GR3024054T3 - Purine derivatives as interleukin-1 inhibitors - Google Patents

Purine derivatives as interleukin-1 inhibitors

Info

Publication number
GR3024054T3
GR3024054T3 GR970401709T GR970401709T GR3024054T3 GR 3024054 T3 GR3024054 T3 GR 3024054T3 GR 970401709 T GR970401709 T GR 970401709T GR 970401709 T GR970401709 T GR 970401709T GR 3024054 T3 GR3024054 T3 GR 3024054T3
Authority
GR
Greece
Prior art keywords
interleukin
inhibitors
purine derivatives
alleviation
implicated
Prior art date
Application number
GR970401709T
Other languages
English (en)
Inventor
Gerald L Mandell
Gail W Sullivan
William J Novick Jr
Original Assignee
Univ Virginia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Virginia filed Critical Univ Virginia
Publication of GR3024054T3 publication Critical patent/GR3024054T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR970401709T 1986-12-31 1997-07-09 Purine derivatives as interleukin-1 inhibitors GR3024054T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94790586A 1986-12-31 1986-12-31

Publications (1)

Publication Number Publication Date
GR3024054T3 true GR3024054T3 (en) 1997-10-31

Family

ID=25486973

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970401709T GR3024054T3 (en) 1986-12-31 1997-07-09 Purine derivatives as interleukin-1 inhibitors

Country Status (14)

Country Link
EP (1) EP0279079B1 (el)
JP (1) JP2507012B2 (el)
KR (1) KR960015726B1 (el)
AT (1) ATE151290T1 (el)
AU (1) AU668982B2 (el)
CA (1) CA1313137C (el)
DE (1) DE3752048T2 (el)
DK (1) DK482088A (el)
ES (1) ES2103255T3 (el)
GR (1) GR3024054T3 (el)
IE (1) IE873554L (el)
IL (7) IL106861A (el)
WO (1) WO1988004928A1 (el)
ZA (1) ZA879754B (el)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272153A (en) * 1986-12-31 1993-12-21 Hoechst-Roussel Pharmaceuticals, Inc. Method of inhibiting the activity of leukocyte derived cytokines
US5196429A (en) * 1986-12-31 1993-03-23 Hoechst-Roussel Pharmaceuticals Inc. Method of inhibiting the activity of leukocyte derived cytokines
US5196430A (en) * 1986-12-31 1993-03-23 Hoechst-Roussel Pharmaceuticals Inc. Method of inhibiting the activity of leukocyte derived cytokines
US4965271A (en) * 1986-12-31 1990-10-23 Hoechst Roussel Pharmaceuticals, Inc. Method of inhibiting the activity of leukocyte derived cytokines
JPH04506215A (ja) * 1989-06-13 1992-10-29 スミスクライン・ビーチャム・コーポレイション モノカイン活性干渉
DD298051A5 (de) * 1989-08-16 1992-02-06 ��@���������@�������k�� Verfahren zur herstellung eines therapeutischen agens zur behandlung von verdauungskrankheiten
US6420374B1 (en) 1990-11-30 2002-07-16 Fred Hutchinson Cancer Research Center Use of xanthines as immunosuppressants and to inhibit allograft reactions
IL100195A0 (en) * 1990-11-30 1992-08-18 Hoechst Roussel Pharma Use of xanthines for the preparation of a medicament having immuno suppressing activity
IL100194A0 (en) * 1990-11-30 1992-08-18 Hoechst Roussel Pharma Use of xanthines for the preparation of a medicament effective for inhibiting the effects of allograft reaction in humans
JP3566719B2 (ja) * 1991-05-24 2004-09-15 フレッド ハッチンソン キャンサー リサーチ センター 外来性刺激に対する細胞性応答の調整
EP0518263A1 (en) * 1991-06-10 1992-12-16 Hoechst-Roussel Pharmaceuticals Incorporated Micropellets and a process for their manufacture
WO1993003728A1 (en) * 1991-08-27 1993-03-04 Temple University Of The Commonwealth System Of Xanthine suppression of antigen activation of t- or b-cells
JP3623501B2 (ja) * 1991-10-31 2005-02-23 ザ ビクトリア ユニバーシティ オブ マンチェスター インターロイキン−１阻害化合物による神経病学的状態の治療
WO1996005836A2 (en) * 1994-08-25 1996-02-29 Medical University Of South Carolina Methods of treating cold symptoms using pentoxifylline
US5856330A (en) * 1996-07-31 1999-01-05 Hoechst Aktiengesellschaft Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
US5981536A (en) * 1996-07-31 1999-11-09 Hoechst Aktiengesellschaft Use of xanthine derivatives for the modulation of apoptosis
JP3830115B2 (ja) * 1997-10-06 2006-10-04 シャープ株式会社 液晶表示素子
TW561297B (en) * 1997-11-25 2003-11-11 Toshiba Corp Electrode wiring board subjected to counter measure against static electricity and display device using the same
JP3019053B2 (ja) * 1997-12-25 2000-03-13 日本電気株式会社 液晶表示装置及びその製造方法
US20090239886A1 (en) 2008-02-29 2009-09-24 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
US20110053961A1 (en) 2009-02-27 2011-03-03 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
JP2013503883A (ja) 2009-09-02 2013-02-04 コンサート ファーマシューティカルズ インコーポレイテッド 置換キサンチン誘導体
EP2611807A2 (en) 2010-09-01 2013-07-10 Concert Pharmaceuticals Inc. Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3-7-dimethyl-1h-purine-2,6(3h,7h)dione
WO2013013052A1 (en) 2011-07-19 2013-01-24 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
IN2014DN08443A (el) 2012-04-13 2015-05-08 Concert Pharmaceuticals Inc
WO2013159006A1 (en) 2012-04-20 2013-10-24 Concert Pharmaceuticals, Inc. Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3,7-dimethyl-1h-purine-2,6(3h,7h)-dione

