * 1997-05-16 2000-11-24 Adir Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IT1292155B1 (it) * 1997-06-13 1999-01-25 Zambon Spa Derivati naftotiazolonici attivi sul recettore dopaminergico d 3
US6974831B2 (en) * 2000-12-18 2005-12-13 Eli Lilly And Company sPLA2 inhibitors
WO2003013571A1 (en) * 2001-08-10 2003-02-20 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
US7732451B2 (en) * 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7456184B2 (en) * 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7053223B2 (en) * 2003-02-14 2006-05-30 Bristol-Myers Squibb Company Inhibitors of farnesyl protein transferase
US7227023B2 (en) 2003-04-30 2007-06-05 Wyeth Quinoline 3-amino chroman derivatives
US7968548B2 (en) * 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
WO2006040178A1 (en) * 2004-10-14 2006-04-20 Abbott Gmbh & Co.Kg Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to madulation of the dopamine d3 receptor
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
UY32442A (es) * 2009-02-13 2010-09-30 Sanofi Aventis Nuevos indanos sustituidos, procesos para su preparacion y uso de los mismos como un medicamento
RS65417B1 (sr) 2014-01-24 2024-05-31 Turning Point Therapeutics Inc Diaril makrocikli kao modulatori protein kinaza
WO2017004342A1 (en) 2015-07-02 2017-01-05 Tp Therapeutics, Inc. Chiral diaryl macrocycles as modulators of protein kinases
DK3325488T3 (da) 2015-07-21 2020-09-14 Turning Point Therapeutics Inc Chiral diaryl-makrocyklus og anvendelse deraf til behandling af cancer
SG11201900163PA (en) 2016-07-28 2019-02-27 Tp Therapeutics Inc Macrocycle kinase inhibitors
TWI808958B (zh) 2017-01-25 2023-07-21 美商特普醫葯公司 涉及二芳基巨環化合物之組合療法
WO2018151240A1 (ja) * 2017-02-17 2018-08-23 第一三共株式会社 ３，６，７，８－テトラヒドロシクロペンタ［ｅ］インドール化合物
IL271964B1 (en) 2017-07-28 2024-08-01 Turning Point Therapeutics Inc Macrocyclic compounds and their uses
WO2019126122A1 (en) * 2017-12-19 2019-06-27 Tp Therapeutics, Inc. Macrocyclic kinase inhibitors and their use
SI3728271T1 (sl) * 2017-12-19 2023-01-31 Turning Point Therapeutics, Inc. Makrociklične spojine za zdravljenje bolezni
WO2022032147A1 (en) * 2020-08-06 2022-02-10 Tactogen Inc 2-aminoindane compounds for mental disorders or enhancement
CN112724068A (zh) * 2020-12-30 2021-04-30 蔡桂坡 具有hdac抑制活性的吲哚类衍生物的合成方法及肿瘤应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060626A (en) * 1972-01-26 1977-11-29 Boehringer Mannheim G.M.B.H. Indole-carboxylic carbon compounds and pharmaceutical compositions containing them
DE2740836A1 (de) * 1977-09-10 1979-03-22 Troponwerke Gmbh & Co Kg Anellierte indolderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
CA1159459A (en) * 1980-12-11 1983-12-27 Andre A. Asselin 6,7,8,9-tetrahydro-3h-benz¬e| indolamine derivatives
US4510157A (en) * 1982-12-27 1985-04-09 Ayerst, Mckenna & Harrison, Inc. 6,7,8,9-Tetrahydro-1H-benz(g)indol-8-amine derivatives
US4470990A (en) * 1983-03-14 1984-09-11 Ayerst, Mckenna & Harrison Inc. 6,7,8,9-Tetrahydronaphtho(1,2-B)furan-8-amine derivatives and their use as dopamine receptor stimulants
FR2613365B1 (fr) * 1987-04-01 1989-07-28 Adir Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2613364B1 (fr) * 1987-04-01 1989-06-09 Adir Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
EP0510068B1 (en) * 1990-01-11 1999-04-14 PHARMACIA & UPJOHN COMPANY NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS

Also Published As

Publication number Publication date
JPH08508251A (ja) 1996-09-03
EP0690843A1 (en) 1996-01-10
DE69425736D1 (de) 2000-10-05
ATE195935T1 (de) 2000-09-15
EP0690843B1 (en) 2000-08-30
NZ263403A (en) 1996-10-28
WO1994021608A1 (en) 1994-09-29
DE69425736T2 (de) 2001-04-12
ES2149869T3 (es) 2000-11-16
LV12792B (en) 2002-06-20
LV12792A (en) 2002-02-20
PT690843E (pt) 2001-01-31
US5639778A (en) 1997-06-17
DK0690843T3 (da) 2000-11-13
JP3298885B2 (ja) 2002-07-08
AU6408694A (en) 1994-10-11
AU679053B2 (en) 1997-06-19

Similar Documents

Publication Publication Date Title
GR3034906T3 (en) Indoletetralins having dopaminergic activity
MY131641A (en) Indoline derivatives, process of preparation and use
MX9801578A (es) Feniloxazolidinonas que tienen un enlace c-c para anillos heterociclicos de 4-8 miembros.
EP0352123A3 (en) 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
ZA89389B (en) Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia
GR3033629T3 (en) Novel piprazine carboxamides.
ES8505942A1 (es) Un procedimiento para la preparacion de derivados de urea
TW328957B (en) Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
EP0397613A3 (en) Pharmacologically active aminoimidazopyridines
ZA851698B (en) Pharmacologically active piperidine derivatives and their use
SE8800863D0 (sv) 3-(2-haloethyl)-1,4-oxathiins and 2-(2-haloethyl)-1,4-dithiins and treatment of leukemia and tumors therewith
ES2020012A6 (es) Procedimiento para la obtencion de un preparado farmaceutico antimicrobiano de uso topico.
AU588656B2 (en) New fluorine-containing 1,4-dihydropyridines, process for their preparation and their use as medicaments
ES8604122A1 (es) Procedimiento de preparacion de eteres oximas basicos y de sus sales de adicion acidas farmaceuticamente aceptables
CA2157586A1 (en) Indoletetralins having dopaminergic activity
ATE81466T1 (de) Verwendung von 2-oxo-imidazolidin-derivaten zur prophylaxe und zur behandlung von herzinsuffizienz.
MX9801838A (es) Derivados de 4-(cicloalquil)piperidinas y de 4-(cicloalquilalquil)piperidinas, su preparacion y su aplicacion terapeutica.
MX9709833A (es) Uso de benzimidazoles para la fabricacion de un medicamento para el tratamiento de leucemia.

Legal Events

Date Code Title Description
ML Lapse due to non-payment of fees