GR3023932T3 - Pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them - Google Patents

Pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them

Info

Publication number
GR3023932T3
GR3023932T3 GR970401580T GR970401580T GR3023932T3 GR 3023932 T3 GR3023932 T3 GR 3023932T3 GR 970401580 T GR970401580 T GR 970401580T GR 970401580 T GR970401580 T GR 970401580T GR 3023932 T3 GR3023932 T3 GR 3023932T3
Authority
GR
Greece
Prior art keywords
group
optionally substituted
thromboxane
pharmaceuticals
saturated
Prior art date
Application number
GR970401580T
Other languages
English (en)
Inventor
Gilbert Lavielle
Thierry Dubuffet
Olivier Muller
Michel Laubie
Tony Verbeuren
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of GR3023932T3 publication Critical patent/GR3023932T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
GR970401580T 1992-02-12 1997-06-30 Pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them GR3023932T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9201523A FR2687146B1 (fr) 1992-02-12 1992-02-12 Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
GR3023932T3 true GR3023932T3 (en) 1997-09-30

Family

ID=9426530

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970401580T GR3023932T3 (en) 1992-02-12 1997-06-30 Pyrrolidine derivatives substituted in the 3-position with a saturated or insaturated fatty acid group, process for their preparation and pharmaceuticals with thromboxane A2 inhibiting activity containing them

Country Status (13)

Country Link
US (2) US5387591A (el)
EP (1) EP0556119B1 (el)
JP (1) JPH0739385B2 (el)
AT (1) ATE153016T1 (el)
AU (1) AU655868B2 (el)
CA (1) CA2089349C (el)
DE (1) DE69310567T2 (el)
DK (1) DK0556119T3 (el)
ES (1) ES2105145T3 (el)
FR (1) FR2687146B1 (el)
GR (1) GR3023932T3 (el)
NZ (1) NZ245884A (el)
ZA (1) ZA93996B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2685325B1 (fr) * 1991-12-20 1994-02-04 Adir Cie Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2722194B1 (fr) * 1994-07-06 1996-08-23 Adir Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent
JP4057088B2 (ja) * 1996-04-22 2008-03-05 株式会社カネカ ピロリジン誘導体の製造方法
JP2002504088A (ja) * 1996-12-06 2002-02-05 アボツト・ラボラトリーズ ベンゾピラノピロール及びベンゾピラノピリジンアルファ−１アドレナリン作用性化合物
US5891882A (en) * 1996-12-06 1999-04-06 Abbott Laboratories Benzopyranopyrrole and benzopyranopyridine α-1 adenergic compounds
TWI274750B (en) 1999-01-12 2007-03-01 Abbott Gmbh & Co Kg Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same
GB0002100D0 (en) * 2000-01-28 2000-03-22 Novartis Ag Organic compounds
TW200302717A (en) * 2002-02-06 2003-08-16 Schering Corp Novel gamma secretase inhibitors
CN1859914A (zh) * 2003-09-30 2006-11-08 默克公司 苯基吡咯烷醚速激肽受体拮抗剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86173A (en) * 1987-05-01 1992-02-16 Fujisawa Pharmaceutical Co Pyrrolidine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
JPH0798795B2 (ja) * 1987-05-08 1995-10-25 塩野義製薬株式会社 スルホンアミド置換不飽和脂肪酸
US5130323A (en) * 1988-10-31 1992-07-14 Fujisawa Pharmaceutical Co., Ltd. Pyrrolidine derivatives
US5128366A (en) * 1990-07-05 1992-07-07 Shinogi & Co., Ltd. Pyrrole derivatives
US5157128A (en) * 1990-11-30 1992-10-20 Warner-Lambert Company Certain optically active substituted α,α-dialkyl-pyrrolidine-3-methamines useful as intermediates
FR2685325B1 (fr) * 1991-12-20 1994-02-04 Adir Cie Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
FR2687146B1 (fr) 1994-04-01
JPH0739385B2 (ja) 1995-05-01
ES2105145T3 (es) 1997-10-16
ZA93996B (en) 1993-09-20
AU3301093A (en) 1993-08-19
DK0556119T3 (da) 1997-12-15
AU655868B2 (en) 1995-01-12
DE69310567T2 (de) 1997-12-18
NZ245884A (en) 1994-11-25
CA2089349A1 (fr) 1993-08-13
CA2089349C (fr) 2001-10-16
DE69310567D1 (de) 1997-06-19
EP0556119A1 (fr) 1993-08-18
EP0556119B1 (fr) 1997-05-14
FR2687146A1 (fr) 1993-08-13
US5387591A (en) 1995-02-07
ATE153016T1 (de) 1997-05-15
US5407946A (en) 1995-04-18
JPH069552A (ja) 1994-01-18

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