GR3026251T3 - New leukotriene-b 4? antagonists, process for preparing the same and their use as medicaments. - Google Patents

New leukotriene-b 4? antagonists, process for preparing the same and their use as medicaments.

Info

Publication number
GR3026251T3
GR3026251T3 GR980400427T GR980400427T GR3026251T3 GR 3026251 T3 GR3026251 T3 GR 3026251T3 GR 980400427 T GR980400427 T GR 980400427T GR 980400427 T GR980400427 T GR 980400427T GR 3026251 T3 GR3026251 T3 GR 3026251T3
Authority
GR
Greece
Prior art keywords
pct
antagonists
date mar
para
meta
Prior art date
Application number
GR980400427T
Other languages
English (en)
Inventor
Bernd Buchmann
Werner Skuballa
Josef Heindl
Wolfgang Froehlich
Roland Ekerdt
Claudia Giesen
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of GR3026251T3 publication Critical patent/GR3026251T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GR980400427T 1992-08-25 1998-02-27 New leukotriene-b 4? antagonists, process for preparing the same and their use as medicaments. GR3026251T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4228201A DE4228201A1 (de) 1992-08-25 1992-08-25 Neue Leukotrien-B¶4¶-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1993/002225 WO1994004522A1 (de) 1992-08-25 1993-08-19 Neue leukotrien-b4-antagonisten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
GR3026251T3 true GR3026251T3 (en) 1998-05-29

Family

ID=6466382

Family Applications (1)

Application Number Title Priority Date Filing Date
GR980400427T GR3026251T3 (en) 1992-08-25 1998-02-27 New leukotriene-b 4? antagonists, process for preparing the same and their use as medicaments.

Country Status (11)

Country Link
US (1) US5559134A (el)
EP (1) EP0656896B1 (el)
JP (1) JPH08500585A (el)
AT (1) ATE161255T1 (el)
AU (1) AU684724B2 (el)
CA (1) CA2142821A1 (el)
DE (2) DE4228201A1 (el)
ES (1) ES2112428T3 (el)
GR (1) GR3026251T3 (el)
HU (1) HUT70511A (el)
WO (1) WO1994004522A1 (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342510B1 (en) 1995-06-12 2002-01-29 G. D. Searle & Co. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist
ATE296114T1 (de) 1996-02-13 2005-06-15 Searle & Co Zubereitungen, enthaltend einen cyclooxygenase-2- inhibitor und einen leukotrien-b4-rezeptor- antagonisten
DE10121252A1 (de) * 2001-04-30 2002-11-07 Christos C Zouboulis Behandlung der Akne
CN1606552A (zh) * 2001-12-21 2005-04-13 H.隆德贝克有限公司 氨基茚满衍生物作为5－羟色胺和去甲肾上腺素摄取抑制剂
US20060019269A1 (en) * 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
US7507531B2 (en) * 2002-10-17 2009-03-24 Decode Genetics Chf. Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction
WO2005027886A2 (en) * 2003-09-17 2005-03-31 Decode Genetics Ehf. Methods of preventing or treating recurrence of myocardial infarction
US7851486B2 (en) * 2002-10-17 2010-12-14 Decode Genetics Ehf. Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
EP1579010A4 (en) * 2002-10-17 2010-07-21 Decode Genetics Ehf SUSCEPTIBILITY GENE FOR MYOCARDIAL INFARCTION AND METHODS OF TREATMENT
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
TW200819426A (en) * 2006-08-31 2008-05-01 Lundbeck & Co As H Novel indane compounds
US8202686B2 (en) * 2007-03-22 2012-06-19 Advanced Liquid Logic, Inc. Enzyme assays for a droplet actuator
US8093253B2 (en) * 2008-03-06 2012-01-10 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors
US8088936B2 (en) * 2009-03-23 2012-01-03 Hoffman-La Roche Inc. Leukotriene B4 inhibitors
EP2516669B1 (en) 2009-12-21 2016-10-12 Advanced Liquid Logic, Inc. Enzyme assays on a droplet actuator
US9513253B2 (en) 2011-07-11 2016-12-06 Advanced Liquid Logic, Inc. Droplet actuators and techniques for droplet-based enzymatic assays
TW201328692A (zh) * 2011-10-11 2013-07-16 Univ Osaka 脫髓鞘疾病之治療劑及預防劑

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL69691A (en) * 1982-09-23 1988-01-31 Merck Frosst Canada Inc Leukotriene antagonists,their preparation and pharmaceutical compositions containing them
JPH0819041B2 (ja) * 1987-09-10 1996-02-28 杏林製薬株式会社 フェノキシアルキルカルボン酸誘導体及びその製造法
GB8927287D0 (en) * 1988-12-23 1990-01-31 Ici Plc Cyclic ether derivatives

Also Published As

Publication number Publication date
AU4950593A (en) 1994-03-15
CA2142821A1 (en) 1994-03-03
US5559134A (en) 1996-09-24
EP0656896A1 (de) 1995-06-14
DE59307863D1 (de) 1998-01-29
DE4228201A1 (de) 1994-03-03
ATE161255T1 (de) 1998-01-15
WO1994004522A1 (de) 1994-03-03
ES2112428T3 (es) 1998-04-01
HU9500587D0 (en) 1995-04-28
AU684724B2 (en) 1998-01-08
JPH08500585A (ja) 1996-01-23
HUT70511A (en) 1995-10-30
EP0656896B1 (de) 1997-12-17

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