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2967632D1 (en) * 1978-04-22 1986-12-04 Beecham Wuelfing Gmbh & Co Kg Use of a xanthine derivate in the manufacture of a medicament
US4567183A (en) * 1983-03-11 1986-01-28 Analgesic Associates Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
US4636507A (en) * 1984-04-30 1987-01-13 Hoechst-Roussel Pharmaceuticals Inc. Host defense mechanism enhancement
GB8418430D0 (en) * 1984-07-19 1984-08-22 Beecham Wuelfing Gmbh & Co Kg Treatment

Also Published As

Publication number Publication date
CA1313137C (en) 1993-01-26
IE873554L (en) 1988-06-30
DE3752048D1 (de) 1997-05-15
IL100535A (en) 1994-05-30
EP0279079A2 (en) 1988-08-24
KR890700347A (ko) 1989-04-24
DK482088A (da) 1988-10-28
EP0279079A3 (en) 1990-06-13
AU4602793A (en) 1993-11-18
IL100533A (en) 1994-05-30
AU1150588A (en) 1988-07-27
AU619732B2 (en) 1992-02-06
IL106859A (en) 1996-10-16
IL106854A (en) 1996-05-14
IL84934A (en) 1994-08-26
JPH02501829A (ja) 1990-06-21
IL100536A (en) 1994-05-30
AU668982B2 (en) 1996-05-23
JP2507012B2 (ja) 1996-06-12
ATE151290T1 (de) 1997-04-15
IL106861A (en) 1997-02-18
AU637542B2 (en) 1993-05-27
DK482088D0 (da) 1988-08-30
EP0279079B1 (en) 1997-04-09
AU1291892A (en) 1992-05-14
ES2103255T3 (es) 1997-09-16
WO1988004928A1 (en) 1988-07-14
ZA879754B (en) 1989-07-26
KR960015726B1 (ko) 1996-11-20
DE3752048T2 (de) 1997-10-02

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